In this slide contains details about baby care products Presented by: G.CHIRANJEEVI (Department of pharmaceutical analysis).RIPER, anantapur

1. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 1
BABY CARE PRODUCTS
A Seminar as a part of curricular requirement
for I year M.Pharm Ⅱ semester
Presented by
P. CHIRANJEEVI
(Reg. No.20L81S0706)
Pharmaceutical Analysis

2. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 2

3. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 3
• Baby toilet soap shall be a high grade, thoroughly saponified, milled soap
or homogenized soap or both, white or colored, mildly perfumed or
unperfumed, and compressed in firm smooth cakes.
• It shall possess good cleaning and lathering properties. It shall be free from
rancidity
Baby toilet soaps

4. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 4
• TEST FOR FREEDOM FROM GRIT
• DETERMINATION OF NICKEL
• DETERMINATION OF IRON
• DETERMINATION OF COPPER
Methods to evaluate baby toilet soaps

5. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 5
PROCEDURE
• Hold a bar of soap in running tap water and rub between both hands for about 3
minutes.
• No gritty or rough feel should be perceived while rubbing the soap surface.
• Examine the surface of the bar which shall not be rough and shall feel smooth when
the fingers are moved across the surface.
• Set the bar on and let it dry for 24 hours at room temperature and examine its
surface.
• The soap shall be taken to have passed the test if there is no gritty or rough feel on
the surface.
TEST FOR FREEDOM FROM GRIT

6. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 6
• Weigh 50g of soap in a beaker and dissolve in hot water.
• Add to this soap solution 40ml fill of concentrated hydrochloric acid, stir and keep
on steam bath until fatty acid layer separates.
• Add 20g of paraffin wax, stir at intervals and allow it to settle until phases are clear.
Cool to room temperature.
• Remove wax cake with rod, rinse with water and add rinsing to aqueous phase.
Evaporate aqueous phase to about 60ml by gentle boiling.
• Add 100 ml of water and filter through paper washed previously with hydrochloric
acid.
ISOLATION OF METAL FROM
SOAP

7. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 7
• Evaporate filtrate and washings to about 60ml, Cool and transfer to
volumetric flask. Make up the volume to 100 ml.
• Take aliquot portions for metal estimation.

8. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 8
• Take 50ml aliquot of the aqueous solution from the test solution in a 250-ml
beaker. Evaporate the solution to about 15ml by heating.
• Transfer the solution to a 50ml glass stoppered volumetric flask using a
small quantity of water for rinsing the solution from the beaker into the
volumetric flask.
• Add to the flask 3 ml of saturated bromine water and allow to stand for one
minute. Add liquor ammonia dropwise until excess bromine is destroyed as
indicated by the disappearance of brown color.
Determination of nickel

9. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 9
• Then add 5ml of liquor ammonia in excess, If a precipitation occurs, filter the
solution and wash the precipitate with distilled water; combine the filtrate and
the washings and concentrate to a volume of a few mL and transfer to a 50ml
volumetric flask.
• Add 10ml of dimethyl glyoxime solution, followed by 15-20 ml of 95% ethyl
alcohol. Mix thoroughly and make up the volume and again mix thoroughly.
• Allow the solution to stand for 5 min to permit full development of color. The
sample shall be considered to have passed the test if no pink color develops.

10. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 10
• Take 5 ml aliquot of the aqueous solution from the test solution in a 25ml
volumetric flask.
• To this add 4ml citric acid solution and 0.02 ml methyl red indicator and
liquor ammonia till the color of the solution turns yellow.
• Then add 3 ml liquor ammonia in excess. Cool the solution and add 3 ml
thioglycolic acid. Make up the volume to 25 ml and mix the solution
thoroughly.
DETERMINATION OF IRON

11. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 11
• Filter the solution through acid washed and dried filter paper. Measure
absorbance of the clear solution at 540 nm in the spectrophotometer using
water as reference.
• Prepare a calibration curve with standard iron solution and determine the
iron content of the soap sample from it.

12. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 12
• Take 20ml aliquot of the aqueous solution to it add 10 ml of dibenzyl
dithiocarbamate solution followed by 25ml sulphuric acid in a separating
funnel. Shake the solution for 1 min and allow it to settle.
• Run the lower carbon tetrachloride into a 25ml volumetric flask.
• Wash the aqueous layer with carbon tetrachloride and transfer through
glasswool to volumetric flask.
Determination of copper

13. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 13
• Make up the volume and mix well. Measure the absorbance of the clear
solution at 435nm in spectrophotometer.
• Prepare a calibration curve with standard copper solution and determine the
copper content of the soap sample from it.

14. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 14
• Test for freedom from boric acid
• Determination of matter insoluble in boiling water
• Determination of fineness
• Determination of moisture and volatile matter
• DETERMINATION OF PH OF aqueous suspension
• TEST FOR heavy metals
• Determination of arsenic
Methods to evaluate skin powder for
infants

15. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 15
• Weigh about 1 g of the material in a porcelain or china dish.
• Add about 2 ml of concentrated sulphuric acid and stir thoroughly with a
glass rod.
• Then add about 5 ml of rectified spirit and again stir thoroughly.
• Ignite and observe the appearance of the flame.
• The material shall be considered to be free from boric acid if the flame does
not have a green outer edge.
TEST FOR FREEDOM FROM BORIC
ACID

16. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 16
Requirements for Skin Powder for Infants

17. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 17
INDIAN STANDARDS
• IS 3959
• IS 5339
• IS 15153
• IS 6608
• IS 3958
REFERENCES

18. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 18