The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive functioning. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms.
The document summarizes the anatomy of the middle ear, including its walls, contents, spaces, blood supply, and related structures like the ossicles, muscles, nerves and mucosa. It describes the embryology, locations, and relationships between the malleus, incus, stapes, tensor tympani muscle, stapedius muscle, chorda tympani nerve, and tympanic plexus. It also discusses the spaces within the middle ear like the epitympanum, mesotympanum, and hypotympanum.
The ear is divided into three main parts - the outer, middle, and inner ear. The outer ear consists of the pinna and external auditory canal. The pinna contains cartilage and muscles. The middle ear contains the ear ossicles (malleus, incus, stapes), muscles (tensor tympani, stapedius), and is separated from the inner ear by the medial wall. The inner ear contains the bony labyrinth with the vestibule, semicircular canals, and cochlea which houses hair cells for hearing.
The document provides an overview of the anatomy of the human ear, including:
- The external ear is made up of the pinna, external auditory canal, and tympanic membrane.
- The middle ear contains the three ossicles (malleus, incus, stapes), two muscles (tensor tympani and stapedius), and connects to the inner ear via the oval and round windows.
- The inner ear includes the bony and membranous labyrinths, with the cochlea for hearing and the vestibular system including the semicircular canals and saccule/utricle for balance.
The document provides an in-depth overview of the anatomy of the ear in 3 parts: external ear, middle ear, and inner ear. It describes the structures and features of each part in great detail, including the pinna, external auditory canal, tympanic membrane, ossicles, muscles, nerves and blood supply of the middle ear, and structures within the bony and membranous labyrinth of the inner ear. References are provided for additional information.
The document provides information on the anatomy of the ear and auditory pathway. It discusses the three parts of the ear - external ear, middle ear, and inner ear. The external ear includes the pinna and external auditory meatus. The middle ear contains the tympanic membrane, three ossicles (malleus, incus, stapes), and two small muscles (tensor tympani and stapedius). The inner ear is made up of the cochlea and vestibular system. The auditory pathway transmits signals from the inner ear to the brainstem and auditory cortex.
The middle ear consists of the tympanic cavity, Eustachian tube, and mastoid air cell system. The tympanic cavity contains the three ossicles (malleus, incus, stapes), two muscles (tensor tympani and stapedius), nerves (chorda tympani), and is lined by mucosa. The Eustachian tube connects the middle ear to the nasopharynx. The mastoid air cell system is a network of air cells in the mastoid bone behind the ear.
The document summarizes the anatomy of the middle ear. It describes the structures derived from the pharyngeal pouches and arches that make up the middle ear, including the ossicles, muscles, nerves and openings. It provides details on the walls, contents, blood supply and clinical relevance of the middle ear.
The document summarizes the anatomy of the middle ear, including its walls, contents, spaces, blood supply, and related structures like the ossicles, muscles, nerves and mucosa. It describes the embryology, locations, and relationships between the malleus, incus, stapes, tensor tympani muscle, stapedius muscle, chorda tympani nerve, and tympanic plexus. It also discusses the spaces within the middle ear like the epitympanum, mesotympanum, and hypotympanum.
The ear is divided into three main parts - the outer, middle, and inner ear. The outer ear consists of the pinna and external auditory canal. The pinna contains cartilage and muscles. The middle ear contains the ear ossicles (malleus, incus, stapes), muscles (tensor tympani, stapedius), and is separated from the inner ear by the medial wall. The inner ear contains the bony labyrinth with the vestibule, semicircular canals, and cochlea which houses hair cells for hearing.
The document provides an overview of the anatomy of the human ear, including:
- The external ear is made up of the pinna, external auditory canal, and tympanic membrane.
- The middle ear contains the three ossicles (malleus, incus, stapes), two muscles (tensor tympani and stapedius), and connects to the inner ear via the oval and round windows.
- The inner ear includes the bony and membranous labyrinths, with the cochlea for hearing and the vestibular system including the semicircular canals and saccule/utricle for balance.
