This document provides guidance on how to conduct crowdfunded scientific research experiments through Experiment.com. It recommends developing a clear research project, sharing details about the science openly online, and publishing results in order to involve the public and receive funding. Key steps include preparing the project plan, getting early feedback, finding new and existing audiences online, and treating crowdfunding as an opportunity rather than begging for money. The overall goal is to enable more independent scientific research.
Ali Somers, Co-Founder, Apples & Honey Nightingale Nursery facilitated a workshop to look at how to measure your impact of intergenerational projects at GWT's National Conference on Wed 6th March 2019.
Sales management must produce a sales strategy based on an understanding of their sales force strengths and weaknesses. A sales consulting firm can assess your go to market strategy utilizing benchmarks to determine where you should invest in sales performance improvement projects. A presentation by Sales Benchmark Index.
An invited talk given to a group of neuroethics researchers. The focus of the discussion was how we might think about the likely outcomes of engagement activities. This is similar to some previous talks but also includes some new bits and pieces that reflect our continued effort to work through these ideas. Appreciated the chance to share.
Ali Somers, Co-Founder, Apples & Honey Nightingale Nursery facilitated a workshop to look at how to measure your impact of intergenerational projects at GWT's National Conference on Wed 6th March 2019.
Sales management must produce a sales strategy based on an understanding of their sales force strengths and weaknesses. A sales consulting firm can assess your go to market strategy utilizing benchmarks to determine where you should invest in sales performance improvement projects. A presentation by Sales Benchmark Index.
An invited talk given to a group of neuroethics researchers. The focus of the discussion was how we might think about the likely outcomes of engagement activities. This is similar to some previous talks but also includes some new bits and pieces that reflect our continued effort to work through these ideas. Appreciated the chance to share.
Workshop at SciTalk '22 on strategic science communication in which we make a strong argument for focusing on behavioral goals and communication objectives as beliefs, feelings, and frames.
How much can you say in one sentence? Useful Science Keynote Address at ComSc...Useful Science
ComSciCon is a series of workshops on science communication led and attended by graduate students. From April 12th-13th, Useful Science Director Maryse Thomas joined students at ComSciCon Pacific Northwest 2019 in Seattle and delivered the keynote address, encouraging students to take the plunge and kickstart their own sci-comm initiatives.
CHAPTER6RESEARCHLEARNING OBJECTIVES• Describe the importan.docxtiffanyd4
CHAPTER
6
RESEARCH
LEARNING OBJECTIVES
• Describe the importance of responsible research choices
• Outline an effective, efficient research strategy
• Create search terms for focused online searches
• Gather relevant research materials
• Discover the note-taking approach that works best for you
• Evaluate the credibility and usefulness of different sources
• Effectively organize research materials and choose the most useful ones
• Correctly cite your sourcesCHAPTER OUTLINE
• Introduction: Becoming an Expert
• Researching Responsibly
• The Research Process
• How to Conduct an Online Search
• Gathering Your Materials
• Reading Your Materials and Taking Notes
• Evaluating Sources
• Revising Your Claims
• Organizing Your Research Information
• Choosing the Sources for Your Speech
• Citing Your Sources and Avoiding Plagiarism
• Getting Help from a Research Expert
Robert and Dixie have been assigned to speak on either side of an issue, a kind of “pros and cons” format. They chose home schooling as their issue. each has a general position on it (Dixie is in favor, and Robert against) but they admit they just don't know that much about it. So what now? How do they become well enough informed to give a speech on the topic? Where should they even start? How can you keep track of your research? Do you have cite it?Overview
Research is necessary for an effective public speech. This chapter will help you make responsible, well-crafted, and carefully executed research choices. First, we will help you figure out what you already know and translate that knowledge into a research strategy. Next, we will provide some concrete tips on where to go for research (including other people as well as the Internet and the library), how to design a good search query for search engines and databases, and how to narrow your search. After that, we will address what you need to do once you have collected your research material, including how to read through it, take notes, and evaluate which sources are worthwhile. Finally, we will deal with how to use your research process to refine your arguments, choose and organize your quotations, and give proper credit for the sources you use in your speech.
