SIWES-IT Presentation

1. STUDENT INDUSTRIAL WORK EXPERIENCE SCHEME
(SIWES)
HELD AT
BIORAJ AT PHARMACEUTICAL LIMITED
NO. 405 KAIAMA ROAD ILORIN KWARA STATE.
BY
ADELEKE RICHARD KAYODE
16D/57IC/139
SEPTEMBER 2018.
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2. OUTLINES
 INTRODUCTION
 Background of Establishment
 Departments/Units in the Establishment
o ACTUAL WORK DONE IN THE QUALITY CONTROL LAB
 Ibuprofen Analysis (B.P 400mg)
 Physiochemical properties of Ibuprofen powder
 Identification test of ibuprofen powder
 Assay test of ibuprofen caplet
 Equipment used to carry out various test.
o CONCLUSION AND RECOMMENDATION
o REFERENCES
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3. INTRODUCTION
BACKGROUND OF THE ESTABLISHMENT.
BIORAJ pharmaceutical limited is an indigeous pharmaceutical
company established in 2006, which produce or manufacture
drugs of high Quality and Standard of Living to the Society.
Some of drugs registered by NAFDAC:
 IBUPROFEN CAPLET
 BIORAMOL TABLET
 BIORAGYL TABLET
 BIOTONIC SYRUP
 BIOMAG SUSPENSION
 BIORAJ DICLOFENAC
 BIORAJ CIPRO CAPLET
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4. DEPARTMENTS/UNITS IN THE ESTABLISHMENT.
 ADMINSTRATION DEPARTMENT
 QUALITY CONTROL DEPARTMENT
• CHEMISTRY UNIT
• MICROBIOLOGY UNIT
 RAW MATERIAL STORE
 GRANULATION DEPARTMENT
 COMPOUNDING DEPARTMENT
 IN PROCESS UNIT
 COMPRESSION UNIT.....E.T.C
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5. ACTUAL WORK DONE IN THE QUALITY CONTROL
LAB.
Introduction: Analysis on Ibuprofen powder and tablets
 Ibuprofen is a non-steroidal anti-inflammatory drug.
 Belongs to the aryl alkanoic acid derivatives.
 Mainly used as analgesic and anti-pyretic effect such as
pain and fever.
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6. ibuprofen powder
P roperties of Ibuprofen powder
• It is a white crystalline powder.
• Insoluble in water, but freely soluble
in organic solvents such as acetone,
ether, methanol and chloroform.
• As an acid , it can react with base such
as sodium hydroxide to form the
water soluble ibuprofen sodium salt.
• Its molecular weight equals
206.3g/mol.
• C13H18O2
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7. IDENTIFICATION TESTS ON IBUPROFEN POWDER
A. Solution test
To 5ml of sample solution, 0.5ml of 2M Acetic acid and 1.2ml of a
10% w/v solution of Tannic acid was added. A yellow white,
precipitate was produced which dissolves in Ammonia
B. Melting point test
• The capillary tube is filled with ¼ of the given sample of
Ibuprofen,
• And fixed into a melting point machine.
• the sample melted at the normal melting range of ibuprofen,
which is 75 – 78 ◦c
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8. ASSAY OF IBUPROFEN TABLET ( B.P 400MG)
Aim: To ascertain the percentage content of the actives in the
batches of ibuprofen tablet.
Reagents:
• 0.1M NaOH
• 96% Ethanol
• Chloroform
• Phenolphthalein
Apparatus:
• Titration set-up
• Filtration set-up
• Mortar and pestle
• Beaker, funnel
• Volumetric flask.
STUDENT AT WORK
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9. ASSAY TEST: (PROCEDURE)
 20 tablets of ibuprofen was weighed, and grind using a
mortar and a pestle.
 An equivalent amount containing 0.4g ibuprofen from
the powder was dissolved in 20ml of chloroform for 15
mins.
 The solution was filtered, and the residue was washed
with two (5 ml) chloroform.
 The filtrate was evaporated to dryness under current air
 And the solid residue was dissolved in 80ml of absolute
ethanol
 The solution was titrated with 0.1M NaOH using
phenolphthalein as indicator.
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10. EQUATION OF THE REACTION.
 Each 1 ml of 0.1 M NaOH is equivalent to 20.63mg of Ibuprofen.
 %Assay= Titre value×Eqt wt×factor ×100
Weight taken
 According to BP, Ibuprofen tablets should contain not less
than 95% and not more than 105% of the labelled amount of
Ibuprofen.
The chemical equation forthe titration step should be:
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11. LIST OF SOME EQUIPMENT USED TO CARRY OUT VARIOUS
TEST
1.Weighing balance
2. Moisture analyzer
3. Friabilator
4. Disintegrate apparatus
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12. CONCLUSION
 In conclusion, during my Siwes programme, i was
exposed to series of tests such as identification,
assay, melting point, pH, titration was carried out on
both raw materials and finished products which as
made me to appreciate the world of science and
technology.
 I was also exposed to various laboratory
instruments, equipment, professional work methods
and ways to safe guard the work environment in
industries and various organizations.
 This training also gave me the opportunity to
interact, share knowledge and ideas with other
students from different institutions
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13. REFERENCES
 British pharmacopoeia volume I and II 2017
Grysell Ramos, 2013.
 Chemical raw material analysis book, 2nd
Edition
 Bioraj pharmaceutical manual test procedure
(in process log book)
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