This document provides an overview of a custom manufacturing company that specializes in specialty chemicals, intermediates, and APIs. The company began in 1995 and now has facilities in both the US and China, allowing it to perform R&D, process development, and small-scale manufacturing in the US and large-scale commercial manufacturing in China. It has expertise in a wide range of chemistries and capabilities such as fluorination, coupling reactions, and handling air-sensitive compounds.

1. 1
Custom Manufacturing
Capabilities for Specialty
Chemicals, Intermediates
& API’s

2. Presentation Outline
 Company Overview
 Unique Business Model
 Chemistry and Technology
 Analytical Services
 Facilities and Equipment
 Competitive Advantage
 Contact Information

3. Company Overview
 Began as a New Jersey Corporation in 1995
 Moved to Baltimore, Maryland in 1999
 Currently 35 employees in the U.S. operation
 100% U.S. owned subsidiary in China
• Zhejiang ChemPacific located near Shanghai
• Staffed with over 100 employees
• Located on 11 acre chemical industrial park

4. Company Overview
Executive Team
Rebecca Chiu, MS- CEO
Chen Zhou, Ph.D.- Vice President
Tony Liang, MS and MBA- VP of Operations
Bing Li, Ph.D.- Vice President of China Operations
Wuyi Wang, Ph.D. - Senior Director of cGMP program, global
Xianghui Tan, Ph.D.- Director of cGMP Production
Jian Huang, Ph.D.- Director of non-GMP production
James Havlin, MBA- VP of Sales and Marketing

5. Company Overview
 Core Business:
 Research and Production of Fine Chemicals,
Industrial Chemicals, Intermediates and APIs
 Resources:
 Research-driven U.S. Laboratories
 Discover and develop products
 Perform small scale cGMP/ Non-GMP
manufacturing up to 50kg
 Cost-effective plants in China:
 Large scale non-GMP/cGMP manufacturing up to 100
metric ton

6. Company Overview
R&D Contract and Custom Synthesis:
• Unique Projects for Hard to Find Molecules
• High Levels of Communications with Researchers
• Tech Transfer to China for large scale production
Custom Manufacturing/Intermediates:
• Starting with Customer Process or Just a Structure
• Process Development and Optimization performed in the US
• Scale-Up to Commercial Quantities performed in China

7. Unique Business Model
US Facility China Facility
• Non-GMP and cGMP • Non-GMP and cGMP
Manufacturing Manufacturing
• Process Development • Scale-Up
Manufacturing
• Lab Scale (up to 1kg)
• Pilot Plant (10kg to
• Kilo Lab (up to 10kg) 1000kg)
• Commercial (1 MT to
100MT)
3.

8. Chemistry and Technology
•HF and KF Fluorination
•Per-fluorinated Aromatics
•Suzuki Coupling Organics
•Organometallic/Oxygen Sensitive
•Chiral Synthesis
•Unnatural Amino Acids
•Indolines and Indoles
•Heterocyclic Synthesis

9. Chemistry and Technology
 Synthetic organic chemistry expertise
 Non-patent-infringed process route development
 Experience in handling a variety of chemistries
with chiral and non-chiral compounds
 Chemistry R&D and process validation
 Modern Analytical facilities

10. Chemistry and Technology
Example: Chemical Capability- Per-fluorinated Aromatics
A. Per-fluorinated Benzene
B. Per-fluorinated Naphthalene
Commercial Scale

11. Chemistry and Technology
Example: Chemical Capability- 2-bromo-indene
Functionization of 2-Br-Indene
A. 2-Br-Indene Chemistry
p-TSA
Br Br
-H2O
OH
Commercial Scale
B. Cyclopentadiene Chemistry Functionization
Tetramethyl Cp
Pentamethyl Cp

12. Chemistry and Technology
Example: Chemical Capability- Suzuki Coupling Organics
1. RLi handling capability (Organometallic Chemistry Expertise)
2. Low temperature reaction and handling capabilities

13. Facilities and Equipment
Examples of Analytical Lab Instruments include
GC
GC-MS
IR, UV/VIS
NMR (Contract
with UMBC)
Polarimeter
HPLC
LC-MS
Prep HPLC

14. Facilities and Equipment
Research & Development Laboratory in Baltimore, MD
• 12,000 square ft laboratory space
• 50 L Glass reaction vessel
• 2 L Parr reactors with pressure vessels up to 2000 PSI
ChemPacific
Baltimore

15. Facilities and Equipment
Manufacturing Plant in China
ChemPacific Zhejiang:
• Located in a Modern Industrial Park
• 11 Acre site (expandable to 18 acres)
• Capable of Handling Complex Projects
• Multi-Purpose Equipment up to 5000L
• -78°C Reactor (300L)
• Up to 1000 PSI H2 reactor (300L)
• High Vacuum/Thin Film Distillation
• Large-Scale Column Chromatography
• Compartmentalized structure
gives us the capability to expand
with customers’ market demands

16. Competitive Advantage
• Domestic Presence
•Convenience for U.S. customers
•Same time zone
•No language barrier
•Secure business practices
•Troubleshooting handled locally
• Small company
•Personal attention
•Flexibility
•Quick delivery time
•Low overhead- pass lower costs to our
clients

17. Competitive Advantage
•Experience
• Expertise in a wide range of chemistries
• Experienced in manufacturing of hard to find molecules
• Experienced technical team who recognize the
challenges of transitioning from bench to pre-scale
operations.
• Reliable and Financially Stable
• A track record of completed projects and satisfied
customers

18. Some call it the best of both worlds;
we call it, The Best of One World.