The document provides an overview of MADARA Cosmetics Group, an organic cosmetics innovator. It summarizes the company's structure, research and development processes, certifications, hero products, and product range. Key points include that MADARA has a diverse product portfolio including face care, baby care, hair care and body care products. It also details the research behind their flagship anti-aging product using birch water extracts and cell repair bio-complex.
CD Bioparticles is a company that provides customized nanoliposome solutions for drug delivery and cosmetic formulation development. They offer a range of nanoliposomal products encapsulating various active ingredients for cosmetic applications. Some key benefits of nanoliposomes include overcoming issues like low penetration and stability of active ingredients, as well as improving bioavailability. CD Bioparticles provides GMP-grade nanoliposomes using FDA-approved materials to encapsulate ingredients like vitamins, antioxidants, and other natural actives for skin care products.
CD Bioparticles is a company that provides customized nanoliposome solutions for drug delivery and cosmetic formulation development. They offer a range of nanoliposomal products encapsulating various active ingredients for cosmetic applications. Some key benefits of nanoliposomes include overcoming issues like low penetration and stability of active ingredients, as well as improving bioavailability. CD Bioparticles provides GMP-grade nanoliposomes using FDA-approved materials to encapsulate ingredients like vitamins, antioxidants, and other natural actives for skin care products.
Vida-Care Universal Suncreen Blends – The secret to overcoming formulation ch...Mandeesh Suman
The sun protection market is driven by rising consumer awareness about sun protection and skin health, which is fueling growth across all segments including skin care and cosmetics. The availability of sunscreens in various Personal Care categories such as anti-wrinkle lotions, daily wear, cosmetics, children’s and baby care products is also driving suncare product sales.
Lambson has explored the challenges modern formulators come across when meeting consumer demands for UV protection across a broad range of products. Our technical expertise addresses how to overcome such challenges and demonstrates how Vida‐Care Universal Sunscreen Blends (USB’s) can be incorporated into your products with ease. The ready-to-use ingredients are proprietary blends of sunscreen actives, designed to provide photo‐stable broad spectrum UV‐A and UV-B protection. The actives have been selected and blended to work synergistically with each other to provide maximum performance benefits, while remaining within the scope of the EU Cosmetics Regulation.
Presenting up to date market research, we will show the audience how Vida-Care USB’s can be used to overcome formulation challenges faced in a competitive market. Focusing on consumer trends and demands, Lambson is excited to showcase their innovative samples which will be displayed during the seminar.
Vida-Care Universal Suncreen Blends – The secret to overcoming formulation ch...Mandeesh Suman
This document discusses Lambson's Vida-Care Universal Sunscreen Blends (USBs) which are ready-made sunscreen systems that offer formulation flexibility and can provide SPF protection levels from 6-50+ when added to products. The USBs solve challenges of adding UV protection to cosmetics by ensuring broad-spectrum protection, photo-stability, and compatibility. They are suitable for a wide range of formulations like creams, lotions, and sprays. The document provides details on three USB products, their properties, recommended use levels, and advantages for formulators.
Levan has great potential as a functional biopolymer in foods, feeds, cosmetics, and the pharmaceutical and chemical industries. Levan is also shown to exert excellent cell-proliferating, skin moisturizing, and skin irritation-alleviating effects as a blending component in cosmetics. Levan derivatives such as sulphated, phosphated, or acetylated levans are asserted to be anti-ADIS agents. In addition, levan is used as a coating material in a drug delivery formulation moreover has a number of industrial applications such as surfactant for household use due to its excellent surface-active properties, a glycol/levan aqueous two-phase system for the partitioning of proteins, etc.
The document provides an overview of MADARA Cosmetics Group, an organic cosmetics innovator. It summarizes the company's structure, research and development processes, certifications, hero products, and product range. Key points include that MADARA has a diverse product portfolio including face care, baby care, hair care and body care products. It also details the research behind their flagship anti-aging product using birch water extracts and cell repair bio-complex.
CD Bioparticles is a company that provides customized nanoliposome solutions for drug delivery and cosmetic formulation development. They offer a range of nanoliposomal products encapsulating various active ingredients for cosmetic applications. Some key benefits of nanoliposomes include overcoming issues like low penetration and stability of active ingredients, as well as improving bioavailability. CD Bioparticles provides GMP-grade nanoliposomes using FDA-approved materials to encapsulate ingredients like vitamins, antioxidants, and other natural actives for skin care products.
CD Bioparticles is a company that provides customized nanoliposome solutions for drug delivery and cosmetic formulation development. They offer a range of nanoliposomal products encapsulating various active ingredients for cosmetic applications. Some key benefits of nanoliposomes include overcoming issues like low penetration and stability of active ingredients, as well as improving bioavailability. CD Bioparticles provides GMP-grade nanoliposomes using FDA-approved materials to encapsulate ingredients like vitamins, antioxidants, and other natural actives for skin care products.
Vida-Care Universal Suncreen Blends – The secret to overcoming formulation ch...Mandeesh Suman
The sun protection market is driven by rising consumer awareness about sun protection and skin health, which is fueling growth across all segments including skin care and cosmetics. The availability of sunscreens in various Personal Care categories such as anti-wrinkle lotions, daily wear, cosmetics, children’s and baby care products is also driving suncare product sales.
Lambson has explored the challenges modern formulators come across when meeting consumer demands for UV protection across a broad range of products. Our technical expertise addresses how to overcome such challenges and demonstrates how Vida‐Care Universal Sunscreen Blends (USB’s) can be incorporated into your products with ease. The ready-to-use ingredients are proprietary blends of sunscreen actives, designed to provide photo‐stable broad spectrum UV‐A and UV-B protection. The actives have been selected and blended to work synergistically with each other to provide maximum performance benefits, while remaining within the scope of the EU Cosmetics Regulation.