MindTap®
Start with a warm-up activity about Stephanie's speech, and review the chapter's Learning Objectives.INTRODUCTION: BECOMING AN EXPERT
Researching, composing, and delivering an effective public speech requires you to acquire some expertise on your topic. You don't have to be the kind of expert who can produce original facts, figures, and data and publish groundbreaking work regarding your topic. But you do need to become enough of an expert on your topic to translate the research that you have done to an audience that may not have the same background or comfort with concepts and terminology that you have developed in your research. On your topic, you are the expert for your audience's purposes. You should cultivate enough expertise on your topic to bring new insights to .
Presentation on professional branding in the age of the internet, presented to the Postdoctoral Career Symposium at the University of Texas Medical Center.
An introduction to the MYP Personal Project. Includes a visual representation of the year and the Personal Project cycle. Also, advice on drafting highly challenging goals based on the MYP Personal Project Teacher Support Materials.
Board members show up excited to serve and wanting to make a difference, but sometimes that changes. Why? It may be lack of knowledge, boring or uninformative board meetings or orientation. OR maybe you have a board culture that doesn’t invite new ideas and questions.
Board meetings and board communication are critical aspects of causing awesome board members. This webinar with nationally renowned Fundraising Culture Changer & Master Storyteller, Lori L. Jacobwith will help you change your board story.
Join Lori to answer some thought provoking questions about the board experience at your organization. Lori will be sharing templates and tools to help you support the newest or even the most savvy board members and make them feel better equipped to serve on your board.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Workshop at SciTalk '22 on strategic science communication in which we make a strong argument for focusing on behavioral goals and communication objectives as beliefs, feelings, and frames.
How much can you say in one sentence? Useful Science Keynote Address at ComSc...Useful Science
ComSciCon is a series of workshops on science communication led and attended by graduate students. From April 12th-13th, Useful Science Director Maryse Thomas joined students at ComSciCon Pacific Northwest 2019 in Seattle and delivered the keynote address, encouraging students to take the plunge and kickstart their own sci-comm initiatives.
CHAPTER6RESEARCHLEARNING OBJECTIVES• Describe the importan.docxtiffanyd4
CHAPTER
6
RESEARCH
LEARNING OBJECTIVES
• Describe the importance of responsible research choices
• Outline an effective, efficient research strategy
• Create search terms for focused online searches
• Gather relevant research materials
• Discover the note-taking approach that works best for you
• Evaluate the credibility and usefulness of different sources
• Effectively organize research materials and choose the most useful ones
• Correctly cite your sourcesCHAPTER OUTLINE
• Introduction: Becoming an Expert
• Researching Responsibly
• The Research Process
• How to Conduct an Online Search
• Gathering Your Materials
• Reading Your Materials and Taking Notes
• Evaluating Sources
• Revising Your Claims
• Organizing Your Research Information
• Choosing the Sources for Your Speech
• Citing Your Sources and Avoiding Plagiarism
• Getting Help from a Research Expert
Robert and Dixie have been assigned to speak on either side of an issue, a kind of “pros and cons” format. They chose home schooling as their issue. each has a general position on it (Dixie is in favor, and Robert against) but they admit they just don't know that much about it. So what now? How do they become well enough informed to give a speech on the topic? Where should they even start? How can you keep track of your research? Do you have cite it?Overview
Research is necessary for an effective public speech. This chapter will help you make responsible, well-crafted, and carefully executed research choices. First, we will help you figure out what you already know and translate that knowledge into a research strategy. Next, we will provide some concrete tips on where to go for research (including other people as well as the Internet and the library), how to design a good search query for search engines and databases, and how to narrow your search. After that, we will address what you need to do once you have collected your research material, including how to read through it, take notes, and evaluate which sources are worthwhile. Finally, we will deal with how to use your research process to refine your arguments, choose and organize your quotations, and give proper credit for the sources you use in your speech.
