Hi! vets & framers It is the Series of Antibiotics 1.Penicillin 2.Cephalosporine 3.Aminoglycoside 4.Tetracycline 5.Macrolides 6.Sulpha drugs 7.Other Antibiotics I am student of 4th year of DVM.I'll upload informative videos like this. Like , Share & Support by Subscribing the Channel. Must Give feedback in Comments Suggestions are always well come ! THANKU Video to understand Body points: https://youtu.be/a-l5odHagv8 Dog breeds video link : https://youtu.be/oT2j_VQsgiw Introduction of Antibiotics video link : https://youtu.be/SY0DL023fVw Penicillin video link https://youtu.be/TT0GOAVl7iw Follow on Twitter: https://twitter.com/Mushhood_Kazi?s=08 Facebook Page link: https://www.facebook.com/%D8%AC%D8%A7...

1. Aminoglycoside
• Bactericidal
• Against Gram(–) aerobes i.e. Pseudomonas aeruginosa
• Synergistic with β-lactams against many Gram(+) pathogens i.e. E.Coli

2. Aminoglycoside
• Mechanism of action.
The aminoglycosides irreversibly bind to the
30S ribosomal fragment and inhibit the rate of protein synthesis.
Aminoglycoside change the structure of mRNA translation in ribosome
which results in the synthesis of abnormal proteins & lead to death of
bacteria

3. • Therapeutic uses.
The aminoglycosides are used in the treatment of
Gram(–) infections in all species.
1. Streptomycin and Dihydrostreptomycin are the oldest
members of this class of antibiotics.
Narrow spectrum
Use with penicillin in case of mastitis ( penicillin is
against +ve & Streptomycin is against -ve)
Penicillin G + Streptomycin used in Enterococci (resistant
to many antibiotics)
Dihydroxystreptomycin is against vibrosis & pasturolosis.

4. 2. Neomycin
Neomycin differs from other aminoglycosides because it
is only administered topically or orally.
It is used orally for the treatment of enteric infections
and topically for treating skin, ear, and eye infections.
Orally given for Enteric infection
Dogs and Cats
• 10-20 mg/kg q6-12h PO.
Calves, Sheep, Goats.
• 22 mg/kg/day PO

5. 3. Gentamicin are expanded spectrum aminoglycosides with activity
against
Pseudomonas (Gram –ve)
Proteus (Gram –ve)
Staphylococcus (Gram +ve)
Corynebacterium spp.(Gram +ve)
They are used in all species for the treatment of susceptible infections of
the
skin
respiratory tract
ear, eye
 urinary tract, and septicemia.
Not effective streptococci
Drug of choice for enteric infection.

6. Dose rate:
Dogs
• 2-4 mg/kg q8h or 9-14 mg/kg q24h SQ, IM, or IV.
• Once-daily administration is usually the preferred interval.
Cats
• 5-8 mg/kg q24h SQ, IM, or IV.
• Once-daily administration is usually the preferred interval.
Horses
• Adult: 4-6.6 mg/kg q24h IM or IV.
• Foals younger than 2 weeks: 12-14 mg/kg q24h IM or IV.
Calves
• Younger than 2 weeks: 12-15 mg/kg q24h IV or IM.
• Adult cattle: 5-6 mg/kg q24h IM or IV.

7. • Amikacin active against gram -ve bacilli, that are resistant to other drugs.
Amikacin may be more active than gentamicin against many gram -ve
bacteria, especially enteric species.
Amikacin is not absorbed from oral administration.
In horses, used as an intrauterine lavage to treat metritis and other
infections of the genital tract caused by gram -ve bacteria. Amikacin also is
used for regional limb perfusion.
Activity against some bacteria (e.g., Pseudomonas) is enhanced when
combined with a beta-lactam antibiotic

8. Dose Rate
Dogs
• 15-30 mg/kg q24h IV, IM
Cats
• 10-14 mg/kg q24h IV, IM
Horses
• Adult: 4.4-6.6 mg/kg q12h or 10 mg/kg q24h IV or IM.
• Foal: 20-25 mg/kg q24h or 6.6 mg/kg q8h IV or IM.
• Intrauterine use: Administer 2 g (8 mL) diluted in 200-mL sterile saline solutioonce
per day for 3 days.
• Regional limb perfusion: Ranged from 125 mg to 500 mg per limb, diluted in 60
mL saline.
Cattle
• Adult: 10 mg/kg q24h IM, IV,
• Calf (<2 weeks of age): 20 mg/kg q24h IV or IM

9. 4. Kanamycin has an antimicrobial spectrum similar to gentamicin
except it is not effective
against Pseudomonas spp.
It is less active than gentamicin, amikacin, or tobramycin. Therefore
there is little advantage for using kanamycin over the other drugs in
this class.
It is used as an oral preparation combined with bismuth carbonate
and aluminum magnesium silicate for the treatment of bacterial
enteritis in dogs and for symptomatic relief of the associated
diarrhea.

10. Dose Rate
Dogs and Cats
• 10 mg/kg q12h IV or IM.
• 20 mg/kg q24h IV or IM.
Horses
• 10 mg/kg q24h IV.

11. 5. Tobramycin:
Tobramycin is usually more active against Pseudomonas aeruginosa
than gentamicin
Dose Rate:
Dogs
• 9-14 mg/kg q24h SQ, IM, or IV.
• Nebulization therapy is sometimes used in small animals.
Cats
• 5-8 mg/kg q24h SQ, IM, or IV.
Horses
• 4 mg/kg IV, IM

12. • Adverse effects
• 1. The aminoglycosides are relatively more toxic than other classes of
antimicrobials. Toxicity is reversible if the treatment is stopped early.
• They should not be used with other ototoxic or nephrotoxic drugs such as
furosemide or amphotericin B.
• 2. Ototoxicity is due to progressive damage to sensory & vestibular cells of
the inner ear resulting in deafness and ataxia.
• 3. Nephrotoxicity is due to the damage of tubular cells impaired
absorption, proteinuria, and decreased glomerular filtration rate.

13. Penicillin G + Procaine penicillin G + Dihydrostreptomycin Sulfate
L= 5mg/kg
S= 1mg/kg

14. Gentamycin
Horses: 3-6mg/kg BID IM
Ruminants: 3-6mg/kg BID IM

15. Gentamycin

16. Gentamycin + Doxycillin

17. Gentamycin + Trimethoprim + Sulfonamide

18. Amikacin

19. Tylosin

20. Tylosin + Gentamycin

21. Kanamycin
Kanasysm
Kanacon
Kana Kak
Kanamycin
Kanachron
Horses: 12-15mg/kg IM
Ruminants: 12-15 mg/kg IM

22. Kanmycine + Ampicillin + Prednisolone +
Chlorpheniramine
Kapcine