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Regeneative skincare by MEDIPOST
- 2. Company Overview • Founded in 2000, Seoul Korea • A public company listed to KOSDAQ since 2005 (ticker: 078160) • 239 employees (with 106 in R&D and manufacturing) www.medi-post.com Pangyo HQ GMP Facility Cord Blood Bank
- 3. • The first and largest cord blood bank in Korea with 235,000 units under storage (43% market share) 01 MEDIPOST: Major Business Platforms Stem cell banking • World’s leader in MSC therapeutics • World’s first allogeneic stem cell drug of CARTISTEM in 2012 • Clinical trial is ongoing for PNEUMOSTEM for BPD and NEUROSTEM for AD Stem cell therapeutics • hUCB MSC derived conditioned media • Next generation anti-aging brand of NGF37 • NGF-574H, a new approach for hair loss Stem cell based cosmetics
- 4. 01 Skin Aging • Healthy skin constantly refreshes itself in a cycle of 28 days (4 weeks), and the refreshing process is controlled and governed by skin stem cell present in epidermis and dermis in the skin. • Skin stem cell rapidly decreases in number after at the age of 30s and 40s, thus the skin refreshing process is slowed down, which is a root cause of skin aging Ref: H. Akamatsu et al., (2016) J. Dermatol 43: 311
- 5. 01 Stem cell conditioned media • Stem cell conditioned media is a collection of signal traducing molecules secreted by stem cell, and the conditioned media shows a potency to activate indigenous stem cell present in the body • Stem cell conditioned media thus may be able to reverse or at least delay skin stem cell aging process if used as an active ingredient in cosmetic product Activation of indigenous stem cells
- 6. 01 Regenerative skincare • Prof. Uyama Keiko at Tokyo dental university proposes skincare at cellular level for ultimate skin anti- aging and recommends “stem cell conditioned media” to restore aging and diminishing skin stem cells • Prof. Uyama introduces concept of “Regenerative skincare” in her book titled “Beauty in the cell (細胞 美人)”
- 7. 01 Stem Cell Quality • The quality of stem cell conditioned media depends on the quality of stem cell it is derived from. • Stem cell also ages as other types of cell, and thus the regenerative capacity decrease as it ages. • Cautions should be made in choosing stem cell conditioned media cosmetic product about stem cell donor eligibility, quality of stem cell, isolation and processing methods. Ref: Yao B. et al., (2016) Int Wound J 13: 1252
- 8. • NGF37 is a human UBC derived stem cell conditioned media containing 446 protein factors among which 37 growth factors essential in skin physiology is included • NGF37 is registered to ICID (INCI22747, CAS#871903-86-5) and completed all regulatory requirements for safety as a cosmetic ingredient NGF37: New born Growth Factor 37 [37 essential growth factors by human GF array][446 protein factors by human Ab array]
- 9. 01 NGF37: manufacturing • NGF37 is a conditioned media prepared by from new born baby’s umbilical cord blood without experiencing aging process • Manipulation and use of human cord blood is strictly regulated by law in Korea (including donor eligibility) • NGF37 is prepared in compliance with MFDS guideline (KFDA) and manufactured under class 100 sterile conditions at KGMP facility of MEDIPOST Cord blood Collection
- 10. • Effect on wound healing and pigmentation in skin was published in SCI listed academic journals • Clinical study has been conducted with a cosmetic product containing NGF37 at 70,000 ppm to confirm efficacy on human skin against 15 skin troubles including hydration, elasticity, resilience, wrinkle reduction, skin tone & brightness, soothing and dark spot & pigmentation NGF37: skin benefits Link to full paper: 1) wound healing; 2) skin pigmentation
- 11. Selected Product List Brand Line Product Name Image Unit Channel in Korea NGF37 MEDICAL NGF37 SOLUTION 2ml*10ea Hospitals & clinic AFTERCARE NGF37 CELL REPAIR CREAM EXTRABARRIER 75ml NGF37 CELL SOOTHING SUN BLOCK 50ml NGF37 TOTAL SOLUTION SYNERGY AMPOULE 35ml TV home shopping NGF37 TOTAL SOLUTION SYNERGY CREAM 30ml NGF37 TOTAL SOLUTION RADIANCE CREAM 30ml
- 12. NGF37 Solution • The product is for professional facial treatment exclusively at dermatologist clinic • Usually combined with ultrasono-, ionto- or cryo-treatment for maximum efficacy • Treated at more than 100 dermatologist clinics in Korea
- 13. NGF37 Total Solution Synergy Ampoule • The product was originally offered exclusively to clinics and hospitals for VIP customers. • Recently launched to TV home shopping platform with a big commercial success.
- 14. Project Pipeline in Skincare NGF37 NGF574-H PROJECT X API Stem cell conditioned media Stem cell conditioned media Natural cell growth factors Concept • Regenerative skincare by the paracrine action of stem cell conditioned media • Conditioned media from the most fresh stem cell without aging process prepared from umbilical cord blood of new born baby • Stem cell conditioned media optimized specifically for hair loss prevention and hair growth by MEDIPOST’s proprietary “PRIMING TECHNOLOGY” • The optimized combination of natural cell growth factors stimulating stem cells present in epidermis and dermis of human skin Project status Commercialized Registration to functional cosmetics for hair loss in Korea ongoing POC
- 15. (Supplementary) NGF-574H 01 Phototrichogram for hair density hair density hair diameter hair growth rate [POC clinical trial with alopecia patients] • NGF-574H is a newly developed hUCB-MSC conditioned media specifically optimized for hair loss prevention and hair growth by MEDIPOST’s proprietary “priming technology”. • NGF-574H is awarded New Excellent Technology 2017 by Ministry of Health and Welfare Korea. • Market launch is due in 4Q 2018 or 1Q 2019 [Strategy]