The gendered foundations of partner violence and its relationship to HIVHopkinsCFAR
This document discusses the relationship between gender-based violence and HIV. It finds that intimate partner violence (IPV) is the most common form of violence women experience globally. IPV increases women's risk of HIV through multiple pathways, including exposure to higher-risk partners of abusive men, genital trauma from violence increasing susceptibility to infection, and psychological impacts of abuse like PTSD that can influence risk behaviors. While individual, relationship, and community factors all predict violence, the strongest predictors of a population's IPV levels are social norms justifying abuse and gender inequality in areas like ownership rights. Economic development alone does not explain violence levels, but appears to be a marker for related social changes. Addressing underlying gender inequality and social norms is key
The document discusses substance abuse in Michigan based on data from the Michigan Department of Health and Human Services. It finds that among Michigan youth:
- Alcohol/substance use is associated with increased violent and risky behaviors like fighting and carrying weapons, as well as greater mental distress. Binge and current drinkers report more of these issues than non-drinkers.
- Alcohol use is also linked to riskier sexual behaviors like unprotected sex and multiple partners. Binge and current drinkers exhibit these behaviors more frequently.
- Drinkers are more likely to engage in unhealthy weight control methods such as fasting, vomiting, laxative use and diet pills compared to non-drinkers.
- Drinkers
According to the document:
1) In 2011, it was estimated that approximately 21 gay and bisexual men in BC died from HIV disease, and around 18 died from suicide.
2) The estimates of suicide among gay and bisexual men are highly sensitive to assumptions about relative risk and the proportion of males that are gay or bisexual. The estimates could range from 6 to 34 suicides per year.
3) Historically, HIV-related deaths have been higher among gay and bisexual men, but suicide rates may surpass HIV if HIV treatment trends continue successfully. Further study is needed to better understand suicide among gay and bisexual adult men.
This document summarizes a study examining substance use differences between Puerto Rican youth who remained in the New York City area versus those who moved out of the area. The study found significant demographic differences between the two groups, with those who moved out of the area more likely to be older, married, employed, and less reliant on welfare. However, the study found no statistically significant differences in substance use, binge drinking, substance use disorders, or number of delinquent peers between the two groups. Limitations of the study included a small sample size of those who moved out of the area.
A comparative analysis of the health status of men aged 60 74 years and those...paulbourne12
In a comprehensive literature search studies on self-rated
well-being, quality of life and health have mostly singled
out particular cohorts such as young adults or youth [1-4],
population [5-11], elderly [12-26], children [27], and
nations [28]; but none emerges that has compared factors that determine self-rated well-being for young adults and elderly in the English-speaking Caribbean, especially Jamaica.
Violent offending by young people in New Zealand: 'Perception versus reality'...robine
This document discusses perceptions of youth violence in New Zealand. It finds that media portrayals of youth crime exaggerate the level of violence by focusing on individual cases without context. Official statistics show that while youth apprehensions for violence have increased in recent decades, violence offenses make up a small portion of total youth crimes. Public surveys also find that people generally overestimate youth crime levels and support harsh punishments despite a lack of understanding of trends and the youth justice system. The document advocates for prevention and rehabilitation approaches given risk factors for youth violence like behavioral issues, victimization, and substance abuse.
Substance Abuse Vs Suicidal risk report Final Draft 06_04_2015Geoffrey Kip, MPH
1. This study examines the relationship between substance abuse and suicide risk among youth ages 14-24 in Philadelphia. It analyzes whether substance abuse scores and specific drugs (alcohol, marijuana, tobacco, illicit drugs) predict suicide ideation and lifetime suicide scores.
2. The study uses a cross-sectional design and secondary data from behavioral health screens administered in emergency departments, primary care offices, schools and other locations. Logistic regression is used to calculate odds ratios for substance abuse variables predicting suicide history.
3. Preliminary results found that substance abuse scores and use of marijuana, alcohol, tobacco and other illicit drugs were all significant predictors of history of suicide in participants. Race also significantly predicted suicide history for those
The gendered foundations of partner violence and its relationship to HIVHopkinsCFAR
This document discusses the relationship between gender-based violence and HIV. It finds that intimate partner violence (IPV) is the most common form of violence women experience globally. IPV increases women's risk of HIV through multiple pathways, including exposure to higher-risk partners of abusive men, genital trauma from violence increasing susceptibility to infection, and psychological impacts of abuse like PTSD that can influence risk behaviors. While individual, relationship, and community factors all predict violence, the strongest predictors of a population's IPV levels are social norms justifying abuse and gender inequality in areas like ownership rights. Economic development alone does not explain violence levels, but appears to be a marker for related social changes. Addressing underlying gender inequality and social norms is key
The document discusses substance abuse in Michigan based on data from the Michigan Department of Health and Human Services. It finds that among Michigan youth:
- Alcohol/substance use is associated with increased violent and risky behaviors like fighting and carrying weapons, as well as greater mental distress. Binge and current drinkers report more of these issues than non-drinkers.
- Alcohol use is also linked to riskier sexual behaviors like unprotected sex and multiple partners. Binge and current drinkers exhibit these behaviors more frequently.
- Drinkers are more likely to engage in unhealthy weight control methods such as fasting, vomiting, laxative use and diet pills compared to non-drinkers.
- Drinkers
According to the document:
1) In 2011, it was estimated that approximately 21 gay and bisexual men in BC died from HIV disease, and around 18 died from suicide.
2) The estimates of suicide among gay and bisexual men are highly sensitive to assumptions about relative risk and the proportion of males that are gay or bisexual. The estimates could range from 6 to 34 suicides per year.
3) Historically, HIV-related deaths have been higher among gay and bisexual men, but suicide rates may surpass HIV if HIV treatment trends continue successfully. Further study is needed to better understand suicide among gay and bisexual adult men.
This document summarizes a study examining substance use differences between Puerto Rican youth who remained in the New York City area versus those who moved out of the area. The study found significant demographic differences between the two groups, with those who moved out of the area more likely to be older, married, employed, and less reliant on welfare. However, the study found no statistically significant differences in substance use, binge drinking, substance use disorders, or number of delinquent peers between the two groups. Limitations of the study included a small sample size of those who moved out of the area.
A comparative analysis of the health status of men aged 60 74 years and those...paulbourne12
In a comprehensive literature search studies on self-rated
well-being, quality of life and health have mostly singled
out particular cohorts such as young adults or youth [1-4],
population [5-11], elderly [12-26], children [27], and
nations [28]; but none emerges that has compared factors that determine self-rated well-being for young adults and elderly in the English-speaking Caribbean, especially Jamaica.
