Anumana pramana is having a great scope in ayurveda an attempt is made here on general description on anumana pramana as per the syllabus, tarka and significance of Anumana Pramana will be posted soon
This document discusses the concept of guna according to Ayurveda and Vaisesika philosophy. It defines guna as an inherent property that resides in substances and attracts people towards them. According to Ayurveda and Charaka Samhita, there are 41 types of guna categorized into sartha (sense objects), gurvadi (physical properties), paradi (general properties), and atma (self properties). Chakrapanidatta classifies guna into 3 categories - sartha, gurvadi, and paradi/atma. Vaisesika philosophy describes 24 types of guna divided into sartha, paradi, and others including gurutva,
The document discusses the six qualities (gunas) of the soul or self (atma) according to Ayurveda. These six qualities are: desires, aversion, happiness, misery, effort, and intellect. Each quality is defined and their role in physical and mental health is explained. Maintaining balance of these qualities through proper conduct is said to guide people towards fulfilling the four goals of life and achieving optimal health and well-being.
This document discusses the concept of Abhava or non-existence according to various schools of Indian philosophy including Nyaya and Vaisheshika. It defines Abhava as that which depends on its opponent for knowledge and whose existence is negation. There are several types of Abhava including Sansargabhava (temporary non-existence), Pragabhava (non-existence prior to production), Pradhvansabhava (non-existence after destruction), Atyantabhava (absolute and eternal non-existence of one thing in another), and Anyonyabhava (mutual exclusion between two different things). Ayurveda also recognizes Abhava in terms of the absence of disease
This document discusses the concept of Paradi Gunas or essential qualities described in Charaka Samhita for achieving success in treatment. The 10 Paradi Gunas are listed as superiority, planning, numbers, combination, separation, distinguishing factors, measuring, processing, and practice. Each quality is explained in detail providing examples. The Paradi Gunas play an important role in diagnosis, treatment planning, medicine preparation, and ensuring success of treatment according to Ayurvedic principles. Understanding and applying these qualities properly is essential for effective healthcare according to Charaka.
A strong foundation is essential to build an house and for the longevity of a house. As such if the roots of a tree are strong. its life span also will be increased. Like that the entire knowledge of science depends on Moola Siddhantas or Basic Fundamental Principles only.
Kapha - Responsible for taste perception and bringing food into the stomach.
Kledaka Kapha - Mixes with food bolus in the stomach, making it soft and semi-solid for digestion.
Pachaka Pitta - Provides the enzymes for digestion and breaking down of food in the stomach and small intestine.
Samana Vata - Stimulates agni and peristalsis for proper digestion and movement of food and wastes.
Apana Vata - Expels undigested waste and feces from the digestive tract.
The doshas work in a coordinated manner to break down food, extract nutrients, and eliminate waste for proper digestion and nourishment of
Samavaya is the 6th Padartha or category of existence according to Ayurveda. It refers to the inseparable, eternal relationship between substances that are dependent on each other. For example, the relationship between qualities (gunas) and the substances they inhere in (guni), between actions/effects (karmas) and the substances they originate from, and between parts and wholes. This relationship ensures qualities and actions are permanently rooted in substances. Samavaya is important in Ayurveda as it allows physicians to identify appropriate treatments based on the inherent qualities and actions of substances.
This document discusses the concept of guna according to Ayurveda and Vaisesika philosophy. It defines guna as an inherent property that resides in substances and attracts people towards them. According to Ayurveda and Charaka Samhita, there are 41 types of guna categorized into sartha (sense objects), gurvadi (physical properties), paradi (general properties), and atma (self properties). Chakrapanidatta classifies guna into 3 categories - sartha, gurvadi, and paradi/atma. Vaisesika philosophy describes 24 types of guna divided into sartha, paradi, and others including gurutva,
The document discusses the six qualities (gunas) of the soul or self (atma) according to Ayurveda. These six qualities are: desires, aversion, happiness, misery, effort, and intellect. Each quality is defined and their role in physical and mental health is explained. Maintaining balance of these qualities through proper conduct is said to guide people towards fulfilling the four goals of life and achieving optimal health and well-being.
