This document provides information on several oral antifungal drugs: miconazole, itraconazole, voriconazole. Miconazole is an imidazole antifungal primarily used topically and intravaginally to treat fungal infections. Itraconazole is a broad-spectrum triazole antifungal used to treat various fungal infections. Voriconazole is a triazole antifungal used to treat invasive aspergillosis and candidemia. All three drugs work by inhibiting fungal cell membrane synthesis. They can cause mild to potentially life-threatening side effects and require monitoring for drug interactions, liver and heart issues.
The presentation gives an in-depth review of the Anti-fungal drugs used to treat various acute and chronic fungal infections along with their uses and MOA.
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
The presentation gives an in-depth review of the Anti-fungal drugs used to treat various acute and chronic fungal infections along with their uses and MOA.
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
I am Dr. Anil. this is my Lecture delivered to 3rd year MBBS for the subject of Pharmacology. These slides cover basics of Antifungal drugs mainly its pharmacology.
Pharmacology for medical students, nursing students, pharmacology students, and university students!
Great to use as and adjunct for your courses or board exams!
Description on types of fungal organisms with differences between bacteria and fungi. A note on useful and harmful fungi. Brief insight on Antifungal classification, mechanism of actions and pharmacological profile with drug of choices for various fungal infections.
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Itraconazole Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Itraconazole Dosage & Rx Info | Itraconazole Uses, Side Effects -: Indications, Side Effects, Warnings, Itraconazole - Drug Information - Taj Pharma, Itraconazole dose Taj pharmaceuticals Itraconazole interactions, Taj Pharmaceutical Itraconazole contraindications, Itraconazole price, Itraconazole Taj Pharma Itraconazole 100mg Capsules, hard SMPC- Taj Pharma . Stay connected to all updated on Itraconazole Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
I am Dr. Anil. this is my Lecture delivered to 3rd year MBBS for the subject of Pharmacology. These slides cover basics of Antifungal drugs mainly its pharmacology.
Pharmacology for medical students, nursing students, pharmacology students, and university students!
Great to use as and adjunct for your courses or board exams!
Description on types of fungal organisms with differences between bacteria and fungi. A note on useful and harmful fungi. Brief insight on Antifungal classification, mechanism of actions and pharmacological profile with drug of choices for various fungal infections.
Itraconazole 100mg capsules, hard smpc taj pharmaceuticalsTaj Pharma
Itraconazole Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Itraconazole Dosage & Rx Info | Itraconazole Uses, Side Effects -: Indications, Side Effects, Warnings, Itraconazole - Drug Information - Taj Pharma, Itraconazole dose Taj pharmaceuticals Itraconazole interactions, Taj Pharmaceutical Itraconazole contraindications, Itraconazole price, Itraconazole Taj Pharma Itraconazole 100mg Capsules, hard SMPC- Taj Pharma . Stay connected to all updated on Itraconazole Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Voriconazole for Injection Taj Pharma PILTajPharmaQC
Voriconazole for Injection 200mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Voriconazole Dosage & Rx Info | Voriconazole Uses, Side Effects Voriconazole: Indications, Side Effects, Warnings, Voriconazole -Drug Information –Taj Pharma, Voriconazole dose Taj pharmaceuticals Voriconazole interactions, Taj Pharmaceutical Voriconazole contraindications, Voriconazole price, Voriconazole Taj Pharma Voriconazole SmPC-Taj Pharma Stay connected to all updated on Voriconazole Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Gout is a type of inflammatory arthritis that causes permanent disability if left untreated. This presentation focuses on the important salient points we need to remember in Gout in all aspects - diagnosis, managment (both non-pharmacological and pharmacological approaches).
This presentation is useful to both MBBS and Postgraduate students of Pharmacology.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
2. ORAL ANTIFUNGAL
MICONAZOLE
• Overview
• Miconazole (Nitrate) is imidazole-type antifungal. When miconazole was first
released, it was hoped it would replace amphotericin B as a parenteral antifungal
agent. It was soon discovered, however, that miconazole not only failed to offer the
same efficacy as amphotericin B, but also possessed intrinsic toxicities after IV
administration.