MindTap®
Start with a warm-up activity about Stephanie's speech, and review the chapter's Learning Objectives.INTRODUCTION: BECOMING AN EXPERT
Researching, composing, and delivering an effective public speech requires you to acquire some expertise on your topic. You don't have to be the kind of expert who can produce original facts, figures, and data and publish groundbreaking work regarding your topic. But you do need to become enough of an expert on your topic to translate the research that you have done to an audience that may not have the same background or comfort with concepts and terminology that you have developed in your research. On your topic, you are the expert for your audience's purposes. You should cultivate enough expertise on your topic to bring new insights to .
Presentation on professional branding in the age of the internet, presented to the Postdoctoral Career Symposium at the University of Texas Medical Center.
An introduction to the MYP Personal Project. Includes a visual representation of the year and the Personal Project cycle. Also, advice on drafting highly challenging goals based on the MYP Personal Project Teacher Support Materials.
Board members show up excited to serve and wanting to make a difference, but sometimes that changes. Why? It may be lack of knowledge, boring or uninformative board meetings or orientation. OR maybe you have a board culture that doesn’t invite new ideas and questions.
Board meetings and board communication are critical aspects of causing awesome board members. This webinar with nationally renowned Fundraising Culture Changer & Master Storyteller, Lori L. Jacobwith will help you change your board story.
Join Lori to answer some thought provoking questions about the board experience at your organization. Lori will be sharing templates and tools to help you support the newest or even the most savvy board members and make them feel better equipped to serve on your board.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
14. You
NSF / NIH /
Three letter agency
Philanthropic Funding Body
Grant Review Panel
Call for Proposals
Development Office
Research Department
Institutional Administrators
Faculty Committee
Journal Editor
Manuscript Reviewer
Peer Review Panel
Paywall Science Journalist / Media
Public
Government Representatives
15. You
NSF / NIH /
Three letter agency
Philanthropic Funding Body
Grant Review Panel
Call for Proposals
Development Office
Research Department
Institutional Administrators
Faculty Committee
Journal Editor
Manuscript Reviewer
Peer Review Panel
Paywall Science Journalist / Media
Public
Government Representatives
16.
17.
18. You
NSF / NIH /
Three letter agency
Philanthropic Funding Body
Grant Review Panel
Call for Proposals
Development Office
Research Department
Institutional Administrators
Faculty Committee
Journal Editor
Manuscript Reviewer
Peer Review Panel
Paywall Science Journalist / Media
Public
Government Representatives
20. The powers that be want you
to believe that this is how
science is supposed to work.
21. You
NSF / NIH /
Three letter agency
Philanthropic Funding Body
Grant Review Panel
Call for Proposals
Development Office
Research Department
Institutional Administrators
Faculty Committee
Journal Editor
Manuscript Reviewer
Peer Review Panel
Paywall Science Journalist / Media
Public
Government Representatives
22. And we wonder why we have a
science literacy problem.
23. You
NSF / NIH /
Three letter agency
Philanthropic Funding Body
Grant Review Panel
Call for Proposals
Development Office
Research Department
Institutional Administrators
Faculty Committee
Journal Editor
Manuscript Reviewer
Peer Review Panel
Paywall Science Journalist / Media
Public
Government Representatives
67. this requires me to talk to
people…
To get good, it takes practice.
this requires me to use the
internet…
The internet was made for
science.
no one will care about my
work…
68. this requires me to talk to
people…
To get good, it takes practice.
this requires me to use the
internet…
The internet was made for
science.
no one will care about my
work…
Do you care?
74. 1. Is it
research?
2. Are
you real?
3. Can you
meet the
goals?
Our review
criteria
Not raising money
for a company, or
teaching a class. A
research-driven
project.
75. 1. Is it
research?
2. Are
you real?
3. Can you
meet the
goals?
Our review
criteria
Not raising money
for a company, or
teaching a class. A
research-driven
project.
Are you who you
say you are? Can
be paid out to a
U.S. bank account.
76. 1. Is it
research?
2. Are
you real?
3. Can you
meet the
goals?
Our review
criteria
Not raising money
for a company, or
teaching a class. A
research-driven
project.
Are you who you
say you are? Can
be paid out to a
U.S. bank account.
Project goals are
realistic, and you
have the resources
& experience
needed.
