This document discusses patient blood management (PBM) and the nurse's role in implementing PBM programs. It provides background on the frequency, risks, and costs of blood transfusions. It then outlines 12 standards for PBM programs from the Society for the Advancement of Blood Management. The document discusses how PBM works to change clinical behaviors and estimates potential annual savings from adopting PBM practices across Europe. It also addresses factors that can hinder changing practices and provides recommendations for how to implement a PBM program. Finally, it considers the nurse's role in PBM as an educator, researcher, and manager and whether Italy is ready to train nurses for these expanded PBM responsibilities.