Anti depressants, Drugs which are used to relieve or prevent depression by enhancing alertness.They potentiate directly or indirectly the action of : Dopamine Serotonin Non adrenaline They do not have significant effect on Nor epinephrine & Dopamine.

1. Anti-depressants
(Neurology)
By :-
Bhawar Godara
Bhoomi Patidar
Chhaya Chauhan
Deepshikha Tanwar
Sonali Varshney

2. Anti depressants
 Drugs which
are used to
relieve or
prevent
depression by
enhancing
alertness
 The purpose of
antidepressants
is to increase
the
neurotransmitt
ers in the
synapse They potentiate
directly or
indirectly the
action of :
• Dopamine
• Serotonin
• Non adrenaline

3. Classification
(A). Selective
serotonin reuptake
inhibitors (SSRIs)
(B). 5-HT /NE
reuptake inhibitors
(SNRIs)
(C). Tricyclic
antidepressants
(TCSs)
(D). Atypical
antidepressants
(E). Monoamine
oxidase inhibitors

4. Selective serotonin reuptake inhibitors
• 1st drug was fluoxetine which was available
in 1988
• Safest antidepressant for use
• Good absorption after oral administration
• Drugs mostly excreted from kidney
Classification of drugs :
• Citalopram (Celexa)
• Escitalopram (Lexapro)
• Fluoxetine (Prozac)
• Paroxetine (Paxil, Pexeva)
• Sertraline (Zoloft)
• Vilazodone (Viibryd)

5. Mechanism
of action :
Inhibition of
serotonin reuptake
into the
presynaptic cell ,
increasing the level
of serotonin
leading to greater
post synaptic
neuronal activity.
They do not
have
significant
effect on Nor
epinephrine
& Dopamine. They typically take
2-12 weeks to
produce
improvement in
mood .

6. MAJEEDIA HOSPITAL
Dr. Maneesh Gupta (Pshychiatrist)
• Escitalopram (Top brand)
• Peroxitine (Panics and pexidep)
• Sertraline ( Zoloft)
• Zosert
• Serta
WHY?
• Least side effect profile
• Onset of action is faster
10-15 Rx/day

7. MAX HOSPITAL, SAKET
List of Doctors :-
• Dr. Madhusudhan (Psychiatrist)
• Dr. Karuna Thakur (Clinical Psychiatrist)
• Dr. Prashant Saxena (Neurologist)
• Dr. Anand Saxena (Neurologist)
• Dr. Ripen Kumar Gupta (Cardiologist)

8. Dr. Anand Saxena ( senior Doctor )
( Max hospital )
Dr. Sumit kumar Shah ( Junior Doctor )
1. Stalopam ( Lupin )
2. Tryptomer
-- 500 Rx / month
 Why ???
• because the only Side effect was sleep .
(Gets normal in 7 days)
• Its Not habitual

9. 1. Bareja Pharmacy
Brands
• Clonafit
• Nexito
• Citalopam
• Petril
• Zupiz
Company
• Clonazepam ( Mankind )
• Excitulopram ( Sunpharma )
• Citalopram ( Sunpharma)
• Micro labs ltd.
• Intas
15-20 Rx / week
2. Apollo
Brands
• Zolfresh
• Alprex
• Nitrest
Company
• Abbott
• Torrent
• Sunpharma
10-15 Rx / week

10. 3. Shri Kamal Medicals
Brand
• Etizoram
• Zapiz
Company
• Arinna lifescience pvt
ltd
• Intas
8-10 Rx / week
4. Jagdamba Pharmacy
Brand
• Alprax
• Clonotril
Company
• Torrent pharmaceuticals ltd.
• Torrent pharmaceuticals ltd.
2-3 Rx / week

11. 5. Sanjeev pharmacy
Brands
• Clonafit
• Petril
• Stalopam
Company
• Mankind
• Micro labs ltd.
• Lupin
10-12 Rx / week
6. Max hospital pharmacy
Brand
• Alprax
• Clonotril
• Petril
• Stalopam
Company
• Torrent
• Torrent
• Micro labs ltd.
• Lupin

12. Brand Value in cr. Growth rate %
• LONADEP
• NEXITO PLUS
• RIVOTRIL
• STALOPAM
• ZAPIZ
39
38
31
29
27
-1
13
0
12
1
KOLKATA 51 6
UTTARAKHAND
UP EAST
TAMIL NADU
RAJASTHAN
35
34
33
30
6
5
-1
7
Top states :--
Total market – 480 cr.
Growth rate – 5%
Top brands according to AIOCD