Violent offending by young people in New Zealand: 'Perception versus reality'...robine
This document discusses perceptions of youth violence in New Zealand. It finds that media portrayals of youth crime exaggerate the level of violence by focusing on individual cases without context. Official statistics show that while youth apprehensions for violence have increased in recent decades, violence offenses make up a small portion of total youth crimes. Public surveys also find that people generally overestimate youth crime levels and support harsh punishments despite a lack of understanding of trends and the youth justice system. The document advocates for prevention and rehabilitation approaches given risk factors for youth violence like behavioral issues, victimization, and substance abuse.
Substance Abuse Vs Suicidal risk report Final Draft 06_04_2015Geoffrey Kip, MPH
1. This study examines the relationship between substance abuse and suicide risk among youth ages 14-24 in Philadelphia. It analyzes whether substance abuse scores and specific drugs (alcohol, marijuana, tobacco, illicit drugs) predict suicide ideation and lifetime suicide scores.
2. The study uses a cross-sectional design and secondary data from behavioral health screens administered in emergency departments, primary care offices, schools and other locations. Logistic regression is used to calculate odds ratios for substance abuse variables predicting suicide history.
3. Preliminary results found that substance abuse scores and use of marijuana, alcohol, tobacco and other illicit drugs were all significant predictors of history of suicide in participants. Race also significantly predicted suicide history for those
Adolescent suicide risk four psychosocial factorsferrellnl
This document summarizes a study examining four psychosocial factors (hopelessness, hostility, negative self-concept, and low social support) as predictors of suicide risk in adolescents. The study found that adolescents with higher scores on a suicide probability scale had significantly higher levels of hopelessness and reported more serious suicide attempts requiring medical care compared to those with lower scores. While no single demographic predicted risk, collectively the four psychosocial factors correlated with increased risk. The study suggests future research should further examine how addressing these psychosocial factors could help reduce adolescent suicide risk.
The document summarizes the epidemiology of suicide and suicidal behavior based on an updated review of literature. Key points include: (1) suicide rates vary significantly across countries and demographics but onset typically occurs during adolescence/early adulthood; (2) risk factors are consistent cross-
Trauma experiences in the backgrounds of violent young offenders - Gywneth Bo...nacro_programmes
Professor Gywneth Boswell, Visiting Professor at the University of East Anglia and Director of Boswell Research Fellows. Speaking on childhood and adolescent trauma – impacts on development, and on individual health across the lifecourse
Speaking at Beyond Youth Custody's conference: Childhood trauma and young people in the criminal justice system, 19 November 2013.
Gender based violence_in_humanitarian_settings__a_practical_guidlines__by_dr_...Malik Khalid Mehmood
The document provides guidelines for interventions addressing gender-based violence (GBV) in humanitarian settings. It defines GBV as any harmful act perpetrated against a person's will based on gender differences between males and females. The guidelines discuss key concepts around sex and gender, define GBV, and outline types of GBV such as sexual, physical, emotional, and economic violence as well as harmful traditional practices. Root causes of GBV are discussed as gender inequality, abuse of power, and lack of belief in universal human rights, while contributing factors include alcohol abuse, poverty, conflict, and impunity. Global statistics are provided on the prevalence of GBV in various countries.
Beyond Youth Custody's trauma review and consultation - Mark Liddlenacro_programmes
Beyond Youth Custody is focusing on trauma and young offenders through a programme of review and consultation. Previous research and feedback from young people has highlighted trauma-related issues. The review work has identified that there are varying definitions of trauma, and research shows traumatic childhood experiences are common and impact many areas of functioning. Studies also show people with childhood trauma and abuse make up the criminal justice population. The review found adverse childhood experiences can increase traumatic stress risk, and multiple or chronic experiences increase negative impacts, though other factors like resilience can limit this. The next stages involve a national consultation on trauma and resettlement, and finalizing the literature review.
Final slides sexualassault7740compatibleversion (1)Rachel Finch
This work is important because it provides an in-depth analysis of the increasingly visual social problem of Sexual Assault (SA) within the intertwined social networks that college students study, work, and live. I was on a team comprised of University of Missouri females who observed victimization and political barriers for student survivors directly—both in our student social circles, and in the intimate partner violence prevention work we practiced on and off campus. We wanted to examine and report our understandings as female student researchers, using the social work framework for assessment at the level of institution and community. In the years surrounding this presentation, the enforcement of Title IX continues to be increasingly mandated alongside national media coverage of high profile cases of sexual assault in the world of professional and college sports. Our own athletic department at MU has since developed a student-athlete character development program as a component of prevention.
Rural and non-rural sexual minority youth showed similar health indicators, with a few exceptions. Rural sexual minority youth reported poorer mental health, lower safety, and higher substance use than both rural and non-rural heterosexual youth. Compared to heterosexual youth, sexual minority youth were more likely to be involved in social or political activities, perhaps to connect with a supportive community. While urbanicity may no longer confer differences for sexual minority youth, their sexual identity remains associated with greater health risks regardless of rural or non-rural location.
1 suicidejocelyn s. barrioseh1020patti smithsmile790243
This document summarizes the pedagogical aids used in most chapters of the textbook "Role Development in Professional Nursing Practice, Fifth Edition" to drive student comprehension and engagement. It lists learning aids such as chapter objectives, key terms, case studies, and critical thinking questions. The purpose is to address different learning styles and ensure mastery of concepts. Additionally, it provides publishing information for Jones & Bartlett Learning including contact details.
The study found that 8.5% of adolescents and young adults ages 13-20 reported perpetrating some form of sexual violence in their lifetime. Male perpetrators were more likely than females to report attempted rape or coercive sex. Female perpetrators tended to be older and victimize people older than themselves, while male perpetrators tended to be younger when they first offended and target younger victims. Very few sexual violence incidents were reported to authorities, with only one male perpetrator in the study reporting being arrested. The results provide initial nationwide estimates of adolescent sexual violence perpetration but have limitations due to sensitivity of the topic.
This research project aims to examine the family burden of people living with AIDS receiving treatment at BPKIHS. It will use an exploratory research design and survey 30 primary caregiver family members using interviews and assessments of family burden. The study hypothesizes that there will be no association between family burden and caregiver characteristics or social stigma. It seeks to understand the demographic profiles of PLWAs and their families, problems faced by caregivers, and the relationship between family burden and demographics. The results could help develop strategies to better support patients and reduce caregiver burden through education and policy changes.
This document discusses appropriate services for sexual minority youth. It begins by defining terms used to describe various sexual orientations and gender identities. It then estimates that between 2-5% of youth identify as a sexual minority. The document discusses factors that make this group less visible and reluctant to self-identify in more conservative communities. It outlines several risks faced by sexual minority youth, such as homelessness, bullying, substance abuse, and elevated suicide rates. The document stresses the importance of providing non-discriminatory, welcoming, and person-first services to sexual minority youth.