The document provides an in-depth overview of the anatomy of the ear in 3 parts: external ear, middle ear, and inner ear. It describes the structures and features of each part in great detail, including the pinna, external auditory canal, tympanic membrane, ossicles, muscles, nerves and blood supply of the middle ear, and structures within the bony and membranous labyrinth of the inner ear. References are provided for additional information.
The document provides information on the anatomy of the ear and auditory pathway. It discusses the three parts of the ear - external ear, middle ear, and inner ear. The external ear includes the pinna and external auditory meatus. The middle ear contains the tympanic membrane, three ossicles (malleus, incus, stapes), and two small muscles (tensor tympani and stapedius). The inner ear is made up of the cochlea and vestibular system. The auditory pathway transmits signals from the inner ear to the brainstem and auditory cortex.
The middle ear consists of the tympanic cavity, Eustachian tube, and mastoid air cell system. The tympanic cavity contains the three ossicles (malleus, incus, stapes), two muscles (tensor tympani and stapedius), nerves (chorda tympani), and is lined by mucosa. The Eustachian tube connects the middle ear to the nasopharynx. The mastoid air cell system is a network of air cells in the mastoid bone behind the ear.
The document summarizes the anatomy of the middle ear. It describes the structures derived from the pharyngeal pouches and arches that make up the middle ear, including the ossicles, muscles, nerves and openings. It provides details on the walls, contents, blood supply and clinical relevance of the middle ear.
middle ear spaces an important topic otorhinolaryngologyDrsiyaMedfriend
This document discusses the detailed anatomy of the various spaces within the middle ear. It begins with the embryology of the middle ear and then describes each individual space in detail, including their boundaries, contents, and surgical importance. The main spaces discussed are the epitympanum/attic, hypotympanum, mesotympanum, protympanum, retrotympanum, and their subdivisions. For each space, the document outlines their anatomical boundaries, relationships to surrounding structures, and clinical relevance for ear surgeries.
The middle ear cavity lies between the external ear canal and inner ear. It contains the auditory ossicles (malleus, incus, stapes) and has three parts - mesotympanum, epitympanum (attic), and hypotympanum. The mesotympanum contains the ossicles and is lined by epithelium. The hypotympanum is below the eardrum and lined by ciliated epithelium. The epitympanum (attic) is above the eardrum and divided into medial and lateral parts by the ossicles. It provides communication between the middle ear cavity and mastoid air cells.
The document describes the anatomy and structures of the human ear. It is divided into three main parts:
1) The outer ear or external ear collects sound waves and directs them into the middle ear.
2) The middle ear contains the tympanic cavity with the ossicles (malleus, incus, stapes) that vibrate in response to sound and transmit the vibrations into the inner ear. It also contains muscles and nerves.
3) The inner ear or labyrinth contains the bony and membranous structures including the cochlea, vestibule and semicircular canals that sense sound and balance. The cochlea converts sound waves into neural signals that
The document describes the anatomy and structures of the human ear. It is divided into three main parts:
1) The outer ear or external ear collects sound waves and directs them into the middle ear.
2) The middle ear contains the tympanic cavity with the ossicles (malleus, incus, stapes) that vibrate in response to sound and transmit the vibrations into the inner ear. It also contains muscles and nerves.
3) The inner ear or labyrinth contains the bony and membranous structures including the cochlea, vestibule and semicircular canals that sense sound and balance. The cochlea converts sound waves into neural signals that
The document summarizes the anatomy of the middle ear. It describes the three parts of the ear as the external ear, middle ear, and inner ear. The middle ear consists of the tympanic cavity, Eustachian tube, and mastoid air cell system. The tympanic cavity contains the three ossicles (malleus, incus, stapes) and their ligaments, as well as the tensor tympani and stapedius muscles. The tympanic cavity has six walls (roof, floor, lateral, medial, posterior, anterior) and can be divided into three regions. The document outlines the structures and landmarks within the tympanic cavity and discusses the blood supply, nerve supply,
The document describes the anatomy and surgical approaches to the cavernous sinus. It contains the following key points:
1. The cavernous sinus is a paired structure located on either side of the sella turcica. It contains several cranial nerves and the internal carotid artery.