• While miconazole is still marketed in a parenteral formulation, it most commonly is
used topically and intravaginally. Miconazole was approved by the FDA in 1974it
was one of the first azole antifunfal agent to become widely used for treating
mycoses. Miconazole (Nitrate) is a topically used azole.
• Like other azole antifungals, miconazole exerts its effect by altering the fungal cell
membrane. Miconazole inhibits ergosterol synthesis by interacting with 14a
demethylase, a cytochrome P-450 enzyme that is necessary for the conversion of
lanosterol to ergosterol, an essential component of the membrane. Inhibition of
ergosterol synthesis results in increased cellular permeability, causing leakage of
cellular contents. Miconazole does not appear to have the same effect on human
cholesterol synthesis.
3. • Miconazole is the derivative of Miconazole
(Nitrate)Miconazole is the derivative of Miconazole
(Nitrate) It is of Synthetic origin and belongs to
Azole. It belongs to Antifungals pharmacological
group.
• Indications
• Miconazole (Nitrate) is primarily indicated in
conditions like Balanitis, Candidosis, Fungal
infection, Vulvo-vaginal candidosis.
4. • Contraindications
• Miconazole (Nitrate) is contraindicated in conditions like Hypersensitivity
to any component of product.
• Side Effects
• The severe or irreversible adverse effects of Miconazole (Nitrate), which
give rise to further complications include Cardiac arrhythmias, Hepatitis,
Cardiac arrhythmias, Phlebitis, Pruritis, Arachnoiditis.
• Miconazole (Nitrate) produces potentially life-threatening effects which
include Cardiac Arrest, Cardiac arrest, Anaphylaxis. which are
responsible for the discontinuation of Miconazole (Nitrate) therapy.
• The signs and symptoms that are produced after the acute overdosage of
Miconazole (Nitrate) include Vomiting, Diarrhea, Arrhythmias.
• The symptomatic adverse reactions produced by Miconazole (Nitrate) are
more or less tolerable and if they become severe, they can be treated
symptomatically, these include Drowsiness, Anorexia, Rashes, GI upset,
Flushing, Nausea and vomiting, Local irritation.
5. • Dosage
• Miconazole (Nitrate)'s dosage details are as
follows: Dose Single Dose Frequency Route
Instructions
• Adult Dosage
• 2 % As recommended.OphthalmicAs
required.250 mg 6 hourly PO 100 mg24 hourly
Rectal For 14 days.2 % 24 hourly Topical
Once daily
6. • Storage Conditions
• Cream, Vag Supositories, Powder
• Store Below 40°C. Do not Freeze. Protect
from Sunlight and Moisture.
7. ITRACONAZOLE
• Overview
• Itraconazole is a broad-spectrum antifungal agent for oral
treatment of vulvovaginal candidiasis, pityriasis versicolor and
dermatophytoses.itraconazole is a substituted triazole
derivetive.itraconazoleactive against many Candida species,
endemic mycoses and dermatophytes.
• Itraconazole is the most potent of available azoles, but effectiveness
can be limited by reduced bioavailabilty. The requirement for
intravenous administration and the toxicity of the older antifungal
agents created a need for antifungal agents with a better therapeutic
profile.
• The relatively non-toxic oral azole medications represent the first
major advance in this direction. Since their introduction in the
1980s, these medications have played an increasingly important role
in the systemic therapy of fungal disease.
8. • Primary Characterstics
• Itraconazole also known as Oriconazole. Itraconazole also known as
Oriconazole. It is of Synthetic origin and belongs to Triazole. It belongs to
Antifungals pharmacological group.
• Indications
• Itraconazole is primarily indicated in conditions like Advanced breast or
prostate cancer, Antifungal prophylaxis, Candidiasis, Cryptcoccal
meningitis, Dermatophytic infections, Histoplasmosis, Oculomycoses,
Onychomycoses, Oral candidiasis, Oropharangeal candidiasis,
Orophyrangeal candidiasis, Pityriasis versicolor, Sporotrichosis, Superficial
candidiasis, Systemic mycoses, Tinea pedis, Tinae manuum, To reduce
intestinal secretions and vomiting, To reduce intestinal secretions and
vomiting (palliative care), and can also be given in adjunctive therapy as an
alternative drug of choice in Cushing`s syndrome due to malignant disease,
Fungal keratitis, Leishmaniasis, Vulvo-vaginal candidosis.
