This document provides guidelines on the prevention and management of iron deficiency anaemia during pregnancy. It defines anaemia levels and discusses the high prevalence of anaemia among pregnant women in India. The causes of iron deficiency anaemia include inadequate iron intake, poor absorption, and increased requirements during pregnancy. Left untreated, it can lead to maternal and infant complications. The guidelines recommend dietary changes, iron supplementation, investigation and treatment based on anaemia severity. It also covers vitamin B12 and folate deficiency anaemias, including symptoms, investigations and management.
Anemia management of anemia in pregnancyDR MUKESH SAH
Treatment for Anemia
If you are anemic during your pregnancy, you may need to start taking an iron supplement and/or folic acid supplement in addition to your prenatal vitamins. Your doctor may also suggest that you add more foods that are high in iron and folic acid to your diet.
Anemia management of anemia in pregnancyDR MUKESH SAH
Treatment for Anemia
If you are anemic during your pregnancy, you may need to start taking an iron supplement and/or folic acid supplement in addition to your prenatal vitamins. Your doctor may also suggest that you add more foods that are high in iron and folic acid to your diet.
It is a composite graphical recording of cervical dilatation and descent of head against duration of labour in hours.
It also gives information about fetal and maternal condition that are all recorded on single sheet of paper.
This ppt is made by Mr. arkab khan pathan under guidance of Mrs. RAKHI GOAR. this ppt contain the detail and all the lecture notes of HEG.
THANK YOU.
Arkab khan
It is a composite graphical recording of cervical dilatation and descent of head against duration of labour in hours.
It also gives information about fetal and maternal condition that are all recorded on single sheet of paper.
This ppt is made by Mr. arkab khan pathan under guidance of Mrs. RAKHI GOAR. this ppt contain the detail and all the lecture notes of HEG.
THANK YOU.
Arkab khan
This white paper will discuss iron therapy in general, why it is sometimes problematic,mainly due to tolerance and practical issues for those suffering from iron deficiency.
Important groups that are discussed in this aspect are children, young girls, fertile females, seniors and people with chronic diseases such as IBD, CHF, CKD that affect the iron metabolism and how Heme‐Iron supplementation change this situation.
The target is to inform the medicinal and pharmaceutical communities of this relatively
new form of therapy and why it has great benefits compared to the traditional methods.
Anemia in pregnancy &role of parenteral iron therapysusanta12
Iron deficiency anemia is most common anemia during pregnancy whic needs careful evaluation and treatment by Dr Susanta Kumar Behera,Department of Obstetrics & Gynecology, MKCG Medical College, Brahmapur,ODISHA,INDIA
White paper "Iron Therapy without problems"Michael Collan
This white paper will discuss iron therapy in general, why it is sometimes problematic,mainly due to tolerance and practical issues for those suffering from iron deficiency.
Important groups that are discussed in this aspect are children, young girls, fertile females, seniors and people with chronic diseases such as IBD, CHF, CKD that affect the iron metabolism and how Heme‐Iron supplementation change this situation.
The target is to inform the medicinal and pharmaceutical communities of this relatively new form of therapy and why it has great benefits compared to the traditional methods.
Similar to Anaemia in pregnancy ICOG guidelines (20)
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
2. Iron deficiency anaemia
WHO defines anaemia in pregnancy as Hb <11gm/dl
WHO, 2001
ICMR classification
8-11 g% - mild,
5-8 g % - moderate
<5 g% - severe anaemia.
Serum ferritin <12-15μg/l is considered as iron deficiency
56 million women globally, two thirds in Asia
Prevalence of anaemia in India – 58% (NFHS-3, 2007)
78% lactating and 75% pregnant women are anaemic
Anaemia – 20% direct maternal death and 50% indirect
maternal deaths
3. Aetiology of IDA
Inadequate Iron intake-Poor iron content of diet -10-
20 mg/day
Poor absorption- 1-2mg iron absorbed in SI
Increased iron requirement -Total Pregnancy iron
requirement -1000mg
Increased blood loss-Worm infestation, menorrhagia
Poor iron stores – frequent childbirth, inadequate
spacing
4. Outcome of iron deficiency
• Reduced work capacity, intellectual capacity
• Increased maternal mortality
• Affect immune function and increases risk of
infections
Maternal morbidity and
mortality
• Decreased weight on delivery
• Greater risk of anaemia after birth
• Long term deficit in physical and mental
health
• Negatively contribute to infant and social
emotional behaviour
Effect on foetus and infant
• Preterm delivery, LBW and Possibly, placental
abruption and increased peripartum blood loss
• Further research necessary to establish a clear
causal relationship
Effects on pregnancy outcome
5. Investigations
• FBC
• Serum Ferritin
• Serum iron
• Total iron binding capacity
• Zinc protoporphyrin
• Soluble Transferrin Receptor
• Reticulocytes & Bone Marrow Iron (not applicable in routine
practice)
• Iron Therapy - diagnostic whilst being therapeutic at the same time
Signs and symptoms
• Fatigue, weakness, pallor, palpitations, dizziness and dyspnea
• May develop pica
• Temperature regulation may also be affected, leading to cold
intolerance.