The document is a public relations proposal prepared by Axiom Public Relations for the Bowling Green State University Community of Care Coalition. It includes an opportunity statement, situation analysis based on secondary and primary research, target audiences, goals and objectives, strategies and tactics, promotional materials and budget, and evaluation plan. The proposal aims to address issues of sexual assault on campus and establish communication where victims feel comfortable reporting, while promoting the Coalition and generating awareness of sexual assault as a community issue.
This research proposal aims to study factors that lead to higher rates of HIV/AIDS diagnoses among African American men ages 18-24 compared to other groups. The researcher will conduct surveys and interviews with at least 100 men who have sex with men, including those of various races and socioeconomic backgrounds. Key research questions include examining differences in access to healthcare, levels of risk behavior, and how cultural and educational factors may influence HIV transmission patterns between racial groups. The goal is to better understand disparities and empower communities through more effective education and prevention strategies.
Young Gay Couples - How they use drugs and sex to stay safeYTH
Data collected from 199 young gay couples (YMSM couples) recruited through Facebook ads found that men were thoughtful about their drug use and HIV risk reduction strategies within their partnerships.
A research report on root causes, risk factors and preventive strategies. Research by Midrift Hurinet and the Danish Institute Against Torture (DIGNITY).
This study examined predictors of suicide attempts among adolescents attending Seventh-day Adventist schools in the US. It found depression to be the strongest predictor of suicide attempts. Having a negative family climate and less caring parenting also predicted higher rates of suicide attempts, while intrinsic religious orientation predicted lower rates. A survey of over 10,000 students found that depression, family relationships, parenting styles, and religious commitment were significant factors influencing suicidal ideation among this conservative religious group.
The document summarizes key findings from the Edinburgh Study of Youth Transitions and Crime regarding policing and youth justice. It found that 1) persistent serious offending is associated with victimization and social adversity, 2) early identification of at-risk children is difficult and may be counterproductive, 3) critical moments in early teenage years shape pathways in and out of offending, and 4) diversionary strategies help facilitate desistance from crime. The study suggests developing age-graded services including universal support in early years and targeted intervention in teenage years with a focus on social justice rather than criminal justice.
This study analyzed data from a nationally representative sample of 1,143 individuals ages 16-22 to examine patterns of sexual violence perpetration over time. Three key profiles of perpetration were identified for both younger (16-18) and older (19+) age groups: 1) a high perpetration profile with a high probability of sexual harassment, rape, coercive sex, and sexual assault; 2) a middle perpetration profile with a high probability of sexual harassment; and 3) a low perpetration profile with low probabilities of any perpetration. While most individuals remained stable in their perpetration profiles over time, some escalated or reduced their perpetration behaviors. Few gender differences were found except that males ages 16-18 were more
It is an outcome of state of art systematic review of literature. It provides insights about the cause, consequences and future concerns of violence against women in India
Criminal behavior among the homeless individualsRichardWahaba1
1) The documents discuss criminal behavior among homeless individuals, especially those with mental illnesses. Several studies found high rates of arrest, conviction, and incarceration among homeless people with mental disorders, ranging from 63.95-90% arrested.
2) Victimization is also common, with rates of 4.4-35% for any victimization and 7.7-28% for violent victimization. Homeless women and those with a history of prior victimization are at even higher risk.
3) One study in rural China found that 10% of individuals with schizophrenia engaged in criminal behavior, with 2% incarcerated and 8% arrested. Homelessness and mental illness contribute to increased criminal behavior.
Serieswww.thelancet.com Vol 379 June 23, 2012 2373.docxlesleyryder69361
Self-harm and suicide are major public health problems among adolescents. Around 10% of adolescents report having self-harmed, with rates being higher in females. Important contributors include genetic, psychiatric, psychological, familial, social, and cultural factors. Prevention requires both universal measures for all youth and targeted initiatives for high-risk groups. There remains little evidence about effective treatments, and identifying successful prevention initiatives and treatments is a key need.
Sex- and Age-specific Increases in Suicide Attempts by Self-Poisoning in the ...Δρ. Γιώργος K. Κασάπης
There was a more than twofold increase in the rate of suspected self-poisoning suicide cases between 2011 and 2018, according to a new study that looked at more than 1.6 million such cases.
Here’s what else you need to know:
•Overall trends: Cases of suicide attempts by self-poisoning doubled in those aged 10-18 between 2011 and 2018, rising from around 39,000 to more than 78,000.
•Gender: More girls than boys attempted suicide by self-poisoning. The rate of intentional attempts among girls 10-18 also steadily increased from 2011-2018.
•Outcomes: The number of serious outcomes — including death and hospitalizations — as a result of the poisoning increased 235% between 2000 and 2018, and more than 1,400 children died.
Adolescent suicide risk four psychosocial factorsferrellnl
This document summarizes a study examining four psychosocial factors (hopelessness, hostility, negative self-concept, and low social support) as predictors of suicide risk in adolescents. The study found that adolescents with higher scores on a suicide probability scale had significantly higher levels of hopelessness and reported more serious suicide attempts requiring medical care compared to those with lower scores. While no single demographic predicted risk, collectively the four psychosocial factors correlated with increased risk. The study suggests future research should further examine how addressing these psychosocial factors could help reduce adolescent suicide risk.
The document summarizes the epidemiology of suicide and suicidal behavior based on an updated review of literature. Key points include: (1) suicide rates vary significantly across countries and demographics but onset typically occurs during adolescence/early adulthood; (2) risk factors are consistent cross-
Trauma experiences in the backgrounds of violent young offenders - Gywneth Bo...nacro_programmes
Professor Gywneth Boswell, Visiting Professor at the University of East Anglia and Director of Boswell Research Fellows. Speaking on childhood and adolescent trauma – impacts on development, and on individual health across the lifecourse
Speaking at Beyond Youth Custody's conference: Childhood trauma and young people in the criminal justice system, 19 November 2013.
Gender based violence_in_humanitarian_settings__a_practical_guidlines__by_dr_...Malik Khalid Mehmood
The document provides guidelines for interventions addressing gender-based violence (GBV) in humanitarian settings. It defines GBV as any harmful act perpetrated against a person's will based on gender differences between males and females. The guidelines discuss key concepts around sex and gender, define GBV, and outline types of GBV such as sexual, physical, emotional, and economic violence as well as harmful traditional practices. Root causes of GBV are discussed as gender inequality, abuse of power, and lack of belief in universal human rights, while contributing factors include alcohol abuse, poverty, conflict, and impunity. Global statistics are provided on the prevalence of GBV in various countries.
Beyond Youth Custody's trauma review and consultation - Mark Liddlenacro_programmes
Beyond Youth Custody is focusing on trauma and young offenders through a programme of review and consultation. Previous research and feedback from young people has highlighted trauma-related issues. The review work has identified that there are varying definitions of trauma, and research shows traumatic childhood experiences are common and impact many areas of functioning. Studies also show people with childhood trauma and abuse make up the criminal justice population. The review found adverse childhood experiences can increase traumatic stress risk, and multiple or chronic experiences increase negative impacts, though other factors like resilience can limit this. The next stages involve a national consultation on trauma and resettlement, and finalizing the literature review.
