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ISOSORBIDE DINITRATE
ISOSORBIDE MONONITRATE
ANTI ANGINAL DRUGS
ANGINA PECTORIS
CLASSICAL ANGINA
Attacks during rest or sleep due
to
vaso spasm
PRINZMETALS ANGINA
frequency
Duration
Intensity
At rest
UNSTABLE ANGINA
Long Acting Nitrates
Isosorbide dinitrate
Isosorbide mononitrate
Nitrates Available at our pharmacy
Actions:
REDUCTION IN PRELOAD
REDUCTION IN AFTERLOAD
REDISTRIBUTION OF BLOOD
FLOW
Isosorbide dinitrate
ROUTE OF ADMINISTRATION :
SUBLINGUAL AT TIME OF ATTACK
ORAL FOR CHRONIC PROPHYLAXIS
DOSAGE FORMS – SUBLINGUAL AND ORAL
TABS
-SUSTAINED RELEASE
DURATION OF ACTION : 20-40 MIN
SR– 6-10hrs
DOSAGE : 5-10mg SL, 10-20 mg oral
for prophylaxis 20-40 mg
Isosorbide mononitrate
ACTIVE METABOLITE OF IDN
ROUTE OF ADMINISTRATION : ORAL
DOSAGE FORMS – ORAL TABS
- SUSTAINED RELEASE
LONGER ACTING (4-6 HRS).. ONCE A DAY
DOSAGE
DOSAGE 20-40 MG ORAL
Indications:
•ANGINA PECTORIS
• ACUTE CORONARY
SYNDROME
•MYOCARDIAL INFARCTION
•CHF AND ACUTE LVF
•OESOPHAGEAL SPASM
• BILIARY COLIC
SIDE EFECTS:
THROBBING HEADACHES
 PALPITATIONS
SWEATING
DIZZINESS &FAINTING
FLUSHING
WEAKNESS
TOLERANCE
DEPENDENCE
Anti anginal drugs ppt by Dr Sharvani Pai (intern at Goa Medical college and Hospital)

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Anti anginal drugs ppt by Dr Sharvani Pai (intern at Goa Medical college and Hospital)