13. Brand Value in Cr. Growth Rate %
• DEPRAN
• STALOPAM PLUS
• CLONOTRIL
• RIVOTRIL
• NEXITO PLUS
2.28
2.02
1.76
1.51
1.25
69
9
-2
-11
16
Top 5 brands in DELHI :--

16. Depran
Manufacturer Intas pharmaceuticals
Salt Clonazepam + Escitalopram
oxalate
Uses Side effects
• Anxiety disorder • Vomiting
• Confusion
• Memory impairment
• Tiredness
• Anorgasmia
Alternate brands
• Nexito forte
• Clonafit plus
• Stalopam plus
• Sunpharma
• Mankind
• Lupin

17. Stalopam Plus
Manufacturer Lupin ltd.
Salt Escitalopram oxalate + clonazepam
Uses Side effects
• Depression • Low sexual desire
• Insomnia
• Vomiting
• Hypotension
Alternate brands
• Nexito
• Eslika
• Eslopam
• Sunpharma
• Symbiosis Lab
• Genome Therapeutics Corporation

18. Clonotril
Manufacturer Torrent pharmaceutics
Salt Clonazepam
Uses Side effects
• Anxiety disorder
• Epilepsy
• Dizziness
• Fatigue
• Drowsiness
• Coordination impairment
Alternate brands
• Zapiz
• Epitril
• Petril
• Intas pharmaceutics
• Novartis India ltd.
• Micro labs ltd.

19. Rivotril Tab
Manufacturer Abbott
Salt Clonazepam (0.25 mg )
Uses
• Anxiety disorder
• Epilepsy / seizures
Side effects
• Dizziness
• Depression
• Fatigue
• Drowsiness
• Coordination impairment
Alternate brands
• Zapiz
• Clonafit
• Clotas
• Intas pharmaceuticals
• Mankind pharma
• Tas Med India pvt ltd

20. Nexito plus tablet
Manufacturer Sunpharma
Salt Clonazepam + Escitalopram oxalate
Uses Side effects
• Anxiety disorder • Delayed ejaculation
• Confusion
• Vomiting
• Memory impairment
• Drowsiness
• Anorgasmia ( decreased orgasm)
• Less sexual desire
• Diarrhea
• Uncoordinated body movements
Alternate brands
• Rexipra plus • Intas pharmaceuticals
• Stalopam miniplus
• Ezeepam plus 5
• Lupin ltd.
• Eris lifesciences

22. STALOPAM PLUS/ LITE (LUPIN)

23. EPILIVE (LUPIN)

24. COGNISTAR (LUPIN)

25. Differences :-
CLONAZEPAM
(Benzodiazepines)
ESCITALOPRAM
(SSRI’s)
• Clonazepam may reduce
seizure frequency in specific
seizure disorders and can
be used short-term for panic
disorder; however, it can
cause dependence and
withdrawal symptoms on
discontinuation.
• Commonly reported side
effects include: drowsiness.
• Escitalopram relieves
depression and anxiety and
may have less potential for
side effects than some other
antidepressants.
• Commonly reported side
effects include: diarrhoea,
drowsiness, ejaculatory
disorder, headache,
insomnia, nausea, and
delayed ejaculation.

26. CONCLUSION(Reviews)
 Rajat Bhola (Marketing executive, LUPIN)
He said that according to him lupin is somewhere
lacking in the brand promotion strategies.
 Santosh Warmani (Product manager, LUPIN)
Team stability, commercial reasons, Brand loyalty etc.
 Dr. Vibhav Natu (GMP, CIPLA)
Most imp. Factor is what is brand differential,
Communication plays a pivotal role, promotion campaigns
done by the team, STP, and how the company is investing
in the psychiatrists is also very important.
1/2

27. CONCLUSION (4Ps)
 Why is depran on top?
Which makes them on top are the factors related to the
product promotions and strategies. 50% of Intas' total
domestic revenue is generated from Neurology,
Psychiatry and Cardiovascular therapies.
 Why stalopam is on second?
There are many things like
1. brand promotion strategies
2. how you approach to a doctor
3. how you read the market needs
4. out come of patients etc.
All these things work in increasing and decreasing the
brand position
2/2