Presenting up to date market research, we will show the audience how Vida-Care USB’s can be used to overcome formulation challenges faced in a competitive market. Focusing on consumer trends and demands, Lambson is excited to showcase their innovative samples which will be displayed during the seminar.
Vida-Care Universal Suncreen Blends – The secret to overcoming formulation ch...Mandeesh Suman
This document discusses Lambson's Vida-Care Universal Sunscreen Blends (USBs) which are ready-made sunscreen systems that offer formulation flexibility and can provide SPF protection levels from 6-50+ when added to products. The USBs solve challenges of adding UV protection to cosmetics by ensuring broad-spectrum protection, photo-stability, and compatibility. They are suitable for a wide range of formulations like creams, lotions, and sprays. The document provides details on three USB products, their properties, recommended use levels, and advantages for formulators.
Levan has great potential as a functional biopolymer in foods, feeds, cosmetics, and the pharmaceutical and chemical industries. Levan is also shown to exert excellent cell-proliferating, skin moisturizing, and skin irritation-alleviating effects as a blending component in cosmetics. Levan derivatives such as sulphated, phosphated, or acetylated levans are asserted to be anti-ADIS agents. In addition, levan is used as a coating material in a drug delivery formulation moreover has a number of industrial applications such as surfactant for household use due to its excellent surface-active properties, a glycol/levan aqueous two-phase system for the partitioning of proteins, etc.
Virgin coconut oil (VCO) is growing in popularity due to its perceived health benefits. VCO is extracted from fresh coconut meat or milk through natural processes without chemicals or heat treatment. It contains lauric acid and medium chain triglycerides that have antimicrobial properties. VCO production is expected to experience significant market growth. The document provides details on the composition, production process, quality standards, and export potential of VCO.
This document discusses vitamin C skincare products and treatments. It provides information on how vitamin C works in the skin, key vitamin C ingredients, retail vitamin C serum and cream products, professional vitamin C brightening treatments, and massage rituals used in the treatments. The professional brightening treatment uses a high concentration of vitamin C derivatives along with antioxidant superfruit extracts in a 35% formula. It also introduces an updated version of the treatment that includes new jade massage rituals and products to provide clinical results faster than the previous version.
Dyadic International uses its patented C1 fungus platform to produce industrial enzymes for markets like biofuels, chemicals, and biotherapeutics. The presentation overview included Dyadic's products, C1 platform, quality control laboratory, internship assays on cellulase activity, and future plans. The internship project involved testing Dyadic and competitor enzymes using assays like CMCase, xylanase, and beta-glucanase. These assays help ensure enzyme activities meet specifications. The presentation provided advice to biotechnology students and concluded by thanking Dyadic staff.
Development of Enzyme & Biofertilizer from seafood industry.pptxSubrataParai
This document discusses the production of chitinase enzyme and biofertilizer from crustacean shell waste from the seafood industry. It describes how the shells are dried, ground and fermented using chitinolytic organisms to produce a liquid containing chitinase enzyme and a solid residue that can be used as biofertilizer due to its nutrient content. The chitinase enzyme has various applications in agriculture, cosmetics and pharmaceuticals. The biofertilizer improves soil properties and plant growth. The process yields high percentages of these valuable products from waste and provides an environmentally friendly way to manage the waste.
Addressing wrinkles, body odor & dandruff through cosmeceutical preparationsMonika Dovulary
This presentation is a precise yet descriptive information of the topic and will be of extreme use to postgraduate students.
I hope this will be of great help.
This document discusses alkaline protease, an extracellular enzyme that performs protein catabolism through peptide bond hydrolysis. It is active at alkaline pH levels of 8-12 and temperatures of 30-80°C. The document outlines the bacterial and fungal sources of alkaline protease, as well as the genetic engineering methods used to produce it. The production process and uses of alkaline protease in the leather industry are also described, including its advantages over chemicals. Finally, the document notes that the global market for alkaline protease is growing due to its environmentally friendly properties.
Internship report nimir industrial chemical ltdZulqarnan Ch
a comprehensive internship report on Internship report nimir industrial chemical, after one month industrial training. it include complete process description and process flow diagrams.
Protein based Surfactantnfrom de-oiled cakeTejasAgrawal14
A simple overview of the protein-based surfactant and its good effect in oleochemicals industries as a substitute to Petro-based surfactants. Also, it can bring a great revolution in cosmetic industries as a mild surfactant.
- introduction of cosmetic business at MEDIPOST
- stem cell conditioned media cosmetics
- power of stem cell in skincare
- regenerative skincare at cellular level
Cosmeceuticals are ingredients with medicinal properties that provide topical benefits and protect against skin damage. They were coined in 1980 but have no legal definition. They are not considered drugs by the FDA and have less rigorous testing than drugs. Common cosmeceutical ingredients include antioxidants, peptides, retinoids, and exfoliants which treat signs of aging. Cosmeceuticals are generally safer than drugs for long-term use and promote skin health and beauty through natural ingredients.
Aging is a natural part of human life. However, recent discoveries indicate that pharmacological approaches used for the improvement and possibly, for the delay of the aging process, might shed a new light on this topic. This might obviously contribute to the extension of the active life of older people and maintenance of their quality of life, which could consequently reduce both social and economic burden of each country, especially the developed ones.
