This document discusses the harmful effects of alcohol and drugs. It notes that alcohol affects the whole body and can cause hangovers, weight gain, high blood pressure, and various diseases. It provides statistics about drunk driving deaths in Missouri. It profiles a woman who was killed by a drunk driver at age 19. The document also states that tobacco is the leading cause of death in the US and cigarettes lessen life. It shows images comparing a healthy brain to one damaged by drug abuse. Overall, it cautions about the dangers of drinking, driving under the influence of alcohol or drugs, and taking various substances.