Diagnosis & Investigations
6. Prevention of anaemia in pregnancy
Pre-pregnancy counselling and dietary advice
Rich sources of iron include haeme iron (in meat, poultry, fish and egg
yolk), dry fruits, dark green leafy vegetables (spinach, beans, legumes,
lentils) and iron fortified cereals.
Using cast iron utensils for cooking and taking iron with vitamin C (orange
juice) can improve its intake and absorption.
Avoid foods which may inhibit iron absorption - polyphenols (in certain
vegetables, coffee), tannins (in tea), phytates (in bran) and calcium (in
dairy products)
CBC at the booking and at 28 weeks in pregnancy to screen
for anaemia.
Repeat Hb near term in high risk mothers and multiple
pregnancies
7. Prevention of anaemia in pregnancy
Iron supplementation weekly iron (60 mg) and
folic acid (2.8 mg) should be given.
Deworming
Delayed clamping of the umbilical cord at delivery
(by 1–2 min) is important step in prevention of
neonatal anemia.
8. Treatment of anaemia in pregnancy
• A course of iron therapy is simultaneously diagnostic
and therapeutic
• Ferritin levels should be checked if the patient has a
known haemoglobinopathy
• Microcytic or normocytic anaemia can be assumed to
be caused by iron deficiency anaemia until proven
otherwise
• Response to iron is both quick and cost effective; a rise
in Hb should occur within 2 weeks to confirm the
diagnosis.
• Furthermore, if there has been no improvement in Hb
by 2 weeks a referral should be made to secondary care.
9. Management of Iron deficiency
Dietary advice
Physiological iron requirements are three times higher in pregnancy
compared to non-pregnant stage with increasing demand as pregnancy
advances.
Iron absorption depends upon the amount of iron in diet, its
bioavailability and requirements of the body.
The main source of dietary haem iron are haemoglobin and myoglobin
from red meat, fish and poultry.
Haem iron is absorbed more readily than non-haem iron sources.
Vitamin C significantly enhances iron absorption from non -haem
foods.
Germination and fermentation of cereals and legumes improve the
bioavailability of non-haem iron by reducing the content of phytate, a
food substance that inhibits iron absorption.
Tannins in tea inhibit iron absorption when consumed with a meal or
shortly after.
10. Oral iron supplementation
Daily oral iron (60 mg) and folic acid (4 mg) should be started,
and continued up to 6 months' postpartum. The aim is to achieve a
hemoglobin of at least 10 g/dL at term.
The recommended therapeutic dose of iron is 100- 200mg daily.
It is recommended to take iron with orange juice to enhance its
absorption.
Oral ferrous salts are the treatment of choice (ferric salts are less well
absorbed).
11. Oral iron supplementation
Ferrous sulphate 200 mg 2– 3 times daily (each tablet
provides 60 mg elemental iron) is the most common
preparation used.
First week of iron therapy – only reticulocytosis
Second week –Hb starts rising 1g/dl/week
Side effects - nausea, constipation and occasionally
diarrhoea which can be reduced by taking tablets after
meals.
12. Parenteral Iron
Indications of parenteral iron
Intolerance oral iron
Severe anaemia in near term
Failure of oral therapy
Parenteral iron -intramuscular (IM) or intravenous (IV).
The main drawbacks of IM route are pain, staining of skin,
myalgia, arthralgia and injection abscess.
Intravenous iron can be administered as total dose
infusion; however, utmost caution is needed as anaphylaxis
can occur.
Iron dextran and iron polymaltose preparations can be
used by both IM and IV routes.
13. Parenteral Iron
Newer IV preparations – iron sucrose and ferric gluconate are
associated with reduced side-effects.
Iron sucrose- 50 mg elemental iron in one ampoule.
It may be administered undiluted by slow I/V @ 1 mL/mt (20 mg
iron) not exceeding 100 mg iron per injection.
I/V infusion – 2.5ml (50mg) iron sucrose in 100ml NaCl @100mg/15
minutes, 200mg alternate days
Unused diluted solution must be discarded.
Ferrinject (ferric hydroxide carbohydrate complex), IV as a single
dose of 1000mg over 15 minutes (max 15mg/kg by injection or
20mg/kg by infusion)
14.
15. Blood Transfusion
Packed red cell transfusion may be indicated for
pregnant women with
Severe anemia (Hb of 6 g/dL or less) close to due date
or less than 8 g/dL if they have increased risk of blood
loss at delivery
16. Intrapartum Management
IV cannula and blood should be cross-matched in case
of significant hemorrhage at the time of delivery.
Strict asepsis is very important.
Active management of third stage
In case of severe anemia with congestive cardiac
failure, active management of third stage (with
methyl ergometrine) is contraindicated.
17. Postpartum management
Close monitoring should be done to look for signs
of decompensation, infection or thrombosis.
