This document discusses central venous catheters and invasive arterial blood pressure monitoring. It provides information on indications for central lines and arterial catheters including venous access and infusion of irritant drugs. Complications of lines include infection, bleeding, embolism and organ perforation. The document describes how to insert and care for lines, including using ultrasound guidance and maintaining asepsis. It also discusses interpreting central venous pressure and issues like incorrect transducer positioning. Arterial monitoring is described along with complications like thrombosis and embolism."
central venous pressure and intra-arterial blood pressure monitoring. invasiv...prateek gupta
central venous pressure and intra-arterial blood pressure monitoring. various sites for cvp and Ibp insertion. working principle for cvp and ibp. indication and complication. various waveform of cvp and ibp
central venous pressure and intra-arterial blood pressure monitoring. invasiv...prateek gupta
central venous pressure and intra-arterial blood pressure monitoring. various sites for cvp and Ibp insertion. working principle for cvp and ibp. indication and complication. various waveform of cvp and ibp
A lecture highlighting the role of Echocardiography as a major hemodynamic monitoring tool in the Intensive Care settings and the assessment of loading conditions.
The CVP catheter is an important tool used to assess right ventricular function and systemic fluid status. Normal CVP is 2-6 mm Hg. CVP is elevated by : overhydration which increases venous return.
Hemodynamic monitoring of critically ill patientsV4Veeru25
Hemodynamic monitoring measures the blood pressure inside the veins, heart, and arteries. It also measures blood flow and oxygen proportion in the blood. Monitoring hemodynamic events provides information about the adequacy of a patient's circulation , perfusion, and oxygenation of the tissues and organ systems. The effectiveness of hemodynamic monitoring depends both on available technology and on physician ability to diagnose and effectively treat the disease
A lecture highlighting the role of Echocardiography as a major hemodynamic monitoring tool in the Intensive Care settings and the assessment of loading conditions.
The CVP catheter is an important tool used to assess right ventricular function and systemic fluid status. Normal CVP is 2-6 mm Hg. CVP is elevated by : overhydration which increases venous return.
Hemodynamic monitoring of critically ill patientsV4Veeru25
Hemodynamic monitoring measures the blood pressure inside the veins, heart, and arteries. It also measures blood flow and oxygen proportion in the blood. Monitoring hemodynamic events provides information about the adequacy of a patient's circulation , perfusion, and oxygenation of the tissues and organ systems. The effectiveness of hemodynamic monitoring depends both on available technology and on physician ability to diagnose and effectively treat the disease
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Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
2. Central Venous
Catheter/Central Line is:
A catheter inserted into a
large vein of the body
the tip of which lies in or
very near to the right
atrium
3. Indications:
Venous access
Infusion of peripherally irritant substances e.g. caustic
drugs, ionotropic drugs
Administration of TPN
To measure central venous pressure (preload)
Removal of air embolism
4. ContraIndications:
Known deficiencies in collateral circulation, Raynauds
phenomenon, Thromboangitis obliterans, Brachial artery
insufficiency
Infection of the site
Trauma to the proposed site
Excessive anticoagulation
6. Insertion Sites
Internal jugular vein
Right side usually used, lower risk of thrombus formation
(due to rapid blood flow rates), arterial involvement &
pneumothorax.
Risk of air embolism, damage to carotid artery, trachea.
7. Subclavian vein
Lower infection rates, patient comfort, lower risk of
thrombus formation (due to rapid blood flow rates),
displacement of catheter less likely.
Risk of pneumothorax, puncture of subclavian artery,
air embolism,
10. Insertion
Aseptic insertion
Seldinger technique
Trendelenburg position
Ultrasound guidance NICE 2002
Chest x-ray
Infection risk
Multiple lumen catheters versus single lumen catheters
- CVP via distal port
11. Ports & lumens
• 3 or 5 lumen.
• To monitor CVP, always connect
monitoring line to distal port.
• Other ports can be used for fluid /
drug administration.
• N.B. it takes @ 1ml of fluid to prime
the line.
12. Potential complications
Infection
Bleeding
Vascular erosion
Pneumothorax
Arrhythmias
Embolism (air or clot)
Perforation of RA
Cardiac tamponade
14. Central Venous Pressure is:
Pressure exerted by the blood within the
right atrium
Used to measure right atrial filling
pressure
Guide to fluid loading and fluid
replacement…….. but
Also influenced by right ventricular
function, transthoracic pressure and
venous tone.