This document discusses the concept of Abhava or non-existence according to various schools of Indian philosophy including Nyaya and Vaisheshika. It defines Abhava as that which depends on its opponent for knowledge and whose existence is negation. There are several types of Abhava including Sansargabhava (temporary non-existence), Pragabhava (non-existence prior to production), Pradhvansabhava (non-existence after destruction), Atyantabhava (absolute and eternal non-existence of one thing in another), and Anyonyabhava (mutual exclusion between two different things). Ayurveda also recognizes Abhava in terms of the absence of disease
This document discusses the concept of Paradi Gunas or essential qualities described in Charaka Samhita for achieving success in treatment. The 10 Paradi Gunas are listed as superiority, planning, numbers, combination, separation, distinguishing factors, measuring, processing, and practice. Each quality is explained in detail providing examples. The Paradi Gunas play an important role in diagnosis, treatment planning, medicine preparation, and ensuring success of treatment according to Ayurvedic principles. Understanding and applying these qualities properly is essential for effective healthcare according to Charaka.
A strong foundation is essential to build an house and for the longevity of a house. As such if the roots of a tree are strong. its life span also will be increased. Like that the entire knowledge of science depends on Moola Siddhantas or Basic Fundamental Principles only.
Kapha - Responsible for taste perception and bringing food into the stomach.
Kledaka Kapha - Mixes with food bolus in the stomach, making it soft and semi-solid for digestion.
Pachaka Pitta - Provides the enzymes for digestion and breaking down of food in the stomach and small intestine.
Samana Vata - Stimulates agni and peristalsis for proper digestion and movement of food and wastes.
Apana Vata - Expels undigested waste and feces from the digestive tract.
The doshas work in a coordinated manner to break down food, extract nutrients, and eliminate waste for proper digestion and nourishment of
Samavaya is the 6th Padartha or category of existence according to Ayurveda. It refers to the inseparable, eternal relationship between substances that are dependent on each other. For example, the relationship between qualities (gunas) and the substances they inhere in (guni), between actions/effects (karmas) and the substances they originate from, and between parts and wholes. This relationship ensures qualities and actions are permanently rooted in substances. Samavaya is important in Ayurveda as it allows physicians to identify appropriate treatments based on the inherent qualities and actions of substances.
BY
Prof. Dr. N. Satya Prasad, M.D., PGDHM
GOLD MEDALIST
Sr. Reader / Civil Surgeon
Post Graduate department of Kayachikitsa
Dr. B.R.K.R. Government Ayurvedic college
Hyderabad, A.P., India
Email: satyapnamburu@gmail.com
There is a description regarding the Shareera definition, synonyms, shadanga shareera, difference between shareera, shaareera and shareeri, shava chedana vidhi and mahatva, definition of purusha, different types of purusha.
This document discusses the 20 Guruvadi Gunas or qualities described in Ayurveda. It defines each Guna, provides examples, and explains their properties and effects on the doshas. The Gunas influence qualities like heaviness, coldness, oiliness, roughness, and more. Knowing the Gunas is important for understanding the nature and uses of herbs, foods and other substances. It also helps determine which qualities or combinations would be beneficial for different health conditions or body types.
An academic from the Department of Samhita & Siddhanta at BLDEA’S AVS AMV Vijayapur is listed. Dr. Jyothi Alias Jyotsna P Baragi holds the position of Assistant Professor in the department. The document provides her name, title, department, and place of work.
Dik refers to the ten directions in Ayurveda - the four cardinal directions (east, west, north, south), the four intermediate directions (northeast, northwest, southwest, southeast), and up and down. Dik is considered an eternal, omnipresent, and fundamental dravya (substance) in Ayurveda due to its qualities and effects. The directions impact activities like collecting herbs, sleeping, receiving treatment, and plant growth. Certain Ayurvedic procedures also involve directional movements.
