2. Synthesis of Phenothiazine from
Diphenylamine.
Aim:
• To prepare and submit Phenothiazine from Diphenylamine.
Requirements:
• Apparatus: Round bottom flask, reflux condenser, water bath, oil bath.
• Chemicals: Diphenylamine, Iodine, Ethanol, Charcoal, Sulphur.
Theory:
• Diphenylamine when treated with Sulphur undergo fusion reaction in the presence of
iodine to give Phenothiazine a tricyclic compound used as an antihistamine
engagement.
-Pratik Terse
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3. Synthesis of Phenothiazine from
Diphenylamine.
Diphenylamine:
• Molecular formula of Diphenylamine: C12H11N
• Molecular wt. of Diphenylamine: 169 g/mol
Phenothiazine:
• Molecular formula of Phenothiazine: C12H9NS
• Molecular wt. of Phenothiazine : 199 g/mol
-Pratik Terse
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4. Synthesis of Phenothiazine from
Diphenylamine.
Procedure.
• In a round bottom flask fitted with reflux condenser place 6.4 grams of
Suphur, 16.8 gram Diphenylamine, and 300 mg Iodine.
• Reflux the mixture on an oil bath at 190 to 200℃ for 30 to 40 minutes.
• Cool and grind the residue mass in which 5 ml of ethanol and pinch of
animal charcoal is added and heated it until solid mass dissolves.
• Filter the solution while hot and cool in ice bath.
• Filter the reaction mixture and obtain as yellow crystals of phenothiazine.
• Melting point of the product is 184 to 185℃.
-Pratik Terse
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5. Synthesis of Phenothiazine from
Diphenylamine.
Results:
• The practical yield was found to be _____grams and percentage yield
was _____percent and melting point was found to be ___degree Celsius.
Calculation:
Theoretical Yield:
Practical Yield:
% Practical Yield:
-Pratik Terse
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6. • Derivatives of phenothiazine are
highly bioactive and have
widespread uses like promazine
and chlorpromazine as
antipsychotic drugs.
Uses:
-Pratik Terse
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