PRELOAD
15. CVP Trace
A wave – atrial contraction
C wave – tricuspid valve closing
(/bulging)
X descent – atrial relaxation
V wave – atrial filling; increased
atrial pressure prior to TV opening
Y descent atrial emptying, TV open,
blood flows into ventricle
17. Transducer recorded CVP
Central line attached to a fluid filled transducer system
Transducer converts physiological pressure into an
electronic waveform
Readings in mmHg, continuous and real time
18. “Normal Values”
7-14 mmHg (but remember influencing factors)
Readings should be taken from phlebostatic axis.
21. “Zeroing”
Readings have to be taken from the correct point
otherwise they will be inaccurate
Correct point is the source of the pressure level of the
right atrium
External anatomical landmark for right atrium is the
phlebostatic axis
22. Effects of incorrect
positioning
• If the transducer is too low, this will give us a falsely
high CVP reading.
• Likewise, if the transducer is too high, this will give us
a falsely low reading
23. Central venous pressure
monitoring: limitations
Cardiovascular abnormalities:
Systemic venoconstriction (elevates CVP, so
hypovolaemia may go unnoticed).
RV compliance: if RV is constricted,
hypertrophied or ischaemic, then CVP may be
falsely high.
Tricuspid valve disease: CVP will be elevated.
Intracardiac shunts (VSD) make clinical
interpretation of CVP difficult.
24. Central venous pressure
monitoring: limitations
• Increased intrathoracic pressure: PEEP, positive
pressure ventilation elevate CVP
• LV function: CVP and LV filling pressures
correlate in health people, but in LV failure &
pulmonary disease, CVP will tell you nothing
about LV function
25. Removal of Line
Infection risk – remove as soon as possible
Aeseptic procedure
Air embolus – head down/flat, valsalva manoevre, air
occlusive dressing (24 hours), tip culture and
sensitivity.
27. Indications
Intra-arterial blood pressure (IBP) measurement is often considered to
be the gold standard of blood pressure measurement.
Critically ill patients e.g: sepsis, post-arrest, major trauma
Patients undergoing major surgery, anticipated large fluid shifts
Surgeries requiring induced or anticipated hypotension
Patients who require serial ABG sampling
Acute renal failure
Mechanical ventilation
Failure of indirect arterial blood pressure measurement, e.g. burns or
obesity
29. Allens Test
Measuring the flow of arterial blood to the hands.
Patient clenches fist for 1 minute
Pressure is applied over radial arteries
Patient opens fingers of both hands rapidly and colour is
examined.
Initial pallor should be quickly replaced by rubor (flushed)
This may then be repeated using the ulnar artery
32. Fluid filled monitoring
systems
It is important to keep the flush bag primed to 300mmHg
This delivers 3mls/hr of flush solution & keeps the vessel patent
Remember to turn the 3 way tap on the pressure bag off to the
pressure bag so that it doesn’t deflate
34. Zeroing
As with CVP, transducer must be level with Rt atrium
(@4th intercostal space [phlebostatic axis])
If transducer is positioned to low, ABP will read falsely
high
If transducer is positioned incorrectly high, then ABP
will read falsely low
35. Complications
Inadvertent arterial drug
administration
Thrombosis related to: duration
of use, size of cannulae, wrist
size (arterial diameter), catheter
material (Teflon best), flush
system, prolonged systemic
hypotension, number of
insertion attempts.
36. Complications cont..
Haematoma, haemorrhage
Sepsis: local site, bacteraemia
Distal emboli, thumb (see pic) or
hand ischemia proximal forearm
ischemia.
Aneurysm, AV fistulae.
37. General troubleshooting
• Problem:
No waveform
Artifact
Waveform drifting
Unable to flush line
Reading too high
Reading too low
Overdamped waveform
40. Removal of Art line
• Wash hands, put on gloves, gather equipment.
• Remove dressing and sutures (if present).
• Apply firm pressure to insertion site, pull out line
gently.
• Apply manual pressure (this may take up to 10 mins or
longer), elevate limb if desired to aid haemostasis.
• Apply small occlusive dressing, continue to observe for
leakage periodically.
Editor's Notes
IJV – rt side usually used, lower risk of thrombus formation due to rapid blood flow rates, lower risk of hitting an artery, lower risk of causing a pneumothorax
Subclavian vein – associated with lower rates of infection, probably more comfortable for pt, but higher risk of hitting an artery on insertion & causing a pneumothorax.
Why should we measure CVP? Reasons?
Patients with hypotension who are not responding to basic clinical management.
