ANTIEMETIC Drug - Olanzapine
•Download as PPTX, PDF•
0 likes•114 views
This document discusses olanzapine, an atypical antipsychotic drug that is also used as an antiemetic to treat chemotherapy-induced nausea and vomiting (CINV). CINV is classified into 4 types: acute (within 24 hours), delayed (24-48 hours post-chemo), anticipatory (before chemo), and refractory (despite treatment). Olanzapine targets multiple receptor types and has the ability to block dopamine, serotonin, adrenergic, histamine, and muscarinic receptors. The standard dosage is 5-10 mg daily with a maximum of 20 mg, and it can also be given as a rescue dose of 5 mg every 4 hours. Common side effects include som
Report
Share
Report
Share
Recommended
CHEMOTHERAPY-INDUCED NAUSEA AND VOMITING.pptx
This document provides information on chemotherapy-induced nausea and vomiting (CINV). It begins with definitions of nausea and vomiting and discusses the causes and types of CINV, including acute, delayed, anticipatory, breakthrough, and refractory CINV. It then covers the pathophysiology of CINV, which involves neurotransmitter receptors in the brainstem and gastrointestinal tract. Chemotherapy agents are classified based on their emetogenic potential. The document concludes with an overview of anti-emetic agents used to prevent and treat different types of CINV.
CHEMOTHERAPY-INDUCED NAUSEA AND VOMITING.pptx
This document provides information on chemotherapy-induced nausea and vomiting (CINV). It begins with definitions of nausea and vomiting and discusses the causes and types of CINV, including acute, delayed, anticipatory, breakthrough, and refractory CINV. It then covers the pathophysiology of CINV, which involves neurotransmitter receptors in the brainstem and gastrointestinal tract. Chemotherapy agents are classified based on their emetogenic potential. The document concludes with an overview of anti-emetic agents used to prevent and treat different types of CINV.
Onco presentation
This document outlines chemotherapy-induced nausea and vomiting (CINV), including its types, pathophysiology, predictive factors, and prevention/treatment approaches. There are three types of CINV - acute, delayed, and anticipatory. The pathophysiology involves the central nervous system and neurotransmitters like dopamine, serotonin, and substance P. Predictive factors include the chemotherapy agent/dose, patient characteristics, and antiemetic regimen. Prevention/treatment involves 5-HT3 receptor antagonists, neurokinin-1 receptor antagonists, glucocorticoids, and dopamine receptor antagonists. Combination therapy is most effective at preventing both acute and delayed CINV.
Current Indian Guidelines for Antiretriviral Therapy 2012
The document outlines current Indian guidelines for antiretroviral therapy (ART). ART involves the use of combination drug regimens to suppress the HIV virus and improve health outcomes. The guidelines recommend initiating ART early, with preferred first-line regimens including tenofovir/emtricitabine plus efavirenz or nevirapine. Patients on ART require monitoring of viral load and CD4 counts, and clinicians must watch out for potential complications and drug interactions. ART should be changed if the initial regimen fails or becomes suboptimal due to toxicity, interactions or other issues.
Chemotherapy induced nausea and vomiting
The document discusses chemotherapy-induced nausea and vomiting (CINV). It describes CINV as a clinical problem that is not fully understood. There are different categories of CINV including acute (within 24 hours), delayed (24 hours to 7 days), anticipatory (after repeated chemotherapy cycles), breakthrough, and refractory. The mechanisms involve both central and peripheral pathways activating the vomiting center in the brainstem. Management of CINV includes both pharmacological agents like corticosteroids, serotonin antagonists, and NK-1 receptor antagonists as well as non-pharmacological approaches like acupuncture, relaxation, and ginger therapy. Improving the value of CINV care focuses on increasing quality while decreasing costs and side effects.
Chemotheraphy in Animal's
PPT explain genral introduction Regarding chemotheraphy in animals, there scope, advantage & disadvantages.
Modalities of cancer
This document discusses various types of immunotherapy used to treat cancer. It describes monoclonal antibodies which help the immune system destroy cancer cells in several ways such as allowing immune cells to destroy cancer cells, preventing rapid cancer growth, and delivering radiation or chemotherapy directly to cancer cells. Some examples of monoclonal antibodies are given. The document also discusses non-specific immunotherapy like interferons and interleukins which help the immune system produce cells that destroy cancer. Cancer vaccines which can prevent or treat cancer are also summarized. Bone marrow transplantation is defined as replacing diseased bone marrow with healthy stem cells. The nursing management and care provided before, during, and after bone marrow transplantation is outlined.
Chemotherapy
Sidney Farber is considered the father of modern chemotherapy. The history of chemotherapy began with early experiments using heavy metals and immunostimulants in the 1500s-1800s. Significant developments occurred during World Wars I and II, including the discovery of nitrogen mustard's ability to suppress the bone marrow and lymph nodes. In the post-war decades of the 1950s-1970s, chemotherapy drugs were developed and tested through the National Cancer Institute and Children's Cancer Group. Recent decades saw the growth of targeted therapies, monoclonal antibodies, and other novel agents, while many challenges of chemotherapy discovered by early researchers remain relevant today.
