This document discusses using a high seed fed-batch (HSFB) process compared to a standard fed-batch process for monoclonal antibody production. It presents results from experiments conducted using 3L bioreactors. The HSFB process uses an inoculation density of 5x106 cells/mL compared to 0.5x106 cells/mL for the standard process. The HSFB process achieved a titer increase within the variability range and reached that titer 3 days earlier than the standard process. Other metrics like viable cell density, viability, specific productivity, and metabolite levels were also compared between the two processes. The results suggest the HSFB process can accelerate production timelines while maintaining comparable product quality.
Base Pair Case Study: Competitive and Comparative SELEXLisa Thurston
Base Pair Biotechnologies used their patented multiplexed SELEX technique to simultaneously select aptamers against 4 closely related protein targets provided by a client, while also selecting aptamers that did not bind to undesirable background targets. This resulted in 19 unique aptamer sequences that bound to all 4 protein targets but not the background targets. Representative aptamers from this set are currently being characterized for their binding properties and validated by the client. The multiplexed SELEX technique allows for cost-effective development of aptamers in a competitive environment, promoting specificity.
Suthep Liumsirijarern: Biofuels Perspectives and PoliciesVIV Corporate
The document summarizes Thailand's policies and perspectives on biofuels. It discusses Thailand's reliance on natural gas for electricity generation and goals to increase renewable energy such as ethanol and biodiesel. Thailand has a biofuel development plan from 2008-2022 with targets to increase ethanol production to 9 million liters per day from sugarcane, cassava and other feedstocks. The policy provides incentives for flex-fuel vehicles and E20/E85 gasoline to increase biofuel usage. Currently there are 19 ethanol plants operational with a total capacity of 2.93 million liters per day.
VIV Asia 2013: Enzymes in Animal Nutrition, CropTech-FeedTech Conference, co-...VIV Corporate
This document discusses global trends in animal feed and nutrition, and the role of enzymes. It notes rising demand for meat due to population growth and urbanization is increasing pressure on feed resources. Enzyme solutions can help address issues of resource scarcity, environmental impacts, and feed quality. The document reviews DSM's portfolio of feed enzymes including their effects, production methods, formulations to withstand pelleting, and ability to enhance nutrient availability and sustainability in animal agriculture.
Assessment of Heavy Metal Contamination in Vegetables Grown in and Around Nas...IOSR Journals
The study was conducted to find out the content of lead (Pb), cadmium (Cd), arsenic (As) and copper (Cu) in some selected vegetables grown in and around Nashik city, Maharashtra state (India). Vegetable samples from four different sites were collected and digested by using tri-acid digestion method. Concentrations of heavy metals were analyzed by using atomic absorption spectrophotometer. The results of this study showed that there was wide variation in the concentration of these metals in vegetables collected from different sites. Vegetables grown in the vicinity of an industrial area were most contaminated while vegetables grown in rural area were least contaminated. Analytical results indicated that the concentration of lead in 35% vegetable samples collected from industrial area were more than maximum permitted limit. The high concentration of cadmium was found in onion and coriander, while lead content was recorded high in spinach and cauliflower. Arsenic concentration in 25% samples collected from industrial area was more than maximum permitted limit. Copper concentration in most of the vegetable sample was within permissible limit; only two out of forty samples have high concentration of copper. The results of the study showed that consumers are at greater risk of purchasing these fresh vegetables with high levels of heavy metals beyond permissible limits as defined by the Indian Prevention of Food Adulteration Act, 1954.
We, Hindustan Animal Feeds are supplying, distributing, manufacturing, exporting and wholesaling Animal Feed & Poultry Feeds and Supplements. These animal and bird feeds are appreciated for their excellent nutritive content and great taste.
A ring test was organized for the detection of animal proteins in animal feed by microscopy in the framework of the annual ring tests of the IAG - International Association for Feeding stuff Analysis, Section Feeding stuff Microscopy. The organizer of the ring test was RIKILT - Wageningen UR, The Netherlands. The aim of the ring study was to provide the participants information on the performance of the local implementation of the detection method for their local quality systems. A further aim was to gather information about the application of the microscopic method.