Catalog 2022 Peptides - Каталог пептиди на английски част 2Aloha Bulgaria Ltd
SUMMARY LIST OF PEPTIDE CODES . 6A
A MODERN WELLNESS CONCEPT of Peptide and Non-Peptide Bioregulatio 7А
REVILAB ML — anti-age multifunctional
peptide products 8А
RĒVILAB SL — peptide complexes
for sublingual administration 12А
PEPTIDE COMPLEXES — complexes in solution,
natural peptides 16А
REVILAB ANTI-A.G.E. — a new dawn for modern
anti-age medicine . 21А
CYTOGENES — peptide bioregulators
based on synthesized peptides . 22А
CYTOMAXES — peptide bioregulators based
on natural peptides . 26А
ULTRASEPT — hygienic antiseptic lotion . 33А
CYTOGENES LINGUAL — peptide bioregulators based
on synthesized peptides in sublingual form . 34А
CYTOMAXES LINGUAL — peptide bioregulators based
on natural peptides in sublingual form . 38А
VOLUSTOM — dietary fiber complex 45А
TREATMENT-AND-PROPHYLACTIC —
для здоровья, красоты и активной жизни 46А
COMPLEX 3D — complex based on
detoxicants and antioxidants . 47А
REVIFORM — program for the correction of weight and shape . 64А
MESOTEL — antioxidant natural anti-aging agents . 66А
ONCOLOGY SURIES — advanced technologies to
combat the disease of the 21st century 68А
AYURVEDA TEA — time-tested tea drinks . 70А
COMPLEX NB — promising anti-aging technologies . 74А
Monica Machuca is a Pharmacotechnical Development Manager at Aché Laboratórios with over 15 years of experience in research, development, and innovation for skin care and hair care products. She has a degree in Chemistry with a specialization in Dermatological Sciences. Her responsibilities include managing new cosmetic formulation development, product testing, regulatory documentation, and raw material analysis. She has published several papers on skin regeneration and anti-aging products and holds patents for moisturizer and active ingredient delivery systems.
The Vine is an area within the WBWE, conceived to encourage new businesses that evolve around wine and vine industries. Using every resource, and expanding every possibility, such an initiative shows the great potential that can be developed in the sector.
Escuela de Ingenierías Industriales-Universidad de Valladolid, Valladolid, Spain (sorayarr@iq.uva.es; mjcocero@iq.uva.es)
Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal
Instituto de Biologia Experimental e Tecnológica, Oeiras, Portugal
abroBiotec – Grupo Matarromera, Valbuena de Duero, Spain
Further information about "The Vine Science Award" on http://www.worldbulkwine.com/thevine/ing/posters.html
Minimalist is a high-performance skincare brand founded in 2020 with a belief in transparency. They offer efficacious skincare products ranging from cleansers to sunscreens. Their products are developed through scientific research and clinical testing. They have a team of specialists in research and development and manufacturing facilities certified to ISO standards. Minimalist has become one of the top skincare brands in India and its products are also available in several other countries. Their goal is to create clinically-proven products through stringent testing processes.
This document discusses different types of creams and their formulation and preparation methods. It begins with introducing creams as semisolid emulsions for topical application containing one or more drug substances. The main types are oily/oil-in-water creams and aqueous/water-in-oil creams. It then covers the purposes of creams, common ingredients in formulations, quality control testing methods like vertical diffusion cell testing, and provides an example formulation for betamethasone cream. The document aims to provide information on creams for pharmaceutical applications.
TranskinTM : a novel skin penetration enhancing peptide for the transdermal d...Simba Events
TranskinTM is a novel peptide developed by LG Household & Healthcare that enhances skin penetration of protein growth factors. TranskinTM was identified using phage display and conjugated to EGF and hGH. This increased their skin penetration 5-fold and absorption 100-fold while maintaining biological activity. TranskinTM-GFs were non-toxic, non-sensitizing, and non-irritating. Their stability was improved by incorporating them into a microemulsion called TransomeTM. A cosmetic containing TranskinTM-GFs showed improved dermal density, elasticity and wrinkle reduction. TranskinTM-GFs were included in OHUI's The First skincare product.
MicroPRO, A Rapid Microbiology Method Based on Flow Cytometryguest32bcc5
This document provides information on disruptive technologies and rapid microbiology products represented by the company. It summarizes their product range including instruments for biological sample preparation, dissolution/formulation, physico-chemistry analysis, and rapid microbiology detection. It also discusses their markets in pharmaceutical, personal care, fermentation, and more. The MicroPRO instrument allows detection of bacteria, yeast and mold from various samples within 24 hours.
Advances in in vitro testing for regulatory compliance in the chemical industryDr Carol Barker-Treasure
This presentation, originally shared at the Chemical Hazards Communication Society in 2018, discusses the regulatory status of in vitro safety assessments for REACH, CLP Regulation and Biocidal Products Regulation, gives an overview of current key methods for skin irritation, genotoxicity and acute toxicity, shows how finished mixtures or products can be tested, how to interpret results and barriers to progress towards an entirely animal-free testing strategy.
1. Antibiotics are commonly produced through microbial fermentation using bacteria, fungi, and actinomycetes. Penicillin is produced via fermentation of Penicillium chrysogenum fungi.
2. Industrial production of antibiotics involves upstream and downstream processing. Upstream involves fermentation and production, while downstream involves extraction and purification of the antibiotic.
3. Production of penicillin involves growing P. chrysogenum in a fermentor with nutrients like lactose and corn steep liquor. The secreted penicillin is then extracted from the broth and purified through acidification, solvent extraction, and crystallization into its final form.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
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Virgin coconut oil (VCO) is growing in popularity due to its perceived health benefits. VCO is extracted from fresh coconut meat or milk through natural processes without chemicals or heat treatment. It contains lauric acid and medium chain triglycerides that have antimicrobial properties. VCO production is expected to experience significant market growth. The document provides details on the composition, production process, quality standards, and export potential of VCO.
