A 49-year-old female presented with a recurrent brain lesion on MRI after initial radiotherapy for a hypothalamus tumor. 18F-FDG PET and SPECT with 201Tl, 99mTc-MIBI, and 99mTc-ECD showed increased uptake, suggesting the lesion was a tumor recurrence rather than radiation necrosis. A second course of radiotherapy was given. Follow-up found the right frontal lesion had progressed while a new left temporal lesion was detected, both indicative of recurrence based on imaging characteristics.

1. Assessment of Recurrent Brain Tumor by 18 F-FDG PET and SPECT Using 201 Tl, 99m Tc-MIBI, and 99m Tc-ECD

6. TIWI hypointensity with heterogenous enhancement T2WI edema around the lesion

9. FDG-PET Thallium MIBI ECD

11. 89-4 92-8   Pre-R/T 91-10 1st R/T 2ndR/T

12. 91-10 post 1 st R/T 92-8 post 2nd R/T Thallium MIBI MRI (T1WI)

13. 92-8 post 2nd R/T T1WI C(+) Thallium A new lesion in left mesial temporal.

15. Discussion

24. Thank you for your attention!