Final slides sexualassault7740compatibleversion (1)Rachel Finch
This work is important because it provides an in-depth analysis of the increasingly visual social problem of Sexual Assault (SA) within the intertwined social networks that college students study, work, and live. I was on a team comprised of University of Missouri females who observed victimization and political barriers for student survivors directly—both in our student social circles, and in the intimate partner violence prevention work we practiced on and off campus. We wanted to examine and report our understandings as female student researchers, using the social work framework for assessment at the level of institution and community. In the years surrounding this presentation, the enforcement of Title IX continues to be increasingly mandated alongside national media coverage of high profile cases of sexual assault in the world of professional and college sports. Our own athletic department at MU has since developed a student-athlete character development program as a component of prevention.
Rural and non-rural sexual minority youth showed similar health indicators, with a few exceptions. Rural sexual minority youth reported poorer mental health, lower safety, and higher substance use than both rural and non-rural heterosexual youth. Compared to heterosexual youth, sexual minority youth were more likely to be involved in social or political activities, perhaps to connect with a supportive community. While urbanicity may no longer confer differences for sexual minority youth, their sexual identity remains associated with greater health risks regardless of rural or non-rural location.
1 suicidejocelyn s. barrioseh1020patti smithsmile790243
This document summarizes the pedagogical aids used in most chapters of the textbook "Role Development in Professional Nursing Practice, Fifth Edition" to drive student comprehension and engagement. It lists learning aids such as chapter objectives, key terms, case studies, and critical thinking questions. The purpose is to address different learning styles and ensure mastery of concepts. Additionally, it provides publishing information for Jones & Bartlett Learning including contact details.
The study found that 8.5% of adolescents and young adults ages 13-20 reported perpetrating some form of sexual violence in their lifetime. Male perpetrators were more likely than females to report attempted rape or coercive sex. Female perpetrators tended to be older and victimize people older than themselves, while male perpetrators tended to be younger when they first offended and target younger victims. Very few sexual violence incidents were reported to authorities, with only one male perpetrator in the study reporting being arrested. The results provide initial nationwide estimates of adolescent sexual violence perpetration but have limitations due to sensitivity of the topic.
This research project aims to examine the family burden of people living with AIDS receiving treatment at BPKIHS. It will use an exploratory research design and survey 30 primary caregiver family members using interviews and assessments of family burden. The study hypothesizes that there will be no association between family burden and caregiver characteristics or social stigma. It seeks to understand the demographic profiles of PLWAs and their families, problems faced by caregivers, and the relationship between family burden and demographics. The results could help develop strategies to better support patients and reduce caregiver burden through education and policy changes.
This document discusses appropriate services for sexual minority youth. It begins by defining terms used to describe various sexual orientations and gender identities. It then estimates that between 2-5% of youth identify as a sexual minority. The document discusses factors that make this group less visible and reluctant to self-identify in more conservative communities. It outlines several risks faced by sexual minority youth, such as homelessness, bullying, substance abuse, and elevated suicide rates. The document stresses the importance of providing non-discriminatory, welcoming, and person-first services to sexual minority youth.
The document is a public relations proposal prepared by Axiom Public Relations for the Bowling Green State University Community of Care Coalition. It includes an opportunity statement, situation analysis based on secondary and primary research, target audiences, goals and objectives, strategies and tactics, promotional materials and budget, and evaluation plan. The proposal aims to address issues of sexual assault on campus and establish communication where victims feel comfortable reporting, while promoting the Coalition and generating awareness of sexual assault as a community issue.
This research proposal aims to study factors that lead to higher rates of HIV/AIDS diagnoses among African American men ages 18-24 compared to other groups. The researcher will conduct surveys and interviews with at least 100 men who have sex with men, including those of various races and socioeconomic backgrounds. Key research questions include examining differences in access to healthcare, levels of risk behavior, and how cultural and educational factors may influence HIV transmission patterns between racial groups. The goal is to better understand disparities and empower communities through more effective education and prevention strategies.
Young Gay Couples - How they use drugs and sex to stay safeYTH
Data collected from 199 young gay couples (YMSM couples) recruited through Facebook ads found that men were thoughtful about their drug use and HIV risk reduction strategies within their partnerships.
A research report on root causes, risk factors and preventive strategies. Research by Midrift Hurinet and the Danish Institute Against Torture (DIGNITY).
This study examined predictors of suicide attempts among adolescents attending Seventh-day Adventist schools in the US. It found depression to be the strongest predictor of suicide attempts. Having a negative family climate and less caring parenting also predicted higher rates of suicide attempts, while intrinsic religious orientation predicted lower rates. A survey of over 10,000 students found that depression, family relationships, parenting styles, and religious commitment were significant factors influencing suicidal ideation among this conservative religious group.
The document summarizes key findings from the Edinburgh Study of Youth Transitions and Crime regarding policing and youth justice. It found that 1) persistent serious offending is associated with victimization and social adversity, 2) early identification of at-risk children is difficult and may be counterproductive, 3) critical moments in early teenage years shape pathways in and out of offending, and 4) diversionary strategies help facilitate desistance from crime. The study suggests developing age-graded services including universal support in early years and targeted intervention in teenage years with a focus on social justice rather than criminal justice.
This study analyzed data from a nationally representative sample of 1,143 individuals ages 16-22 to examine patterns of sexual violence perpetration over time. Three key profiles of perpetration were identified for both younger (16-18) and older (19+) age groups: 1) a high perpetration profile with a high probability of sexual harassment, rape, coercive sex, and sexual assault; 2) a middle perpetration profile with a high probability of sexual harassment; and 3) a low perpetration profile with low probabilities of any perpetration. While most individuals remained stable in their perpetration profiles over time, some escalated or reduced their perpetration behaviors. Few gender differences were found except that males ages 16-18 were more
It is an outcome of state of art systematic review of literature. It provides insights about the cause, consequences and future concerns of violence against women in India
Criminal behavior among the homeless individualsRichardWahaba1
1) The documents discuss criminal behavior among homeless individuals, especially those with mental illnesses. Several studies found high rates of arrest, conviction, and incarceration among homeless people with mental disorders, ranging from 63.95-90% arrested.
2) Victimization is also common, with rates of 4.4-35% for any victimization and 7.7-28% for violent victimization. Homeless women and those with a history of prior victimization are at even higher risk.
3) One study in rural China found that 10% of individuals with schizophrenia engaged in criminal behavior, with 2% incarcerated and 8% arrested. Homelessness and mental illness contribute to increased criminal behavior.
