This document discusses the application of damage control surgery principles from trauma surgery to non-traumatic abdominal emergencies. Damage control surgery involves abbreviated laparotomy to control hemorrhage or contamination, followed by physiological resuscitation and delayed definitive repair. While evidence is limited to retrospective case series, damage control surgery is increasingly used for conditions like uncontrolled bleeding, sepsis, and mesenteric ischemia. It facilitates life-saving intervention for critically ill patients and allows physiological restoration before definitive repair. The benefits depend on careful patient selection and application of a staged surgical approach when patients present with physiological derangement from hemorrhagic or septic shock.
Colonoscopic localisation accuracy for colorectal resectionsDamian Ianno
The Australasian Students’ Surgical Conference (ASSC) is the leading surgical conference for medical students in Australia and New Zealand. ASSC is designed to coincide yearly with the RACS Annual Scientific Conference and was held this year in Perth, Western Australia from 1-3 May 2015.
Enhanced Recovery after Surgery its relevance - Evidence BasedDeep Goel
Enhanced recovery programs are evidence-based protocols designed to standardize medical care, improve outcomes, and lower health care costs. These protocols include evidence-based techniques to minimize surgical trauma and postoperative pain, reduce complications, improve outcomes, and decrease hospital length of stay, while expediting recovery following elective procedures.Protocols have been developed for colorectal surgery patients to reduce physiological stress and postoperative organ dysfunction through optimization of perioperative care and recovery
Colonoscopic localisation accuracy for colorectal resectionsDamian Ianno
The Australasian Students’ Surgical Conference (ASSC) is the leading surgical conference for medical students in Australia and New Zealand. ASSC is designed to coincide yearly with the RACS Annual Scientific Conference and was held this year in Perth, Western Australia from 1-3 May 2015.
Enhanced Recovery after Surgery its relevance - Evidence BasedDeep Goel
Enhanced recovery programs are evidence-based protocols designed to standardize medical care, improve outcomes, and lower health care costs. These protocols include evidence-based techniques to minimize surgical trauma and postoperative pain, reduce complications, improve outcomes, and decrease hospital length of stay, while expediting recovery following elective procedures.Protocols have been developed for colorectal surgery patients to reduce physiological stress and postoperative organ dysfunction through optimization of perioperative care and recovery
Hirschsprung’s disease in adults: Clinical and therapeutic featuresPremier Publishers
Hirschsprung’s disease (HD) is rare in adults and it is thus often undiagnosed or misdiagnosed. Through this series of 12 patients we try to study the clinical characteristics of this pathology, to define its diagnostic clues and to assess the different therapeutic approaches.
Definitive diagnosis is established on histology of specimens from the rectum and colon. The disease involved the rectum and the sigmoid colon in 2 patients and was confined to the rectum, in the 10 others.
Treatment was in all cases surgical consisting of recto-colic resection associated with coloanal anastomosis and a protective right lateral ileostomy.
We conclude that Hirschsprung’s disease is rare in adults but by no means exceptional. It should be considered in young adults with a history of chronic constipation. Diagnosis is first of all clinical. When barium enema appearances are pathognomonic we needn’t resort to histology to confirm the diagnosis. Anorectal manometry does not usually show RAIR. Current primary treatment of HD diagnosed in adults consists mainly of surgical resection.
Enhanced recovery care pathways: a better journey for patients seven days a week and a better deal for the NHS - presentation from the Health and Care Innovation Expo 2014 - Sue Cottle, Amy Kerr and Neil Betteridge
Regional Anesthesia and Bundled Payments – Opioid-sparing Pain Management for...Wellbe
Speaker: Sonia Szlyk, MD, Director of Regional Anesthesia, Mid-Atlantic Division, North American Partners in Anesthesia
This webinar will:
-Discuss Enhanced Recovery After Surgery (ERAS) protocols for joint replacement
-Review the positive impact of regional anesthesia throughout the episode of care
-Spotlight the key components of successful value-based orthopedic care – length of stay, discharge to home, patient and surgeon satisfaction
About the Speaker:
Sonia Szlyk, MD, is the Director of Regional Anesthesia for North American Partners in Anesthesia’s Mid-Atlantic division. Dr. Szlyk orchestrates an outcomes-based regional anesthesia service focused on patient and surgeon satisfaction, safety, and efficiency. She oversees regional anesthesia quality metrics, billing compliance, strategic growth, and education. Dr. Szlyk specializes in opioid-sparing ERAS protocols for joint replacement, sports medicine, colorectal, general, and cosmetic surgery. Her initiatives highlight the value of regional anesthesia in the evolving era of bundled payments.
Dr. Szlyk served as the Director of Regional Anesthesia at the Ambulatory Surgery Center of Bethesda, MD where she oversaw the design and implementation of anesthesia services as well as AAAHC accreditation. The center’s comprehensive pain management program included ultrasound-guided peripheral nerve blocks and catheters for outpatient knee and hip replacements, and sports medicine procedures.
Dr. Szlyk is a board-certified anesthesiologist. She completed medical school and anesthesia residency at the George Washington University School of Medicine and was a Clinical Instructor in regional anesthesia at Stanford University Hospital.
Non-operative Treatment Compared to Surgery in the Management of Uncomplicate...asclepiuspdfs
Purposes: We are aiming to investigate the safety and efficacy of the non-operative treatment (NOT) for the management of acute appendicitis (AA), to avoid the risk of unnecessary surgery. Methods: The study includes 400 consecutive patients who were diagnosed as AA. The study involved patients with symptoms <72 h and the first attack of AA. Patients divided into two equal groups using the “alternation” method. In the first group, patients were hospitalized and received medical treatment, while in the second group, appendectomy was done. After discharge, follow-up was done in all cases for 2 years. Data collected and statistically analyzed.
