This document summarizes the mode of action and synthesis of three benzodiazepine drugs: diazepam, lorazepam, and bromazepam. It explains that these drugs work by binding to GABA-A receptors in the brain, inhibiting the flow of chloride ions and delaying neural signaling. Diazepam was the first synthesized in 1963 as Valium, while lorazepam and bromazepam were also patented by Roche in 1963 under the brand names Ativan and Lexotan, respectively. All three drugs are used to treat anxiety, insomnia, seizures, and muscle symptoms but can cause side effects with overdose like coma, respiratory depression, and confusion.