Serieswww.thelancet.com Vol 379 June 23, 2012 2373.docxlesleyryder69361
Self-harm and suicide are major public health problems among adolescents. Around 10% of adolescents report having self-harmed, with rates being higher in females. Important contributors include genetic, psychiatric, psychological, familial, social, and cultural factors. Prevention requires both universal measures for all youth and targeted initiatives for high-risk groups. There remains little evidence about effective treatments, and identifying successful prevention initiatives and treatments is a key need.
Sex- and Age-specific Increases in Suicide Attempts by Self-Poisoning in the ...Δρ. Γιώργος K. Κασάπης
There was a more than twofold increase in the rate of suspected self-poisoning suicide cases between 2011 and 2018, according to a new study that looked at more than 1.6 million such cases.
Here’s what else you need to know:
•Overall trends: Cases of suicide attempts by self-poisoning doubled in those aged 10-18 between 2011 and 2018, rising from around 39,000 to more than 78,000.
•Gender: More girls than boys attempted suicide by self-poisoning. The rate of intentional attempts among girls 10-18 also steadily increased from 2011-2018.
•Outcomes: The number of serious outcomes — including death and hospitalizations — as a result of the poisoning increased 235% between 2000 and 2018, and more than 1,400 children died.
A survey of over 900 youth ages 16-24 in Cape Town, South Africa found that rates of anal sex were higher among boys (31%) than girls (11%). Youth who had engaged in anal sex were more likely to have negative views of abstinence, inconsistent condom use, experience or perpetrate dating violence and sexually coercive behaviors. While rates differed between boys and girls, risk factors associated with anal sex were similar, indicating a need for harm reduction programs addressing anal sex and its integration into relationship education curriculum.
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This document summarizes a webinar on co-occurring risk behaviors during adolescence. The webinar objectives were to describe how youth risk behaviors are correlated, identify factors that place youth at risk for multiple outcomes, consider how teen pregnancy programs address overlapping risk factors, and discuss implications for partnerships and sustainability. The webinar included an overview of youth risk behaviors, lessons from a teen pregnancy prevention program in New Orleans that addressed trauma and mental health needs, and implications for considering common and unique risk factors in programming.
Deliberate Self Harm Among Children And Adolescentsgaz12000
This document provides a summary of a research briefing on deliberate self-harm among children and adolescents. It defines self-harm and notes that it most often involves overdoses and cutting. Repeated self-harm is associated with increased suicide risk. Girls self-harm more than boys up to age 16. Factors that increase self-harm risk include mental health issues, a history of self-harm, an abusive home life, poor parent communication, and living in care. Common triggers are stressful life events like abuse. Self-harm is often considered a coping strategy and way to relieve pain or communicate distress.
Abuse and mistreatment in the adolescent period - by Dr. Bozzi Domenico (Mast...dott. Domenico Bozzi
UNICEF has highlighted how children suffer violence throughout all stages of childhood and adolescence, in different contexts, and often at the hands of people they trust and interact with on a daily basis.
Violent corporal punishment, 300 million children between 2 and 4 years old in the world regularly suffer violence from their family/guardians (about 3 out of 4), 250 million of these are punished physically (about 6 out of 10).
Sexual violence, Sexual violence occurs against children of all ages: 15 million girls aged 15 to 19 have experienced incidents of sexual violence in their lives, and 2.5 million young women in 28 European countries report having suffered episodes of sexual violence before the age of 15.
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Bulling as the Leading Cause of Teen Suicide among Adolescents between 14 and 16 Years of Age in Schools in the United States
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Bulling as the Leading Cause of Teen Suicide among Adolescents between 14 and 16 Years of Age in Schools in the United States
Abstract
This paper examines bullying as the prevalent cause of teen suicide among adolescents between fourteen and sixteen years of age within schools in America. “Bullying” refers to a dangerous factor associate with suicidal thoughts and trials amongst teenagers. In many schools in the United States, school-age teenagers are subjected to bullying, resulting in suicide.
Introduction
Suicide is one of the principal reasons for mortality for teenagers aged fourteen to sixteen. Teenage suicide is an awful worldwide public health concern affecting teens (Baiden & Tadeo, 2020; Okafor et al., 2020). The relatively and associates stay emotionally distressed lives following the loss of their young ones. About one in six elementary school children has seriously opted to commit suicide, while one in twelve has tried it (Baiden et al., 2020). Furthermore, suicide tolls among teenagers have been amplifying for the last few years, from six percent in early 2009 to eight percent in late 2011 (Baiden & Tadeo, 2020; Okafor et al., 2020). Besides, evidence reveals a vibrant link between victimization and suicide, as recommended by current bullying-associated suicide mortalities.
Hook
The grounds behind a teenager's suicide might be challenging. Even though suicide is somehow unusual amongst kids, the level of attempted suicides intensifies significantly during the teenage years (Baiden et al., 2020; Tang et al., 2020).
Background Information
Within the previous years, headings reporting the sad accounts of a teens’ suicide connected to bullying have become prevalent. The family is left with much pain after losing their loved ones. Even society is affected because they lose someone from their community (Baiden et al., 2020; Campisi et al., 2020). Losing such as young, energetic soul to suicide snatches a blessing from both the community and the family.
Problem Statement
This research will address bullying as the leading cause of suicide between teenagers aged fourteen to sixteen. If this issue is not addressed, we will keep on losing young ones to this menace.
Research Question
What could be done to address the risk of suicide prevalent in teens aged between fourteen to sixteen years old in school?
Hypothesis
The study hypothesizes that increased exposure to bullying deeds in schools would escalate the danger of stress, suicidal thoughts, and attempted murder.
Thesis Statement
The purpose of this paper is to demonstrate the relationship between Bullying and Suicide, in adolescents between 14 and 16 years of age, in the school of the United States.
Literature Review
The Centers for Disease Control ...
12Bulling as the Leading Cause of Teen Suicide amoAnastaciaShadelb
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Bulling as the Leading Cause of Teen Suicide among Adolescents between 14 and 16 Years of Age in Schools in the United States
Student's Name
Institutional Affiliation
Course Name
Instructor's Name
Submission Date
Bulling as the Leading Cause of Teen Suicide among Adolescents between 14 and 16 Years of Age in Schools in the United States
Abstract
This paper examines bullying as the prevalent cause of teen suicide among adolescents between fourteen and sixteen years of age within schools in America. “Bullying” refers to a dangerous factor associate with suicidal thoughts and trials amongst teenagers. In many schools in the United States, school-age teenagers are subjected to bullying, resulting in suicide.
Introduction
Suicide is one of the principal reasons for mortality for teenagers aged fourteen to sixteen. Teenage suicide is an awful worldwide public health concern affecting teens (Baiden & Tadeo, 2020; Okafor et al., 2020). The relatively and associates stay emotionally distressed lives following the loss of their young ones. About one in six elementary school children has seriously opted to commit suicide, while one in twelve has tried it (Baiden et al., 2020). Furthermore, suicide tolls among teenagers have been amplifying for the last few years, from six percent in early 2009 to eight percent in late 2011 (Baiden & Tadeo, 2020; Okafor et al., 2020). Besides, evidence reveals a vibrant link between victimization and suicide, as recommended by current bullying-associated suicide mortalities.