Presentation from the Enhanced Recovery Summit 2012 by Professor Henrik Kehlet
Enhanced recovery - future developments and transferability into acute medicine
Incidence of VTE in the First Postoperative 24 Hours after Abdominopelvic Sur...semualkaira
A good number of research reports the incidence of postoperative venous thromboembolism (VTE) mostly looks at longer postoperative duration, usually days after surgery.
Hirschsprung’s disease in adults: Clinical and therapeutic featuresPremier Publishers
Hirschsprung’s disease (HD) is rare in adults and it is thus often undiagnosed or misdiagnosed. Through this series of 12 patients we try to study the clinical characteristics of this pathology, to define its diagnostic clues and to assess the different therapeutic approaches.
Definitive diagnosis is established on histology of specimens from the rectum and colon. The disease involved the rectum and the sigmoid colon in 2 patients and was confined to the rectum, in the 10 others.
Treatment was in all cases surgical consisting of recto-colic resection associated with coloanal anastomosis and a protective right lateral ileostomy.
We conclude that Hirschsprung’s disease is rare in adults but by no means exceptional. It should be considered in young adults with a history of chronic constipation. Diagnosis is first of all clinical. When barium enema appearances are pathognomonic we needn’t resort to histology to confirm the diagnosis. Anorectal manometry does not usually show RAIR. Current primary treatment of HD diagnosed in adults consists mainly of surgical resection.
Enhanced recovery care pathways: a better journey for patients seven days a week and a better deal for the NHS - presentation from the Health and Care Innovation Expo 2014 - Sue Cottle, Amy Kerr and Neil Betteridge
Regional Anesthesia and Bundled Payments – Opioid-sparing Pain Management for...Wellbe
Speaker: Sonia Szlyk, MD, Director of Regional Anesthesia, Mid-Atlantic Division, North American Partners in Anesthesia
This webinar will:
-Discuss Enhanced Recovery After Surgery (ERAS) protocols for joint replacement
-Review the positive impact of regional anesthesia throughout the episode of care
-Spotlight the key components of successful value-based orthopedic care – length of stay, discharge to home, patient and surgeon satisfaction
About the Speaker:
Sonia Szlyk, MD, is the Director of Regional Anesthesia for North American Partners in Anesthesia’s Mid-Atlantic division. Dr. Szlyk orchestrates an outcomes-based regional anesthesia service focused on patient and surgeon satisfaction, safety, and efficiency. She oversees regional anesthesia quality metrics, billing compliance, strategic growth, and education. Dr. Szlyk specializes in opioid-sparing ERAS protocols for joint replacement, sports medicine, colorectal, general, and cosmetic surgery. Her initiatives highlight the value of regional anesthesia in the evolving era of bundled payments.
Dr. Szlyk served as the Director of Regional Anesthesia at the Ambulatory Surgery Center of Bethesda, MD where she oversaw the design and implementation of anesthesia services as well as AAAHC accreditation. The center’s comprehensive pain management program included ultrasound-guided peripheral nerve blocks and catheters for outpatient knee and hip replacements, and sports medicine procedures.
Dr. Szlyk is a board-certified anesthesiologist. She completed medical school and anesthesia residency at the George Washington University School of Medicine and was a Clinical Instructor in regional anesthesia at Stanford University Hospital.
Non-operative Treatment Compared to Surgery in the Management of Uncomplicate...asclepiuspdfs
Purposes: We are aiming to investigate the safety and efficacy of the non-operative treatment (NOT) for the management of acute appendicitis (AA), to avoid the risk of unnecessary surgery. Methods: The study includes 400 consecutive patients who were diagnosed as AA. The study involved patients with symptoms <72 h and the first attack of AA. Patients divided into two equal groups using the “alternation” method. In the first group, patients were hospitalized and received medical treatment, while in the second group, appendectomy was done. After discharge, follow-up was done in all cases for 2 years. Data collected and statistically analyzed.
Presentation from the Enhanced Recovery Summit 2012 by Professor Henrik Kehlet
Enhanced recovery - future developments and transferability into acute medicine
Incidence of VTE in the First Postoperative 24 Hours after Abdominopelvic Sur...semualkaira
A good number of research reports the incidence of postoperative venous thromboembolism (VTE) mostly looks at longer postoperative duration, usually days after surgery.
Current Role of Surgery in Endometriosis; Indications and ProgressCrimsonpublisherssmoaj
Endometriosis is a chronic debilitating disease , which affects women of reproductive age group, although medical therapy may be helpful in managing pain associated with Endometriosis or infertility, surgery becomes an integral part of managing this disease .Although initially surgery was limited to l aporotomy associated with ovarian cystectomy and/or TAH with BSO. Laporoscopy gradually replaced that. Though diagnostic laparoscopy is used for confirmation of endometriosis by histological examination, it is not acceptable that Laporoscopy be done in multiple steps, initially to diagnose and later for treatment. Recently a lot of advancement has come in the imaging techniques by which one can combine planning of surgery based on the imaging classification. Deep endometriosis involving bowel, genitourinary tract can be dealt by careful dissection in controlled trained hands, in a well equipped set up to achieve the optimum results .Endometriosis associated infertility may or may not warrant surgery as with multiple studies operation on ovarian endometriomas might land up in reducing ovarian reserve - while doing straight IVF may result in better pregnancy rates ,getting good oocyte retrieval in contrast to poor ovarian reserve resulting from damage to ovarian morphology. Use of laser for ovarian cystectomy helps in getting better outcomes than simple drainage and coagulation procedures. Robotic surgery is the latest addition, which aids in better dissection and management but its problem is its cost, not accessible to many patients and not many trained personnel available.
