This article discusses an assessment of the effectiveness of strategic e-mentoring in improving self-efficacy and retention of alternatively certified novice teachers in an inner city school district. The study is important because research shows teachers with higher self-efficacy are more effective in the classroom. They are more innovative, open to student ideas, and able to motivate students to learn. The purpose is to understand how developing self-efficacy affects high attrition rates among these teachers. Social learning theory and adult learning theory provide frameworks. Data was collected using Bandura's Teacher Efficacy Scale to measure self-efficacy before and after e-mentoring interventions. The results can help educators better prepare and support alternatively certified novice teachers.