Continuous Reactions
    at Albemarle


                       1
Outline
• Albemarle Capability

• Some Existing Continuous Reactions

• Bench Scale Equipment

• Multipurpose Continuous Assets


                                       2
Albemarle Corporation
2011 Net Sales Distribution - $2.9 billion
                                          • Global provider of value
                            Fine            added technical solutions
                          Chemistry
                            25%
                                          • Comprised of three business
 Catalysts
   38%
                                            segments with balanced
                                            product portfolios

                                          • Proprietary technology and
                                            service-driven business model

                                          • Fundamentally strong margin
                                            and cash flow businesses
             Polymer
             Solutions   Fine Chemistry
               37%       Services
                                      Go to: www.albemarle.com
                                                                            3
We Offer
• US-based leading cGMP and custom manufacturing production
  capabilities

• Full project support (Technical, Regulatory, HSE, Information
  Management, Logistics)

• Extensive process development and scale-up capabilities

• Expertise in the development of complex syntheses

• Long Term Relationship / Production Partner




                                                                  4
We Have
• Excellent safety record (top 10% of ACC)

• Innovative technical staff that says YES!

• FDA registered facilities with no 483s in last inspections

• ISO certified custom manufacturing facilities

• State-of-the-art analytical support

• Raw material sourcing assets in China




                                                               5
We Have – Manufacturing Capability
• Five Commercial Scale Multipurpose Plants
   • South Haven, MI (cGMP)
   • Orangeburg, SC (including cGMP)
   • Tyrone, PA
   • Pasadena, TX
   • Baton Rouge, LA




                                              6
We Have – Manufacturing Capability
• cGMP capability - kilo, pilot and commercial
• 25 L to 16,000 gal Reactors of all MOCs
• Distillation and Wiped Film Evaporators
• Most types of solids handling
• Full Utilities
  • Cryogenic to hot oil
  • Pressures to 1000 PSI
• Short lead time for Environmental Permits



                                                 7
We Have – Development Capability




                                                            Full Scale
        Lab
                         Kilo Lab         Pilot Plant      Commercial
      Synthesis
                                                              Plant
  Baton Rouge, LA   Baton Rouge, LA   Baton Rouge, LA   Baton Rouge, LA
  South Haven, MI   South Haven, MI   South Haven, MI   South Haven, MI
     Tyrone, PA      LLN, Belgium        Tyrone, PA       Tyrone , PA
   LLN, Belgium                                         Orangeburg, SC
                                                         Pasadena, TX
                       Customer Driven

                                                                          8
Albemarle Continuous Capability
• Over 40 years of Experience

• World Scale Plants (100’s to >10,000’s TPY)

• Existing processes at Multiple Plants

• Long Term Supply

• Proven Record with Recent Successes


                                                9
Ag Chemical
• Long Term Relationship

• Expanding as Customer Grows
  • Started <500 TPY
  • Debottlenecked existing asset to > 1500 TPY
  • Further capacity increase with new asset
• Process Includes
  • Hazardous Chemicals




                                                  10
Brominated Flame Retardant
• World Scale plant

• Complex process

• All Unit Ops Integrated




                             11
Personal Care Intermediates
• Multiple Products

• Tubular Plug Flow / High Pressure

• Long Term Supplier




                                      12
Pyrophorics
• Multiple Products

• Extremely Exothermic
  • Adiabatic Temperature Rise > 2000 °C
  • Unique Technical Solutions


• Long Term Supplier




                                           13
Custom Lubricant Production
• Albemarle selected as Scale up Partner

• Commercial Plant Operational in 21 months
  • 15,000 TPY established in first month


• Scale up from Lab Directly to Commercial
  • No Pilot Plant




                                              14
Bench Scale Equipment
• We have a Modular Multipurpose Apparatus
• Multiple Reactor Configurations
  •   Currently up to 3 different feed streams
  •   CSTR (single or series)
  •   Tubular Fixedbed
  •   Tubular Plug Flow




                                                 15
Bench Scale Equipment
• Temperature range
  • –100 to 200 C with circulators
  • higher with electric heating
• Pressure range
  • Vacuum to 1000 PSI
  • >1000 PSI in High Pressure Lab
• Feed rates
  • 1 g/min to 100 g/min




                                     16
Bench Scale Equipment

• Computer
  Controlled
  Valves

• Versatile Feed
  Configurations


• Computer
  Interfaced
  Scales

                        17
Bench Scale Equipment




                        18
Small Pilot Scale Equipment

Continuous                  Loop Type CFR
 Distillation




                            Feed Pumps
                                         19
Skid Mount Pilot Unit




                        20
Multipurpose Continuous Assets
• Existing Idle Equipment with World Scale Logistics
  Support (rail and ship)

• Distillation Columns (100 PSI, 300 C)

• Continuous Hydrogenation Columns (500 PSI)

• High Pressure Reactors(1000 PSI, 300 C)



                                                       21
Why Choose Albemarle?
• Successfully Partner with both Small and Large
  Companies

• Leading cGMP and Custom Manufacturing Facilities

• Competency in the Development of Complex Syntheses

• Extensive Process Development and Scale-up Capabilities




                                                            22
Why Choose Albemarle?
• Excellent Safety and Regulatory Record

• Demonstrated Consistent Success

• Large Scale Equipment Available

• Long Term Partner




                                           23
Find out how Albemarle
           says YES!
        to your project.
Americas                        Europe, Middle East, Africa
  • Fine Chemistry Services       • EMA Fine Chemistry Services
  • Tel: +1 225 388 7402          • Tel: +32 10 48 1711
  • ALBSales@albemarle.com        • EMASales@albemarle.com

