Acivir DT (Generic Acyclovir Tablets) is used to treat Herpes simplex virus infections of the skin and mucous membrane, including initial and recurrent genital herpes, suppression of recurrent Herpes simplex infections in immune-competent patients, prophylaxis of Herpes simplex infection in immunocompromised patients, chickenpox (varicella) and Herpes zoster (shingles) infections as well as management of severely immunocompromised patients.

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Acivir DT Tablets (Generic Acyclovir Tablets)

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Acivir DT Tablets (Generic Acyclovir Tablets)
Acivir DT (Generic Acyclovir Tablets) is used to treat
Herpes simplex virus infections of the skin and mucous
membrane, including initial and recurrent genital herpes,
suppression of recurrent Herpes simplex infections in
immune-competent patients, prophylaxis of Herpes
simplex infection in immunocompromised patients,
chickenpox (varicella) and Herpes zoster (shingles)
infections as well as management of severely
immunocompromised patients.

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Acivir DT Tablets (Generic Acyclovir Tablets)
Active Ingredient
The active ingredient contained in in Acivir DT tablets is
Acyclovir . Each dispersible tablet contains 200 mg, 400 mg or 800
mg of Acyclovir, BP.

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Acivir DT Tablets (Generic Acyclovir Tablets)
Chemical Structure
The structure of Acyclovir is given below:

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Acivir DT Tablets (Generic Acyclovir Tablets)
Acivir DT Tablets are manufactured by Cipla Limited, India
in the strengths of 200 mg, 400 mg and 800 mg.
( Website: https://www.cipla.com/ )
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Acivir DT Tablets (Generic Acyclovir Tablets)
Acyclovir Tablets – Brand Names
Acyclovir tablets are available under various
drug trade names that include Zovirax,
Acivir DT, Herpex, Lovir, Ocuvir DT,
Axovir, Zoylex-DT and Herpesafe DT.

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Acivir DT Tablets (Generic Acyclovir Tablets)
Uses of Acivir DT Tablets
Acivir DT (Generic Acyclovir Tablets) belongs to the family of medicines
called antivirals and is used to treat the symptoms of chickenpox, shingles,
herpes virus infections of the genitals (sex organs), the skin, the brain, and
mucous membranes (lips and mouth), and widespread herpes virus
infections in newborns. Acyclovir is also used to prevent recurrent genital
herpes infections.
Although acyclovir will not cure herpes, it does help relieve the pain and
discomfort and helps the sores (if any) heal faster.
Acyclovir may also be used for other virus infections as determined by
your doctor. However, it does not work in treating certain virus infections,
such as the common cold.
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Acivir DT Tablets (Generic Acyclovir Tablets)
Acivir DT Tablets Dosage
Disperse Acivir DT tablet in a teaspoonful (5 ml) of boiled and
cooled water before administration.
The dosage of Acivir DT tablets (Generic Acyclovir Tablets) is
given below:
Acute Treatment of Herpes Zoster:
800 mg every 4 hours orally, 5 times daily for 7 to 10 days.
Genital Herpes:
Treatment of Initial Genital Herpes: 200 mg every 4 hours, 5 times daily
for 10 days.
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Acivir DT Tablets (Generic Acyclovir Tablets)
Acivir DT Tablets Dosage
The dosage of Acivir DT tablets (Generic Acyclovir Tablets) is given
below:
Genital Herpes: Chronic Suppressive Therapy for Recurrent Disease:
400 mg 2 times daily for up to 12 months, followed by re-evaluation.
Alternative regimens have included doses ranging from 200 mg 3 times daily to
200 mg 5 times daily. The frequency and severity of episodes of untreated
genital herpes may change over time. After 1 year of therapy, the frequency and
severity of the patient’s genital herpes infection should be re-evaluated to assess
the need for continuation of therapy with Acivir DT Tablets.
Genital Herpes: Intermittent Therapy:
200 mg every 4 hours, 5 times daily for 5 days. Therapy should be initiated at
the earliest sign or symptom of recurrence.
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Acivir DT Tablets (Generic Acyclovir Tablets)
Acivir DT Tablets Dosage
The dosage of Acivir DT tablets (Generic Acyclovir Tablets) is given
below:
Treatment of Chickenpox:
Children (2 years of age and older):
20 mg/kg per dose orally 4 times daily (80 mg/kg/day) for 5 days.
Children over 40 kg should receive the adult dose for chickenpox.
Adults and Children over 40 kg:
800 mg 4 times daily for 5 days.
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Acivir DT Tablets (Generic Acyclovir Tablets)
Contraindications
Acivir DT is contraindicated in patients with a hypersensitivity
to Acyclovir, Valacyclovir or any other component of this
medication.
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Acivir DT Tablets (Generic Acyclovir Tablets)
Storage Instructions
Acivir DT Tablets (Generic Acyclovir Tablets)
have to be stored at controlled room
temperature i.e. from 20°C to 25°C (68°F to
77°F) with excursions permitted between 15°
to 30°C (59° to 86°F).
Keep this as well as all other medicines away
from children and pets.
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Acivir DT Tablets (Generic Acyclovir Tablets)
Warnings
This medicine may rarely make you dizzy or drowsy. Do not drive, use
machinery, or do any activity that requires alertness until you are sure you
can perform such activities safely. Limit alcoholic beverages.
Before using this medicine, inform your doctor or pharmacist your medical
history, especially of: kidney problems, conditions related to a weakened
immune system (such as HIV disease, bone marrow transplant, kidney
transplant).
Older adults can be more sensitive to the side effects of this medicine,
especially kidney problems (change in the amount of urine, back/side
pain), dizziness, drowsiness, and mental/mood changes (such as confusion,
hallucinations, loss of consciousness).
Renal failure, in some cases resulting in death, has occurred with Acyclovir
therapy.