Recommended
CHEMOTHERAPY-INDUCED NAUSEA AND VOMITING.pptx
This document provides information on chemotherapy-induced nausea and vomiting (CINV). It begins with definitions of nausea and vomiting and discusses the causes and types of CINV, including acute, delayed, anticipatory, breakthrough, and refractory CINV. It then covers the pathophysiology of CINV, which involves neurotransmitter receptors in the brainstem and gastrointestinal tract. Chemotherapy agents are classified based on their emetogenic potential. The document concludes with an overview of anti-emetic agents used to prevent and treat different types of CINV.
CHEMOTHERAPY-INDUCED NAUSEA AND VOMITING.pptx
This document provides information on chemotherapy-induced nausea and vomiting (CINV). It begins with definitions of nausea and vomiting and discusses the causes and types of CINV, including acute, delayed, anticipatory, breakthrough, and refractory CINV. It then covers the pathophysiology of CINV, which involves neurotransmitter receptors in the brainstem and gastrointestinal tract. Chemotherapy agents are classified based on their emetogenic potential. The document concludes with an overview of anti-emetic agents used to prevent and treat different types of CINV.
Onco presentation
This document outlines chemotherapy-induced nausea and vomiting (CINV), including its types, pathophysiology, predictive factors, and prevention/treatment approaches. There are three types of CINV - acute, delayed, and anticipatory. The pathophysiology involves the central nervous system and neurotransmitters like dopamine, serotonin, and substance P. Predictive factors include the chemotherapy agent/dose, patient characteristics, and antiemetic regimen. Prevention/treatment involves 5-HT3 receptor antagonists, neurokinin-1 receptor antagonists, glucocorticoids, and dopamine receptor antagonists. Combination therapy is most effective at preventing both acute and delayed CINV.
Current Indian Guidelines for Antiretriviral Therapy 2012
The document outlines current Indian guidelines for antiretroviral therapy (ART). ART involves the use of combination drug regimens to suppress the HIV virus and improve health outcomes. The guidelines recommend initiating ART early, with preferred first-line regimens including tenofovir/emtricitabine plus efavirenz or nevirapine. Patients on ART require monitoring of viral load and CD4 counts, and clinicians must watch out for potential complications and drug interactions. ART should be changed if the initial regimen fails or becomes suboptimal due to toxicity, interactions or other issues.
Chemotherapy induced nausea and vomiting
The document discusses chemotherapy-induced nausea and vomiting (CINV). It describes CINV as a clinical problem that is not fully understood. There are different categories of CINV including acute (within 24 hours), delayed (24 hours to 7 days), anticipatory (after repeated chemotherapy cycles), breakthrough, and refractory. The mechanisms involve both central and peripheral pathways activating the vomiting center in the brainstem. Management of CINV includes both pharmacological agents like corticosteroids, serotonin antagonists, and NK-1 receptor antagonists as well as non-pharmacological approaches like acupuncture, relaxation, and ginger therapy. Improving the value of CINV care focuses on increasing quality while decreasing costs and side effects.
Chemotheraphy in Animal's
PPT explain genral introduction Regarding chemotheraphy in animals, there scope, advantage & disadvantages.
Modalities of cancer
This document discusses various types of immunotherapy used to treat cancer. It describes monoclonal antibodies which help the immune system destroy cancer cells in several ways such as allowing immune cells to destroy cancer cells, preventing rapid cancer growth, and delivering radiation or chemotherapy directly to cancer cells. Some examples of monoclonal antibodies are given. The document also discusses non-specific immunotherapy like interferons and interleukins which help the immune system produce cells that destroy cancer. Cancer vaccines which can prevent or treat cancer are also summarized. Bone marrow transplantation is defined as replacing diseased bone marrow with healthy stem cells. The nursing management and care provided before, during, and after bone marrow transplantation is outlined.
Chemotherapy
Sidney Farber is considered the father of modern chemotherapy. The history of chemotherapy began with early experiments using heavy metals and immunostimulants in the 1500s-1800s. Significant developments occurred during World Wars I and II, including the discovery of nitrogen mustard's ability to suppress the bone marrow and lymph nodes. In the post-war decades of the 1950s-1970s, chemotherapy drugs were developed and tested through the National Cancer Institute and Children's Cancer Group. Recent decades saw the growth of targeted therapies, monoclonal antibodies, and other novel agents, while many challenges of chemotherapy discovered by early researchers remain relevant today.