This document discusses vitamin C skincare products and treatments. It provides information on how vitamin C works in the skin, key vitamin C ingredients, retail vitamin C serum and cream products, professional vitamin C brightening treatments, and massage rituals used in the treatments. The professional brightening treatment uses a high concentration of vitamin C derivatives along with antioxidant superfruit extracts in a 35% formula. It also introduces an updated version of the treatment that includes new jade massage rituals and products to provide clinical results faster than the previous version.
Dyadic International uses its patented C1 fungus platform to produce industrial enzymes for markets like biofuels, chemicals, and biotherapeutics. The presentation overview included Dyadic's products, C1 platform, quality control laboratory, internship assays on cellulase activity, and future plans. The internship project involved testing Dyadic and competitor enzymes using assays like CMCase, xylanase, and beta-glucanase. These assays help ensure enzyme activities meet specifications. The presentation provided advice to biotechnology students and concluded by thanking Dyadic staff.
Development of Enzyme & Biofertilizer from seafood industry.pptxSubrataParai
This document discusses the production of chitinase enzyme and biofertilizer from crustacean shell waste from the seafood industry. It describes how the shells are dried, ground and fermented using chitinolytic organisms to produce a liquid containing chitinase enzyme and a solid residue that can be used as biofertilizer due to its nutrient content. The chitinase enzyme has various applications in agriculture, cosmetics and pharmaceuticals. The biofertilizer improves soil properties and plant growth. The process yields high percentages of these valuable products from waste and provides an environmentally friendly way to manage the waste.
Addressing wrinkles, body odor & dandruff through cosmeceutical preparationsMonika Dovulary
This presentation is a precise yet descriptive information of the topic and will be of extreme use to postgraduate students.
I hope this will be of great help.
This document discusses alkaline protease, an extracellular enzyme that performs protein catabolism through peptide bond hydrolysis. It is active at alkaline pH levels of 8-12 and temperatures of 30-80°C. The document outlines the bacterial and fungal sources of alkaline protease, as well as the genetic engineering methods used to produce it. The production process and uses of alkaline protease in the leather industry are also described, including its advantages over chemicals. Finally, the document notes that the global market for alkaline protease is growing due to its environmentally friendly properties.
Internship report nimir industrial chemical ltdZulqarnan Ch
a comprehensive internship report on Internship report nimir industrial chemical, after one month industrial training. it include complete process description and process flow diagrams.
Protein based Surfactantnfrom de-oiled cakeTejasAgrawal14
A simple overview of the protein-based surfactant and its good effect in oleochemicals industries as a substitute to Petro-based surfactants. Also, it can bring a great revolution in cosmetic industries as a mild surfactant.
- introduction of cosmetic business at MEDIPOST
- stem cell conditioned media cosmetics
- power of stem cell in skincare
- regenerative skincare at cellular level
Cosmeceuticals are ingredients with medicinal properties that provide topical benefits and protect against skin damage. They were coined in 1980 but have no legal definition. They are not considered drugs by the FDA and have less rigorous testing than drugs. Common cosmeceutical ingredients include antioxidants, peptides, retinoids, and exfoliants which treat signs of aging. Cosmeceuticals are generally safer than drugs for long-term use and promote skin health and beauty through natural ingredients.
Aging is a natural part of human life. However, recent discoveries indicate that pharmacological approaches used for the improvement and possibly, for the delay of the aging process, might shed a new light on this topic. This might obviously contribute to the extension of the active life of older people and maintenance of their quality of life, which could consequently reduce both social and economic burden of each country, especially the developed ones.
Catalog 2022 Peptides - Каталог пептиди на английски част 2Aloha Bulgaria Ltd
SUMMARY LIST OF PEPTIDE CODES . 6A
A MODERN WELLNESS CONCEPT of Peptide and Non-Peptide Bioregulatio 7А
REVILAB ML — anti-age multifunctional
peptide products 8А
RĒVILAB SL — peptide complexes
for sublingual administration 12А
PEPTIDE COMPLEXES — complexes in solution,
natural peptides 16А
REVILAB ANTI-A.G.E. — a new dawn for modern
anti-age medicine . 21А
CYTOGENES — peptide bioregulators
based on synthesized peptides . 22А
CYTOMAXES — peptide bioregulators based
on natural peptides . 26А
ULTRASEPT — hygienic antiseptic lotion . 33А
CYTOGENES LINGUAL — peptide bioregulators based
on synthesized peptides in sublingual form . 34А
CYTOMAXES LINGUAL — peptide bioregulators based
on natural peptides in sublingual form . 38А
VOLUSTOM — dietary fiber complex 45А
TREATMENT-AND-PROPHYLACTIC —
для здоровья, красоты и активной жизни 46А
COMPLEX 3D — complex based on
detoxicants and antioxidants . 47А
REVIFORM — program for the correction of weight and shape . 64А
MESOTEL — antioxidant natural anti-aging agents . 66А
ONCOLOGY SURIES — advanced technologies to
combat the disease of the 21st century 68А
AYURVEDA TEA — time-tested tea drinks . 70А
COMPLEX NB — promising anti-aging technologies . 74А
Monica Machuca is a Pharmacotechnical Development Manager at Aché Laboratórios with over 15 years of experience in research, development, and innovation for skin care and hair care products. She has a degree in Chemistry with a specialization in Dermatological Sciences. Her responsibilities include managing new cosmetic formulation development, product testing, regulatory documentation, and raw material analysis. She has published several papers on skin regeneration and anti-aging products and holds patents for moisturizer and active ingredient delivery systems.