All four samples used in the ring test were based on an artificial feed with a formulation comparable to that of an average cattle feed. A mix of minerals was included at a level of 1%. The contaminations were: no animal proteins (blank), 2% of fish meal, 0.05% of land animal material, and 0.1% of tricalcium phosphate (TCP).
Most of the specificity and sensitivity scores were at good levels. The specificity score for incorrect detection of meat and bone meal (MBM) in the blank is acceptable (0.94). The detection of 0.05% of MBM in feed appeared to be perfect (1.0). The TCP, which is a legal ingredient for non-ruminant feeds, was detected in a vast majority of cases as animal proteins in the sense of the legislation. Four participants reported fish in the presence of TCP. For the first time in the ring test of IAG section Microscopy participants were requested to report on their examination of either the flotate or the raw material of the sample. The results show a rather diverse view. The results for the blank were at a reasonable level (0.91). The detection of animal material (0.05%) in either flotate or raw material needs further improvement (0.34). According to the new procedure the results for examination of sediment and of flotate/raw material need to be combined in one result. Therefore, the sensitivity for the examination of flotate or raw material does not have a direct effect on the performance of the method. The share of the sediment used for examination differed between 2% and 100%. This difference showed to have an effect on the sensitivity of the method.
This document discusses using a high seed fed-batch (HSFB) process compared to a standard fed-batch process for monoclonal antibody production. It presents results from experiments conducted using 3L bioreactors. The HSFB process uses an inoculation density of 5x106 cells/mL compared to 0.5x106 cells/mL for the standard process. The HSFB process achieved a titer increase within the variability range and reached that titer 3 days earlier than the standard process. Other metrics like viable cell density, viability, specific productivity, and metabolite levels were also compared between the two processes. The results suggest the HSFB process can accelerate production timelines while maintaining comparable product quality.
Base Pair Case Study: Competitive and Comparative SELEXLisa Thurston
Base Pair Biotechnologies used their patented multiplexed SELEX technique to simultaneously select aptamers against 4 closely related protein targets provided by a client, while also selecting aptamers that did not bind to undesirable background targets. This resulted in 19 unique aptamer sequences that bound to all 4 protein targets but not the background targets. Representative aptamers from this set are currently being characterized for their binding properties and validated by the client. The multiplexed SELEX technique allows for cost-effective development of aptamers in a competitive environment, promoting specificity.
Suthep Liumsirijarern: Biofuels Perspectives and PoliciesVIV Corporate
The document summarizes Thailand's policies and perspectives on biofuels. It discusses Thailand's reliance on natural gas for electricity generation and goals to increase renewable energy such as ethanol and biodiesel. Thailand has a biofuel development plan from 2008-2022 with targets to increase ethanol production to 9 million liters per day from sugarcane, cassava and other feedstocks. The policy provides incentives for flex-fuel vehicles and E20/E85 gasoline to increase biofuel usage. Currently there are 19 ethanol plants operational with a total capacity of 2.93 million liters per day.
VIV Asia 2013: Enzymes in Animal Nutrition, CropTech-FeedTech Conference, co-...VIV Corporate
This document discusses global trends in animal feed and nutrition, and the role of enzymes. It notes rising demand for meat due to population growth and urbanization is increasing pressure on feed resources. Enzyme solutions can help address issues of resource scarcity, environmental impacts, and feed quality. The document reviews DSM's portfolio of feed enzymes including their effects, production methods, formulations to withstand pelleting, and ability to enhance nutrient availability and sustainability in animal agriculture.