Information about Fast Track Surgery by Dr. Dhaval Mangukiya
Details of Fast Track Surgery, ERAS, Sir David Cuthbertson, Procedure-Specific fast-track surgery results, Colorectal surgery, Esophageal Resection, Pancreatic Surgery, Liver Surgery, Cochrane Database of Systematic Reveiws, Primary outcomes, Secondary outcomes, and Results
https://drdhavalmangukiya.com/
http://www.youtube.com/c/DrDhavalMangukiyaGastrosurgeonSurat
https://gastrosurgerysurat.blogspot.com/
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay
Medical Management of Chronic Pelvic Pain: The Evidence.Alex Swanton
Chronic pelvic pain (CPP) is a significant problem for both general practitioners in the primary care setting and gynaecologists alike. The incidence of CPP has often been overlooked due, partially, to an inappropriate referral pattern, but also due to the inherent difficulty in correctly diagnosing the condition.
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
The Appendicitis Inflammatory Response Score: A Tool for the
Diagnosis of Acute Appendicitis that Outperforms the Alvarado
Score
Manne Andersson Æ Roland E. Andersson
The Alvarado score for predicting acute
appendicitis: a systematic review
Robert Ohle†
, Fran O’Reilly†
, Kirsty K O’Brien, Tom Fahey and Borislav D Dimitrov
CRISPR-Cas9, a revolutionary gene-editing tool, holds immense potential to reshape medicine, agriculture, and our understanding of life. But like any powerful tool, it comes with ethical considerations.
Unveiling CRISPR: This naturally occurring bacterial defense system (crRNA & Cas9 protein) fights viruses. Scientists repurposed it for precise gene editing (correction, deletion, insertion) by targeting specific DNA sequences.
The Promise: CRISPR offers exciting possibilities:
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Agriculture: Engineering crops resistant to pests and harsh environments.
Research: Studying gene function to unlock new knowledge.
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Off-target Effects: Unintended DNA edits can have unforeseen consequences.
Eugenics: Misusing CRISPR for designer babies raises social and ethical questions.
Equity: High costs could limit access to this potentially life-saving technology.
The Path Forward: Responsible development is crucial:
International Collaboration: Clear guidelines are needed for research and human trials.
Public Education: Open discussions ensure informed decisions about CRISPR.
Prioritize Safety and Ethics: Safety and ethical principles must be paramount.
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The dimensions of healthcare quality refer to various attributes or aspects that define the standard of healthcare services. These dimensions are used to evaluate, measure, and improve the quality of care provided to patients. A comprehensive understanding of these dimensions ensures that healthcare systems can address various aspects of patient care effectively and holistically. Dimensions of Healthcare Quality and Performance of care include the following; Appropriateness, Availability, Competence, Continuity, Effectiveness, Efficiency, Efficacy, Prevention, Respect and Care, Safety as well as Timeliness.
How many patients does case series should have In comparison to case reports.pdfpubrica101
Pubrica’s team of researchers and writers create scientific and medical research articles, which may be important resources for authors and practitioners. Pubrica medical writers assist you in creating and revising the introduction by alerting the reader to gaps in the chosen study subject. Our professionals understand the order in which the hypothesis topic is followed by the broad subject, the issue, and the backdrop.
https://pubrica.com/academy/case-study-or-series/how-many-patients-does-case-series-should-have-in-comparison-to-case-reports/
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Pediatric nurses play a vital role in the health and well-being of children. Their responsibilities are wide-ranging, and their objectives can be categorized into several key areas:
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Objective: Provide comprehensive and compassionate care to infants, children, and adolescents in various healthcare settings (hospitals, clinics, etc.).
This includes tasks like:
Monitoring vital signs and physical condition.
Administering medications and treatments.
Performing procedures as directed by doctors.
Assisting with daily living activities (bathing, feeding).
Providing emotional support and pain management.
2. Health Promotion and Education:
Objective: Promote healthy behaviors and educate children, families, and communities about preventive healthcare.
This includes tasks like:
Administering vaccinations.
Providing education on nutrition, hygiene, and development.
Offering breastfeeding and childbirth support.
Counseling families on safety and injury prevention.
3. Collaboration and Advocacy:
Objective: Collaborate effectively with doctors, social workers, therapists, and other healthcare professionals to ensure coordinated care for children.
Objective: Advocate for the rights and best interests of their patients, especially when children cannot speak for themselves.
This includes tasks like:
Communicating effectively with healthcare teams.
Identifying and addressing potential risks to child welfare.
Educating families about their child's condition and treatment options.
4. Professional Development and Research:
Objective: Stay up-to-date on the latest advancements in pediatric healthcare through continuing education and research.
Objective: Contribute to improving the quality of care for children by participating in research initiatives.
This includes tasks like:
Attending workshops and conferences on pediatric nursing.
Participating in clinical trials related to child health.
Implementing evidence-based practices into their daily routines.
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We understand the unique challenges pickleball players face and are committed to helping you stay healthy and active. In this presentation, we’ll explore the three most common pickleball injuries and provide strategies for prevention and treatment.