1. Chemo in the home
This document provides information on chemotherapy including its classifications, administration routes, settings, and common side effects. Chemotherapy is classified based on its mechanism of action and includes alkylating agents, antimetabolites, antitumor antibiotics, plant alkaloids, hormones, and biological therapies. It can be administered through various routes depending on the treatment plan and is often given in cycles with rest periods in between. The setting for chemotherapy may be a hospital, clinic, or patient's home depending on factors like the drug and patient's condition. Common side effects involve the blood, gastrointestinal system, and other organs.
Cancer induced nausea and vomiting.pptx
This document discusses chemotherapy-induced nausea and vomiting (CINV). It begins by outlining CINV as the most common and feared side effect of chemotherapy. It then defines nausea and vomiting and lists risk factors. It describes the centers in the brain involved in vomiting and the pathophysiology of CINV. It classifies the different types of CINV and rates the emetic risk of different chemotherapy agents. The document stresses the importance of managing CINV and outlines both pharmacological and non-pharmacological management strategies. It discusses guidelines for managing CINV based on emetogenic risk and lists potential complications of uncontrolled CINV.
Advances in chemotherapy techniques and common chemotherapy strategies
Recent advances in chemotherapy techniques
approaches done so far to get targetted release of chemo drugs
chemotherapy
cancer drugs
Chemotherapeutic Agents And an Antibiotic
This document discusses chemotherapy and antibiotics. It defines chemotherapy as the treatment of diseases, like cancer, using chemical compounds that selectively target abnormal cells. Chemotherapy drugs work by stopping cancer cell growth and reproduction. Common side effects are also discussed. The document also defines antibiotics as molecules that kill or inhibit the growth of microorganisms like bacteria and fungi. It discusses the medical and non-medical uses of antibiotics and provides an overview of how antibiotics are classified based on their producing microorganisms, activity spectrum, metabolic pathways, and chemical structures.
Mode of Action of an antibiotic on Microorganisms
This document discusses chemotherapy and antibiotics. It defines chemotherapy as the treatment of diseases, like cancer, using chemical compounds that selectively target abnormal cells. Chemotherapy drugs work by stopping cancer cell growth and reproduction. Common side effects are also discussed. The document also defines antibiotics as molecules that kill or inhibit the growth of microorganisms like bacteria and fungi. It discusses the medical and non-medical uses of antibiotics and provides an overview of how antibiotics are classified based on their producing microorganisms, activity spectrum, metabolic pathways, and chemical structures.
Mechanisms of action of antibacterial drugs
Chemotherapeutic agents include antibiotics and chemotherapy drugs. Antibiotics kill or inhibit the growth of microorganisms like bacteria and fungi. They are commonly classified based on their structure and target of action. Common mechanisms of action for antibiotics include inhibiting cell wall synthesis, disrupting cell membranes, interfering with metabolism, and inhibiting protein or nucleic acid synthesis. Chemotherapy drugs treat cancer by selectively killing cancer cells and are often given in combination to minimize side effects, which commonly include fatigue, hair loss, nausea, and changes in blood cell counts.
Mechanisms of action of antifungal drugs
This document discusses chemotherapy and antibiotics. It defines chemotherapy as the treatment of diseases, like cancer, using chemical compounds that selectively target abnormal cells. Chemotherapy drugs work by stopping cancer cell growth and reproduction. Common side effects are also discussed. The document also defines antibiotics as molecules that kill or inhibit the growth of microorganisms like bacteria and fungi. It discusses the medical and non-medical uses of antibiotics and provides an overview of how antibiotics are classified based on their producing microorganisms, activity spectrum, metabolic pathways, and chemical structures.
Mechanisms of action of antiviral drugs
This document discusses chemotherapy and antibiotics. It defines chemotherapy as the treatment of diseases, including cancer, with chemical compounds that selectively target abnormal or invading cells. Chemotherapy drugs work by stopping cancer cell growth and reproduction. Common side effects are also discussed. The document also defines antibiotics as molecules that kill or inhibit the growth of microorganisms like bacteria and fungi. It discusses the medical and non-medical uses of antibiotics and provides an overview of how antibiotics are classified.
ADR.pptx
PHARMACOLOGY IS CHALLENGING SUBJECT TO TEACH AND UNDERSTAND ALSO .....THEIR INTERESTING PART IS TO LEARN ABOUT ADR
Post chemotherapy care ver 1.0
This document provides information on post-chemotherapy care and management of side effects. It discusses extravasation, which is when chemotherapy leaks from the vein into surrounding tissue. It classifies extravasation reactions and describes how to recognize and manage it. It also covers chemotherapy-induced nausea and vomiting (CINV), discussing pathophysiology and providing recommendations for preventing nausea based on emesis risk. The document further addresses febrile neutropenia, defining it and outlining management strategies. It then discusses anemia as a side effect of chemotherapy and radiation, describing treatment goals and options. Finally, the document defines mucositis as inflammation of mucosal surfaces throughout the body.