Assessment of Heavy Metal Contamination in Vegetables Grown in and Around Nas...IOSR Journals
The study was conducted to find out the content of lead (Pb), cadmium (Cd), arsenic (As) and copper (Cu) in some selected vegetables grown in and around Nashik city, Maharashtra state (India). Vegetable samples from four different sites were collected and digested by using tri-acid digestion method. Concentrations of heavy metals were analyzed by using atomic absorption spectrophotometer. The results of this study showed that there was wide variation in the concentration of these metals in vegetables collected from different sites. Vegetables grown in the vicinity of an industrial area were most contaminated while vegetables grown in rural area were least contaminated. Analytical results indicated that the concentration of lead in 35% vegetable samples collected from industrial area were more than maximum permitted limit. The high concentration of cadmium was found in onion and coriander, while lead content was recorded high in spinach and cauliflower. Arsenic concentration in 25% samples collected from industrial area was more than maximum permitted limit. Copper concentration in most of the vegetable sample was within permissible limit; only two out of forty samples have high concentration of copper. The results of the study showed that consumers are at greater risk of purchasing these fresh vegetables with high levels of heavy metals beyond permissible limits as defined by the Indian Prevention of Food Adulteration Act, 1954.
We, Hindustan Animal Feeds are supplying, distributing, manufacturing, exporting and wholesaling Animal Feed & Poultry Feeds and Supplements. These animal and bird feeds are appreciated for their excellent nutritive content and great taste.
A ring test was organized for the detection of animal proteins in animal feed by microscopy in the framework of the annual ring tests of the IAG - International Association for Feeding stuff Analysis, Section Feeding stuff Microscopy. The organizer of the ring test was RIKILT - Wageningen UR, The Netherlands. The aim of the ring study was to provide the participants information on the performance of the local implementation of the detection method for their local quality systems. A further aim was to gather information about the application of the microscopic method.
All four samples used in the ring test were based on an artificial feed with a formulation comparable to that of an average cattle feed. A mix of minerals was included at a level of 1%. The contaminations were: no animal proteins (blank), 2% of fish meal, 0.05% of land animal material, and 0.1% of tricalcium phosphate (TCP).
Most of the specificity and sensitivity scores were at good levels. The specificity score for incorrect detection of meat and bone meal (MBM) in the blank is acceptable (0.94). The detection of 0.05% of MBM in feed appeared to be perfect (1.0). The TCP, which is a legal ingredient for non-ruminant feeds, was detected in a vast majority of cases as animal proteins in the sense of the legislation. Four participants reported fish in the presence of TCP. For the first time in the ring test of IAG section Microscopy participants were requested to report on their examination of either the flotate or the raw material of the sample. The results show a rather diverse view. The results for the blank were at a reasonable level (0.91). The detection of animal material (0.05%) in either flotate or raw material needs further improvement (0.34). According to the new procedure the results for examination of sediment and of flotate/raw material need to be combined in one result. Therefore, the sensitivity for the examination of flotate or raw material does not have a direct effect on the performance of the method. The share of the sediment used for examination differed between 2% and 100%. This difference showed to have an effect on the sensitivity of the method.
Jan Cortenbach: Future arrangements on feed safety and qualityVIV Corporate
The document discusses quality management in the feed industry. It outlines various quality systems like ISO, HACCP, GMP, and lab certification that are used to ensure feed safety. However, it notes that proper sampling and analysis are also critical since no system can guarantee a good product on its own. Key challenges include sampling given the small amounts of contaminants involved and ensuring uniform distribution of nutrients. Proper manufacturing processes from raw material intake to delivery are also important to maintain consistent high quality feed.
VIV Animal Health Summit Closing CEO-level Conference, Mr. James Campbell, VI...VIV Corporate
This document discusses antimicrobial resistance data from humans and animals in Vietnam. It provides data on resistance levels of various bacteria like Campylobacter, E. coli, and Salmonella found in pigs, poultry, and humans. The data indicates high levels of resistance to commonly used antibiotics. The document also discusses antimicrobial use on farms and in communities in Vietnam. It suggests interventions like improving rational antibiotic use, controlling community antibiotic use, and using diagnostics to guide treatment in animals instead of blanket use.
