More Related Content
What's hot
proteomics, mass spectrometry, science, bioinformatics, electrophoresis, liqu...proteomics, mass spectrometry, science, bioinformatics, electrophoresis, liqu...Amit Yadav
Similar to Akshay Be Day Poster
Similar to Akshay Be Day Poster (20)
![Introduction ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Polymeric drug delivery systems (DDS) Paclitaxel (PTX) Polyglutamyl-glutamate Paclitaxel (PGG Paclitaxel) ,[object Object],[object Object],Size and shape affects drug delivery Methods ( ab initio methodology) : Middle Ends ,[object Object],[object Object],0 ns 33 ns 66 ns 100 ns 0 ns 25 ns 50 ns 80 ns __ 50 nm Summary and Conclusion: References: 1. Seow WY et al. Biomaterials (2007). 2. Duncan R. Nature Rev (2006). 3. Ferrari et al. Nature (2008). 4. Marrink SJ et al. J Phys Chem B (2007). 5. Monticelli et al. J Chem Theory Comp (2008). 6. Tryslska J et al. Biophys J (2005). Elucidating Primary Structure of the Nanovector Poly (glutamyl – glutamate) Paclitaxel : a Coarse Grained Study Akshay S. Chaudhari †, § , Vincent M. Wong †, § , Lili X. Peng † and David Gough † † Department of Bioengineering, ‡Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0412, § Both authors contributed equally to the work. ,[object Object],Adhesion properties Entry into tumors Rate of endocytosis by tumor cells Ferrari et al., Nature 2008 ,[object Object],[object Object],The first three terms account for pseudo-bond, pseudo-angle and pseudo-dihedral interactions between the first two, three and four successive beads in each chain, respectively. ,[object Object],[object Object],1. Plot bond dist./angles against time. 2. Draw a probability distribution curve of the bond distances or angle. 3. Normalize the above generated probability distribution. 4. Apply the Boltzmann Inversion to calculate the mean potential energies. __ 50 nm Even Clusters Random 0 ns 33 ns 66 ns 100 ns 0 ns 25 ns 50 ns 75 ns Atomistic simulations – PGG Paclitaxel (37%) Results Side 0 ns 25 ns 50 ns 80 ns 0 ns 40 ns 80 ns 120 ns ,[object Object],[object Object],[object Object],[object Object],[object Object],Future Work: ,[object Object],[object Object],[object Object],[object Object],[object Object],(Derived from the Boltzmann inversion) ,[object Object],[object Object]](https://image.slidesharecdn.com/akshaybedayposter-090601010108-phpapp01/85/akshay-be-day-poster-1-320.jpg)
