Edward Frenkel discusses the interplay between mathematics and physics in an interview with Matthew Putman, emphasizing that while some mathematical theories can describe physical reality, many exist as abstract constructs. He argues for the beauty and freedom in mathematics, noting that it can challenge our understanding of concepts such as space and infinity, drawing on historical figures like Riemann and Cantor. The conversation touches upon the limitations of physical theories compared to mathematical truths and the evolving nature of scientific understanding.