Appropriate thromboprophylaxis and
contraceptive advice should be provided and
haematinic supplementation should continue
18. Overview of treatment of IDA
Pre-pregnancy Antenatal Delivery
Dietary advice and iron
therapy
Iron therapy without
iron studies with 60mg
in second trimester.
Cross match blood in
case of severe anaemia
Folic Acid supplement
(which also prevent
NTDs)
Hb <10, Oral 100-200mg
elemental iron with Vit
C, deworming, treatment
for malaria
Active management of
third stage of labour
Blood transfusion if Hb
is <6g/dl
Intolerance to oral iron,
Malabsorption, non
compliance/poor, follow
up
Continue iron for three
months in post natal
period
20. Recommendations
There is variation in definition of normal Hb levels in pregnancy. A
level of ≥ 11g/dl appears adequate in the first trimester and ≥ 10.5g/dl
in the second and third trimesters (1B).
Postpartum anaemia is defined as Hb <10g/dl (1B
Full blood count should be assessed at booking and at 28 weeks.
For anaemic women, a trial of oral iron should be considered as the
first line diagnostic test, increase demonstrated in two weeks is a
positive result.
All women should be counselled regarding diet in pregnancy including
details of iron rich food sources and factors that may inhibit or promote
iron absorption and why maintaining adequate iron stores in pregnancy is
important. This should be consolidated by the provision of an information
leaflet in the appropriate language (1A).
21. Recommendations
Women should be counselled as to how to take oral iron supplements
correctly. This should be on an empty stomach, 1 hour before meals, with a
source of vitamin C (ascorbic acid) such as orange juice to maximise
absorption. Other medications or antacids should not be taken at the same
time (1A).
Women with known haemoglobinopathy should have serum ferritin checked
and offered oral supplements if ferritin level is <30 ug/l.
Women with unknown haemoglobinopathy status with a normocytic or microcytic
anaemia, should start a trial of oral iron and screening should be commenced
without delay.
Women should undergo specialist assessment if there is a lack of response
(increase of less than 2 g/100 mL in the haemoglobin level) after 2–4 weeks.
Once haemoglobin concentration and red cell indices are normal, iron treatment
should be continued for 3 months to aid replenishment of iron stores, and then
stopped. The person's full blood count should be monitored every 3 months for 1
year.
22. Vitamin B12 deficiency anaemia
SYMPTOMS
• Anaemia can result in many complications, including cardiovascular
symptoms, reduced physical and mental performances, reduced immune
function and fatigue.
• For the foetus consequences include growth retardation, prematurity, amnion
rupture, neural tube defects, low birth weight and even intrauterine death.
• The association between B12 deficiency and neural defects has been noted
multiple times.
• Very low B12 can cause anencephaly, due to its use in the metabolism of neural
tissue, resulting in demyelination, axonal degeneration and neuronal death.
23. Vitamin B12 deficiency anaemia
INVESTIGATIONS
• B12 deficiency leads to megaloblastic anaemia, leading to vomiting,
diarrhoea and pyrexia, with oedema and albuminuria occurring at later
stages.
• Neurological involvements may be present, including mental slowness,
memory defects, hallucinations and numbness/tingling in the
extremities.
• The diagnosis of anaemia occurs fist by determining Hb levels, with a
threshold of 110 g/L.
• If the MCV is above 100fl, and the peripheral blood picture suggests B12
deficiency appropriate investigations should be carried out.
24. Treatment
B12 deficiency can be prevented with a rich B12 diet, thus avoiding the need
for supplementation.
However, if Vitamin B12 deficiency is suspected (caution in interpreting B12
levels as lower in pregnancy), therapy should be started if neurologic signs
are present.
Cyanocobalamin or hydroxycobalamin 1mg is given three times a week for 2
weeks and then every 3 months.
Prenatal Labour and postpartum
2.6mcg of vitamin B12 is
the recommended daily
intake in pregnancy.
Continuation of
maintenance
therapy is needed
In strict vegetarians oral
supplementation might
be necessary.
25. Folate Deficiency
Investigations
The clinical features of folate deficiency include symptoms of anaemia,
hyperpigmentation and low grade fever, falling after vitamin therapy.
Neuropsychiatric symptoms may be present in conjunction with B12 deficiency.
Laboratory investigations include serum folate, red cell folate assay, serum B12, serum
homocyestein and methylmalonic acid.
Bone marrow aspiration may be considered for megaloblastic changes suggestive of B12
or folate deficiency, and liver/thyroid function tests to find causes of macrocytosis.
The criteria for folate deficiency is serum folate below 2.0 ug/L and red cell folate
concentration below 160 ug/L.
Due to their close relation, it is important to rule out B12 deficiency as a cause of any
neuropsychiatric symptoms, as they will not improve with folic acid therapy.
26. Management of folate deficiency anaemia
Prenatal Labour Post natal
5mg of folic acid
daily
No specific management
apart from the previously
mentioned is needed.
WHO recommends
400mcg folic acid along
with 60mg iron for 6
months in pregnancy and
for 3
months postpartum in
areas with poor nutrition
Women with
haemolytic
anaemia require
high
doses (5-10mg)