Stem cell therapy has the potential to provide many benefits to Botswana. It could help treat diseases like Parkinson's, Alzheimer's, heart disease, and diabetes by generating healthy replacement cells. This would reduce morbidity and mortality rates. Allowing stem cell research could also attract skilled researchers and doctors from other countries, boosting the economy. It would lower healthcare costs by providing treatments for HIV/AIDS and other diseases that burden the healthcare system. Stem cells could also be used to test new drugs safely and efficiently, saving the country money currently spent importing drugs. Overall, stem cell research offers hope for curing many diseases and improving lives in Botswana.
Jillian Hastings Ward: Genomics England Towards 5 Million Genomes in the UKJoe Ball
A presentation by Jillian Hastings Ward regarding Genomics England's progress on sequencing 5 million genomes in the UK, delivered at Sano Genetics' Demystifying Genomics for Patient Registries Event on 11th July 2019.
Immunotone is an immunoenhancing, antistress, antiaging and rejuvenating herbal formulation which executes its therapeutic effect by complex synergistic interaction.
Jillian Hastings Ward: Genomics England Towards 5 Million Genomes in the UKJoe Ball
A presentation by Jillian Hastings Ward regarding Genomics England's progress on sequencing 5 million genomes in the UK, delivered at Sano Genetics' Demystifying Genomics for Patient Registries Event on 11th July 2019.
Immunotone is an immunoenhancing, antistress, antiaging and rejuvenating herbal formulation which executes its therapeutic effect by complex synergistic interaction.
Cancer hospital- we offer the best Cancer clinic, that stands as a pioneer in the field of Herbal & Ayurvedic Treatment for Cancer, get the best cancer hospital.
Cellular and gene therapies are now on the cusp of realizing the early promise of treating, and perhaps curing diseases that previously had little or no available therapeutic options. However, the journey from the laboratory to the clinic has been bumpy, with a history of disappointments, especially in the early 1990's where gene therapy had received much hype and publicity.
In conclusion, both cell strains and primary cells have played vital roles in advancing our understanding of cellular processes, disease mechanisms, and drug discovery. While cell strains provide a continuous and convenient supply of cells, primary cells offer a more authentic representation of human biology, enabling researchers to study specific tissues and diseases in a physiologically relevant context. The growth of cell strains and the significance of primary cells have propelled biomedical research forward, leading to breakthroughs in various fields and fostering the development of innovative therapeutic strategies. As technologies continue to evolve, primary cells will remain indispensable in further unraveling the complexities of human health and disease.
Summarize the key insights from the blog series, emphasizing the transformative impact of stem cell regeneration in modern healthcare. Conclude by expressing optimism for a future where stem cell therapies become more commonplace, offering new avenues for healing and improved patient outcomes.
Cancer hospital- we offer the best Cancer clinic, that stands as a pioneer in the field of Herbal & Ayurvedic Treatment for Cancer, get the best cancer hospital.
Cellular and gene therapies are now on the cusp of realizing the early promise of treating, and perhaps curing diseases that previously had little or no available therapeutic options. However, the journey from the laboratory to the clinic has been bumpy, with a history of disappointments, especially in the early 1990's where gene therapy had received much hype and publicity.
In conclusion, both cell strains and primary cells have played vital roles in advancing our understanding of cellular processes, disease mechanisms, and drug discovery. While cell strains provide a continuous and convenient supply of cells, primary cells offer a more authentic representation of human biology, enabling researchers to study specific tissues and diseases in a physiologically relevant context. The growth of cell strains and the significance of primary cells have propelled biomedical research forward, leading to breakthroughs in various fields and fostering the development of innovative therapeutic strategies. As technologies continue to evolve, primary cells will remain indispensable in further unraveling the complexities of human health and disease.
Summarize the key insights from the blog series, emphasizing the transformative impact of stem cell regeneration in modern healthcare. Conclude by expressing optimism for a future where stem cell therapies become more commonplace, offering new avenues for healing and improved patient outcomes.
This pdf is about the Schizophrenia.