Hook
The grounds behind a teenager's suicide might be challenging. Even though suicide is somehow unusual amongst kids, the level of attempted suicides intensifies significantly during the teenage years (Baiden et al., 2020; Tang et al., 2020).
Background Information
Within the previous years, headings reporting the sad accounts of a teens’ suicide connected to bullying have become prevalent. The family is left with much pain after losing their loved ones. Even society is affected because they lose someone from their community (Baiden et al., 2020; Campisi et al., 2020). Losing such as young, energetic soul to suicide snatches a blessing from both the community and the family.
Problem Statement
This research will address bullying as the leading cause of suicide between teenagers aged fourteen to sixteen. If this issue is not addressed, we will keep on losing young ones to this menace.
Research Question
What could be done to address the risk of suicide prevalent in teens aged between fourteen to sixteen years old in school?
Hypothesis
The study hypothesizes that increased exposure to bullying deeds in schools would escalate the danger of stress, suicidal thoughts, and attempted murder.
Thesis Statement
The purpose of this paper is to demonstrate the relationship between Bullying and Suicide, in adolescents between 14 and 16 years of age, in the school of the United States.
Literature Review
The Centers for Disease Control ...
Understanding the Female OffenderV O L . 1 8 N O . 2.docxouldparis
Understanding the Female Offender
V O L . 1 8 / N O . 2 / FA L L 2 0 0 8 1 1 9
Understanding the Female Offender
Elizabeth Cauffman
Summary
Although boys engage in more delinquent and criminal acts than do girls, female delinquency
is on the rise. In 1980, boys were four times as likely as girls to be arrested; today they are only
twice as likely to be arrested. In this article, Elizabeth Cauffman explores how the juvenile
justice system is and should be responding to the adolescent female offender.
Cauffman begins by reviewing historical trends in arrest rates, processing, and juvenile justice
system experiences of female offenders. She also describes the adult outcomes commonly
observed for female offenders and points out that the long-term consequences of offending for
females are often more pronounced than those for males, with effects that extend to the next
generation. She also considers common patterns of offending in girls, as well as factors that may
increase or decrease the likelihood of offending. She then reviews what is known about effec-
tive treatment strategies for female offenders.
Female delinquents have a high frequency of mental health problems, suggesting that effective
prevention efforts should target the mental health needs of at-risk females before they lead to
chronic behavior problems. Once girls with mental health problems come into the juvenile jus-
tice system, says Cauffman, diverting them to community-based treatment programs would not
only improve their individual outcomes, but allow the juvenile justice system to focus on cases
that present the greatest risk to public safety.
Evidence is emerging that gender-specific treatment methods can be effective for female
offenders, especially when treatment targets multiple aspects of offenders’ lives, including fam-
ily and peer environments. But it is also becoming clear that female offenders are not a homo-
geneous group and that treatment ultimately should be tailored to suit individual needs defined
more specifically than by gender alone.
Despite myriad differences between male and female offending, many of the primary causes
of offending, says Cauffman, are nevertheless similar. The most effective policies for reducing
juvenile crime, she argues, will be those that foster development in a safe and nurturing envi-
ronment throughout childhood. Cauffman concludes that female offenders are likely to require
continued support long after their direct involvement with the juvenile justice system.
www.futureofchildren.org
Elizabeth Cauffman is an associate professor in psychology and social behavior at the University of California–Ir vine.
Elizabeth Cauffman
1 2 0 T H E F U T U R E O F C H I L D R E N
S
ince the inception of the juvenile
justice system, policies and prac-
tices regarding juvenile offending
have focused on the behavior,
treatment, and outcomes of a
population heavily dominated by males. The
li ...
Global Medical Cures™ | HIV among YOUTH
DISCLAIMER-
Global Medical Cures™ does not offer any medical advice, diagnosis, treatment or recommendations. Only your healthcare provider/physician can offer you information and recommendations for you to decide about your healthcare choices.
This study examined the relationship between state-level mental health treatment capacity and suicide rates among adolescents and young adults aged 10-24 from 2002-2017. The study found a statistically significant inverse relationship between nonfirearm suicide rates and mental health treatment capacity, such that a 10% increase in a state's mental health workforce was associated with a 1.35% reduction in nonfirearm suicide rates. However, no significant relationship was found between mental health treatment capacity and firearm suicide rates. The findings suggest greater access to mental health treatment has a protective effect against nonfirearm suicide but that firearm suicide prevention may require firearm safety and storage policies.
This document provides a grant proposal for a program to address sexually transmitted infections (STIs) among students at The College at Brockport. It includes an epidemiological assessment noting high STI rates locally and among young people. Factors contributing to STIs include lack of condom use and testing. The program aims to increase condom use and testing by 10% through a theoretical framework of the Health Belief Model. It will provide STI education and resources in freshman residence halls and the student union.
This document discusses juvenile delinquency, particularly female juvenile delinquency. It notes that while juvenile delinquency rates are declining, girls are the fastest growing segment of the juvenile justice system. There is a lack of appropriate programs and services for female juvenile offenders, especially pregnant teens, as the system was designed for males. Child abuse and family dysfunction are discussed as factors that can contribute to female juvenile delinquency.
A new data brief reports that deaths from drug abuse among millennials has increased by 400% in the past 20 years. The opioid crisis partly explains the increase, but millennials also face other problems, including high living costs. Here’s more on what the report calls “deaths of despair”:
•Drug deaths: The number of deaths among those in their 20s and 30s went up by 108% between 2007 and 2017.
•Alcohol-related deaths: These deaths in those aged 18-34 went up by nearly 70% between 2007 and 2017, and nearly doubled since 1999.
•Suicides: Between 2011 and 2016, suicide was the second leading cause of death among those aged 15-34, and the following year, suicide rates across all ages increased by 4%.
Copyright 2017 American Medical Association. All rights reserv.docxmelvinjrobinson2199
Copyright 2017 American Medical Association. All rights reserved.
Difference-in-Differences Analysis of the Association
Between State Same-Sex Marriage Policies and Adolescent
Suicide Attempts
Julia Raifman, ScD; Ellen Moscoe, MA; S. Bryn Austin, ScD; Margaret McConnell, PhD
IMPORTANCE Suicide is the second leading cause of death among adolescents between the
ages of 15 and 24 years. Adolescents who are sexual minorities experience elevated rates of
suicide attempts.
OBJECTIVE To evaluate the association between state same-sex marriage policies and
adolescent suicide attempts.