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Acivir DT Tablets (Generic Acyclovir Tablets)
Warnings
Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome
(TTP/HUS), which has resulted in death, has occurred in
immunocompromised patients receiving treatment with Acyclovir.
Hydration status: Care should be taken to maintain adequate hydration in
patients receiving high oral doses of aciclovir. The risk of renal impairment
is increased by use with other nephrotoxic drugs.

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Acivir DT Tablets (Generic Acyclovir Tablets)
Acivir DT Side Effects
Short-Term Administration: The most frequent side effects reported during clinical
trials of treatment of genital herpes with Acyclovir 200 mg (Acivir DT tablets)
administered orally five times daily every 4 hours for 10 days were nausea and/or
vomiting in 8 of 298 patient treatments (2.7%). Nausea and/or vomiting occurred
in 2 of 287 (0.7%) patients who received placebo.
Long-Term Administration: The most frequent side effects reported in a clinical
trial for the prevention of recurrences with continuous administration of 400 mg
(two 200 mg capsules) Acyclovir (Acivir DT tablets) two times daily for 1 year in
586 patients treated with aciclovir were nausea (4.8%) and diarrhoea (2.4%). The
589 control patients receiving intermittent treatment of recurrences with aciclovir
for 1 year reported diarrhoea (2.7%), nausea (2.4%) and headache (2.2%).
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Acivir DT Tablets (Generic Acyclovir Tablets)
Side Effects
The following events have been identified during post-approval use of Acyclovir
(Acivir DT tablets).
General: Anaphylaxis, angio-oedema, fever, headache, pain, peripheral oedema.
Nervous: Aggressive behaviour, agitation, ataxia, coma, confusion, decreased
consciousness, delirium, dizziness, dysarthria, encephalopathy, hallucinations,
paraesthesia, psychosis, seizure, somnolence, tremors. These symptoms may be
marked, particularly in older adults or in patients with renal impairment.
Digestive:Diarrhoea , gastrointestinal distress, nausea.
Haematologic and Lymphatic: Anaemia, leucocytoclastic vasculitis, leucopenia,
lymphadenopathy, thrombocytopenia.
Hepatobiliary Tract and Pancreas: Elevated liver function tests, hepatitis,
hyperbilirubinaemia, jaundice.
Musculoskeletal: Myalgia.
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Acivir DT Tablets (Generic Acyclovir Tablets)
Side Effects
The following events have been identified during post-approval use of
Acyclovir (Acivir DT tablets).
Skin: Alopecia, erythema multiforme, photosensitive rash, pruritus, rash,
Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria.
Special Senses: Visual abnormalities.
Urogenital: Renal failure, renal pain (may be associated with renal
failure), elevated blood urea nitrogen, elevated creatinine, haematuria.
Respiratory: Dyspnoea
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Acivir DT Tablets (Generic Acyclovir Tablets)
Acivir DT Tablets Overdose
Patients have ingested overdoses of up to 20 g Acyclovir on a single
occasion, usually without toxic effects. Accidental, repeated overdoses of
oral Acyclovir over several days have been associated with
gastrointestinal effects (such as nausea and vomiting) and neurological
effects (headache and confusion). Overdosage of IV Acyclovir has
resulted in elevations of serum creatinine, blood urea nitrogen and
subsequent renal failure.
Neurological effects including confusion, hallucinations, agitation,
seizures and coma have been described in association with intravenous
overdosage.
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Acivir DT Tablets (Generic Acyclovir Tablets)
Treatment of Acivir DT Tablets Overdose
Patients should be observed closely for signs of toxicity. Haemodialysis
significantly enhances the removal of Acyclovir (Acivir DT tablets)
from the blood and may, therefore, be considered a management
option in the event of symptomatic overdose.
Treatment is symptomatic and supportive.
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Acivir DT Tablets (Generic Acyclovir Tablets)
Acivir DT Tablets During Pregnancy
Acyclovir (Acivir DT tablets) has been classified by the US
FDA as Pregnancy Category B.
There are no adequate and well-controlled studies done in
pregnant women.
Aciclovir (Acivir DT) can be used during pregnancy only
if the potential benefit justifies the potential risk to the
foetus.
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Acivir DT Tablets (Generic Acyclovir Tablets)
For more details on
Acivir DT Tablets click here
Acivir DT Tablets (Generic Acyclovir Tablets) by Cipla
Limited, India.
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