The Vine is an area within the WBWE, conceived to encourage new businesses that evolve around wine and vine industries. Using every resource, and expanding every possibility, such an initiative shows the great potential that can be developed in the sector.
Escuela de Ingenierías Industriales-Universidad de Valladolid, Valladolid, Spain (sorayarr@iq.uva.es; mjcocero@iq.uva.es)
Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal
Instituto de Biologia Experimental e Tecnológica, Oeiras, Portugal
abroBiotec – Grupo Matarromera, Valbuena de Duero, Spain
Further information about "The Vine Science Award" on http://www.worldbulkwine.com/thevine/ing/posters.html
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This document discusses different types of creams and their formulation and preparation methods. It begins with introducing creams as semisolid emulsions for topical application containing one or more drug substances. The main types are oily/oil-in-water creams and aqueous/water-in-oil creams. It then covers the purposes of creams, common ingredients in formulations, quality control testing methods like vertical diffusion cell testing, and provides an example formulation for betamethasone cream. The document aims to provide information on creams for pharmaceutical applications.
TranskinTM : a novel skin penetration enhancing peptide for the transdermal d...Simba Events
TranskinTM is a novel peptide developed by LG Household & Healthcare that enhances skin penetration of protein growth factors. TranskinTM was identified using phage display and conjugated to EGF and hGH. This increased their skin penetration 5-fold and absorption 100-fold while maintaining biological activity. TranskinTM-GFs were non-toxic, non-sensitizing, and non-irritating. Their stability was improved by incorporating them into a microemulsion called TransomeTM. A cosmetic containing TranskinTM-GFs showed improved dermal density, elasticity and wrinkle reduction. TranskinTM-GFs were included in OHUI's The First skincare product.
MicroPRO, A Rapid Microbiology Method Based on Flow Cytometryguest32bcc5
This document provides information on disruptive technologies and rapid microbiology products represented by the company. It summarizes their product range including instruments for biological sample preparation, dissolution/formulation, physico-chemistry analysis, and rapid microbiology detection. It also discusses their markets in pharmaceutical, personal care, fermentation, and more. The MicroPRO instrument allows detection of bacteria, yeast and mold from various samples within 24 hours.
Advances in in vitro testing for regulatory compliance in the chemical industryDr Carol Barker-Treasure
This presentation, originally shared at the Chemical Hazards Communication Society in 2018, discusses the regulatory status of in vitro safety assessments for REACH, CLP Regulation and Biocidal Products Regulation, gives an overview of current key methods for skin irritation, genotoxicity and acute toxicity, shows how finished mixtures or products can be tested, how to interpret results and barriers to progress towards an entirely animal-free testing strategy.
1. Antibiotics are commonly produced through microbial fermentation using bacteria, fungi, and actinomycetes. Penicillin is produced via fermentation of Penicillium chrysogenum fungi.
2. Industrial production of antibiotics involves upstream and downstream processing. Upstream involves fermentation and production, while downstream involves extraction and purification of the antibiotic.
3. Production of penicillin involves growing P. chrysogenum in a fermentor with nutrients like lactose and corn steep liquor. The secreted penicillin is then extracted from the broth and purified through acidification, solvent extraction, and crystallization into its final form.
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- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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Does Over-Masturbation Contribute to Chronic Prostatitis.pptxwalterHu5
In some case, your chronic prostatitis may be related to over-masturbation. Generally, natural medicine Diuretic and Anti-inflammatory Pill can help mee get a cure.
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Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
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4. about us
Founded in 2015, Beri Pharma Co., Ltd. is a
national high-tech enterprise focusing on the R &
D and manufacturing of raw materials and
preparations for great health (pharmaceuticals and
health products) and cosmetics.
Cosmetic Raw Materials
· Whitening & Anti-oxidation
· Moisturizing & Anti-aging
· Collagen
· Anti Hair Loss & Hair-growth
· Anti-inflammatory & Repair
· Sterilization & Acne treatment &
Anti- dangdruff
· Heat Sensitive Agent
· Nanoparticles
Raw Materials for
Pharmaceuticals &
Health Products
· API
· Pharmaceutical
intermediates
· Dietary supplement
5. BERI PHARM
Production area:
≥10000 sqm
Production equipments:
≥80 pieces of
Annual capacity: 400 tons
R & D center: ≥2200 sqm, with
synthesis room, fermentation
room, preparation room,
physical and chemical room,
safety and efficacy evaluation
room, nano liposome
laboratory, etc.