AMA-_Antimicrobials_Intro.pdf
Pharmacology Lecture Slides on Antimicrobials intro by Sanjaya Mani Dixit Assistant Professor of Pharmacology at Kathmandu Medical College
Antibiotics requiring therapeutic drug monitoring(1)
This document provides information on therapeutic drug monitoring of aminoglycosides and vancomycin. It discusses pharmacokinetics concepts such as absorption, distribution, metabolism, and elimination of drugs. It explains that intravenous administration provides full bioavailability without first-pass metabolism. The document also covers pharmacodynamics predictors of antibiotic efficacy like time above MIC, AUC/MIC ratio, and Cmax/MIC ratio. It states that aminoglycosides and vancomycin require therapeutic drug monitoring due to their narrow therapeutic indices to ensure efficacy and prevent toxicity.
cancer care - the role of anaesthetists.pptx
The document discusses the role of anesthetists in cancer care. It covers topics such as the epidemiology of cancer, the role of anesthetists in pain management, perioperative care of cancer patients, the effects of different anesthetic agents and techniques on cancer outcomes, and recommendations for improving multidisciplinary cancer care. Anesthetists play a key role in facilitating cancer treatment through safe provision of anesthesia and improving long term outcomes by minimizing immunosuppression during surgery and cancer recurrence.
MHSS TMS, OCD, Ketamine Training Deck, 03.03.21.pdf
Transcranial magnetic stimulation (TMS) and ketamine therapies are emerging treatments for treatment-resistant depression. Rates of major depressive disorder in the US have tripled during the COVID-19 pandemic. TMS uses magnetic pulses to target brain regions implicated in depression, while ketamine has rapid antidepressant effects through glutamate modulation and synaptogenesis. Both therapies show response rates of 50-70% within 1-2 weeks and have generally mild side effect profiles compared to medications. However, maintenance treatment is often needed to sustain benefits.
Adjuvant therapy - Dr. Roda Amaria
Dr. Roda Amaria presents the latest on adjuvant therapy for melanoma at the MRF's Patient Symposium at MD Anderson Cancer Center on January 31, 2015.
Supportive Care of Cancer
This document provides an overview of chemotherapy-induced nausea and vomiting (CINV). It discusses the pathophysiology of CINV, focusing on areas in the central nervous system and gastrointestinal tract that are involved in vomiting. These include the vomiting center, chemoreceptor trigger zone, and enterochromaffin cells. The document also describes the classification of CINV into acute, delayed, anticipatory, and refractory types and lists factors that influence the incidence and severity of CINV, such as the emetogenic potential of chemotherapy agents and patient characteristics.
Chp no 2 anti-microbial.pptx
This document discusses antimicrobial drugs and provides information about their use. It begins by defining antimicrobial drugs as substances that kill or suppress microorganisms like bacteria, fungi, viruses and more. It then lists some common infections treated with antimicrobial drugs. The document goes on to discuss antimicrobial terminology, mechanisms of action, principles of selecting the appropriate drug, indications for use, and appropriate nursing implications when administering antimicrobial drugs to patients. It emphasizes the importance of preventing resistance, assessing treatment response and monitoring for adverse effects.
Antibiotic prophylaxis
Antibiotic prophylaxis aims to prevent surgical site infections by administering antibiotics before and during surgery to eliminate bacteria and create an unfavorable environment for infection. The risk of surgical site infection depends on factors like the type of surgery (clean vs. contaminated), insertion of implants, duration of surgery, and patient comorbidities. Common pathogens include Staphylococcus aureus and streptococci for skin wounds, and oral anaerobes for head/neck surgery. Guidelines recommend evaluating risks and benefits of prophylaxis as well as considering antibiotic susceptibility of likely contaminants when determining appropriate prophylactic regimens.
Adverse Drug Reactions of Chemotherapy 1.pptx
This document outlines adverse drug reactions (ADRs) associated with chemotherapy. It discusses common ADRs like nausea/vomiting, mucositis, alopecia, and their causes, risk factors, management. It notes that ADRs occur in 6.5-10.9% of hospital admissions. The role of pharmacists is to monitor medication profiles, educate patients on ADRs, document ADRs, and assist in managing supportive care like nausea/pain. Close collaboration between pharmacists and oncologists can help optimize outcomes for patients undergoing chemotherapy.
HUMAN EYE By-R.M Class 10 phy best digital notes.pdf
Class 10 human eye notes physics
Handwritten best quality
More Related Content
Similar to ANTIEMETIC Drug - Olanzapine
1. Chemo in the home
This document provides information on chemotherapy including its classifications, administration routes, settings, and common side effects. Chemotherapy is classified based on its mechanism of action and includes alkylating agents, antimetabolites, antitumor antibiotics, plant alkaloids, hormones, and biological therapies. It can be administered through various routes depending on the treatment plan and is often given in cycles with rest periods in between. The setting for chemotherapy may be a hospital, clinic, or patient's home depending on factors like the drug and patient's condition. Common side effects involve the blood, gastrointestinal system, and other organs.
