The study is designed with the main objectives of:- Highest selling brand used by the doctor for treatment of diabetes. Top 3 highest selling companies in market. These brands comparison with other brands having same API class. Comparison in terms of cost per unit. Quantitative and qualitative analysis. Diabetes mellitus, commonly known as diabetes, is a metabolic disease that causes high levels of sugar in blood. It is diagnosed when fasting blood glucose exceeds 126 mg/dl. With diabetes, your body either does not make enough insulin or can’t effectively use the insulin it does make. There are basically two types of diabetes – Type 1 diabetes is an autoimmune disease in which the immune system attacks and destroys beta cells in the pancreas. It’s unclear what causes this attack. About 10% of people with diabetes have this type ( insulin therapy). Type 2 diabetes occurs when your body becomes resistant to insulin, and sugar builds up in your blood (insulin, oral hypoglycemic therapy). It is the most common type of diabetes which affects 90-95 % of population according to CDC (The Centers for Disease Control and Prevention).

1. ANTI- DIABETICS DRUGS
PREPARED BY- GUIDE-
SHASHWAT KHARE DR. P.S. RAYCHAUDHURI
SHIVAM MANOCHA ( PROGRAM COORDINATOR)
SHIVAM SHUKLA
SHREAA
TANYA SRIVASTAVA
JAMIA HAMDARD

2. Introduction
 Diabetes mellitus, commonly known as diabetes, is a metabolic disease that
causes high levels of sugar in blood. It is diagnosed when fasting blood glucose
exceeds 126 mg/dl. With diabetes, your body either does not make enough insulin
or can’t effectively use the insulin it does make.
 There are basically two types of diabetes –
a. Type 1 diabetes is an autoimmune disease in which the immune system attacks
and destroys beta cells in the pancreas. It’s unclear what causes this attack.
About 10% of people with diabetes have this type ( insulin therapy).
b. Type 2 diabetes occurs when your body becomes resistant to insulin, and sugar
builds up in your blood (insulin, oral hypoglycemic therapy). It is the most
common type of diabetes which affects 90-95 % of population according to
CDC (The Centers for Disease Control and Prevention).

3. • The Indian diabetes market reached a value of US4 1,954 Million in 2018. The market is
further expected to grow at a CAGR of 16.7% during 2019-2024.
• Diabetes is rapidly gaining the status of a otential epidemic in India with around 65
million people currently affected by it.
• The overall market size of diabetes drugs in India is Rs 10,534 Crore, according to
Quintiles IMS data.
• According to AIOCD data (October 2018), India’s anti-diabetic market is one of the
fastest growing therapy segments, with growth exceeding 25% at Rs 7,638 Crore.
Scenario of Indian Anti- Diabetic Market

4. Objective
The study is designed with the main objectives of:-
 Highest selling brand used by the doctor for treatment of diabetes.
 Top 3 highest selling companies in market.
 These brands comparison with other brands having same API class.
 Comparison in terms of cost per unit.
 Quantitative and qualitative analysis.

5. Methodology
 Data collected from retail pharmacy shops, by consulting the
doctors and the medical representatives of the companies.
 We’ve done a survey near Tughlakabad Extension (Delhi),
Lucknow (UP), Yamunanagar (Haryana).

6. Questions asked to Doctors and Chemists (Type 1
Diabetes)
1. Most recommended brands?
 Humalog, Huminsulin (N,R), Lantus, Mixtard
2. Prescription therapy? Single or multiple.
 Dose is decided on the basis of blood sugar levels (by monitoring blood sugar levels each day)
3. Availability in the pharmacies?
 Good availability in pharmacies.
4. Which brand you preferred and why?
 Good availability, therapeutic efficacy, patient compliance.
5. Type of dosage recommended?
 Insulin pumps
6. Side effects?
a) Insulin can lead to hypoglycemic condition which may lead to unconsciousness and to normalize
the levels of blood sugar, the patient must be given sugar cubes immediately.
b) Insulin leads to kidney damage and finally can lead to death.