Continuing hypovolaemia secondary to major fluid shifts or loss.
Patients requiring infusions of inotropes.
Limitations: in some kinds of heart valve disease and high blood pressure within the lungs, CVP becomes less reliable reflection of Rt sided filling pressure
Tricuspid regurgitation – loss of waveform due to blood re-entering atrium
Tricuspid stenosis – ‘sharper’ waveform due to poor functioning valve
Constrictive pericarditis / Chronic inflammation– (thickened fibrotic pericardiam) limiting adequate contraction, therefore poor ejection.
Atrial septal defect – Backflow of blood from LA on filling
AF - Irregular
First degree – c interval (closing of tricuspid) is prolonged.
Complete – atrium contracts with ventricle at the same time. Disassociation.
Pulsatile pressure from the catheter tip is transmitted through the fluid filled monitoring tubing to a pressure sensitive diaphragm / membrane within the transducer.
The diaphragm is moved by pressure waves, which are converted into electrical signals.
These signals are converted into real time pressure waves on the monitor.
The phlebostatic axis is located at the fourth intercostal space at the mid-anterior-posterior diameter of the chest wall. This is the location of the right atrium,
In either case the CVP must be ‘zeroed’ at the level of the right atrium. This is usually taken to be the level of the 4th intercostal space in the mid-axillary line while the patient is lying supine.
Zeroing eliminates the effects of atmospheric pressure and gives the transducer a neutral point from which to begin measurement.
THIS IS AN ASEPTIC PROCEDURE – STERILE GLOVES, STERILE FIELD, DRESSING PACK, CLEAN SITE WHEN DRESSING REMOVED
THE PATIENT SHOULD BE SUPINE WITH HEAD TILTED DOWN
ENSURE NO DRUGS ARE ATTACHED AND RUNNING VIA THE CENTRAL LINE
REMOVE DRESSING
CUT THE STITCHES
SLOWLY REMOVE THE CATHETER
IF THERE IS RESISTENCE THEN CALL FOR ASSISTANCE
APPLY DIGITAL PRESSURE WITH GAUZE UNTIL BLEEDING STOPS
DRESS WITH GAUZE AND CLEAR OCCLUSIVE DRESSING EG TEGADERM
No absolute contraindications
Perform Allens test first - radial artery is best: it is most accessible, less susceptible to venous sampling, and easiest to clean (see below).
Swab the skin.
The original test proposed by Allen is performed as follows:[1]
1 The patient is asked to clench both fists tightly for 1 minute at the same time.
2 Pressure is applied over both radial arteries simultaneously so as to occlude them.
3 The patient then opens the fingers of both hands rapidly, and the examiner compares the colour of both. The initial pallor should be replaced quickly by rubor.
4 The test may be repeated, this time occluding the ulnar arteries.
SHOW ABG SYRINGE
Small gauge needle should be used - this is much less painful, may eliminate the need for local anesthetic, but local is often used
Hold the syringe like a pencil and enter the skin over the site of the palpated pulse, aiming proximally at an angle of 30°
Use one hand to feel the radial pulse and insert the syringe at a 30° angle to the skin surface.
Advance slowly along the line of the artery until you see a flashback of blood.
If you fail to see a flashback, withdraw the needle slowly. Try palpating the artery again.
Hold the syringe steady and allow the syringe to fill. You might need to draw back gently on the plunger if using a small needle.
Once you have 0.5 ml of blood, withdraw the syringe and press firmly over the puncture site with a gauze pad for 2–3 min. Attach the gauze pad tightly to the skin with tape.
Take the needle off the syringe and dispose of it in a hazardous material container. Carefully expel any air from the syringe (some packs have a filter that you can attach to the syringe to help with this).
Cap the syringe with the cap provided and tip upside down a few times to mix well.
Take the sample to the blood gas machine yourself or, if it needs to be sent to the biochemistry lab, place the sample in a plastic bag with a few ice cubes. Don't forget to put a label on the syringe.
Dicrotic knotch - secondary upstroke in the descending part of a pulse trace corresponding to the transient increase in aortic pressure upon closure of the aortic valve
Overshoot causes: long tubing, stiff tubing, increased vascular resistance
Undershoot causes: bubbles in tubing, catheter kinks, clots. low flush bag pressure, overly compliant tubing
Square wave test – (dynamic response testing)
Fast flush – there should be no more then 2 oscillations (wave forms) following the fast flush. And the amplitude of each oscilation should be no greater then 1/3rd of the previous oscillation
See above example for oscilations after the fast flush.