Cancer induced nausea and vomiting.pptx
This document discusses chemotherapy-induced nausea and vomiting (CINV). It begins by outlining CINV as the most common and feared side effect of chemotherapy. It then defines nausea and vomiting and lists risk factors. It describes the centers in the brain involved in vomiting and the pathophysiology of CINV. It classifies the different types of CINV and rates the emetic risk of different chemotherapy agents. The document stresses the importance of managing CINV and outlines both pharmacological and non-pharmacological management strategies. It discusses guidelines for managing CINV based on emetogenic risk and lists potential complications of uncontrolled CINV.
Advances in chemotherapy techniques and common chemotherapy strategies
Recent advances in chemotherapy techniques
approaches done so far to get targetted release of chemo drugs
chemotherapy
cancer drugs
Chemotherapeutic Agents And an Antibiotic
This document discusses chemotherapy and antibiotics. It defines chemotherapy as the treatment of diseases, like cancer, using chemical compounds that selectively target abnormal cells. Chemotherapy drugs work by stopping cancer cell growth and reproduction. Common side effects are also discussed. The document also defines antibiotics as molecules that kill or inhibit the growth of microorganisms like bacteria and fungi. It discusses the medical and non-medical uses of antibiotics and provides an overview of how antibiotics are classified based on their producing microorganisms, activity spectrum, metabolic pathways, and chemical structures.
Mode of Action of an antibiotic on Microorganisms
This document discusses chemotherapy and antibiotics. It defines chemotherapy as the treatment of diseases, like cancer, using chemical compounds that selectively target abnormal cells. Chemotherapy drugs work by stopping cancer cell growth and reproduction. Common side effects are also discussed. The document also defines antibiotics as molecules that kill or inhibit the growth of microorganisms like bacteria and fungi. It discusses the medical and non-medical uses of antibiotics and provides an overview of how antibiotics are classified based on their producing microorganisms, activity spectrum, metabolic pathways, and chemical structures.
Mechanisms of action of antibacterial drugs
Chemotherapeutic agents include antibiotics and chemotherapy drugs. Antibiotics kill or inhibit the growth of microorganisms like bacteria and fungi. They are commonly classified based on their structure and target of action. Common mechanisms of action for antibiotics include inhibiting cell wall synthesis, disrupting cell membranes, interfering with metabolism, and inhibiting protein or nucleic acid synthesis. Chemotherapy drugs treat cancer by selectively killing cancer cells and are often given in combination to minimize side effects, which commonly include fatigue, hair loss, nausea, and changes in blood cell counts.
Mechanisms of action of antifungal drugs
This document discusses chemotherapy and antibiotics. It defines chemotherapy as the treatment of diseases, like cancer, using chemical compounds that selectively target abnormal cells. Chemotherapy drugs work by stopping cancer cell growth and reproduction. Common side effects are also discussed. The document also defines antibiotics as molecules that kill or inhibit the growth of microorganisms like bacteria and fungi. It discusses the medical and non-medical uses of antibiotics and provides an overview of how antibiotics are classified based on their producing microorganisms, activity spectrum, metabolic pathways, and chemical structures.
Mechanisms of action of antiviral drugs
This document discusses chemotherapy and antibiotics. It defines chemotherapy as the treatment of diseases, including cancer, with chemical compounds that selectively target abnormal or invading cells. Chemotherapy drugs work by stopping cancer cell growth and reproduction. Common side effects are also discussed. The document also defines antibiotics as molecules that kill or inhibit the growth of microorganisms like bacteria and fungi. It discusses the medical and non-medical uses of antibiotics and provides an overview of how antibiotics are classified.
ADR.pptx
PHARMACOLOGY IS CHALLENGING SUBJECT TO TEACH AND UNDERSTAND ALSO .....THEIR INTERESTING PART IS TO LEARN ABOUT ADR
Post chemotherapy care ver 1.0
This document provides information on post-chemotherapy care and management of side effects. It discusses extravasation, which is when chemotherapy leaks from the vein into surrounding tissue. It classifies extravasation reactions and describes how to recognize and manage it. It also covers chemotherapy-induced nausea and vomiting (CINV), discussing pathophysiology and providing recommendations for preventing nausea based on emesis risk. The document further addresses febrile neutropenia, defining it and outlining management strategies. It then discusses anemia as a side effect of chemotherapy and radiation, describing treatment goals and options. Finally, the document defines mucositis as inflammation of mucosal surfaces throughout the body.