R & D team: composed of PhD,
Masters / Undergraduates
Proportion of R&D staff: ≥30%
6. Honors & Qualitifications
ISO9001 ISO14001 ISO45001
Specialized Innovation Enterprise of
Guangdong Province
National High-tech Enterprise
Innovational Enterprise of Guangdong Province Innovation-driven Enterprise of Zhuhai
Technical Enterprise of Guangdong Province TOP 100 - Zhuhai Innovation Enterprises
7. R & D Equipments
R & D Lab GC PLC
HPLC
LC-MS
R & D Lab GC HPLC-CAD
8. R & D Equipments
3D Facial Imager Transdermal tester LC-MS Nano particle size meter
Enzyme marker Stereomicroscope
Transdermal moisture loss meter
Skin cortical meter
Skin elasticity meter
Cuticle hydration meter
9. Efficacy testing instrument
Antera 3D facial imager
Skin elasticity meter
Skin sebum measuring
instrument
Cuticle hydration meter
Transcutaneous
moisture loss meter
10. Product Catalog
Whitening & Anti-oxidation
• BeriCos® VCIP I Ascorbyl Tetraisopalmitate (VC-IP)
• BeriCos® EAA I Ethyl Ascorbic Acid (EAA)
• BeriCos® VCG I Ascorbyl Glucosoide (VCG/AA2G)
• BeriCos® W-37 I Phenylethyl Resorcinol (377)
• BeriCos® W-47 I 4-Butylresorcinol
• BeriCos® 4MSK I Potassium Methoxysalicylate
• BeriCos® Pterostilbene I Pterostilbene
• BeriCos® GSH I Glutathione (GSH)
• BeriCos® FerAC I Ferulic Acid
• BeriCos® TA I Tranexamic Acid
• BeriCos® EUK 134 I EUK 134
• BeriCos® Peptidomidex I Peptidomidex
Moisturizing & Anti-aging
• BeriCos® GG I Glyceryl Glucoside
• BeriCos® Proxylane-POW I Hydroxypropyl
Terrahydropy Rantriol
• BeriCos® HPR I Hydroxypinacolone Retinoate
• BeriCos® Chromanol I Dimethylmethoxy Chromanol
• BeriCos® DCP I Dimethylmethoxy Chromanyl Palmitate
• BeriCos® IDBN I Hydroxydecyl Ubiquinone (Idebenone)
• BeriCos® Thiotaurine I Thiotaurine
Anti Hair Loss & Hair-growth
• BeriCos® Copyrrol I Pyrrolidinyl
Diaminopyrimidine Oxide
• BeriCos® Copexil I Diaminopyrimidine
Oxide
• BeriCos® Minoxidil /Minoxidil Aqua I
Minoxidil/Minoxidil Aqua
• BeriCos® BM I Bimatoprost
Anti-inflammatory & Repair
• BeriCos® Ectoin I Ectoin
• BeriCos® BeCalmin I Hydroxyphenyl
Propamidobenzoic Acid
Sterilization & Acne treatment
& Anti-dangdruff
Heat Sensitive Agent
• BeriCos® VBE I Vanillyl butyl ether
Single Ingredient
• BeriCos® OCT I Piroctone Olamine (PO, OCT)
• BeriCos® HD-100 I 2-hydroxyethanesulphonic Acid
• BeriCos® PQ73 I Quaternium-73 (Pionin)
• BeriCos® VB6-Trip I Pyridoxine Tripalmitate
• BeriCos® Azelamide MEA I Azelamide MEA
11. Product Catalog
• BeriCos® VCIP-Nano——Sub-nano emulsion of VC-IP
• BeriCos® Nano-ACE—— Sub-nano emulsion of HPR, VC-IP,
Tocopheryl Acetate
• BeriCos® 477-Nano——Nano liposome of 4-Butylresorcinol
• BeriCos® GSH-Nano——Nano liposome of Glutathione
• BeriCos® NanoWhite——Multi whitening nano liposome
(4-Butylresorcinol, VC-IP, GSH)
• BeriCos® AzA-Nano——Nano inclusion complex of Azelaic acid
• BeriCos® AzA-60——60% Ultrafine Azelaic acid
• BeriCos® ALA-Nano——Nano inclusion complex of Thioctic Acid
• BeriCos® Pterostilbene-Nano——Nano of Pterostilbene
Nano Products
12. 产 品 介 绍
l P r o d u c t I n t r o d u c t i o n
13. Product introduction
Tetraisopalmitate ascorbate(abbreviation VC-IP),It is an esterified
vitamin C derivative and a new generation of derivatives.
Other names: tetrahexyl decanol ascorbic acid ester, esterified VC, fat
soluble vitamin C.
Take the letters in its English name:Vitamin C tetra-isopalmitate,
abbreviation VC-IP;
INCI :Ascorbyl Tetraisopalmitate
14. Prototype VC has several disadvantages:
• Poor stability, easy to discolor and oxidize under air and light
• VC must be kept below pH 3.5 and is therefore irritating to the
skin
• Because VC is water-soluble, but our skin has a "strong" lipid
bilayer, so this makes it difficult to work through the skin.
Comparative advantage
产品介绍
Instability
15. VC derivative:
Water soluble derivative
Vitamin C Magnesium Phosphate
Vitamin C Glucoside
Oil soluble derivative :
Ascorbic acid dipalmitate (Vitamin C Dipalmitate)
Tetraisopalmitate ascorbate (VC-IP)
contrast :
• Under the same conditions, oil soluble components generally have better transdermal
absorption ability than water-soluble components;
• The solubility of ascorbic acid tetraisopropyl palmitate is better than that of ascorbic acid
dipalmitate.