This document discusses the concepts of dhatus (body tissues) and dhatu nirmana (formation of tissues) and poshan krama (process of nourishment) in Ayurveda. It defines the seven dhatus - rasa, rakta, mamsa, medas, asthi, majja, shukra. It explains the theories of dhatu transformation - Ksheer Dadhi Nyaya (whole conversion), Kedar Kulya Nyaya (sequential conversion), and Khale Kapot Nyaya (selective process). It states that all the theories are correct in their respective contexts to explain the complex process of digestion and nourishment of tissues that occurs simultaneously throughout the
The document defines and provides synonyms for the terms "Sharira" and "Kriya" in Ayurveda. It states that Sharira refers to the living body composed of the panchamahabhutas in which life resides. Kriya refers to any act or function, physical or psychological, related to the living body. It then describes the three doshas - Vata, Pitta, and Kapha that affect the physical body, and the two mental doshas of Rajas and Tamas. Finally, it outlines the relationships between the tridoshas, panchmahabhutas, and trigunas.
snayu are rope like fibrous structures which help to binds together the mamsa, asthi & medas in joints & different structures of the body and maintain the body postures by providing weight carrying capacity.
The document discusses the Sira (veins) according to Ayurvedic classics like Charak Samhita, Sushruta Samhita and Vagbhata. It defines Sira as structures that carry substances from one place to another. It describes the development of Sira from Vata dosha along with other factors. There are said to be 700 total Sira in the body, originating from the essence of Rakta and connecting to the umbilicus. The 10 Moola Sira are specifically connected to the heart and transport essence to all body parts. Sira have a branching structure like veins in a leaf. The relationship between Sira and the umbilicus is also explained, with
The document discusses the concept of Agni according to Ayurveda. It defines Agni as the digestive fire that is essential for digestion and maintenance of the body. It describes the 13 types of Agni according to Charaka, with Jatharagni (stomach fire) being the most important. Jatharagni digests foods into nutrients and separates wastes. Bhutagni (5 types) digest elemental qualities of food. Dhatvagni (7 types) further digest nutrients into dhatus. The document covers other topics like the role of Agni in digestion, types based on strength, and importance in health and disease.
The document summarizes the Sankhya philosophy's view on the evolution of the universe according to Samkhya Darshana. It discusses that Samkhya Darshana believes the universe evolved from primordial nature (Prakriti) through a series of transformations. It describes the stages of evolution starting from Prakriti to Mahat (intellect) to ego (Ahankara) to the five elements to the sixteen elements to Purusha (consciousness). It also discusses the three gunas (qualities) of Prakriti, the 25 tatwas (elements/principles), the means of understanding them through three pramanas (proofs), and the two philosophical theories of
In Ayurvedic curriculum, Rachana Sharir(Anatomy) is taught . This presentation is useful for students of first year BAMS & MD in the subject Rachana Sharir. It describes the different types of bones as per Ayurved.
This document discusses the Ayurvedic concept of Karya Karana Bhava or the theory of causation. It begins by defining key terms like karya (effect), karana (cause), and bhava (becoming) and explains how karya is manifested from karana. It then describes the different types of causes in Ayurveda - samavayi (inherent), asamavayi (non-inherent), and nimitta (instrumental). The utility of this theory in understanding disease manifestation and treatment is highlighted. Various philosophies of causation from Ayurveda and other schools of thought like Satkarya vada, Parinamav
This document discusses the concepts of Karya (effect) and Karana (cause) in Ayurveda. It defines Karya as something produced that did not previously exist, and Karana as that which is essential for the production of the Karya. There are three types of Karana: Samavayi (inherent), Asamavayi (non-inherent but essential) and Nimitta (supportive). The Satkarya vada philosophy believes the Karya already exists in the Karana in an unmanifested form. It provides arguments like "asat cannot be produced" to establish this. There are two interpretations of Satkarya vada -
a detail & easy description about the asthi sharira in Ayurveda, which covers all parameters & create a clear vision of bones. this ppt provides all information & deep knowledge about the human asthi sharira.