AMA-_Antimicrobials_Intro.pdf
Pharmacology Lecture Slides on Antimicrobials intro by Sanjaya Mani Dixit Assistant Professor of Pharmacology at Kathmandu Medical College
Antibiotics requiring therapeutic drug monitoring(1)
This document provides information on therapeutic drug monitoring of aminoglycosides and vancomycin. It discusses pharmacokinetics concepts such as absorption, distribution, metabolism, and elimination of drugs. It explains that intravenous administration provides full bioavailability without first-pass metabolism. The document also covers pharmacodynamics predictors of antibiotic efficacy like time above MIC, AUC/MIC ratio, and Cmax/MIC ratio. It states that aminoglycosides and vancomycin require therapeutic drug monitoring due to their narrow therapeutic indices to ensure efficacy and prevent toxicity.
cancer care - the role of anaesthetists.pptx
The document discusses the role of anesthetists in cancer care. It covers topics such as the epidemiology of cancer, the role of anesthetists in pain management, perioperative care of cancer patients, the effects of different anesthetic agents and techniques on cancer outcomes, and recommendations for improving multidisciplinary cancer care. Anesthetists play a key role in facilitating cancer treatment through safe provision of anesthesia and improving long term outcomes by minimizing immunosuppression during surgery and cancer recurrence.
MHSS TMS, OCD, Ketamine Training Deck, 03.03.21.pdf
Transcranial magnetic stimulation (TMS) and ketamine therapies are emerging treatments for treatment-resistant depression. Rates of major depressive disorder in the US have tripled during the COVID-19 pandemic. TMS uses magnetic pulses to target brain regions implicated in depression, while ketamine has rapid antidepressant effects through glutamate modulation and synaptogenesis. Both therapies show response rates of 50-70% within 1-2 weeks and have generally mild side effect profiles compared to medications. However, maintenance treatment is often needed to sustain benefits.
Adjuvant therapy - Dr. Roda Amaria
Dr. Roda Amaria presents the latest on adjuvant therapy for melanoma at the MRF's Patient Symposium at MD Anderson Cancer Center on January 31, 2015.
Supportive Care of Cancer
This document provides an overview of chemotherapy-induced nausea and vomiting (CINV). It discusses the pathophysiology of CINV, focusing on areas in the central nervous system and gastrointestinal tract that are involved in vomiting. These include the vomiting center, chemoreceptor trigger zone, and enterochromaffin cells. The document also describes the classification of CINV into acute, delayed, anticipatory, and refractory types and lists factors that influence the incidence and severity of CINV, such as the emetogenic potential of chemotherapy agents and patient characteristics.
Chp no 2 anti-microbial.pptx
This document discusses antimicrobial drugs and provides information about their use. It begins by defining antimicrobial drugs as substances that kill or suppress microorganisms like bacteria, fungi, viruses and more. It then lists some common infections treated with antimicrobial drugs. The document goes on to discuss antimicrobial terminology, mechanisms of action, principles of selecting the appropriate drug, indications for use, and appropriate nursing implications when administering antimicrobial drugs to patients. It emphasizes the importance of preventing resistance, assessing treatment response and monitoring for adverse effects.
Antibiotic prophylaxis
Antibiotic prophylaxis aims to prevent surgical site infections by administering antibiotics before and during surgery to eliminate bacteria and create an unfavorable environment for infection. The risk of surgical site infection depends on factors like the type of surgery (clean vs. contaminated), insertion of implants, duration of surgery, and patient comorbidities. Common pathogens include Staphylococcus aureus and streptococci for skin wounds, and oral anaerobes for head/neck surgery. Guidelines recommend evaluating risks and benefits of prophylaxis as well as considering antibiotic susceptibility of likely contaminants when determining appropriate prophylactic regimens.
Adverse Drug Reactions of Chemotherapy 1.pptx
This document outlines adverse drug reactions (ADRs) associated with chemotherapy. It discusses common ADRs like nausea/vomiting, mucositis, alopecia, and their causes, risk factors, management. It notes that ADRs occur in 6.5-10.9% of hospital admissions. The role of pharmacists is to monitor medication profiles, educate patients on ADRs, document ADRs, and assist in managing supportive care like nausea/pain. Close collaboration between pharmacists and oncologists can help optimize outcomes for patients undergoing chemotherapy.
Similar to ANTIEMETIC Drug - Olanzapine (20)
Advances in chemotherapy techniques and common chemotherapy strategies
Advances in chemotherapy techniques and common chemotherapy strategies
Antibiotics requiring therapeutic drug monitoring(1)
Antibiotics requiring therapeutic drug monitoring(1)
MHSS TMS, OCD, Ketamine Training Deck, 03.03.21.pdf
MHSS TMS, OCD, Ketamine Training Deck, 03.03.21.pdf
Recently uploaded
HUMAN EYE By-R.M Class 10 phy best digital notes.pdf
Class 10 human eye notes physics
Handwritten best quality
Mending Clothing to Support Sustainable Fashion_CIMaR 2024.pdf
Ozturkcan, S., Berndt, A., & Angelakis, A. (2024). Mending clothing to support sustainable fashion. Presented at the 31st Annual Conference by the Consortium for International Marketing Research (CIMaR), 10-13 Jun 2024, University of Gävle, Sweden.