7. Observation (Type 1 Diabetes)
COMPANY NAME BRAND NAME API
Eli Lilly Company • Mixtard (30/70, 50/50, 75/25)
• Humalog (50/50, 75/25)
• Huminsulin N (30/70)
• Huminsulin R (30/70)
• Huminsulin NPH
• Normal Insulin/ Isophane Insulin
• Insulin Lispro (SC)
• Insulin Human, Protamine sulfate,
Metacresol, Dibasic sodium phosphate
• Insulin Human, Metacresol
• Insulin Human, Protamine sulfate,
Metacresol, Dibasic sodium phosphate,
Phenol
Sanofi India Ltd • Lantus
• Apidra
• Insulin glargine
• Insulin glulisine
Novo Nordisk India Ltd • Levemir • Insulin Detemir

8. Observation (Primary Data)
 Type 1 Diabetes
0
10
20
30
40
50
1
PRESCRIPTIONPERMONTH
BRAND NAME
TOP BRAND
LEVEMIR LANTUS HUMALOG MIXTARD INSUGEN N 40 APIDRA
10
10
25
35
50
0 10 20 30 40 50 60
ABBOTT INDIALTD.
BIOCON LTD.
NOVO NORDISK PHARMA INDIA LTD.
SANOFI INDIA LTD
ELI-LILLY AND COMPANY INDIA
AMOUNT OF PRESCRIPTION
COMPANYNAME
TOP COMPANIES

9. Result
 Quantitative
a) According to no. of presecription generated
in the market, we found:
1. Type 1 Diabetes- In type 1 Diabetes patients,
insulin is directly administered via different
routes to cater the need of insulin in body.
According to no. of prescription generated,
Humalog is the most prescribed brand by
physicians.
Humalog (by Eli Lilly &
Company India with 50
prescriptions, having MRP
as 544 Rs)
Lantus (by Sanofi with 35
prescriptions, having MRP
as 656 Rs)
Levemir (by Novo Nordisk India
with 25 prescriptions,
having MRP as 1090 Rs)

10. Result (Secondary Data Type-1 Diabetes)
Quantitative aspect
TOP COMPANIES BRAND NAME MRP
Eli Lilly Company & India • Humalog 554 Rs
Sanofi India Ltd • Lantus 656 Rs
Novo Nordisk Pharma India
Ltd
• Levemir 1090 Rs

11. Type 2 diabetes (Secondary Data)
0
10
20
30
40
50
60
70
80
90
PPGmet
ZOMELISMET50/1000
EUGLUC-ON
DIABETROL
GLYXAMBI
JARDIANCE
Tradjenta
FORXIGA
XIGDUOXR
Onglyza
GLINILTAB
INVOKANA
INVOKAMET
INVOKAMETXR
VOKANAMET
GLUCONORMG3FORT
GIBTULIO
Januvia
Janumet
DAONILTAB
ISTAMET50/100
ISTAVEL100
OXRA
OXRAMET/XR
GLYBORAL
SULISENT
NUMBEROFPRESCRIPTION
BRANDNAMES
0
20
40
60
80
100
120
140
160
112
150
54 55
24 27 18 16 21 12
PRESCRIPTI0N(PERMONTH)
COMPANYNAME
TOP COMPANIES

12. Result
Quantitative aspect
 Type 2 Diabetes- Oral hypoglycemic agentsare given. According to no. of
prescriptions generated,
Top 3 Brands with their top selling production
according to number of prescriptions generated
are-
• Istamet 50/100
• Istavel 100
• Oxra
• Oxramet/XR• PPG MET
• Zomelis
MET
• Euglucon
• Diabetrol
• Gluconorm G3
Forte
• Gibtulio
• Onderomet

13. Observation (Secondary Data- Type 2 Diabetes)
TOP COMPANIES BRAND NAME ACTIVE PHARMACEUTICAL
INGEDIENT
MRP(IN RUPEES)
SUN PHARMA • OXRAMET/ XR
• OXRA
• ISTAMET 50/100
• ISTAVEL 100
• Dapaglifozin + Metformin
• Dapagliflozin
• Metformin + Sitagliptin
• Sitagliptin
• 415.6
• 692
• 391
• 351
ABBOTT • PPG MET
• ZOMELIS MET
50/1000
• EUGLUCON
• DIABETROL
• Metformin Hydrochloride+ Voglibose
• Metformin Hydrochloride+
Vildagliptin
• Glibenclamide
• Glibenclamide+ Metformin
• 127.76 Rs
• 227.1 Rs
• 9.78 Rs
• 43.75 Rs
LUPIN LTD • GLUCONORM G3
FORT
• ONDEROMET
• GIBTULIO
• Glimepiride + Metformin
• Linagliptin + Metformin
• Empaglifozin
• 171 Rs
• 222 Rs
• 470 Rs