The document discusses the clinical importance of Pittadhara Kala, which is one of the seven Kala in Ayurveda. It notes that many modern diseases are related to specific Kala, such as Grahani (Pittadhara Kala) and infertility (Shukradhara Kala). It emphasizes the need to examine both structural and functional disturbances of the Kala, especially Pittadhara Kala, which is responsible for digestion. The document outlines the roles of Pittadhara Kala in digestion including collection of food, digestion, separation and absorption. It also discusses how impairment of Pittadhara Kala and Agni can lead to Ama formation.
pramana sharira is a method of measurement of body & parts of body in Ayurveda as well as ancient time period. anjali pramana is the tools and techniques of measurement of volume where as angula pramana is used for length and dimensions of body and its anga pratayana (organs & parts).
This document discusses the Ayurvedic concept of Asthi, which refers not just to bones but also other hard structures in the body. It begins by explaining how Asthi is understood differently in Ayurveda than in modern sciences. It then provides definitions of Asthi from several Ayurvedic texts, noting that Asthi refers to any hard substance that remains after death. The document outlines the panchabhautic constitution, functions, types and locations of different Asthi. It lists the total number of Asthi according to different texts, ranging from 300-360. In summary, the document explores the classical Ayurvedic perspectives on Asthi as a broader concept than just bones.
BY
Prof. Dr. N. Satya Prasad, M.D., PGDHM
GOLD MEDALIST
Sr. Reader / Civil Surgeon
Post Graduate department of Kayachikitsa
Dr. B.R.K.R. Government Ayurvedic college
Hyderabad, A.P., India
Email: satyapnamburu@gmail.com
There is a description regarding the Shareera definition, synonyms, shadanga shareera, difference between shareera, shaareera and shareeri, shava chedana vidhi and mahatva, definition of purusha, different types of purusha.
This document discusses the 20 Guruvadi Gunas or qualities described in Ayurveda. It defines each Guna, provides examples, and explains their properties and effects on the doshas. The Gunas influence qualities like heaviness, coldness, oiliness, roughness, and more. Knowing the Gunas is important for understanding the nature and uses of herbs, foods and other substances. It also helps determine which qualities or combinations would be beneficial for different health conditions or body types.
An academic from the Department of Samhita & Siddhanta at BLDEA’S AVS AMV Vijayapur is listed. Dr. Jyothi Alias Jyotsna P Baragi holds the position of Assistant Professor in the department. The document provides her name, title, department, and place of work.
Dik refers to the ten directions in Ayurveda - the four cardinal directions (east, west, north, south), the four intermediate directions (northeast, northwest, southwest, southeast), and up and down. Dik is considered an eternal, omnipresent, and fundamental dravya (substance) in Ayurveda due to its qualities and effects. The directions impact activities like collecting herbs, sleeping, receiving treatment, and plant growth. Certain Ayurvedic procedures also involve directional movements.
This document discusses the concepts of dhatus (body tissues) and dhatu nirmana (formation of tissues) and poshan krama (process of nourishment) in Ayurveda. It defines the seven dhatus - rasa, rakta, mamsa, medas, asthi, majja, shukra. It explains the theories of dhatu transformation - Ksheer Dadhi Nyaya (whole conversion), Kedar Kulya Nyaya (sequential conversion), and Khale Kapot Nyaya (selective process). It states that all the theories are correct in their respective contexts to explain the complex process of digestion and nourishment of tissues that occurs simultaneously throughout the
The document defines and provides synonyms for the terms "Sharira" and "Kriya" in Ayurveda. It states that Sharira refers to the living body composed of the panchamahabhutas in which life resides. Kriya refers to any act or function, physical or psychological, related to the living body. It then describes the three doshas - Vata, Pitta, and Kapha that affect the physical body, and the two mental doshas of Rajas and Tamas. Finally, it outlines the relationships between the tridoshas, panchmahabhutas, and trigunas.
snayu are rope like fibrous structures which help to binds together the mamsa, asthi & medas in joints & different structures of the body and maintain the body postures by providing weight carrying capacity.