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Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Mammalian Pineal Body Structure and Also Functions
benefit of stem cell thearapy to a country
1. POTENTIAL BENEFIT OF STEM CELL
THERAPY TO BOTSWM
STEM CELL
LUCKY MOYENGWE
“I am pro-life.Ibelievehumanlifebeginsat
conception.Ialsobelieve thatembryonicstemcell
researchshouldbe encouragedandsupported”-
FormerU.S. SenatorBill Frist,speech(2005)
16000314
2. Stem cell therapy, also classified as regenerative medicine, is known to promotes the repair
response of diseased, dysfunctional or injured tissue using stem cells. Stem cells can be used to
develop organs in vitro and use them for organ transplantations instead of donor organs, which are
limited in supply. Stem cells can be grown in a lab. These stem cells can be manipulated to produce
desired specific types of cells, such as heart muscle cells, blood cells or nerve cells. The specialized
cells can then be implanted into a person to repair damaged and diseased cells or tissues. If country
like Botswana allows, make rules that regulate stem cell therapy will gain a lot of benefits, that
include increase understanding of how diseases occur, generate healthy cells to replace diseased
cells and test new drugs for safety and effectiveness.
Stem cells, directed to differentiate into specific cell types, offer the possibility of a renewable
source of replacement cells and tissues to treat diseases including Parkinson's and Alzheimer's
diseases, spinal cord injury, stroke, burns, heart disease, diabetes, osteoarthritis, and rheumatoid
arthritis. Stem cell therapy can help reduce the morbidity rate in the country and help increase our
mortality rate since stem cell research is based on trying to improve our lives and remove all
disease related issues that put our life at risk. The rate at which people are dying is so high and
stem cell has the potential to change the live of every living human being.
If a country like Botswana allow stem cell research and therapy through the elimination of all
Federal laws prohibiting the use of stem cells use and remove all funding restriction. This is going
to be a long-term benefit for the country’s economic status. A significant proportion of the country
budget is allocated to the HIV/AIDS and other diseases since they affect the mortality rate and the
morbidity rates of the population. The that is most affected by the diseases is mostly the
economically active sector of the population. Stem cell therapy has the potential to address all the
diseases that are a burden to the country. The specific fields of future that can help the patients to
get back on their feet include hematopoietic stem cell transplantation and hematological
malignancies, hematopoietic transplantation of engineered autologous cells to provide resistance
to HIV/AIDS, mesenchymal stem cell transplantation for cardiovascular regeneration and the
treatment of diabetes. The scope of the disease burden is large, and a well-developed strategic plan
is therefore needed. The active sector can get back to doing their day to day job with ease.
Funding of stem cell research and therapy can also attract high skilled stem researcher and doctors
from foreign countries which do not permit the use of stem cells. Chronic diseases and injuries are
on the rise and have a profound economic and societal impact in the developing countries like
Botswana and the country is already low populated. There is going to a lot of migrants coming
into our country for stem cell research and therapy. Funding and allowing stem cell therapy may
help to lure private companies to also lend a helping in terms of funding the stem cell research and
centers. These funds can help Botswana to establish facilities that support stem cell research
programs that encompass of research that will help during the discovery to development, testing
of cures, therapies and diagnostics stem cell centers. These facilities will help better the health
status and health care of the citizen of Botswana.
3. The development of new drugs is costly and time consuming and Cell based in vitro assays with
high human relevance are needed during clinical trials hence a suitable model is needed so that it
can be used when testing for effect and safety of medical drugs during development. Stem cell
models could serve as screening platforms during drug assessment. Stem cell therapy can benefit
Botswana in drug development as the country spends more money in importing medical drugs
from foreign countries. This money can be invested into creating stem cell models for drug testing
and screening. Stem cells are more accurate since they can be coaxed into developing into cells of
human organs since they are of human pluripotent cell lines, which are stem cells capable of
developing into any type of cell or tissue except those that form a placenta, and this will eliminate
the use of animals and humans during clinical trials. Adopting stem cells for research, for testing
the toxicity of drugs and identifying potential new therapies is less costly for the country and for
drug producing countries. Not only is there an endless supply of them, but they provide a more
consistent basis for drug testing.
Stem cells can lead to major innovations and subsequent improvements in the quality of life,
investing stem cell therapy and research scientific research, can improve the human condition and
alleviate suffering and better the way we live. It is a responsibility of government to ensure that
they sensitize the citizens about stem and the potential benefit they may do to the country as a way
of trying to curb the ethical issues and moral issues.