1. Review
Damage control surgery for abdominal emergencies
D. G. Weber, C. Bendinelli and Z. J. Balogh
Department of Traumatology, John Hunter Hospital and University of Newcastle, Newcastle, New South Wales, Australia
Correspondence to: Professor Z. J. Balogh, Department of Traumatology, Division of Surgery, John Hunter Hospital and University of Newcastle, Locked
Bag 1, Hunter Region Mail Centre, Newcastle, New South Wales 2310, Australia (e-mail: zsolt.balogh@hnehealth.nsw.gov.au)
Background: Damage control surgery is a management sequence initiated to reduce the risk of death
in severely injured patients presenting with physiological derangement. Damage control principles have
emerged as an approach in non-trauma abdominal emergencies in order to reduce mortality compared
with primary definitive surgery.
Methods: A PubMed/MEDLINE literature review was conducted of data available over the past decade
(up to August 2013) to gain information on current understanding of damage control surgery for
abdominal surgical emergencies. Future directions for research are discussed.
Results: Damage control surgery facilitates a strategy for life-saving intervention for critically ill
patients by abbreviated laparotomy with subsequent reoperation for delayed definitive repair after
physiological resuscitation. The six-phase strategy (including damage control resuscitation in phase
0) is similar to that for severely injured patients, although non-trauma indications include shock from
uncontrolled haemorrhage or sepsis. Minimal evidence exists to validate the benefit of damage control
surgery in general surgical abdominal emergencies. The collective published experience over the past
decade is limited to 16 studies including a total of 455 (range 3–99) patients, of which the majority are
retrospective case series. However, the concept has widespread acceptance by emergency surgeons, and
appears a logical extension from pathophysiological principles in trauma to haemorrhage and sepsis.
The benefits of this strategy depend on careful patient selection. Damage control surgery has been
performed for a wide range of indications, but most frequently for uncontrolled bleeding during elective
surgery, haemorrhage from complicated gastroduodenal ulcer disease, generalized peritonitis, acute
mesenteric ischaemia and other sources of intra-abdominal sepsis.
Conclusion: Damage control surgery is employed in a wide range of abdominal emergencies and is an
increasingly recognized life-saving tactic in emergency surgery performed on physiologically deranged
patients.
Paper accepted 27 September 2013
Published online 25 November 2013 in Wiley Online Library (www.bjs.co.uk). DOI: 10.1002/bjs.9360
Introduction
During the past two decades, damage control surgery has
become the standard of care in the treatment of injured
patients with severe physiological compromise who require
surgical intervention1–3
. Damage control is not a surgical
manoeuvre but an alternative treatment mode to primary
definitive surgical care. The principles of damage control
surgery in trauma care include abbreviated surgery to
control blood loss and contamination in the abdomen,
simultaneous resuscitation of physiology, and definitive
surgical management at a later stage after restoration of
the physiology4,5. This approach resulted in improved
survival of critically injured and shocked patients based on
retrospective case series and when compared with historical
controls6–9
. Acute-care/emergency general surgeons who
regularly practise damage control surgery in injured
patients have applied these principles to severely ill surgical
patients in the non-trauma setting1,2,10,11. This review
summarizes the damage control concept and presents the
current evidence to support the extension of its principles
in non-traumatic abdominal emergencies.
Methods
A literature review was conducted to present the current
understanding of damage control surgery, with a focus
on the applicability of this strategy in patients with
non-traumatic abdominal emergencies. A comprehensive
search was undertaken of PubMed, MEDLINE and
2013 BJS Society Ltd BJS 2014; 101: e109–e118
Published by John Wiley & Sons Ltd
2. e110 D. G. Weber, C. Bendinelli and Z. J. Balogh
Embase, using the following keywords: damage control,
general surgery, acute care surgery and emergency surgery.
Articles were screened by title and abstract to identify
papers reporting clinical experiences of applying damage
control surgery in non-trauma, emergency general surgery.
Reference lists of identified articles were searched to
identify further articles of interest. Acute physiological
derangement was a necessary component in the definition
of damage control surgery.
Developing the rationale from trauma surgery
to emergency general surgery
Primary definitive repair of severe injuries in patients
with deranged physiology is detrimental to outcome1–5,10
.
Where surgery is unavoidable, damage control surgery,
with rapid haemorrhage and contamination control, and
without further major tissue injury or delay, makes it
possible to correct the physiology and save some of
the most critically injured patients1–5,10. The phases
of damage control surgery are defined by five steps
(Table 1): first, identification of the ill patient based on
injury pattern (or underlying disease) and pathophysiology;
second, abbreviated surgery to control bleeding and
contamination; third, reassessment of the parameters while
the patient is still on the operating table; fourth, continued
restoration of the physiology in the intensive care unit; and,
finally, definitive surgical repair5
. This staged management
prevents the physiological exhaustion of the traumatic
shock and allows definitive reconstruction with the patient
in a more favourable physiological condition.
The damage control concept has been transferred
to patients undergoing emergency general surgery for
non-traumatic abdominal conditions by trauma surgeons
also practising in acute general surgery1,2,10,11. However,
there are significant differences between the physiological
insults experienced by these two patient populations.
In trauma, the pathophysiology is traumatic shock (the
combination of tissue injury and haemorrhagic shock),
whereas in emergency general surgery the shock is
typically either haemorrhagic (without tissue injury)
or septic (from perforation and/or obstruction of the
gastrointestinal tract, with or without abdominal organ
ischaemia/necrosis). This extension of the damage control
strategy to abdominal emergencies has been a relatively
intuitive next step for the general surgeon, who is
frequently treating both types of patient. The application
to general surgical abdominal emergencies instinctively
acknowledges that many critically ill general surgical
patients do better with a staged approach to surgical
care overarched by modern critical and intensive care
management1,2,10,12,13
.