The document discusses the Sira (veins) according to Ayurvedic classics like Charak Samhita, Sushruta Samhita and Vagbhata. It defines Sira as structures that carry substances from one place to another. It describes the development of Sira from Vata dosha along with other factors. There are said to be 700 total Sira in the body, originating from the essence of Rakta and connecting to the umbilicus. The 10 Moola Sira are specifically connected to the heart and transport essence to all body parts. Sira have a branching structure like veins in a leaf. The relationship between Sira and the umbilicus is also explained, with
The document discusses the concept of Agni according to Ayurveda. It defines Agni as the digestive fire that is essential for digestion and maintenance of the body. It describes the 13 types of Agni according to Charaka, with Jatharagni (stomach fire) being the most important. Jatharagni digests foods into nutrients and separates wastes. Bhutagni (5 types) digest elemental qualities of food. Dhatvagni (7 types) further digest nutrients into dhatus. The document covers other topics like the role of Agni in digestion, types based on strength, and importance in health and disease.
The document summarizes the Sankhya philosophy's view on the evolution of the universe according to Samkhya Darshana. It discusses that Samkhya Darshana believes the universe evolved from primordial nature (Prakriti) through a series of transformations. It describes the stages of evolution starting from Prakriti to Mahat (intellect) to ego (Ahankara) to the five elements to the sixteen elements to Purusha (consciousness). It also discusses the three gunas (qualities) of Prakriti, the 25 tatwas (elements/principles), the means of understanding them through three pramanas (proofs), and the two philosophical theories of
In Ayurvedic curriculum, Rachana Sharir(Anatomy) is taught . This presentation is useful for students of first year BAMS & MD in the subject Rachana Sharir. It describes the different types of bones as per Ayurved.
This document discusses the Ayurvedic concept of Karya Karana Bhava or the theory of causation. It begins by defining key terms like karya (effect), karana (cause), and bhava (becoming) and explains how karya is manifested from karana. It then describes the different types of causes in Ayurveda - samavayi (inherent), asamavayi (non-inherent), and nimitta (instrumental). The utility of this theory in understanding disease manifestation and treatment is highlighted. Various philosophies of causation from Ayurveda and other schools of thought like Satkarya vada, Parinamav
This document discusses the concepts of Karya (effect) and Karana (cause) in Ayurveda. It defines Karya as something produced that did not previously exist, and Karana as that which is essential for the production of the Karya. There are three types of Karana: Samavayi (inherent), Asamavayi (non-inherent but essential) and Nimitta (supportive). The Satkarya vada philosophy believes the Karya already exists in the Karana in an unmanifested form. It provides arguments like "asat cannot be produced" to establish this. There are two interpretations of Satkarya vada -
a detail & easy description about the asthi sharira in Ayurveda, which covers all parameters & create a clear vision of bones. this ppt provides all information & deep knowledge about the human asthi sharira.
The document discusses the clinical importance of Pittadhara Kala, which is one of the seven Kala in Ayurveda. It notes that many modern diseases are related to specific Kala, such as Grahani (Pittadhara Kala) and infertility (Shukradhara Kala). It emphasizes the need to examine both structural and functional disturbances of the Kala, especially Pittadhara Kala, which is responsible for digestion. The document outlines the roles of Pittadhara Kala in digestion including collection of food, digestion, separation and absorption. It also discusses how impairment of Pittadhara Kala and Agni can lead to Ama formation.
pramana sharira is a method of measurement of body & parts of body in Ayurveda as well as ancient time period. anjali pramana is the tools and techniques of measurement of volume where as angula pramana is used for length and dimensions of body and its anga pratayana (organs & parts).
This document discusses the Ayurvedic concept of Asthi, which refers not just to bones but also other hard structures in the body. It begins by explaining how Asthi is understood differently in Ayurveda than in modern sciences. It then provides definitions of Asthi from several Ayurvedic texts, noting that Asthi refers to any hard substance that remains after death. The document outlines the panchabhautic constitution, functions, types and locations of different Asthi. It lists the total number of Asthi according to different texts, ranging from 300-360. In summary, the document explores the classical Ayurvedic perspectives on Asthi as a broader concept than just bones.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.