This document provides an economic analysis for a proposed commercial poultry feed mill called Shamim Feed Mill in Bahawalpur. It estimates the total project cost to be Rs. 585,395,010 which includes land and buildings, plant machinery, laboratory equipment, employee salaries, raw materials, and overhead costs. The projected monthly feed production is 200,000-250,000 bags which is estimated to generate Rs. 460,000,000 in sales revenue per month. Based on the estimated costs and revenues, the annual profit is projected to be Rs. 44,510,000.
The document summarizes several animal feed products from Godrej Agrovet including Summer Kool, Bovino Calf Starter, Moo Magicmix, Prepwell, and Super Star. It provides details on the purpose, benefits, directions for use, and packaging for each product. The products are designed to reduce heat stress, support milk production, develop calves faster, balance nutrient intake, prepare animals for calving, and support faster growth and lower feed conversion ratios.
Ajith organiations study at kerala feeds ltdLibu Thomas
The document describes an organisational study of Kerala Feeds Limited, a government company that manufactures cattle feed in Kerala, India. It outlines the company's objectives, departments, production process, quality control measures, and SWOT analysis. The key findings are that the company focuses on product quality using advanced MMCP technology, but that raw material costs are high compared to competitors. It suggests expanding production capacity and markets to meet growing demand for cattle feed.
This document discusses procurement and sampling of animal feed units. It outlines that procurement involves acquiring goods and services at the best cost while meeting quality and quantity needs. Safety of animal feed is the primary objective to minimize health risks. Feeds and ingredients should come from safe sources and be stored and transported properly to prevent contamination. Critical control points should be identified and monitored according to hazard analysis principles. Samples should be taken randomly and representatively from feeds and sent for analysis of nutrients, pathogens, toxins and other undesirable substances. Key components analyzed include dry matter, proteins, fibers and energy content.
Dr. Jason Woodworth - What Can We Do In Feed Processing To Reduce RiskJohn Blue
What Can We Do In Feed Processing To Reduce Risk - Dr. Jason Woodworth, from the 2015 Allen D. Leman Swine Conference, September 19-22, 2015, St. Paul, Minnesota, USA.
More presentations at http://www.swinecast.com/2015-leman-swine-conference-material
This document discusses challenges facing the biopharmaceutical industry and introduces BioPharm Services' BioSolve software solutions. It summarizes that:
1) Biopharma industry costs are rising due to more expensive facilities, uncertain sales forecasts, and increasing biosimilar threats.
2) BioSolve provides integrated process modeling software to help standardize data, model processes, and assess costs early in development.
3) BioSolve Connect is an enterprise solution that centrally manages process resources and models to facilitate decision making across organizations.
A review / introduction of problem solving tools for achieving process improvement / control and waste reduction - this is available as an animated PowerPoint presentation
Clinical Data Management Training @ Gratisol LabsGratisol Labs
Clinical data management involves processing clinical trial data using computer applications and database systems. It supports the collection, cleaning, and management of subject data. Key aspects of clinical data management include CRF design, database setup, data entry, discrepancy management, medical coding, quality control, and database lock. The goal is to ensure the integrity and quality of clinical trial data.
The document outlines key aspects of analytical quality by design for pharmaceutical methods and products. It discusses analytical method classifications, parameters for validation, terminology, and international guidelines. Quality by design aims to minimize variability and improve quality through understanding sources of error, selectivity, method transfers, and controlling critical method parameters.
Jan Cortenbach: Future arrangements on feed safety and qualityVIV Corporate
The document discusses quality management in the feed industry. It outlines various quality systems like ISO, HACCP, GMP, and lab certification that are used to ensure feed safety. However, it notes that proper sampling and analysis are also critical since no system can guarantee a good product on its own. Key challenges include sampling given the small amounts of contaminants involved and ensuring uniform distribution of nutrients. Proper manufacturing processes from raw material intake to delivery are also important to maintain consistent high quality feed.