BIRDS DIVERSITY OF SOOTEA BISWANATH ASSAM.ppt.pptx
Ahota Beel, nestled in Sootea Biswanath Assam , is celebrated for its extraordinary diversity of bird species. This wetland sanctuary supports a myriad of avian residents and migrants alike. Visitors can admire the elegant flights of migratory species such as the Northern Pintail and Eurasian Wigeon, alongside resident birds including the Asian Openbill and Pheasant-tailed Jacana. With its tranquil scenery and varied habitats, Ahota Beel offers a perfect haven for birdwatchers to appreciate and study the vibrant birdlife that thrives in this natural refuge.
Pests of Storage_Identification_Dr.UPR.pdf
InIndia-post-harvestlosses-unscientificstorage,insects,rodents,micro-organismsetc.,accountforabout10percentoftotalfoodgrains
Graininfestation
Directdamage
Indirectly
•theexuviae,skin,deadinsects
•theirexcretawhichmakefoodunfitforhumanconsumption
About600speciesofinsectshavebeenassociatedwithstoredgrainproducts
100speciesofinsectpestsofstoredproductscauseeconomiclosses
Sexuality - Issues, Attitude and Behaviour - Applied Social Psychology - Psyc...
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Compositions of iron-meteorite parent bodies constrainthe structure of the pr...
Magmatic iron-meteorite parent bodies are the earliest planetesimals in the Solar System,and they preserve information about conditions and planet-forming processes in thesolar nebula. In this study, we include comprehensive elemental compositions andfractional-crystallization modeling for iron meteorites from the cores of five differenti-ated asteroids from the inner Solar System. Together with previous results of metalliccores from the outer Solar System, we conclude that asteroidal cores from the outerSolar System have smaller sizes, elevated siderophile-element abundances, and simplercrystallization processes than those from the inner Solar System. These differences arerelated to the formation locations of the parent asteroids because the solar protoplane-tary disk varied in redox conditions, elemental distributions, and dynamics at differentheliocentric distances. Using highly siderophile-element data from iron meteorites, wereconstruct the distribution of calcium-aluminum-rich inclusions (CAIs) across theprotoplanetary disk within the first million years of Solar-System history. CAIs, the firstsolids to condense in the Solar System, formed close to the Sun. They were, however,concentrated within the outer disk and depleted within the inner disk. Future modelsof the structure and evolution of the protoplanetary disk should account for this dis-tribution pattern of CAIs.
Embracing Deep Variability For Reproducibility and Replicability
Embracing Deep Variability For Reproducibility and ReplicabilityUniversity of Rennes, INSA Rennes, Inria/IRISA, CNRS
Embracing Deep Variability For Reproducibility and Replicability
Abstract: Reproducibility (aka determinism in some cases) constitutes a fundamental aspect in various fields of computer science, such as floating-point computations in numerical analysis and simulation, concurrency models in parallelism, reproducible builds for third parties integration and packaging, and containerization for execution environments. These concepts, while pervasive across diverse concerns, often exhibit intricate inter-dependencies, making it challenging to achieve a comprehensive understanding. In this short and vision paper we delve into the application of software engineering techniques, specifically variability management, to systematically identify and explicit points of variability that may give rise to reproducibility issues (eg language, libraries, compiler, virtual machine, OS, environment variables, etc). The primary objectives are: i) gaining insights into the variability layers and their possible interactions, ii) capturing and documenting configurations for the sake of reproducibility, and iii) exploring diverse configurations to replicate, and hence validate and ensure the robustness of results. By adopting these methodologies, we aim to address the complexities associated with reproducibility and replicability in modern software systems and environments, facilitating a more comprehensive and nuanced perspective on these critical aspects.
https://hal.science/hal-04582287
JAMES WEBB STUDY THE MASSIVE BLACK HOLE SEEDS
The pathway(s) to seeding the massive black holes (MBHs) that exist at the heart of galaxies in the present and distant Universe remains an unsolved problem. Here we categorise, describe and quantitatively discuss the formation pathways of both light and heavy seeds. We emphasise that the most recent computational models suggest that rather than a bimodal-like mass spectrum between light and heavy seeds with light at one end and heavy at the other that instead a continuum exists. Light seeds being more ubiquitous and the heavier seeds becoming less and less abundant due the rarer environmental conditions required for their formation. We therefore examine the different mechanisms that give rise to different seed mass spectrums. We show how and why the mechanisms that produce the heaviest seeds are also among the rarest events in the Universe and are hence extremely unlikely to be the seeds for the vast majority of the MBH population. We quantify, within the limits of the current large uncertainties in the seeding processes, the expected number densities of the seed mass spectrum. We argue that light seeds must be at least 103 to 105 times more numerous than heavy seeds to explain the MBH population as a whole. Based on our current understanding of the seed population this makes heavy seeds (Mseed > 103 M⊙) a significantly more likely pathway given that heavy seeds have an abundance pattern than is close to and likely in excess of 10−4 compared to light seeds. Finally, we examine the current state-of-the-art in numerical calculations and recent observations and plot a path forward for near-future advances in both domains.