Application of damage control surgery
to abdominal emergencies
Only level III and IV data exist to establish the role of
damage control surgery in abdominal general surgical
emergencies14–29
. Studies identified by the literature
review are presented in Table 2; case reports are not
included. In spite of the minimal, published, direct
Table 1 Phases of damage control for trauma and abdominal emergencies
Non-traumatic abdominal emergencies
Trauma surgery Haemorrhagic shock Septic shock
Phase 0 Initiation of goal-directed haemostatic
resuscitation without delaying surgery
Initiation of goal-directed haemostatic
resuscitation without delaying surgery
Preoperative resuscitation with fluids and
vasoconstrictors
Hypothermia correction
Antibiotic administration
Phase 1 Identification of the patient: Identification of the patient: Identification of the patient:
Injury pattern Pathology Pathology
Physiology Physiology Physiology
Phase 2 Control haemorrhage
Control contamination
Control haemorrhage Decontamination
Sepsis source control
Phase 3 Reassessment during surgery Reassessment during surgery Reassessment during surgery
Phase 4 Physiological restoration in intensive care
Optimization of haemodynamics
Correction of acidosis, hypothermia and
coagulopathy
Optimization and support of vital organs
Physiological restoration in intensive care
Optimization of haemodynamics
Correction of acidosis, hypothermia and
coagulopathy
Optimization and support of vital organs
Physiological restoration in intensive care
Optimization of haemodynamics
Correction of acidosis, hypothermia and
coagulopathy
Optimization and support of vital organs
Specific antibiotic therapy based on
resistance
Phase 5 Definitive repair
Abdominal wall closure
Definitive repair
Abdominal wall closure
Definitive repair
Abdominal wall closure
2013 BJS Society Ltd www.bjs.co.uk BJS 2014; 101: e109–e118
Published by John Wiley & Sons Ltd
3. Damage control surgery for abdominal emergencies e111
Table 2 Studies reporting on damage control surgery in general surgical abdominal emergencies
Reference Year Study design
Level of
evidence
No. of
patients Pathology (n) Comparison cohort
Finlay et al.14 2004 Prospective
comparative study
III 14 Intra-abdominal sepsis, secondary
visceral perforation (9)
POSSUM
P-POSSUM
Ruptured abdominal aortic aneurysm (3)
Postoperative bleed (1)
Retroperitoneal bleed (1)
Freeman and
Graham15
2005 Retrospective
comparative study
III 3 Acute mesenteric ischaemia Non-randomized
concurrent patients
Banieghbal and
Davies16
2004 Prospective series IV 27 Neonatal generalized necrotizing
enterocolitis
–
Tamijmarane et al.17 2006 Retrospective series IV 25 Complicated elective pancreatic surgery –
Stawicki et al.18 2008 Retrospective
comparative study
III 16 Sepsis (6) APACHE II
Intraoperative bleeding (5) POSSUM
Ischaemia (3)
Necrotizing pancreatitis (2)
Person et al.19 2009 Retrospective
comparative series
III 31 Peritonitis (15) Non-randomized
concurrent patientsMesenteric ischaemia (10)
Bleeding (3)
Obstruction (2)
Other (1)
Ball et al.20 2010 Retrospective series IV 6 Haemorrhage during pancreatic
necrosectomy
–
Filicori et al.21 2010 Retrospective
comparative study
III 8 Intra-abdominal haemorrhage APACHE II
Gong et al.22 2010 Retrospective series IV 15 Acute mesenteric ischaemia –
Morgan et al.23 2010 Retrospective series IV 8 Complicated elective pancreatic
resections
–
Intraoperative haemorrhage (4)
Sepsis at reoperation (2)
Haemorrhage at reoperation (2)
Perathoner et al.24 2010 Prospective
comparative series
III 9 Complicated diverticulitis Non-randomized
concurrent patients
Subramanian et al.25 2010 Retrospective series IV 88 Planned relook (32)* –
Abdominal compartment syndrome (26)
Contamination (29)
Necrotizing fasciitis (15)
Ischaemic bowel (14)
Haemodynamic instability (10)
Tadlock et al.26 2010 Retrospective
comparative series
III 13 Ruptured abdominal aortic aneurysm Non-randomized
concurrent patients
Kafka-Ritsch et al.27 2012 Prospective series IV 51 Perforated diverticulitis –
Khan et al.28 2013 Retrospective series IV 42 Bowel ischaemia (13) –
Haemorrhage (13)
Peritonitis (10)
Physiological instability (6)
Goussous et al.29 2013 Retrospective series IV 99 Bowel ischaemia (25) –
Bowel perforation (21)
Haemorrhage (15)
Anastomotic leak (10)
Abdominal compartment syndrome (7)
Incarcerated hernia (6)
Ruptured abdominal aortic aneurysm (5)
Enterocutaneous fistula (3)
Necrotizing pancreatitis (2)
Necrotizing fasciitis (2)
Other (3)
*Several patients had multiple indications. POSSUM, Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity;
P-POSSUM, Portsmouth predictor equation for POSSUM; APACHE, Acute Physiology And Chronic Health Evaluation.
2013 BJS Society Ltd www.bjs.co.uk BJS 2014; 101: e109–e118
Published by John Wiley & Sons Ltd
4. e112 D. G. Weber, C. Bendinelli and Z. J. Balogh
0
1990
1991
1992
1993
1994
1995
1996
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
5
10
15
20
25
30
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40
45 Trauma surgery
Non-traumatic abdominal emergencies
No.ofarticles
Fig. 1 Articles with ‘damage control’ in the title by year of publication
evidence to substantiate this application of damage
control to the non-trauma setting, the concept has been
promulgated widely by acceptance in recent reviews and
editorials1,10,11,30,31.