2. There are various surgical approaches to access different regions of the cavernous sinus such as the frontotemporal approach, transzygomatic approach, and endoscopic endonasal approach.
3. Extradural bone removal such as sphenoid wing reduction and optic canal unroofing provide a wider surgical corridor. Intradural dissection of the cavernous sinus exposes the cranial nerves
Temporal bone anatomy and surgical significancepptxdruttamnepal
This document discusses the surgical anatomy of the temporal bone, lateral skull base, venous sinuses, and differences between the temporal bone in adults and children. It covers the external anatomy of the temporal bone including landmarks like the mastoid process and tip. It describes the vascular anatomy including arteries like the internal carotid and veins like the sigmoid sinus. It discusses the divisions of the lateral skull base into areas like the pharyngeal and tubal areas. Finally, it briefly mentions the venous sinuses and differences in temporal bone between adults and children.
The middle ear is located within the tympanic cavity and consists of the auditory tube, tympanic cavity, and mastoid air cells. It develops from the first and second pharyngeal arches. The tympanic cavity contains the ossicles (malleus, incus, stapes), muscles (tensor tympani, stapedius), nerves (facial, chorda tympani), and openings (oval window, round window). The mastoid air cells are pneumatized spaces that communicate with the mastoid antrum and tympanic cavity. The eustachian tube connects the middle ear to the nasopharynx and allows for pressure equalization.
The ear is divided into three parts - external, middle, and inner ear. The external ear includes the auricle and external auditory canal. The middle ear, or tympanic cavity, contains the three ossicles (malleus, incus, stapes) and two small muscles (tensor tympani and stapedius). It is separated from the inner ear by the oval and round windows. The complex anatomy of the middle ear, including its walls, spaces, folds, and vascular and neural supply, allow it to efficiently transmit sound vibrations from the outer to inner ear.
The document summarizes the anatomy of the ear in 3 parts - external, middle, and inner ear. It describes the external ear in detail including the pinna, cartilage, ligaments, muscles, blood supply, nerves, and lymphatic drainage. It then describes the anatomy of the external auditory canal. Finally, it provides an in-depth summary of the anatomy of the middle ear, including the walls, structures, blood supply and nerves of the tympanic cavity.
The document summarizes the anatomy of the ear in 3 parts - external, middle, and inner ear. It provides detailed descriptions of the structures within each part, including:
The external ear is divided into the auricle/pinna and external auditory canal. The auricle has cartilage, ligaments, muscles and blood supply. The external auditory canal has cartilage in the lateral 1/3 and bone in the medial 2/3.
The middle ear, or tympanic cavity, has 6 walls and 3 compartments. It contains the ossicles - malleus, incus and stapes. The tympanic membrane separates the external ear from the middle ear.
The inner ear contains
Anatomy of ear by dr. bomkar bam (MS) entBomkar Bam
The document summarizes the anatomy of the ear in 3 parts:
1) The external ear including the auricle, external auditory canal, and tympanic membrane.
2) The middle ear including the tympanic cavity bounded by six walls and containing the ossicles.
3) The inner ear which is not described in detail.
The summary provides a high-level overview of the key structures and organization of the ear in 3 sentences.
The document provides details on the anatomy of the middle ear. It describes the contents of the middle ear which include the ossicles (malleus, incus, stapes), muscles (tensor tympani, stapedius), Eustachian tube, cavities, and mastoid. It outlines the walls, relations, blood supply, lymphatic drainage and embryology of the middle ear. Key structures mentioned are the ossicles and their ligaments, Eustachian tube, tympanic plexus, oval and round windows, sinuses, and the facial nerve's relation.
I have tried my level best to complete this one. Basics & subjective details as much possible, are included here with understandable diagrams, CT-scans & charts. Clinical associations with possible anatomical structures are also touched . Frequent questions based on the topic discussed, will be there at the middle & end of presentation.
If you find it helpful then please like it & if any query regarding this ppt or upcoming ppts then mail me
drsuraj1997@gmail.com
Development of the middle ear is not covered in this presentation. If you are interested then please mail me. I will try to upload it as a separate one.
Mucosal folds and ventilation of middle ear AlkaKapil
The document discusses the anatomy and embryology of the middle ear spaces and mucosal folds.