Comparative advantage
Product introduction
16. STABILITY OF VC-IP
VC-IP Store at 40 ℃ or 60 ℃ for 1 month. There is no obvious
change in appearance and hue. The measured vc-ip is heated
at the rate of 5 ℃ / min at 200 ℃, and its weight remains
unchanged at 30-500 ℃. These results show that vc-ip has
good thermal stability (Fig. 1)
Feature 1: strong stability
Product introduction
17. test method:
NHDF was administered with 20-
50um vc-ip or VC for 2 hours,
homogenized and extracted under
the conditions of 3%
metaphosphoric acid and 0.2%
ethanol, and then separated by
high performance liquid
chromatography on ODS column。
• Vc-ip increased the accumulation of VC
in cells
• about 14 times than VC itself. After
lipolysis, vc-ip is transformed into VC in
skin cells, so as to play the role of VC。
The uptake concentration
distribution of vc-ip and VC at
every 20um concentration was
10.2nmol/106 cells and
0.7nmol/106 cells。
Feature 2: oil soluble, skin
friendly, lipophilic, excellent
transdermal absorption
Product introduction
18. Metabolic activity*
Activated cell
*Accelerate collagen
synthesis
antioxidant
‧Prevent sebum peroxidation
‧Prevent DNA damage
prevent cells from being
damaged by ultraviolet light
Whitening effect
*Inhibition of tyrosinase activity
*Inhibition of melanocytes
Product introduction
Mechanism and efficacy
19. ROS
UV
Stress signal release
(IL、TNF-alpha)
Protective activity
(wrinkles)
Destroy
immunity
ageing
inflammation
cancer
cell death
Sunscreen
antioxidant
Strengthen immunity
VC-IP
Product introduction
Anti inflammatory
effect
20. test method:
Human melanoma cells (hm-3-ko) were cultured
with VC-IP in the concentration range of 0% - 0.2%
for 4 days. The cells were then collected with
trypsin and centrifugation. After the cells were
counted, the melanin density of the cells was
measured by Marcia laser densitometer.
VC-IP inhibits tyrosinase activity and
melanin production
Compared with the control group, the
melanin synthesis of VC-IP decreased
from 72% to 12%
Inhibit the formation of melanin
Product introduction
21. test method:
Use the serum-free conditioned medium was cultured in
50um with or without VC-IP for 48 hours, the NHDF cells
were ultrafiltration and concentrated on a SDS-
polyacrylamide gel containing 0.2% gelatin under non
reducing conditions, followed by Coomasie Brilliant Blue
R250 staining, and then measured with a laser densitometer。
VC-IP significantly inhibited the activity of MMPs and the
increase of collagenase induced by UV irradiation
When VC-IP (20-50um) was used, the
activities of MMP-2 and MMP-9 degrading
gelatin were inhibited to 18% - 23% and
10% - 17% respectively. The activity of
MMPs in VC (20-50um) group was 39% -
46% and 42% - 52% respectively.
Product introduction
Inhibit the activity of matrix metalloproteinases (MMPs)
22. test method :
Human skin fibroblast NHDF cells
were given L - [2,3h] proline for 24
hours in the presence or absence of
vc-ip or VC (20-50um), followed by
cell lysis and subsequent
neutralization by NaOH treatment.
The obtained cell extract was
thoroughly hydrolyzed with
collagenase of Clostridium
perfringens, centrifuged after
tcatennin treatment to produce
supernatant, precipitated into
collagen and non collagen
components, and evaluated by
Aloka liquid scintillation counter lc-
3600 SCI.
The decrease of collagen is manifested
in the photoaging of human skin. It is
reported that the degradation of
collagenase is accelerated due to the
release of collagenase from infiltrating
cells induced by ultraviolet light.
In this case, the degradation rate of
collagen exceeds the rate of
biosynthesis, resulting in the reduction
of collagen.
The effect of VC-IP on promoting collagen synthesis
is about 3.5 times than VC.
VC-IP increased collagen synthesis of
human skin fibroblasts by 170% - 195% in
the concentration range of 20-50um, while
VC increased collagen synthesis by 112% -
127% in the same concentration range。
Promote collagen synthesis
Product introduction
23. VC-IP
(-)
VC-IP
(+)
0 0.5 1 3 6(hr)
Testing method:
HaCaT cells were treated with 80
mm VC IP. After UVA irradiation,
8-OHdG was detected by
immunohistochemistry with
anti-8-ohdg antibody.
Inhibit the release of 8-OHdG and protect cells from
UVA damage
Inhibit UVA damage to DNA
Product introduction
24. • In cell proliferation, it may promote
skin aging. Tumor suppressor gene
p53 plays an important role in
maintaining cell genetic stability after
DNA (such as ultraviolet irradiation).
After ultraviolet irradiation, the
content of p53 protein increased.
Therefore, p53 can be used as a
candidate marker of DNA damage
induced by UV radiation.
VC-IP can inhibit the increase of p53 expression, so as to
protect DNA from UVB damage.
VC-IP was 0.005% and 0.01% respectively,
and p53 expression was down regulated
to 68% and 58%.
Inhibit UVA damage to DNA
Product introduction
25. test method:
Irradiate the skin with ultraviolet rays to
cause obvious sunburn. Continuously use
VC-IP cream containing 2% and ordinary
cream for 5 days, and compare the skin
dark spots.
The test results show that VC-IP can effectively repair the damage of
ultraviolet rays to the skin and reduce dark spots.
Inhibit UVA damage to DNA
Product introduction
Contain
2%VC-IP
placebo
26. test method:
For small spots after sun
exposure, use
Contains 5% VC-IP essential
oil, every day.
Apply twice for 90 days.
The test results show that VC-IP can effectively
activate cell regeneration and reduce color spots.
Inhibit UVA damage to DNA
Product introduction
27. whitening ultraviolet-proof
Brighten skin Protect DNA
Promote collagen synthesis
anti-aging
antioxidant
Neutralizing free radical
B E R I P H A R M A
Product introduction
Efficacy conclusion
28. Product introduction
Technical
indicators
B E R I P H A R M A
Test items standard
appearance Colorless to light yellow liquid
smell Slight special smell
purity (HPLC) ≥98%
Color value(APHA) ≤ 100
proportion 0.930-0.943
Refractive index (25℃) 1.459-1.465
heavy metal ≤ 20ppm
arsenic ≤ 2ppm
Total colony ≤200 cfu/g
29. test method:
Determine the solubility of vc-ip in
various cosmetic raw materials (5%,
10% and 50% concentration) at 25
° C, 50 ° C and 70 ° C。
S=Soluble
I=Insoluble
Solubility
Product introduction
conclusion:VC-IP is soluble in most oils, both polar and nonpolar.