DESIGN, SETTING, AND PARTICIPANTS This study used state-level Youth Risk Behavior
Surveillance System (YRBSS) data from January 1, 1999, to December 31, 2015, which are
weighted to be representative of each state that has participation in the survey greater than
60%. A difference-in-differences analysis compared changes in suicide attempts among all
public high school students before and after implementation of state policies in 32 states
permitting same-sex marriage with year-to-year changes in suicide attempts among high
school students in 15 states without policies permitting same-sex marriage. Linear regression
was used to control for state, age, sex, race/ethnicity, and year, with Taylor series linearized
standard errors clustered by state and classroom. In a secondary analysis among students
who are sexual minorities, we included an interaction between sexual minority identity and
living in a state that had implemented same-sex marriage policies.
INTERVENTIONS Implementation of state policies permitting same-sex marriage during the
full period of YRBSS data collection.
MAIN OUTCOMES AND MEASURES Self-report of 1 or more suicide attempts within the past 12
months.
RESULTS Among the 762 678 students (mean [SD] age, 16.0 [1.2] years; 366 063 males and
396 615 females) who participated in the YRBSS between 1999 and 2015, a weighted 8.6% of
all high school students and 28.5% of students who identified as sexual minorities reported
suicide attempts before implementation of same-sex marriage policies. Same-sex marriage
policies were associated with a 0.6–percentage point (95% CI, –1.2 to –0.01 percentage
points) reduction in suicide attempts, representing a 7% relative reduction in the proportion
of high school students attempting suicide owing to same-sex marriage implementation. The
association was concentrated among students who were sexual minorities.
CONCLUSIONS AND RELEVANCE State same-sex marriage policies were associated with a
reduction in the proportion of high school students reporting suicide attempts, providing
empirical evidence for an association between same-sex marriage policies and mental health
outcomes.
JAMA Pediatr. 2017;171(4):350-356. doi:10.1001/jamapediatrics.2016.4529
Published online February 20, 2017. Last corrected on April 24, 2017.
Editorial page 322
Author Audio Interview
JAMA Pediatrics Patient Page
page 404
Supplemental cont.
Copyright 2017 American Medical Association. All rights reserv.docxbobbywlane695641
Copyright 2017 American Medical Association. All rights reserved.
Difference-in-Differences Analysis of the Association
Between State Same-Sex Marriage Policies and Adolescent
Suicide Attempts
Julia Raifman, ScD; Ellen Moscoe, MA; S. Bryn Austin, ScD; Margaret McConnell, PhD
IMPORTANCE Suicide is the second leading cause of death among adolescents between the
ages of 15 and 24 years. Adolescents who are sexual minorities experience elevated rates of
suicide attempts.
OBJECTIVE To evaluate the association between state same-sex marriage policies and
adolescent suicide attempts.
DESIGN, SETTING, AND PARTICIPANTS This study used state-level Youth Risk Behavior
Surveillance System (YRBSS) data from January 1, 1999, to December 31, 2015, which are
weighted to be representative of each state that has participation in the survey greater than
60%. A difference-in-differences analysis compared changes in suicide attempts among all
public high school students before and after implementation of state policies in 32 states
permitting same-sex marriage with year-to-year changes in suicide attempts among high
school students in 15 states without policies permitting same-sex marriage. Linear regression
was used to control for state, age, sex, race/ethnicity, and year, with Taylor series linearized
standard errors clustered by state and classroom. In a secondary analysis among students
who are sexual minorities, we included an interaction between sexual minority identity and
living in a state that had implemented same-sex marriage policies.
INTERVENTIONS Implementation of state policies permitting same-sex marriage during the
full period of YRBSS data collection.
MAIN OUTCOMES AND MEASURES Self-report of 1 or more suicide attempts within the past 12
months.
RESULTS Among the 762 678 students (mean [SD] age, 16.0 [1.2] years; 366 063 males and
396 615 females) who participated in the YRBSS between 1999 and 2015, a weighted 8.6% of
all high school students and 28.5% of students who identified as sexual minorities reported
suicide attempts before implementation of same-sex marriage policies. Same-sex marriage
policies were associated with a 0.6–percentage point (95% CI, –1.2 to –0.01 percentage
points) reduction in suicide attempts, representing a 7% relative reduction in the proportion
of high school students attempting suicide owing to same-sex marriage implementation. The
association was concentrated among students who were sexual minorities.
CONCLUSIONS AND RELEVANCE State same-sex marriage policies were associated with a
reduction in the proportion of high school students reporting suicide attempts, providing
empirical evidence for an association between same-sex marriage policies and mental health
outcomes.
JAMA Pediatr. 2017;171(4):350-356. doi:10.1001/jamapediatrics.2016.4529
Published online February 20, 2017. Last corrected on April 24, 2017.
Editorial page 322
Author Audio Interview
JAMA Pediatrics Patient Page
page 404
Supplemental cont.
- The geriatric population living in nursing facilities is at high risk for falls due to multiple intrinsic and extrinsic risk factors.
- Intrinsic risk factors include advanced age, history of falls, gait and balance impairments, muscle weakness, visual impairments, cognitive impairments, and chronic conditions like arthritis and diabetes.
- Extrinsic risk factors include environmental hazards within the nursing facility like uneven surfaces, poor lighting, lack of grab bars in bathrooms, and unsafe footwear.
- Comprehensive fall risk assessments and targeted interventions are needed to address both intrinsic and extrinsic risk
CLASSIFICATION OF H1 ANTIHISTAMINICS-
FIRST GENERATION ANTIHISTAMINICS-
1)HIGHLY SEDATIVE-DIPHENHYDRAMINE,DIMENHYDRINATE,PROMETHAZINE,HYDROXYZINE 2)MODERATELY SEDATIVE- PHENARIMINE,CYPROHEPTADINE, MECLIZINE,CINNARIZINE
3)MILD SEDATIVE-CHLORPHENIRAMINE,DEXCHLORPHENIRAMINE
TRIPROLIDINE,CLEMASTINE
SECOND GENERATION ANTIHISTAMINICS-FEXOFENADINE,
LORATADINE,DESLORATADINE,CETIRIZINE,LEVOCETIRIZINE,
AZELASTINE,MIZOLASTINE,EBASTINE,RUPATADINE. Mechanism of action of 2nd generation antihistaminics-
These drugs competitively antagonize actions of
histamine at the H1 receptors.
Pharmacological actions-
Antagonism of histamine-The H1 antagonists effectively block histamine induced bronchoconstriction, contraction of intestinal and other smooth muscle and triple response especially wheal, flare and itch. Constriction of larger blood vessel by histamine is also antagonized.
2) Antiallergic actions-Many manifestations of immediate hypersensitivity (type I reactions)are suppressed. Urticaria, itching and angioedema are well controlled.3) CNS action-The older antihistamines produce variable degree of CNS depression.But in case of 2nd gen antihistaminics there is less CNS depressant property as these cross BBB to significantly lesser extent.