VIV Animal Health Summit Closing CEO-level Conference, Mr. James Campbell, VI...VIV Corporate
This document discusses antimicrobial resistance data from humans and animals in Vietnam. It provides data on resistance levels of various bacteria like Campylobacter, E. coli, and Salmonella found in pigs, poultry, and humans. The data indicates high levels of resistance to commonly used antibiotics. The document also discusses antimicrobial use on farms and in communities in Vietnam. It suggests interventions like improving rational antibiotic use, controlling community antibiotic use, and using diagnostics to guide treatment in animals instead of blanket use.
This document provides an economic analysis for a proposed commercial poultry feed mill called Shamim Feed Mill in Bahawalpur. It estimates the total project cost to be Rs. 585,395,010 which includes land and buildings, plant machinery, laboratory equipment, employee salaries, raw materials, and overhead costs. The projected monthly feed production is 200,000-250,000 bags which is estimated to generate Rs. 460,000,000 in sales revenue per month. Based on the estimated costs and revenues, the annual profit is projected to be Rs. 44,510,000.
The document summarizes several animal feed products from Godrej Agrovet including Summer Kool, Bovino Calf Starter, Moo Magicmix, Prepwell, and Super Star. It provides details on the purpose, benefits, directions for use, and packaging for each product. The products are designed to reduce heat stress, support milk production, develop calves faster, balance nutrient intake, prepare animals for calving, and support faster growth and lower feed conversion ratios.
Ajith organiations study at kerala feeds ltdLibu Thomas
The document describes an organisational study of Kerala Feeds Limited, a government company that manufactures cattle feed in Kerala, India. It outlines the company's objectives, departments, production process, quality control measures, and SWOT analysis. The key findings are that the company focuses on product quality using advanced MMCP technology, but that raw material costs are high compared to competitors. It suggests expanding production capacity and markets to meet growing demand for cattle feed.
This document discusses procurement and sampling of animal feed units. It outlines that procurement involves acquiring goods and services at the best cost while meeting quality and quantity needs. Safety of animal feed is the primary objective to minimize health risks. Feeds and ingredients should come from safe sources and be stored and transported properly to prevent contamination. Critical control points should be identified and monitored according to hazard analysis principles. Samples should be taken randomly and representatively from feeds and sent for analysis of nutrients, pathogens, toxins and other undesirable substances. Key components analyzed include dry matter, proteins, fibers and energy content.
Dr. Jason Woodworth - What Can We Do In Feed Processing To Reduce RiskJohn Blue
What Can We Do In Feed Processing To Reduce Risk - Dr. Jason Woodworth, from the 2015 Allen D. Leman Swine Conference, September 19-22, 2015, St. Paul, Minnesota, USA.
More presentations at http://www.swinecast.com/2015-leman-swine-conference-material
This document discusses challenges facing the biopharmaceutical industry and introduces BioPharm Services' BioSolve software solutions. It summarizes that:
1) Biopharma industry costs are rising due to more expensive facilities, uncertain sales forecasts, and increasing biosimilar threats.
2) BioSolve provides integrated process modeling software to help standardize data, model processes, and assess costs early in development.
3) BioSolve Connect is an enterprise solution that centrally manages process resources and models to facilitate decision making across organizations.
A review / introduction of problem solving tools for achieving process improvement / control and waste reduction - this is available as an animated PowerPoint presentation
Clinical Data Management Training @ Gratisol LabsGratisol Labs
Clinical data management involves processing clinical trial data using computer applications and database systems. It supports the collection, cleaning, and management of subject data. Key aspects of clinical data management include CRF design, database setup, data entry, discrepancy management, medical coding, quality control, and database lock. The goal is to ensure the integrity and quality of clinical trial data.
The document outlines key aspects of analytical quality by design for pharmaceutical methods and products. It discusses analytical method classifications, parameters for validation, terminology, and international guidelines. Quality by design aims to minimize variability and improve quality through understanding sources of error, selectivity, method transfers, and controlling critical method parameters.