31. Application direction
• Skin care products
• Cosmetic products (lipstick / lipstick, etc., which play an
important role in anti oxidant and gloss enhancement.)
• Essential oil products (Whitening Essential Oil)
• Sunscreen Products
• Facial mask
Product introduction
32. Regulatory
safety
China:<< list of used cosmetic raw materials>>
Europe: allowed for personal care products
USA: allowed for personal care products
Japan: allowed for personal care products
Korea: allowed for personal care products
Australia: allowed for personal care products
Rest of the world: most Asian countries allow it
VC-IP has been widely used as
cosmetic raw materials in the
world for nearly two decades
Product introduction
33. • Foreign products of the Ministry of medicine approved by the
Ministry of health, labor and welfare of Japan (Quasi-drug Active)
• One of Nine "whitening functional cosmetic ingredients"
officially approved by South Korea(Functional Ingredient for
Skin Lightening)”
• The only "medicated cosmetics" among the 13 whitening
ingredients approved by Taiwan's Ministry of health and welfare
Regulatory safety
Product introduction
34. M a r k e t I n s t a n c e
M a r k e t I n s t a n c e
35. SK II lIntensive research freckle
removing and whitening cream
Dr.Ci:LabolBrighten the essence of
musculus translucent
HABA lThree bright white
beauty essence RHOTO lWhitening vitamin
C essence
Market application
36. Hoolflower Brilliance Essence oil
Shiseidol New whitening and beautifying skin
brightening and freckle removing protective milk
MARUMI l White love pure white milk Chanell Light and white essence
Market application
39. • VC-IP is soluble in most oils (whether
polar or nonpolar), except Polyols (such
as glycerol, propylene glycol,
butanediol). VC-IP can be quickly
dissolved in ethanol, hydrocarbons,
esters and vegetable oils, such as
propylene glycol monooctanoate,
castor oil, glycerol triisooctanoate
(glycerol triethylhexanoate), olive oil,
cetyl alcohol ethyl hexanoate and
mineral oil。
• The pH value of the designed formula
(in aqueous phase) shall not exceed 6.
Although VC-IP has good oil solubility,
its stability will be affected by pH value.
Therefore, it is recommended to adjust
the pH value below 6.0 before adding
VC-IP (the pH value cannot be adjusted
after adding). Vc-ip can also be used in
formulations with pH 7 when used in
combination with chelating agents and
antioxidants。
• Keep away from active catalysts
(metal ions of inorganic sunscreen
or organic clay materials)
• Chelating agents and antioxidants
(tocopherol) are recommended in the
formula to effectively prevent
discoloration。
Reference formula
40. Reference formula
Operation process:
1. Phase A is heated to 80 ℃, and phase B is
heated to 80 ℃;
2. Phase B is pumped into phase A,
homogenized for 5 minutes, phase C is added,
homogenized for 3 minutes and cooled;
3. Dissolve phase D in advance, reduce it to 45 ℃,
add phase D and E, and stir well.
Reference formula 1:Anti
wrinkle moisturizing cream
41. Operation process:
1. Heat A and B until dissolved;
2. While shaking B at 4000rpm, add A to B;
3. emulsification (5,000rpm, 3min./200g);
4. Cool to room temperature, then add C to B;
5. Remove air with a defoamer
Reference formula
Reference formula2:
new life Essence
42. Operation process:
1. Heat phase A to 50 ° C and stir; Stir phase B;
2. Add A to B, stir and homogenize;
3. Add C and D, stir and homogenize。
Reference formula
Reference formula 3 :
Whitening light spot gel
45. [1] Cosmetic Ingredient Review. (2016).Safety Assessment of Ethers and
Esters of Ascorbic Acid as Used in Cosmetics
[2]Taiwan food and drug administration (2013). You must know the skin
whitening knowledge (II), drug and food safety weekly, vol 424
[3] Cytoprotective effects of the lipoidic-liquiform pro-vitamin C tetra-
isopalmitoyl-ascorbate (VC-IP) against ultraviolet-A ray-induced injuries
in human skin cells together with collagen retention, MMP inhibition
and p53 gene repression.[J]. Journal of Cellular Biochemistry, 2010,
106(4):589-598
[4] Marina Mandelli de Almeda, et al. [J]. Brazilian Journal of
Pharmaceutical Science, vol. 46, n 1, jan/mar, 2010
[5] Patricia M.B.G. Maia Campos, Gisele M. S. Goncalves, Gaspar L R.[J].
Skin Research and Technology, 2008, 14(3):376-380.
[6] Li Xiao. Cytoprotective Effects of the Lipoidic-Liquiform Pro-Vitamin
C Tetra-Isopalmitoyl-
Ascorbate (VC-IP) Against[J]. Journal of Cellular Biochemistry, 2009
Reference formula
46. THANK YOU
B
E
R
I
P
H
A
R
M
A
B E R I
Headquarters : No. 2, Fourth Nanhua Road, Nanshui Town, Gaolangang
District, Zhuhai City, Guangdong Province, China
Guangzhou Branch:Room 1305, Tower B, Jiada Plaza, 303 Guangyun
Road, Jiahe street, Baiyun District, Guangzhou
www.zhberi.com Tel: 86-756-8699456 Email: sales@zhberi.com
Committed to providing professional empowerment solutions for customers