POWERED BY PERFORMANCE OurTyrone plant has a long history of satisfying customers who demand quick turnaround, superior products, scale-up/scale-down flexibility and a wide range of industry experience. The ISO-9000 and RC-14000-registered facility sits on 120 acres in a small town, employs more than 150 area residents and boasts an excellent safety record.

1. Tyrone: Custom manufacturing
hits perfect stride at
Pennsylvania facility.
POWERED BY PERFORMANCE Our Tyrone plant has a long history
of satisfying customers who demand quick turnaround, superior products, scale-up/scale-down
flexibility and a wide range of industry experience. The ISO-9000 and RC-14000-registered facility sits on
120 acres in a small town, employs more than 150 area residents and boasts an excellent safety record.
FLEXIBILIT Y: THE TYRONE TR ADEMARK EXEMPL ARY QUALIT Y
• ISO 9000 and RC 14000
• Production capabilities from kilo-lab scale through hundreds
of metric tons per year • OSHA PSM
• More than 30 reactors, from 30 gallons through 4,000 gallons • Recordable rate below industry average
• Proven expertise in countless quick-turn situations • Excellent compliance history
• Especially well-equipped for complex, multi-step synthesis, • Receptive to customer audits
with various materials of construction and almost every unit
operation available PILOT PL ANT MANUFACTURING
• Synthetic minor air permit — eliminates permitting delays
Reactors
• On-site waste treatment system removes organic
contaminants from wastewater • Glass-lined
• Cryogenic Ag reactions • 30 to 500 gallons
• Up to ~150 PSI
• Temperature range: -90° C to 250° C
R&D LABOR ATORY C APABILITIES
Isolation Equipment
Chemists
• Centrifuges
• Nine chemists on-site (5 PhD, 4 BS)
• Nutsche filters
• Average experience: more than 12 years
• Supplemented by extensive R&D resources in Baton Rouge, LA Support Equipment
• Dryers (rotary, Littleford®, tray)
Equipment
• Wiped film evaporators (glass, stainless steel)
• Fume hoods, walk-in hood
• Glassware from 100 mL to 22 L
• Lab-scale wiped film evaporator (glass) In search of a plant that’s ideally suited for rapid response and
• Lab-scale high-pressure reactors (300 mL to 4 L) high-quality non-GMP production? Learning more about Albemarle’s
• High-throughput parallel reactor system Tyrone, Pennsylvania, facility is well worth your effort.
Support Equipment
• Dryers (roto-evaporators, vacuum ovens)
• Filtration devices, distillation systems, etc.

2. COMMERCIAL MANUFACTURING ANALYTIC AL SUPPORT
Reactors Instrumentation
• Over 60,000 gallons of capacity • Numerous GCs (HP 6890) equipped with auto-samplers
• Glass-lined, stainless steel, Hastelloy® alloy, nickel, zirconium • Numerous LCs (HP 1100) equipped with auto-samplers
• 500 to 4,000 gallons • GC with mass spec detector
• Up to ~150 PSI • NMR (400 MHz)
Isolation Equipment Additional Support
• Centrifuges, belt filters, filter presses • Flashpoint, melting point, ash, FT-IR, UV, others
• Rosenmund® Nutsche filters • Autotitrator, Coulometric KF
• Viscosity (Brookfield® viscometer,
Support Equipment
Ubbelohde/oil bath method)
• Dryers (rotary, Littleford®, fluidized bed, tray)
• Ion chromatography (anion/cation), size-exclusion
• Wiped film evaporators (glass, SS)
chromatography
• Distillation columns
• DSC
Find out how we say yes to hundreds of fine chemistry projects annually.
Albemarle is experienced and equipped to provide high-quality APIs to pharmaceutical customers worldwide. To
learn more about how our Tyrone facility adds to our yes formula, contact your Albemarle Representative today.
AMERICAS E U R O P E , M I D D L E E A S T, A F R I C A
Fine Chemistry Services EMA Fine Chemistry Services
Tel: +1 225 388 7402 Tel: +32 10 48 1711
ALBSales@albemarle.com EMASales@albemarle.com
www.albemarle.com
The information presented herein is believed to be accurate and reliable, but is presented without guarantee or responsibility on the part of Albemarle Corporation. It is the responsibility
of the user to comply with all applicable laws and regulations and to provide for a safe workplace. The user should consider any information contained herein, including information about
any health or safety hazards, only as a guide, and should take those precautions that are necessary or prudent to instruct employees and to develop work practice procedures in order to
promote a safe work environment. Further, nothing contained herein shall be taken as an inducement or recommendation to manufacture or use any of the herein described materials or
processes in violation of existing or future patents.
FCS-0003 (01/11)