13. 急性冠症候群 acute coronary syndrome
• ST 上昇型心筋梗塞 STEMI
• 不安定狭心症 uAP/
非 ST 上昇型心筋梗塞 non-STEMI
冠動脈プラークの破綻やびらんに伴う冠動
脈内血栓形成により突然に心筋酸素供給が
減少することが原因。
14. 心筋マーカーの感度、特異度は?
increase peak return
Sensitivity
(10 hour)
Specificity
(10 hour)
Troponin I 3-12
hour
24-48
hour
5-14 days 96% 93%
CK-MB 3-12
hour
24 hour 3 days 91% 89%
Troponins are the prefered marker for the diagnosis
of myocardial injury.
UP TO DATE,2007 joint ESC/ACCF/AHA/WHF task force
17. Features Increasing Likelihood of AMI
Clinical FeatureClinical Feature Likelihood Ratio (95%CI)Likelihood Ratio (95%CI)
Pain in chest or left armPain in chest or left arm 2.72.7
Chest pain radiationChest pain radiation
Right ShoulderRight Shoulder 2.9 (1.4-6.0)2.9 (1.4-6.0)
Left armLeft arm 2.3 (1.7-3.1)2.3 (1.7-3.1)
Both left and right armBoth left and right arm 7.1 (3.6-14.2)7.1 (3.6-14.2)
Chest pain most important symptomChest pain most important symptom 2.02.0
History of MIHistory of MI 1.5-3.01.5-3.0
Nausea or vomitingNausea or vomiting 1.9 (1.7-2.3)1.9 (1.7-2.3)
DiaphoresisDiaphoresis 2.0 (1.9-2.2)2.0 (1.9-2.2)
Third heart soundThird heart sound 3.2 (1.6-6.5)3.2 (1.6-6.5)
Hypotension (SBP<80)Hypotension (SBP<80) 3.1 (1.8-5.2)3.1 (1.8-5.2)
Pulmonary rales on examPulmonary rales on exam 2.1 (1.4-3.1)2.1 (1.4-3.1)
Panju, et al. JAMA 1998;280:14:1256-1263Panju, et al. JAMA 1998;280:14:1256-1263