Three case series14,18,21
compared the observed out-
comes in patients receiving damage control surgery with
those predicted by outcome prediction scores (Acute Phys-
iology And Chronic Health Evaluation (APACHE) II; and
Physiological and Operative Severity Score for the enU-
meration of Mortality and morbidity (POSSUM)). The
total of 38 patients reported in these three studies showed
a lower than predicted mortality, and in one series14 this
observation achieved statistical significance. The patholo-
gies undergoing a damage control treatment strategy
comprised a mixture of septic and haemorrhagic shock,
including gastrointestinal perforations, bowel ischaemia,
intraoperative and postoperative bleeding in elective
operations, and emergency ruptured aortic aneurysms
(Table 2).
Given the largely retrospective nature of these studies,
discrepancies in definitions of damage control strategies,
and poor documentation of the extent of physiological
derangement, as well as almost certain publication bias
favouring a positive outcome from damage control, these
data can be used only cautiously to advocate damage
control strategies in general surgery. Regardless of
their limitations, the general trend towards adoption of
damage control strategies for abdominal general surgical
emergencies is similar to that in the literature reporting
damage control experiences in trauma surgery during
the early 1990s, at the time of its spread into routine
practice (Fig. 1).
Application to intra-abdominal bleeding or
severe sepsis
Despite the lack of high-level evidence, the translation
of damage control principles for abdominal emergencies
is straightforward in terms of practical application. The
same five phases of response (Table 1) may be used
to standardize the surgical strategies, although slightly
different approaches are proposed depending on the type
of shock and abdominal pathology when either bleeding or
sepsis is the main problem. An additional phase (phase 0)
has been included to relay the importance of preoperative
resuscitation – this represents so-called ‘damage control
resuscitation’.
For haemorrhagic shock, the process is essentially the
same as in trauma. Haemorrhage control is paramount and
cannot wait. In these patients, the lack of major generalized
tissue injury in association with a usually well defined,
single area of bleeding provides a tempting opportunity
for primary definitive care; however, if the patient is
already injured physiologically (acidotic, hypothermic
and/or coagulopathic), a staged approach appears safer.
This is of particular relevance when vascular control
has been associated with intestinal ischaemia–reperfusion
injury, and/or vascular repair requires cross-clamping of
major vessels with resulting tissue ischaemia.
For septic shock, the clinical presentation and inflam-
matory aetiology of the shock is fundamentally different
from that of traumatic or haemorrhagic shock. There
is growing evidence that these patients benefit from a
period of resuscitation before surgical intervention and
sepsis source control4,13,31–34. The damage control pro-
cedure is thereby delayed for a short period until cardiac
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5. Damage control surgery for abdominal emergencies e113
contractility, preload and afterload are optimized, intravas-
cular volume is restored, and broad-spectrum antibiotics
are administered. To achieve these goals, this initial resusci-
tation phase should utilize goal-directed methods to guide
treatment33,34
. Central venous pressure, mean arterial pres-
sure, urine output and central or mixed venous oxygen
saturations are measured, and acted on in real time to
titrate crystalloid boluses for intravascular volume resus-
citation, and vasopressor dosing. This resuscitation phase
is complex, invasive and resource intensive, and is typi-
cally conducted in an intensive care environment. To assist
clinicians in various aspects of treatment, the different
components of this resuscitation phase may be grouped
together as bundles, as advocated by the Surviving Sepsis
Campaign33
. These protocolized treatment bundles min-
imize omission of critical therapies during busy clinical
resuscitations. Use of such modern resuscitative strategies
may decrease the frequency of circulatory collapse during
surgery, and further contribute to improved outcomes13,32.
Patient selection
Correct patient selection is crucial for the benefit from
a damage control strategy to be maximized; not applying
the strategy to critically ill patients will increase their risk
of death, although its overuse will expose patients to the
risks of multiple operations, open abdomen management
and prolonged intensive care stay, negating the potential
benefits of the concept1,3
. Recent investigation35
has
demonstrated the potential for harm if the damage control
strategy is overused. Fewer than 30 per cent of civilian
trauma laparotomies typically benefit from a damage
control strategy in modern trauma surgery, although this
number varies greatly depending on the mechanism of
injury and population affected1,3,35. The authors estimate
that an even lower number, perhaps not more than a
few per cent, of all non-traumatic abdominal emergencies
would benefit from this strategy. This prediction reflects
the fact that most of these abdominal emergencies will
not reach the critical level of physiological compromise at
which a damage control strategy is indicated. Insufficient
data exist to define the precise incidence accurately.
Although selection of the right patient for the right
treatment (damage control versus primary definitive
surgery) is critical, it is important to highlight that these
treatment modes may be interchanged depending on the
improvement or deterioration of the patient’s condition
and should not be followed rigidly once indicated; constant
re-evaluation is essential.
The indications for damage control surgery in trauma
scenarios may be grouped as: patient factors (compromised
Table 3 Factors to consider for damage control strategy in
abdominal emergencies
Patient factors Medical and surgical history
Concurrent illness
Medication
Injury/disease factors Nature of pathology
Severity of pathology
Expected natural history
Physiological factors Hypothermia
Coagulopathy
Organ dysfunction
Haemodynamic instability
Severity of inflammation/sepsis
Treatment factors Magnitude and quality of resuscitation
Duration and physiological effect of surgery
Magnitude of definitive surgery
physiological reserve owing to co-morbidities, anticoag-
ulation, etc.); local/general injury severity/pattern (blunt
polytrauma, multiple penetrating torso trauma, severe con-
tamination, major bleeding sources in other regions); phys-
iological parameters (hypothermia, acidosis, coagulopathy,
early organ dysfunction); and treatment/iatrogenic fac-
tors (magnitude and quality of resuscitation, time spent in
surgery, requirement for major vessel cross-clamping)1–5
.