1. The middle ear develops from the tubotympanic recess which buds into sacs including the saccus anticus, medius, superior and posterior. Remnants of mesenchyme become ligaments and blood vessels.
2. The middle ear is divided into several compartments by mucosal folds including the protympanum, mesotympanum, epitympanum, hypotympanum, and retrotympanum.
3. The epitympanum or attic is further divided by mucosal folds into the upper unit above
The external ear consists of the pinna, external auditory canal, and tympanic membrane. The pinna is made of elastic cartilage covered in skin and collects sound. The external auditory canal is S-shaped and carries the sound waves to the tympanic membrane. The tympanic membrane, or eardrum, separates the external ear from the middle ear and transmits vibrations to the ossicles. When viewed through an otoscope, the normal tympanic membrane appears pearly grey and concave laterally.
The document discusses the anatomy of the middle ear. It begins by describing the embryonic development of the middle ear from the first and second pharyngeal arches. It then details the boundaries and contents of the middle ear cavity, including the ossicles (malleus, incus, stapes), muscles (stapedius, tensor tympani), nerves (chorda tympani, facial), epithelium, blood supply and compartments. It concludes by summarizing the development of the ossicles and muscles from the pharyngeal arches and their attachments via ligaments in the adult middle ear.
This document provides a detailed overview of CT imaging and anatomy of the temporal bone. It describes the CT imaging protocol used, including axial and coronal views. It then reviews the anatomy of each segment of the temporal bone - squamous, mastoid, petrous, tympanic and styloid. For the petrous segment, it describes the subsegments and key structures like the internal acoustic meatus. It reviews the anatomy of the outer, middle and inner ear, including structures like the cochlea and semicircular canals. Pathologies affecting the temporal bone like otitis externa and cholesteatoma are also summarized.
This document provides an overview of the anatomy of the middle ear and Eustachian tube. It describes the structures of the middle ear, including the ossicles (malleus, incus, stapes), muscles (tensor tympani and stapedius), nerves (chorda tympani and tympanic plexus), and contents. It also details the walls and parts of the tympanic cavity, mastoid air cells, blood supply, and differences between adult and infant anatomy of the Eustachian tube. Key structures like the oval window, round window, facial nerve canal, and mastoid antrum are defined.
anaesthesia.Airway evaluation and management.(dr.ameer)student
The document provides an overview of airway anatomy, evaluation, and management techniques. It discusses the relevant anatomy, components of an airway exam, principles of mask ventilation and intubation. Key areas covered include the larynx, trachea, bronchial tree, airway assessment process, common airway devices like oral/nasal airways and laryngeal mask airways, indications for intubation, potential complications, and differences between orotracheal and nasotracheal intubation.
middle ear spaces an important topic otorhinolaryngologyDrsiyaMedfriend
This document discusses the detailed anatomy of the various spaces within the middle ear. It begins with the embryology of the middle ear and then describes each individual space in detail, including their boundaries, contents, and surgical importance. The main spaces discussed are the epitympanum/attic, hypotympanum, mesotympanum, protympanum, retrotympanum, and their subdivisions. For each space, the document outlines their anatomical boundaries, relationships to surrounding structures, and clinical relevance for ear surgeries.
The middle ear cavity lies between the external ear canal and inner ear. It contains the auditory ossicles (malleus, incus, stapes) and has three parts - mesotympanum, epitympanum (attic), and hypotympanum. The mesotympanum contains the ossicles and is lined by epithelium. The hypotympanum is below the eardrum and lined by ciliated epithelium. The epitympanum (attic) is above the eardrum and divided into medial and lateral parts by the ossicles. It provides communication between the middle ear cavity and mastoid air cells.
The document describes the anatomy and structures of the human ear. It is divided into three main parts:
1) The outer ear or external ear collects sound waves and directs them into the middle ear.
2) The middle ear contains the tympanic cavity with the ossicles (malleus, incus, stapes) that vibrate in response to sound and transmit the vibrations into the inner ear. It also contains muscles and nerves.