4) Anticholinergic action- many H1 blockers
in addition antagonize muscarinic actions of ACh. BUT IN 2ND gen histaminics there is Higher H1 selectivitiy : no anticholinergic side effects
Giloy in Ayurveda - Classical Categorization and SynonymsPlanet Ayurveda
Giloy, also known as Guduchi or Amrita in classical Ayurvedic texts, is a revered herb renowned for its myriad health benefits. It is categorized as a Rasayana, meaning it has rejuvenating properties that enhance vitality and longevity. Giloy is celebrated for its ability to boost the immune system, detoxify the body, and promote overall wellness. Its anti-inflammatory, antipyretic, and antioxidant properties make it a staple in managing conditions like fever, diabetes, and stress. The versatility and efficacy of Giloy in supporting health naturally highlight its importance in Ayurveda. At Planet Ayurveda, we provide a comprehensive range of health services and 100% herbal supplements that harness the power of natural ingredients like Giloy. Our products are globally available and affordable, ensuring that everyone can benefit from the ancient wisdom of Ayurveda. If you or your loved ones are dealing with health issues, contact Planet Ayurveda at 01725214040 to book an online video consultation with our professional doctors. Let us help you achieve optimal health and wellness naturally.
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7shruti jagirdar
Unit 4: MRA 103T Regulatory affairs
This guideline is directed principally toward new Molecular Entities that are
likely to have significant use in the elderly, either because the disease intended
to be treated is characteristically a disease of aging ( e.g., Alzheimer's disease) or
because the population to be treated is known to include substantial numbers of
geriatric patients (e.g., hypertension).
Computer in pharmaceutical research and development-Mpharm(Pharmaceutics)MuskanShingari
Statistics- Statistics is the science of collecting, organizing, presenting, analyzing and interpreting numerical data to assist in making more effective decisions.
A statistics is a measure which is used to estimate the population parameter
Parameters-It is used to describe the properties of an entire population.
Examples-Measures of central tendency Dispersion, Variance, Standard Deviation (SD), Absolute Error, Mean Absolute Error (MAE), Eigen Value
Nano-gold for Cancer Therapy chemistry investigatory projectSIVAVINAYAKPK
chemistry investigatory project
The development of nanogold-based cancer therapy could revolutionize oncology by providing a more targeted, less invasive treatment option. This project contributes to the growing body of research aimed at harnessing nanotechnology for medical applications, paving the way for future clinical trials and potential commercial applications.
Cancer remains one of the leading causes of death worldwide, prompting the need for innovative treatment methods. Nanotechnology offers promising new approaches, including the use of gold nanoparticles (nanogold) for targeted cancer therapy. Nanogold particles possess unique physical and chemical properties that make them suitable for drug delivery, imaging, and photothermal therapy.
Allopurinol, a uric acid synthesis inhibitor acts by inhibiting Xanthine oxidase competitively as well as non- competitively, Whereas Oxypurinol is a non-competitive inhibitor of xanthine oxidase.
Discover the benefits of homeopathic medicine for irregular periods with our guide on 5 common remedies. Learn how these natural treatments can help regulate menstrual cycles and improve overall menstrual health.
Visit Us: https://drdeepikashomeopathy.com/service/irregular-periods-treatment/
As the world population is aging, Health tourism has become vitally important and will be increased day by day. Because
of the availability of quality health services and more favorable prices as well as to shorten the waiting list for medical
services regionally and internationally. There are some aspects of managing and doing marketing activities in order for
medical tourism to be feasible, in a region called as clustering in a region with main stakeholders groups includes Health
providers, Tourism cluster, etc. There are some related and affecting factors to be considered for the feasibility of medical
tourism within this study such as competitiveness, clustering, Entrepreneurship, SMEs. One of the growth phenomenon
is Health tourism in the city of Izmir and Turkey. The model of five competitive forces of Porter and The Diamond model
that is an economical model that shows the four main factors that affect the competitiveness of a nation and its industries
in this study. The short literature of medical tourism and regional clustering have been mentioned.
Storyboard on Skin- Innovative Learning (M-pharm) 2nd sem. (Cosmetics)MuskanShingari
Skin is the largest organ of the human body, serving crucial functions that include protection, sensation, regulation, and synthesis. Structurally, it consists of three main layers: the epidermis, dermis, and hypodermis (subcutaneous layer).
1. **Epidermis**: The outermost layer primarily composed of epithelial cells called keratinocytes. It provides a protective barrier against environmental factors, pathogens, and UV radiation.
2. **Dermis**: Located beneath the epidermis, the dermis contains connective tissue, blood vessels, hair follicles, and sweat glands. It plays a vital role in supporting and nourishing the epidermis, regulating body temperature, and housing sensory receptors for touch, pressure, temperature, and pain.
3. **Hypodermis**: Also known as the subcutaneous layer, it consists of fat and connective tissue that anchors the skin to underlying structures like muscles and bones. It provides insulation, cushioning, and energy storage.
Skin performs essential functions such as regulating body temperature through sweat production and blood flow control, synthesizing vitamin D when exposed to sunlight, and serving as a sensory interface with the external environment.
Maintaining skin health is crucial for overall well-being, involving proper hygiene, hydration, protection from sun exposure, and avoiding harmful substances. Skin conditions and diseases range from minor irritations to chronic disorders, emphasizing the importance of regular care and medical attention when needed.
Gene therapy can be broadly defined as the transfer of genetic material to cure a disease or at least to improve the clinical status of a patient.
One of the basic concepts of gene therapy is to transform viruses into genetic shuttles, which will deliver the gene of interest into the target cells.
Safe methods have been devised to do this, using several viral and non-viral vectors.
In the future, this technique may allow doctors to treat a disorder by inserting a gene into a patient's cells instead of using drugs or surgery.
The biggest hurdle faced by medical research in gene therapy is the availability of effective gene-carrying vectors that meet all of the following criteria:
Protection of transgene or genetic cargo from degradative action of systemic and endonucleases,
Delivery of genetic material to the target site, i.e., either cell cytoplasm or nucleus,
Low potential of triggering unwanted immune responses or genotoxicity,
Economical and feasible availability for patients .
Viruses are naturally evolved vehicles that efficiently transfer their genes into host cells.
Choice of viral vector is dependent on gene transfer efficiency, capacity to carry foreign genes, toxicity, stability, immune responses towards viral antigens and potential viral recombination.
There are a wide variety of vectors used to deliver DNA or oligo nucleotides into mammalian cells, either in vitro or in vivo.
The most common vector system based on retroviruses, adenoviruses, herpes simplex viruses, adeno associated viruses.
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
BBB and BCF
control the entry of compounds into the brain and
regulate brain homeostasis.
restricts access to brain cells of blood–borne compounds and
facilitates nutrients essential for normal metabolism to reach brain cells