None of these indications is absolute in isolation, but
many of them tend to present simultaneously to identify
the physiologically compromised severely injured patient.
These four categories can be well applied to general sur-
gical catastrophes (Table 3), where patient factors, such as
co-morbidities, are frequently more dominant in decision-
making than in injured patients. The disease type (malig-
nancy, inflammatory disease, etc.) can be varied and the
local pathology can be due to processes of varying aetiology.
Specific trigger points to indicate damage control
surgery for injured patients have been published2
,
but validated variably. Similar trigger points may be
used for non-traumatic abdominal emergencies31
, such
as hypothermia (temperature below 35◦
C), metabolic
acidosis (pH less than 7·20, base excess below −8·0), or
a demonstrable coagulopathy, to name a few. However,
there are insufficient published data to validate these
parameters in absolute terms, or currently to establish
clinical rules. This difficult situation is further complicated
by the variable time frame of presentation (particularly
in the case of septic shock), and by the great diversity in
the pathologies and types of shock causing non-traumatic
abdominal emergency. Therefore, until further research
becomes available, the correct patient selection for damage
control surgery in non-traumatic abdominal emergencies
will remain a complex, multifactorial decision, representing
a critical clinical challenge that calls on the judgement of
the treating clinician and team. Challengingly, the correct
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6. e114 D. G. Weber, C. Bendinelli and Z. J. Balogh
decision may vary in identical patients, but who have been
resuscitated or are being operated on by different teams.
Open abdomen after emergency surgery
Laparostomy was described intermittently in the surgical
literature during the last century. However, this idea
was not discussed widely until the late 1980s, when
larger case series reporting survival benefits from this
technique in patients with severe abdominal sepsis became
available36–39
. Before this, surgical techniques focused
on mass closure of the tense abdomen, with multiple
drains in the peritoneal recesses, and tension sutures in
the abdominal wall. This strategy can lead to abdominal
compartment syndrome, a fatal condition in critically ill
and injured patients34,40–43
.
The laparostomy forms an integral step in most patients
with abdominal trauma managed by a damage control
strategy1–5. This should be the same in abdominal general
surgical catastrophes34,40–43
. Tissue inflammation may
directly preclude a definitive closure without tension
and a resulting abdominal compartment syndrome.
Furthermore, the evolving inflammatory process places
these patients at high risk of developing abdominal
compartment syndrome during the next days42,43. The
actual incidence of abdominal compartment syndrome in
current practice is difficult to define owing to the absence
of recent published cohorts. However, the incidence has
reduced markedly since the late 1990s (when up to
15 per cent of trauma intensive care admissions were
diagnosed with the condition). This is likely to be the
result of advances in modern damage control resuscitation
strategies. Even so, injured and acute surgical patients
admitted to intensive care remain at risk44,45
.
The high morbidity and mortality rates associated
with an abdominal compartment syndrome43,45 suggest
that a low threshold should be applied to pre-empt
this complication, leaving an abdomen open to avoid
the syndrome altogether. The practical aspects of easy
abdominal re-entry required in staged operations serve
further to make this practice attractive. However, damage
control surgery does not equate to, or mandate, a
laparostomy. The frequent association exists owing to the
positive correlation between this surgical strategy and the
presence or risk of abdominal compartment syndrome44
.
To decide which patients will benefit from a laparostomy
requires the same clinical judgement as that used to
identify patients who may benefit from the damage
control strategy in the first place. The strategy should
be applied to the patients at highest risk of abdominal
compartment syndrome. Unfortunately, there is little other
direct evidence to guide this decision. Individual patient
factors, the degree of tissue injury from the haemorrhagic
and/or septic shock, the nature of the pathology (such
as severe acute pancreatitis or visceral obstruction), the
severity of the physiological effects, and the quality of the
resuscitation and treatment, are all critical determinants of
the overall risk44,45
. Further research is required to guide
this difficult decision.
Several medical appliances are now available to allow
effective and efficient temporary abdominal closure. These
devices provide relatively straightforward control of the
laparostomy wound between procedures. Apart from
facilitating reopening, they aim to protect the abdominal
contents from the external environment (minimizing
bacterial contamination, heat exchange and evaporation),
drain the abdominal cavity, minimize acute adhesions
between the intestine and the abdominal wall, and prevent
the development of abdominal compartment syndrome41
.
Major complications linked to the management of
an open abdomen are infection, fistula formation and
failure to obtain fascial closure34,40,46,47
. All of these
complications are challenging to prevent and manage.
Potentially they may be minimized by judicious intravenous
fluid management, early enteral nutrition, strategically
planned returns to theatre, and dynamic and continuous
tension on the fascial layers45.
Damage control in abdominal haemorrhagic
shock
Bleeding duodenal/gastric ulcer
Endoscopic control of bleeding ulcers has minimized the
role of laparotomy; in only a minority of these patients does
endoluminal treatment fail, necessitating a duodenotomy
for gastroduodenal artery ligature or gastric resection48,49
.
Some patients in this subgroup have experienced a large
physiological insult owing to protracted haemorrhagic
shock. These patients are typically acidotic, hypothermic
and coagulopathic, and it is in these situations that a
damage control strategy is recommended. The aim at
this initial operation is only to stop the bleeding: by
direct suture, by resection, or even by direct packing on
the luminal surface. An extensive surgical reconstruction
should not be attempted, but instead deferred until
after a period of resuscitation. The abdomen may be
left open temporarily to avoid abdominal compartment
syndrome, and facilitate re-exploration, if required. The
definitive anatomical restoration and abdominal closure
may then be performed when the patient’s physiology
has normalized, usually not later than 48 h after initial
surgery50
.