3) The inner ear or labyrinth contains the bony and membranous structures including the cochlea, vestibule and semicircular canals that sense sound and balance. The cochlea converts sound waves into neural signals that
The document describes the anatomy and structures of the human ear. It is divided into three main parts:
1) The outer ear or external ear collects sound waves and directs them into the middle ear.
2) The middle ear contains the tympanic cavity with the ossicles (malleus, incus, stapes) that vibrate in response to sound and transmit the vibrations into the inner ear. It also contains muscles and nerves.
3) The inner ear or labyrinth contains the bony and membranous structures including the cochlea, vestibule and semicircular canals that sense sound and balance. The cochlea converts sound waves into neural signals that
The document summarizes the anatomy of the middle ear. It describes the three parts of the ear as the external ear, middle ear, and inner ear. The middle ear consists of the tympanic cavity, Eustachian tube, and mastoid air cell system. The tympanic cavity contains the three ossicles (malleus, incus, stapes) and their ligaments, as well as the tensor tympani and stapedius muscles. The tympanic cavity has six walls (roof, floor, lateral, medial, posterior, anterior) and can be divided into three regions. The document outlines the structures and landmarks within the tympanic cavity and discusses the blood supply, nerve supply,
The document describes the anatomy and surgical approaches to the cavernous sinus. It contains the following key points:
1. The cavernous sinus is a paired structure located on either side of the sella turcica. It contains several cranial nerves and the internal carotid artery.
2. There are various surgical approaches to access different regions of the cavernous sinus such as the frontotemporal approach, transzygomatic approach, and endoscopic endonasal approach.
3. Extradural bone removal such as sphenoid wing reduction and optic canal unroofing provide a wider surgical corridor. Intradural dissection of the cavernous sinus exposes the cranial nerves
Temporal bone anatomy and surgical significancepptxdruttamnepal
This document discusses the surgical anatomy of the temporal bone, lateral skull base, venous sinuses, and differences between the temporal bone in adults and children. It covers the external anatomy of the temporal bone including landmarks like the mastoid process and tip. It describes the vascular anatomy including arteries like the internal carotid and veins like the sigmoid sinus. It discusses the divisions of the lateral skull base into areas like the pharyngeal and tubal areas. Finally, it briefly mentions the venous sinuses and differences in temporal bone between adults and children.
The middle ear is located within the tympanic cavity and consists of the auditory tube, tympanic cavity, and mastoid air cells. It develops from the first and second pharyngeal arches. The tympanic cavity contains the ossicles (malleus, incus, stapes), muscles (tensor tympani, stapedius), nerves (facial, chorda tympani), and openings (oval window, round window). The mastoid air cells are pneumatized spaces that communicate with the mastoid antrum and tympanic cavity. The eustachian tube connects the middle ear to the nasopharynx and allows for pressure equalization.
The ear is divided into three parts - external, middle, and inner ear. The external ear includes the auricle and external auditory canal. The middle ear, or tympanic cavity, contains the three ossicles (malleus, incus, stapes) and two small muscles (tensor tympani and stapedius). It is separated from the inner ear by the oval and round windows. The complex anatomy of the middle ear, including its walls, spaces, folds, and vascular and neural supply, allow it to efficiently transmit sound vibrations from the outer to inner ear.
The document summarizes the anatomy of the ear in 3 parts - external, middle, and inner ear. It describes the external ear in detail including the pinna, cartilage, ligaments, muscles, blood supply, nerves, and lymphatic drainage. It then describes the anatomy of the external auditory canal. Finally, it provides an in-depth summary of the anatomy of the middle ear, including the walls, structures, blood supply and nerves of the tympanic cavity.
The document summarizes the anatomy of the ear in 3 parts - external, middle, and inner ear. It provides detailed descriptions of the structures within each part, including:
The external ear is divided into the auricle/pinna and external auditory canal. The auricle has cartilage, ligaments, muscles and blood supply. The external auditory canal has cartilage in the lateral 1/3 and bone in the medial 2/3.
The middle ear, or tympanic cavity, has 6 walls and 3 compartments. It contains the ossicles - malleus, incus and stapes. The tympanic membrane separates the external ear from the middle ear.
