This document summarizes research on novel topical drug carriers for the treatment of psoriasis. Liposomes, nanostructured lipid carriers, and other novel carriers can help deliver antipsoriatic drugs to the skin in a site-specific manner, improving drug solubilization and bioavailability. These carriers have advantages over traditional topical therapies by reducing side effects and increasing efficacy. Recent studies have investigated liposomes, deformable liposomes, and vesicular gels for delivering drugs like calcipotriol, methotrexate, and tacrolimus to treat psoriasis.