2-64 Multi-Fermentation POD For High Density Recombinant Protein Expression and Production From 80 ml Up to 10L Scale
‘‘More than a Product, the bioPOD is a Concept
with Innovation as a Continuous Improvement”
UBS West Coast Life Science Bus Tour presented an overview of Thermo Fisher Scientific. [1] It discussed the company's two business segments: Analytical Technologies and Laboratory Products and Services. [2] New products were highlighted in areas like sample preparation, analysis, and data interpretation. [3] Technologies like mass spectrometry, RNAi, and the Exactive were discussed as enabling key applications in areas such as proteomics, stem cell research, and screening.
UBS hosted a life science bus tour for investors at Thermo Fisher Scientific in San Jose, CA. The agenda included a company overview, technology overview, and factory tour. Thermo Fisher Scientific is a $10.5 billion company with 34,000 employees serving over 350,000 customers in 150 countries. It has two business segments: analytical technologies focused on scientific instruments; and laboratory products and services focused on consumables and services. The company discussed opportunities in areas like stem cell research, protein research using mass spectrometry, and RNAi technology, demonstrating new products in these areas. The tour concluded with an overview of Thermo Fisher's San Jose facility and product lines.
This document provides an overview of standard costing concepts, processes, and functionality in Oracle Process Manufacturing (OPM). It discusses how OPM calculates standard costs based on formulas, resources, operations, routings, and recipes. It also addresses actual and lot costing methods at a high level. Key aspects covered include common costing setups, establishing standard costs through material and conversion costs, and calculating costs during the rollup process.
Monsanto's document discusses their biotechnology pipeline and commitment to safety. It provides an overview of Monsanto's technology development activities, R&D strategies for driving innovation, and the expansion of agricultural biotech traits globally. Charts show growing adoption of traits like Roundup Ready corn and YieldGard Rootworm corn by US farmers due to superior performance and cost benefits over insecticide treatments.
Throughout the feed value chain our customers rely on the accuracy of the information provided by FOSS analytical solutions. With rapid and reliable measurements of crucial parameters, at-line and inline, our instruments and software allow you to leverage real-time production data and take action that saves costly rework and wastage of valuable resources. FOSS NIR solutions include instrumentation, calibrations, calibration development software, instrument network software as well as instrumentation for wet chemistry reference methods.
Risk reduction in tablet dosage form development and manufacturingDipankar Dey
This article describes how measuring material properties that
relate directly to the final tablet product, including the inherent
ability of materials to form tablets (compressibility) reduces the
overall risk in tablet development and manufacture. A case
study illustrates the benefits of rapid compressibility assessment.
The document discusses using quality by design (QbD) and risk assessment for the success of quality by design. It emphasizes using risk management and design of experiments (DoE) together under a QbD framework. The document provides examples of initial risk analysis steps like process flow charts and risk analysis tables. It suggests ways to make the risk analysis more standardized and homogeneous, such as defining risks for product safety, efficacy, and availability and identifying general causes and risk control measures. The goal is to adapt the risk analysis for each specific process like fermentation, chromatography and ultrafiltration.
What Does It Cost? Activity Based Cost Managementalanlund
This document discusses activity-based costing (ABC) and its benefits. ABC assigns overhead costs to products and services based on their consumption of resources rather than traditional methods that allocate costs in proportion to direct costs. The document recommends developing a cost management strategy including mapping processes, reviewing general ledger accounts, and developing an ABC cost model to determine unit costs for products/services by factors like customers and cost centers. ABC provides decision makers profitability information and highlights how efficiently activities are performed and who benefits from activities.
The document discusses the SNIA Emerald Power Efficiency Measurement Specification and SNIA Emerald Program. It describes how the specification provides a standardized methodology and metrics for measuring the energy efficiency of storage systems through idle and active testing. It also establishes a taxonomy for classifying different types of storage systems. The SNIA Emerald Program allows vendors to submit test results according to the specification for publication in a test data report.
