Dr. Kenneth Dickie from Royal Centre of Plastic Surgery in Barrie, Ontario explained the refining experience for Ambulatory Surgery.
If you have any questions, please contact Dr. Kenneth Dickie at http://royalcentreofplasticsurgery.com/
Acute pain after surgery - lessons learned from the last decade - Stephan Sch...scanFOAM
A talk by Stephan Schug at the 2017 meeting of the Scandinavian Society of Anaestesiology and Intensive Care Medicine.
All of the conference content can be found here: https://scanfoam.org/ssai2017/
Dr. Kenneth Dickie from Royal Centre of Plastic Surgery in Barrie, Ontario explained the refining experience for Ambulatory Surgery.
If you have any questions, please contact Dr. Kenneth Dickie at http://royalcentreofplasticsurgery.com/
Acute pain after surgery - lessons learned from the last decade - Stephan Sch...scanFOAM
A talk by Stephan Schug at the 2017 meeting of the Scandinavian Society of Anaestesiology and Intensive Care Medicine.
All of the conference content can be found here: https://scanfoam.org/ssai2017/
The presentation deals with the basics of pre anesthetic checkups, its only for the educations purpose!
Any kind of replication, modifications and republication is strictly prohibited.
All Rights reserved to the Author. 2016
40%-80% of auto accident claimants have overlooked diagnoses. The most commonly overlooked are thoracic outlet syndrome, cervical disc damage mistakenly called sprain or whiplash, post-concussion syndrome, slipping rib syndrome, Tietze syndrome and Tempro-mandibular joint syndrome. This article tells readers the clinical sign and symptoms of each and the correct medical tests to use, which are employed by doctors at Johns Hopkins Hospital. It also described an on-line questionnaire at www.DiagnoseThePains.com which gives diagnoses with a 96% correlation with diagnoses of Johns Hopkins Hospital doctors.
Missed Diagnoses association in Rear end collisions Nelson Hendler
There are a number of overlooked diagnoses which occur after a rear-end accident. This paper shows an attorney how to convert a misdiagnosed 'soft tissue injury case" into damaged cervical disc,TMJ, thoracic outlet syndrome,and post concussion syndrome using a diagnostic paradigm to get diagnoses with a 96% correlation with diagnoses of Johns Hopkins Hospital doctors. This improves patient care and increases recovery.
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share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
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Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
DISSERTATION on NEW DRUG DISCOVERY AND DEVELOPMENT STAGES OF DRUG DISCOVERYNEHA GUPTA
The process of drug discovery and development is a complex and multi-step endeavor aimed at bringing new pharmaceutical drugs to market. It begins with identifying and validating a biological target, such as a protein, gene, or RNA, that is associated with a disease. This step involves understanding the target's role in the disease and confirming that modulating it can have therapeutic effects. The next stage, hit identification, employs high-throughput screening (HTS) and other methods to find compounds that interact with the target. Computational techniques may also be used to identify potential hits from large compound libraries.
Following hit identification, the hits are optimized to improve their efficacy, selectivity, and pharmacokinetic properties, resulting in lead compounds. These leads undergo further refinement to enhance their potency, reduce toxicity, and improve drug-like characteristics, creating drug candidates suitable for preclinical testing. In the preclinical development phase, drug candidates are tested in vitro (in cell cultures) and in vivo (in animal models) to evaluate their safety, efficacy, pharmacokinetics, and pharmacodynamics. Toxicology studies are conducted to assess potential risks.
Before clinical trials can begin, an Investigational New Drug (IND) application must be submitted to regulatory authorities. This application includes data from preclinical studies and plans for clinical trials. Clinical development involves human trials in three phases: Phase I tests the drug's safety and dosage in a small group of healthy volunteers, Phase II assesses the drug's efficacy and side effects in a larger group of patients with the target disease, and Phase III confirms the drug's efficacy and monitors adverse reactions in a large population, often compared to existing treatments.
After successful clinical trials, a New Drug Application (NDA) is submitted to regulatory authorities for approval, including all data from preclinical and clinical studies, as well as proposed labeling and manufacturing information. Regulatory authorities then review the NDA to ensure the drug is safe, effective, and of high quality, potentially requiring additional studies. Finally, after a drug is approved and marketed, it undergoes post-marketing surveillance, which includes continuous monitoring for long-term safety and effectiveness, pharmacovigilance, and reporting of any adverse effects.