                  Web: www.Albemarle.com

                                                                  24

Albemarle Continuous Reactions Presentation

  • 1.
    Continuous Reactions at Albemarle 1
  • 2.
    Outline • Albemarle Capability •Some Existing Continuous Reactions • Bench Scale Equipment • Multipurpose Continuous Assets 2
  • 3.
    Albemarle Corporation 2011 NetSales Distribution - $2.9 billion • Global provider of value Fine added technical solutions Chemistry 25% • Comprised of three business Catalysts 38% segments with balanced product portfolios • Proprietary technology and service-driven business model • Fundamentally strong margin and cash flow businesses Polymer Solutions Fine Chemistry 37% Services Go to: www.albemarle.com 3
  • 4.
    We Offer • US-basedleading cGMP and custom manufacturing production capabilities • Full project support (Technical, Regulatory, HSE, Information Management, Logistics) • Extensive process development and scale-up capabilities • Expertise in the development of complex syntheses • Long Term Relationship / Production Partner 4
  • 5.
    We Have • Excellentsafety record (top 10% of ACC) • Innovative technical staff that says YES! • FDA registered facilities with no 483s in last inspections • ISO certified custom manufacturing facilities • State-of-the-art analytical support • Raw material sourcing assets in China 5
  • 6.
    We Have –Manufacturing Capability • Five Commercial Scale Multipurpose Plants • South Haven, MI (cGMP) • Orangeburg, SC (including cGMP) • Tyrone, PA • Pasadena, TX • Baton Rouge, LA 6
  • 7.
    We Have –Manufacturing Capability • cGMP capability - kilo, pilot and commercial • 25 L to 16,000 gal Reactors of all MOCs • Distillation and Wiped Film Evaporators • Most types of solids handling • Full Utilities • Cryogenic to hot oil • Pressures to 1000 PSI • Short lead time for Environmental Permits 7
  • 8.
    We Have –Development Capability Full Scale Lab Kilo Lab Pilot Plant Commercial Synthesis Plant Baton Rouge, LA Baton Rouge, LA Baton Rouge, LA Baton Rouge, LA South Haven, MI South Haven, MI South Haven, MI South Haven, MI Tyrone, PA LLN, Belgium Tyrone, PA Tyrone , PA LLN, Belgium Orangeburg, SC Pasadena, TX Customer Driven 8
  • 9.
    Albemarle Continuous Capability •Over 40 years of Experience • World Scale Plants (100’s to >10,000’s TPY) • Existing processes at Multiple Plants • Long Term Supply • Proven Record with Recent Successes 9
  • 10.
    Ag Chemical • LongTerm Relationship • Expanding as Customer Grows • Started <500 TPY • Debottlenecked existing asset to > 1500 TPY • Further capacity increase with new asset • Process Includes • Hazardous Chemicals 10
  • 11.
    Brominated Flame Retardant •World Scale plant • Complex process • All Unit Ops Integrated 11
  • 12.
    Personal Care Intermediates •Multiple Products • Tubular Plug Flow / High Pressure • Long Term Supplier 12
  • 13.
    Pyrophorics • Multiple Products •Extremely Exothermic • Adiabatic Temperature Rise > 2000 °C • Unique Technical Solutions • Long Term Supplier 13
  • 14.
    Custom Lubricant Production •Albemarle selected as Scale up Partner • Commercial Plant Operational in 21 months • 15,000 TPY established in first month • Scale up from Lab Directly to Commercial • No Pilot Plant 14
  • 15.
    Bench Scale Equipment •We have a Modular Multipurpose Apparatus • Multiple Reactor Configurations • Currently up to 3 different feed streams • CSTR (single or series) • Tubular Fixedbed • Tubular Plug Flow 15
  • 16.
    Bench Scale Equipment •Temperature range • –100 to 200 C with circulators • higher with electric heating • Pressure range • Vacuum to 1000 PSI • >1000 PSI in High Pressure Lab • Feed rates • 1 g/min to 100 g/min 16
  • 17.
    Bench Scale Equipment •Computer Controlled Valves • Versatile Feed Configurations • Computer Interfaced Scales 17
  • 18.
  • 19.
    Small Pilot ScaleEquipment Continuous Loop Type CFR Distillation Feed Pumps 19
  • 20.
  • 21.
    Multipurpose Continuous Assets •Existing Idle Equipment with World Scale Logistics Support (rail and ship) • Distillation Columns (100 PSI, 300 C) • Continuous Hydrogenation Columns (500 PSI) • High Pressure Reactors(1000 PSI, 300 C) 21
  • 22.
    Why Choose Albemarle? •Successfully Partner with both Small and Large Companies • Leading cGMP and Custom Manufacturing Facilities • Competency in the Development of Complex Syntheses • Extensive Process Development and Scale-up Capabilities 22
  • 23.
    Why Choose Albemarle? •Excellent Safety and Regulatory Record • Demonstrated Consistent Success • Large Scale Equipment Available • Long Term Partner 23
  • 24.
    Find out howAlbemarle says YES! to your project. Americas Europe, Middle East, Africa • Fine Chemistry Services • EMA Fine Chemistry Services • Tel: +1 225 388 7402 • Tel: +32 10 48 1711 • ALBSales@albemarle.com • EMASales@albemarle.com Web: www.Albemarle.com 24