This document discusses alternative routes of administration for oral medications when the oral route is not viable, such as in cases of nausea, vomiting, or dysphasia. It provides recommendations for rectal, sublingual, or buccal administration of several common medications. For each medication, it summarizes available evidence regarding efficacy, safety, and dosing considerations for alternative routes of administration based on clinical literature. Overall, the document aims to guide appropriate use of alternative routes for acute situations while noting variability in absorption compared to oral dosing.