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Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
3. -AWARENESS PROBLEMS
-INTRODUCTION
---Awareness in anesthesia during operation occurs, when a patient becomes conscious
during a surgical procedure performed under GA and subsequently has recall of these
events
=A-For Anesthesiologists, AAranks second only to death as a “Dreaded” complication
=Incidence:-o.1% to o.2%
-Cardiac surgery 1.1% to 1.5%
-Obstetric C/S (0.4%)
-Surgery in Trauma cases (11% to 43%)
=Significantly influence the cognitive and psychological functions of the patients
=Medicolegal issue
5. -AWARENESS PROBLEMS
WHO IS AT RISK FOR
-ANESTHESIA AWARENESS
--1-Women > Men
--2-Age < 60 years
--3-TIVA > Inhalational
--4-Long Duration of surgery
--5-Previous Awareness history
--6-People with natural Red Hair
6. -AWARENESS PROBLEMS
-CAUSES OF AWARENESS
A-LIGHT ANESTHESIA
a-Cardiac surgeries
b-C/S
c-Surgery in Trauma
d-ASA physical status 4 or 5
e-Premature discontinuation of
anesthetic agents
7. - AWARENESS PROBLEMS --WHO IS AT RISK FOR
-ANESTHESIA AWARENESS
B-INCREASED ANESTHETIC REQUIREMENTS
a-chronic use of Benzodiazepines or opioids
b-Alcoholics
c-Severly anxious patients
d-Difficult Intubation
e-Previous awareness experience
C-IMPROPER EQUIPMENT MAINTAINENCE
OR ANESTHESIOLOGISTS ERROR
a-Failure to fill vaporizers with inhalational agents
b-Judgement errors related to drug and volatile agents
c-Disconnections and Kinks in tubes from the ventilator
9. -AWARENESS PROBLEMS
-PATIENTS PERCEPTION OF AWARENESS
--Recall immediately after surgery, Recovery room
or Several days later
MOST COMMON
a-Sounds and conversations – 89% to 100%
b-Sensation of Paralysis – 85%
c-Anxiety and Panic
d-Helplessness and powerlessness
e-Pain 39%
LEAST COMMON
a-Visual Perceptions
b-Intubation or tube
c-Feeling the operation without pain
10. -AWARENESS PROBLEMS
-AFTER EFFECTS
--1-Sleep disturbances
--2-Repititive nightmares
--3-Anxiety and panic attacks
--4-Depression
--5-Flash backs
--6-Avoidence of Medical care
--7-Suicide
--8-Post-Traumatic stress disorders(PTSD)
11. -AWARENESS PROBLEMS
-PREVENTION OF AWARENESS
--A- PRE-OPERATIVE EVALUATION
--1-History(proper and detailed)
--2-Thorough Physical examination
--3-Identifying patients risk factors for intra-operative
awareness
--4-Informing high risk patients regarding the possibility of
intra-operative awareness
--B- PRE-INDUCTION OF GENERAL ANESTHESIA
--5-Prophylactic administration of Benzodiazepines
--6-Checking the functioning of Anesthesia delivery system
12. -AWARENESS PROBLEMS
-PREVENTION OF AWARENESS
--C- INTRA-OPERATIVE INTERVENTIONS
--1-Cautionary use of the Neuromuscular Blocking agents
--2-Inhalant Anesthetics must be monitored with End-Tidal-Gas
analyzers and the minimum alveolar concentration (MAC)
of anesthetic agents should be maintained >0.8
--3-BIS value < 60
--D- POST-OPERATIVE INTERVENTIONS
--4-Post-operative interview to report awareness
a-What is the last thing you remember before surgery
b-What is first thing you remember after surgery
c-Do you remember anything during the procedure
d-Did you dream during the procedure
--5-Providing post-operative counseling or psychological support
13. -AWARENESS PROBLEMS
METHODS OF MONITORING
CONCIOUSNESS
DURING GENERAL ANESTHESIA
--A- CLINICAL SIGNS
--1-Sympathetic activity
-HR
-BP
-SWEATING
-PUPILARY DILATATION
*-LACRIMATION
-UNRELIABLE SIGNS ALSO
14. -AWARENESS PROBLEMS METHODS OF MONITORING
CONCIOUSNESS
DURING GENERAL ANESTHESIA
--B---ISOLATED FOREARM TECHNIQUE
--1-Tourniquet applied to the patient’s forearm before
the administration of muscle relaxants
--2-Moves fingers if aware
--3-Verbal command to confirm
15. -AWARENESS PROBLEMS METHODS OF MONITORING
CONCIOUSNESS
DURING GENERAL ANESTHESIA
--C---MONITORING OF BRAIN ELECTRICAL ACTIVITY
--1-BIS (bispectral index monitoring)
a-EEG derived multivariant scale
b-0 to 100 (For GA 40 to 60)
--2-AEP (Auditory evoked potential)
--3-Narcotrend
16. -AWARENESS PROBLEMS
METHODS OF MONITORING
CONCIOUSNESS
DURING GENERAL ANESTHESIA
--D- MEASUREMENTS OF LOWER ESOPHAGEAL
SPHINCTER CONTRACTIONS
--E- EEG OF FRONTALIS MUSCLE