The inner ear contains
Anatomy of ear by dr. bomkar bam (MS) entBomkar Bam
The document summarizes the anatomy of the ear in 3 parts:
1) The external ear including the auricle, external auditory canal, and tympanic membrane.
2) The middle ear including the tympanic cavity bounded by six walls and containing the ossicles.
3) The inner ear which is not described in detail.
The summary provides a high-level overview of the key structures and organization of the ear in 3 sentences.
The document provides details on the anatomy of the middle ear. It describes the contents of the middle ear which include the ossicles (malleus, incus, stapes), muscles (tensor tympani, stapedius), Eustachian tube, cavities, and mastoid. It outlines the walls, relations, blood supply, lymphatic drainage and embryology of the middle ear. Key structures mentioned are the ossicles and their ligaments, Eustachian tube, tympanic plexus, oval and round windows, sinuses, and the facial nerve's relation.
I have tried my level best to complete this one. Basics & subjective details as much possible, are included here with understandable diagrams, CT-scans & charts. Clinical associations with possible anatomical structures are also touched . Frequent questions based on the topic discussed, will be there at the middle & end of presentation.
If you find it helpful then please like it & if any query regarding this ppt or upcoming ppts then mail me
drsuraj1997@gmail.com
Development of the middle ear is not covered in this presentation. If you are interested then please mail me. I will try to upload it as a separate one.
Mucosal folds and ventilation of middle ear AlkaKapil
The document discusses the anatomy and embryology of the middle ear spaces and mucosal folds.
1. The middle ear develops from the tubotympanic recess which buds into sacs including the saccus anticus, medius, superior and posterior. Remnants of mesenchyme become ligaments and blood vessels.
2. The middle ear is divided into several compartments by mucosal folds including the protympanum, mesotympanum, epitympanum, hypotympanum, and retrotympanum.
3. The epitympanum or attic is further divided by mucosal folds into the upper unit above
The external ear consists of the pinna, external auditory canal, and tympanic membrane. The pinna is made of elastic cartilage covered in skin and collects sound. The external auditory canal is S-shaped and carries the sound waves to the tympanic membrane. The tympanic membrane, or eardrum, separates the external ear from the middle ear and transmits vibrations to the ossicles. When viewed through an otoscope, the normal tympanic membrane appears pearly grey and concave laterally.
The document discusses the anatomy of the middle ear. It begins by describing the embryonic development of the middle ear from the first and second pharyngeal arches. It then details the boundaries and contents of the middle ear cavity, including the ossicles (malleus, incus, stapes), muscles (stapedius, tensor tympani), nerves (chorda tympani, facial), epithelium, blood supply and compartments. It concludes by summarizing the development of the ossicles and muscles from the pharyngeal arches and their attachments via ligaments in the adult middle ear.
This document provides a detailed overview of CT imaging and anatomy of the temporal bone. It describes the CT imaging protocol used, including axial and coronal views. It then reviews the anatomy of each segment of the temporal bone - squamous, mastoid, petrous, tympanic and styloid. For the petrous segment, it describes the subsegments and key structures like the internal acoustic meatus. It reviews the anatomy of the outer, middle and inner ear, including structures like the cochlea and semicircular canals. Pathologies affecting the temporal bone like otitis externa and cholesteatoma are also summarized.
This document provides an overview of the anatomy of the middle ear and Eustachian tube. It describes the structures of the middle ear, including the ossicles (malleus, incus, stapes), muscles (tensor tympani and stapedius), nerves (chorda tympani and tympanic plexus), and contents. It also details the walls and parts of the tympanic cavity, mastoid air cells, blood supply, and differences between adult and infant anatomy of the Eustachian tube. Key structures like the oval window, round window, facial nerve canal, and mastoid antrum are defined.
anaesthesia.Airway evaluation and management.(dr.ameer)student
The document provides an overview of airway anatomy, evaluation, and management techniques. It discusses the relevant anatomy, components of an airway exam, principles of mask ventilation and intubation. Key areas covered include the larynx, trachea, bronchial tree, airway assessment process, common airway devices like oral/nasal airways and laryngeal mask airways, indications for intubation, potential complications, and differences between orotracheal and nasotracheal intubation.
