The document describes a toolkit for comparing variant calls from different variant callers and sequencing technologies. It proposes establishing a set of true variants by comparing calls across multiple callers and technologies on gold standard genomes. The toolkit includes a comparison architecture that analyzes variants, identifies real variants by summarizing metrics, and scales to large numbers of variants and samples. It also describes building analysis pipelines in Clojure and providing comparison results through a web interface with metrics. The goal is to help answer biological questions by determining true variants and prioritizing based on existing evidence.