Synopsis presentation VDR gene polymorphism and anemia (2).pptx
I am the PhD scholar of FND department, Assam down town University
Male reproduction physiology by Suyash Garg .pptx
Physiology of Male reproduction.
Video mentioned at page no. 23 as summary for better understanding
seed production, Nursery & Gardening.pdf
This presentation offers a general idea of the structure of seed, seed production, management of seeds and its allied technologies. It also offers the concept of gene erosion and the practices used to control it. Nursery and gardening have been widely explored along with their importance in the related domain.
11.1 Role of physical biological in deterioration of grains.pdf
Storagedeteriorationisanyformoflossinquantityandqualityofbio-materials.
Themajorcausesofdeteriorationinstorage
•Physical
•Biological
•Mechanical
•Chemical
Storageonlypreservesquality.Itneverimprovesquality.
Itisadvisabletostartstoragewithqualityfoodproduct.Productwithinitialpoorqualityquicklydepreciates
Recently uploaded (20)
HUMAN EYE By-R.M Class 10 phy best digital notes.pdf
HUMAN EYE By-R.M Class 10 phy best digital notes.pdf
Mending Clothing to Support Sustainable Fashion_CIMaR 2024.pdf
Mending Clothing to Support Sustainable Fashion_CIMaR 2024.pdf
BIRDS DIVERSITY OF SOOTEA BISWANATH ASSAM.ppt.pptx
BIRDS DIVERSITY OF SOOTEA BISWANATH ASSAM.ppt.pptx
Sexuality - Issues, Attitude and Behaviour - Applied Social Psychology - Psyc...
Sexuality - Issues, Attitude and Behaviour - Applied Social Psychology - Psyc...
Clinical periodontology and implant dentistry 2003.pdf
Clinical periodontology and implant dentistry 2003.pdf
Compositions of iron-meteorite parent bodies constrainthe structure of the pr...
Compositions of iron-meteorite parent bodies constrainthe structure of the pr...
Embracing Deep Variability For Reproducibility and Replicability
Embracing Deep Variability For Reproducibility and Replicability
Nutaceuticsls herbal drug technology CVS, cancer.pptx
Nutaceuticsls herbal drug technology CVS, cancer.pptx
Synopsis presentation VDR gene polymorphism and anemia (2).pptx
Synopsis presentation VDR gene polymorphism and anemia (2).pptx
11.1 Role of physical biological in deterioration of grains.pdf
11.1 Role of physical biological in deterioration of grains.pdf
ANTIEMETIC Drug - Olanzapine
- 1. CANCER SIDE EFFECT TREATING DRUG - OLANZAPINE AJIT. SL (M.Sc.,) HUMAN GENETICS & MOLECULAR BIOLOGY BHARATHIAR UNIVERSITY, COIMBATORE
- 2. ANITEMETIC DRUG: It’s a Antipsychoti agent. This medicine is also used to ANTI-EMETIC drug. After chemo therapy, normally the cancer patients are affecting by Nausea (60%) and vomiting (30%). This side effect are shortly known as CINV (Chemotherapy Induced Nausea and Vomiting).
- 3. Atypical antipsychotic agent of the thiobenzodiazepine class, has the ability to target many different receptors, making it an attractive antiemetic agent. CINV are classified @ 4 : 1. Acute CINV 2. Delayed CINV 3. Anticipatory CINV 4. Refractive CINV
- 4. 1. ACUTE CINV: Acute CINV occurs within 24 hours of receiving chemotherapy. 2. DELAYED CINV : Delayed CINV occurs most frequently 24 to 48 hours after chemotherapy but can occur up to 5 days post chemotherapy. 3. ANTICIPATORY CINV : Anticipatory CINV can occur hours to days before a patient receives chemotherapy
- 5. 4. REFRACTORY CINV : Refractory CINV can occur at any point in a treatment cycle, despite adequate therapy for acute and delayed CINV.
- 6. BLOCK RECEPTORS: It has the ability to block many different receptors. Olanzapine targets, Dopaminergic (D1, D2, D3, D4), Serotonergic (5-HT2A, 5-HT2C, 5-HT3, 5-HT6), Adrenergic (á1), Histaminergic (H1), Muscarinic (m1, m2, m3, m4)
- 7. DOSAGE LEVEL; The standard dosage of olanzapine for prophylaxis and treatment is 5 to 10 mg per day, with a maximum dose of 20 mg per day. Recommended starting doses are lower for women and elderly patients than for others. Olanzapine can also be given as a rescue dose: 5 mg every 4 hours on an as-needed basis.
- 8. SIDE EFFECTS: Tolerable and mild and include somnolence, Postural hypotension, Constipation, Dizziness, Fatigue, Dyspepsia, Restlessness, Weight gain