14. Qualitative
b) According to cost of unit dose per day, top 3 highest cost brands are:
1) Invokamet (by Janssen Pharmaceuticals)
2) Oxramet/XR and Oxra by Sun
Pharma, Forxiga by Astrazeneca
3) Januvia by MSD Pharmaceuticals

15. Quantitative
b) According to
average monthly
cost, top 3 highest
cost brands:
• Invokamet XR by
Janssen
Pharmaceuticals
• Glyxambi by
Boehringer Ingelheim
• Oxramet/XR & Oxra
by Sun Pharma,
Fraxiga by
Astrazeneca

16. Brand comparison of top 3 companies with same
class of API drugs
PARAMETERS SUN
PHARMACEUTICALS
LTD. (Istamet 500/1000)
ABBOTT INDIA LTD.
(Zomelis MET)
LUPIN LTD. (Ondero
MET)
API Metformin/Sitagliptin Metformin/ Vildagliptin Metformin/ Linagliptin
Dose recommended Once a day Once a day Once a day
Per unit dose cost (Rs) 39.1 24.7 22.213
Average monthly cost 1173 741 666.39
Side effects Hypoglycemia, lactic
acidosis, anxiety.
Swelling of face, lips,
eyelids, tongue, hands
and feet and weight
gain.
Anxiety, weakness, sore
throat.

17. Conclusion
 Field assignment provided us with real-world experience, increased
the quality of education, and improved the social relations outside
of the four walls of a classroom. It gave us experiential learning,
conceptual knowledge which helped us in developing a deeper
understanding towards assignment. Field assignment was
embedded with educational content as well as team-building
activities, such as working together to complete assignments and
projects. Good field assignment can provide an integral part of the
learning experience if they are planned well. The aim of this project
is to consider how effective field assignments are in providing
conceptual knowledge.
 Our findings are still on going in areas like accurate market share
of top three companies dealing with diabetes segment.

18. Source of Reference (Secondary Aspects)
 https://www.ijmrhs.com/abstract/cost-analysis-study-of-oral-antidiabetic-
drugs-available-in-indian-market-91.html
 https://www.marketresearchreports.com/blog/2019/06/10/top-10-
antidiabetics-pharma-companies-world
 https://timesofindia.indiatimes.com/business/india-business/Five-
diabetes-drugs-in-top-10-selling-list/articleshow/53311742.cms
 https://www.consumerreports.org/cro/2012/12/treating-type-2-
diabetes/index.htm
 file:///C:/Users/hp/Desktop/books/DiabetesUpdate-FINAL-Feb09.pdf
 https://www.business-standard.com/article/companies/here-are-top-20-
generic-drugs-in-india-anti-diabetic-medicines-top-list-
117051300977_1.html
 https://en.wikipedia.org/wiki/List_of_largest_selling_pharmaceutical_prod

19. Source of Reference (Primary Data)
CONSULTING DOCTORS
 Dr. Sunil Kohli
 Dr. S Jain
 Dr. Sunindar S. Arora
 Dr. kamal Jeet Singh
 Dr. Arun Dhiwan
 Dr. Prem Kapoor
• Dr. H.S. Gupta (Retired CMO Allahabad, UP)
• Dr. K.B. Srivastava
• Dr. Alok Saxena
• Dr. D.K. Singh
• Dr. Sudhir Kumar Yadav
• Dr. S.N. Shukla
• Dr. Seema Shukla
• Dr. Ghanshyam Aggarwal (Endocrinologist)
• Dr. Rajnesh Mittal
Name of pharmacy shops
 Mansuri medicos
 Parvati medicos
 New Priya medicos
 Bhatia medical
 Bansal medical store
 Vicky medicos
 Balaji medicos
 Goyal chemist
 Apollo pharmacy
 Mr. Vijay Rawat(Pharmacy Manager HIMSAR)
 Majeedia hospital pharmacy
 Batra hospital pharmacy
 H Plus Pharmacy
 HD Medico
 Bareja sons chemist shop

20. LINKEDIN CONTACTS

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