9. • Side Effects
• The severe or irreversible adverse effects of Itraconazole, which give rise to
further complications include Hypotension, Hepatitis, Hypotension.
• Itraconazole produces potentially life-threatening effects which include
Dysrhythrics. which are responsible for the discontinuation of Itraconazole
therapy.
• The signs and symptoms that are produced after the acute overdosage of
Itraconazole include Constipation, Gastritis, Depression.
• The symptomatic adverse reactions produced by Itraconazole are more or
less tolerable and if they become severe, they can be treated
symptomatically, these include Dizziness, Vertigo, Headache, Fatigue,
Nausea, Vomiting, Diarrhea, Abdominal pain, Pruritus, Hallucination,
Somnolence, Hair loss, Edema, Photophobia, Vasculitis, dizziness.
10. • Dosage
• Itraconazole's dosage details are as follows:
Dose Single Dose Frequency Route
Instructions
• Adult Dosage
• 200 mg 24 hourlyPO For a Week
11. • Warning / Precautions
• Itraconazole should be used with caution in patients with allliver
disease, heart rhythm disorders (arrhythmias) and of any drug
ergies. It should be used with caution while engaging in activities
requiring alertness because this medication causes dizziness or
drowsiness. It should be used only when clearly needed during
pregnancy or lactation.
• Safe use of itraconazole in the children under the age 16 has not
been established. The drug should be used with caution in the
patients with azole hypersensitivity. Patients who develop abnormal
liver function tests during itraconazole therapy should be monitored
and therapy discontinued if symptoms of the liver disease develop.
Should not be administered to treat onchonycosis in pateints with
ventricular dysfurution.
12. • Storage Conditions
• Caps
• Store Between 15°C-30°C. Protect from
Sunlight, Moisture and Heat.
• Soln
• Store at room temperature, Below 25°C. Do
not Freeze. Protect from Sunlight and Heat.
13. Voriconzaole
• Overview
• Voriconazole is a triazole antifungal agent.
Voriconazole is designated chemically as (2R,3S)-
2-(2,4-difluorophenyl)-3-(5-fluoro-4
pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol.
• It is available as a lyophilized powder for solution
for intravenous infusion, film-coated tablets for
oral administration, and as a powder for oral
suspension.
14. • Primary Characterstics
• It is of Synthetic origin and belongs to
phenylpropylamines. It belongs to Antifungals
pharmacological group.
• Indications
• VORICONAZOLE is primarily indicated in
conditions like candidemia, Candidiasis,
Invasive aspergillosis.
15. • Side Effects
• The symptomatic adverse reactions produced
by VORICONAZOLE are more or less
tolerable and if they become severe, they can
be treated symptomatically, these include
Headache, Nausea, Vomiting, Fever,
Tachycardia, Chills, Hallucination, Visual
disturbances, Rash, Tachycardia.
16. • Dosage
• VORICONAZOLE's dosage details are as
follows: Dose Single Dose Frequency Route
Instructions
• Adult Dosage
• 0 to 6 mg/kg 2 hourly IV100 mg 2 hourlyPO
less than 40 kg 200 mg 2 hourly PO (40 kg or
more)
17. • Warning / Precautions
• Hepatic Toxicity: Serious hepatic reactions reported. Evaluate liver
function tests at start of and during voriconazole therapy. Visual
Disturbances (including optic neuritis and papilledema): Monitor visual
function if treatment continues beyond 28 days.
• Embryo-Fetal Toxicity: Do not administer to pregnant women unless the
benefit to the mother outweighs the risk to the fetus. Inform pregnant
patient of hazard.
• Patients with Hereditary Galactose Intolerance Lapp Lactase Deficiency or
Glucose-Galactose Malabsorption: Do not use. Arrhythmias and QT
Prolongation: Correct potassium, magnesium and calcium prior to use;
caution patients with proarrhythmic conditions. Infusion Related Reactions
(including anaphylaxis): Stop the infusion. Dermatological Reactions:
Discontinue for exfoliative cutaneous reactions or phototoxicity. Avoid
sunlight due to risk of photosensitivity.Skeletal Events: Fluorosis and
periostitis with long-term voriconazole therapy. Discontinue if these events
occur