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
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Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
33. THE POSTERIOR WALL
Aditus Ad AntrumOpening to Mastoid Antrum
Fossa Incudis Contain Short Process Of Incus & It’s
Suspensory Ligament
Pyramid Attaches Stapedius & It’s tendon
43. ISTHMUS TYMPANI
Narrow elongated space
Medially
Facial Nerve Canal
Lateral SCC
Divided by Long Process Of Incus
Isthmus Tympani Anticus
Isthmus Tympani Posticus
44. Prussack’s Space
Boundaries:
Medially: Neck Of Malleus
Laterally: Pars Flaccida
Inferiorly: Lateral Process Of Malleus
Superiorly: Lateral Malleolar Fold
Posteriorly: Posterior Malleolar Fold
Clinical Significance:
Pars flaccida acquired cholesteatoma formation
45. SPRE AD OF CHOLE STE ATOMA FROM PRUSSAK ’ S SPACE
46. PATTERN OF SPREAD OF CHOLESTEATOMA
Posterior Epitympanum
(Through Superior Incudal Space)
Posterior Mesotympanum
(Through Posterior Pouch Of Von Tröltsch)
Anterior Epitympanum
(Anterior to head of malleus to Supratubal recess)
47. EUSTACHIAN TUBE
Bony Part (Lateral 1/3rd)
12mm , Rectangular opening
Cartilaginous (Medial 2/3rd)
24mm
Torus Tubaris
Blood Supply
Ascending Pharyngeal A.
Middle Meningeal A.
50. IMPROPER FUNCTIONING OF EUSTACHIAN
TUBE
Recurrent URTI, Enlarged Adenoids
Larger Diameter & Shorter Length
Malfunctioning of Tubal Muscles
Reduction in Size Of Ostmann’s Fat Pad
Atrophy Of Tensor Veli Palatini
Collagen Diseases
Loss Of Ciliated Epithelium
Abonormally Thick & Tenacious Secretions
51. MASTOID AIR CELL SYSTEM
Lies in Petrous Bone
Volume2mL
1. The Posterosuperior Tract
2. The Posteromedial Tract
3. The Subarcuate Tract
4. The Perilabyrinthine Tract
5. The Peritubal Tract
56. 2 Parts:-
Bony Labyrinth
Membranous Labyrinth
2 Types Of Fluids:-
Perilymph
Similarity with ECF
Rich in Na+
Communicates with CSF-Aqueduct Of Cochlea
Endolymph
Similarity with ICF
Rich in K+
Secreted by
Secretory Cells Of Striae Vascularis Of Cochlea
Dark Cells In Utricle & Ampulla Of SCC
66. Inner Hair Cell Outer Hair Cell
Single Longitudinal Row
Located on the inner side of
sensory region
3-5 Layers
Located on the outer side of
sensory region
67. Function of Organ Of Corti:
Mechanoelectrical Transduction
Neural Signalling IHCs
Amplification of sound waves OHCs
Transmission to Auditory Nerve & Higher Centres
68. OHC--ULTRASTRUCTURE
2 Ends:-
Apical End
Sensory part with stereocilia
Flattened
Basal End
Synaptic Pole
Stereocilia:-
W or V Pattern
3-5 Rows
Cylindrical
Angled towards each other
Tip Links
69. Dense Rootlets
Tropomyosin with actin
filaments
Stereociliary Membrane
Calcium controlling
proteins
Ion Channels
Deflections Of Hair
Bundle Controls the
opening & Closing of ion
channels
71. IHC--ULTRASTRUCTURE
Flask Shaped Body
3-4 rows of stereocilia
Height increases in stepwise manner
Cellular structure similar to OHC
Deflections brought by
Sound induced motions of B.M.
Endolymphatic fluid motion
Depolarization of IHC
Release of Amino Acid Glutamate
Calcium Mediated
72. THE ASCENDING AUDITORY PATHWAYS
Major components are:-
The Cochlear Nuclear Complex
The Superior Olivary Complex
Inferior Colliculus
Medial Geniculate Body
Auditory Cortex