This document discusses developing robust and controlled bioanalytical methods through the use of statistics and experimental design. It emphasizes scoping potential method parameters through screening experiments, using designs of experiments to understand interactions and optimize conditions, and validating methods to verify robustness under deliberate variations. The goal is to generate data-driven methods with well-defined performance that can be reliably transferred to quality control and brought into routine use.
This document provides a summary of key concepts for developing bioanalytical methods in a statistically sound manner. It discusses the importance of understanding assay variability through statistical analysis in order to control methods and ensure reliability. The document recommends a quality by design approach involving scoping experiments, design of experiments, and method optimization to build understanding and control. It emphasizes involving a statistician from the start and using statistical process control charts to monitor methods and manage risk on an ongoing basis. The overall message is that a data-driven method development strategy incorporating statistical principles can improve bioanalytical method performance and control.
Mark Anderson is the CEO of AC Group, a national healthcare IT consulting firm. He has over 36 years of experience in healthcare IT, including serving as CIO for multiple regional healthcare systems. He regularly speaks on electronic health records (EHRs) and healthcare IT. The document discusses EHR trends, challenges with adoption and use, and the need for a strategic, enterprise-wide approach to business intelligence to improve outcomes and efficiencies across the healthcare organization. It also addresses issues around data integration, clinician buy-in, and the importance of an accountable culture for dashboard and scorecard applications.
NG BB 23 Measurement System Analysis - IntroductionLeanleaders.org
This document discusses measurement system analysis (MSA) and evaluating measurement systems to ensure reliable data collection for process improvement efforts. It introduces the eight-step CPI roadmap and explains why accurate measurements are important. Sources of variation are described, including repeatability, reproducibility, and bias. Conducting a gage R&R study to quantify measurement system variation is recommended so that variation due to the measurement process can be distinguished from natural process variation. The goal is to eliminate measurement system variation and rely on data to make good decisions about process performance and improvement opportunities.
Pragmatic implementation of single use technologies to deliver clinical supplyDr. Priyabrata Pattnaik
This document discusses implementing single-use technologies for a clinical drug supply pilot run. It summarizes:
1) A template process and pre-selected operating parameters were used to minimize process development work and reduce timelines.
2) A 100L pilot scale run was conducted using commercially available single-use systems and assemblies to scale up a downstream process developed at bench scale.
3) Comparison of bench and pilot scale runs showed similar impurity clearance, charge variant distribution, and overall yields, demonstrating successful scale up using single-use technologies.
Similar to VIV Asia 2013, Adifo: fine tuning between feed formulation, CropTech-FeedTech debate, co-organized by Perendale (20)
Pragmatic implementation of single use technologies to deliver clinical supply
VIV Asia 2013, Adifo: fine tuning between feed formulation, CropTech-FeedTech debate, co-organized by Perendale
1. Fine tuning between Feed
Formulation, Quality Control
and Production
“Managing and using quality control data”
Hans van der Waal
Market Development manager
ADIFO
2. Least cost formulation, the basics …
“If you take into account the nutrient
content variation of raw material
you will save between 20 – 40 USD
Raw Material cents / MT”
Price Big feed mill in Western Europe
Least
Cost
Formula
Raw material
nutritional Requirements
values & Constraints
3. Integrated platform for quality control
Raw Materials
& End Products Intake Production
Production NIR
software FOSS,
Recipe + Bruker ..
Declaration
values products
Sample Results
+ status NIR
results
Nutritional
BESTMIX® values of
BESTMIX®
Formulation recipes LIMS
Samples
to Lab
Online
Laboratory
Update (outsource)
matrix LAB
Process :
results
Average
values
4. Updating the ingredient matrix
Advantage of integrated process:
• Full control over the sample data before updating
• Transparency on actual matrix data
Leads towards using more accurate matrix values
Save money and deliver what you promise