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7. Damage control surgery for abdominal emergencies e115
Uncontrollable venous bleeding during pancreatic
surgery
Accidental injury to the portal or retroperitoneal venous
structures during elective pancreaticoduodenectomy is
difficult to control surgically, and is associated with a
high mortality rate20,23
. Initial control is best achieved
with local compression. From an anatomical perspective
alone, the ideal repair is facilitated by rapid division
of the pancreas, adequate exposure with proximal and
distal control, and a primary repair or interposition
graft. However, the operation should shift from the
elective approach to a damage control strategy as the
patient’s physiology will rapidly deteriorate from this
insult. As a damage control alternative to the definitive
repair suggested above, the venous bleeding may be
packed, or controlled by direct ligation. Both of these
strategies have been reported successfully in the recent
literature20,23. Furthermore, the elective procedure is then
aborted, and anatomical reconstruction deferred until a
subsequent laparotomy is performed, after physiological
stabilization and resuscitation. Enteric and vascular
continuity may be established days later. The bowel
oedema secondary to acute portal hypertension can cause
abdominal compartment syndrome, emphasizing the role
of open abdomen with a temporary abdominal closure.
Damage control for severe abdominal sepsis
Gastrointestinal perforation with generalized
peritonitis
Prompt diagnosis of gastrointestinal perforation usually
allows definitive surgery, aimed at primary repair or resec-
tion of the pathology and final closure of the abdominal
wall13,31,49. However, in the most severe instances, when
generalized peritonitis and septic shock dominate the clin-
ical phenotype, the patient’s compromised physiology may
preclude a safe primary definitive surgical strategy31
. An
anastomosis or large anatomical reconstruction performed
in this clinical situation would probably fail owing to
the severe physiological compromise. Furthermore, it is
unlikely that this failure would be tolerated in this already
critical situation. In these extreme situations, the patient
may benefit from a damage control strategy.
The patient is brought to the operating theatre after
appropriate, intensive, goal-directed resuscitation and
administration of broad-spectrum antibiotics, as standard-
ized by the Surviving Sepsis Campaign33
. Once in theatre,
the aim of the damage control procedure is to control the
source of the sepsis; the anatomical reconstruction and
abdominal closure are a secondary goal, and are deferred to
the secondary procedure after physiological normalization.
The precise technical procedure used to achieve source
control of the sepsis will vary greatly depending on
the situation and pathology encountered. For example,
if faeculent peritonitis has developed from perforated
sigmoid diverticulitis in a severely shocked individual, the
patient may best be served by peritoneal lavage and tran-
section of the immediate upstream descending colon, with
a view to delaying the definitive resection and/or recon-
struction (with or without stoma) until after physiological
normalization. On the other hand, if a small duodenal
ulcer is the source of sepsis, a definitive suture repair with
omental patch may be adequate49
. The intraoperative
pathological findings need to be incorporated into the
intraoperative reassessment of whether or not to continue
with the damage control strategy. It should be noted that
peritoneal contamination by itself is not an indication for
a planned relook/debridement, and an on-demand relook
laparotomy strategy should be used instead40
. The need
for, and role of, a damage control strategy is dependent on
the primary pathology and its physiological manifestations.
Damage control procedures for acute diverticulitis have
been reported successfully by several authors24,27,31
.
The abdomen is typically left open to avoid abdominal
compartment syndrome, and to facilitate a non-traumatic
re-entry. However, as discussed above, the reduced
incidence of this syndrome, in association with modern
resuscitation practices, may make this step less important in
the future.
Acute mesenteric ischaemia
Among the abdominal surgical catastrophes, acute mesen-
teric ischemia has one of the highest rates of misdiagnosis
owing to its often non-specific clinical presentation and
frequently inconclusive investigation findings51,52
. The
possible delays in diagnosis compound the already severe
physiological insult associated with the primary pathology.
The treatment involves resection of infarcted bowel and
revascularization. Because of the deranged physiology, a
long procedure with vascular repair and immediate bowel
resection is not advisable; a staged procedure adhering to
damage control principles is recommended15
. At the first
laparotomy, gangrenous bowel is resected, with the ends
stapled off, and the abdomen closed with a temporary clo-
sure. A diagnostic angiogram is then performed, with the
intention of endovascular reperfusion. Following a period
of resuscitation, the peritoneal cavity is re-explored, with
a view to re-establishing bowel continuity and definitive
closure of the abdominal wall. On occasion more bowel
resection may be required; there may be a need for further
delayed laparotomies15
.
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8. e116 D. G. Weber, C. Bendinelli and Z. J. Balogh
Toxic megacolon
Standard surgical resection of a toxic megacolon is normally
limited to a subtotal colectomy, with the remaining distal
sigmoid colon and rectum left in situ53–55. This approach
evolved as significantly increased mortality was observed
if total proctocolectomy was carried out during the acute
phase of illness. This is a damage control strategy, although
it has not been labelled as such in the colorectal literature;
the subtotal colectomy does not remove the entire diseased
organ or attempt to re-establish gut continuity (this
combination would be a primary, definitive procedure),
but it is sufficient to control the inflammatory stimulus and
arrest the inflammatory cascade that may lead to multiple
organ failure. The remaining colon/rectum may then be
dealt with after recovery from the acute illness, as may the
possible enteric anastomosis.
Acute cholecystitis
The current standard of emergency cholecystectomy for
acute cholecystitis is based largely on experiences from
physiologically normal patients who typically make up the
participants in trials56,57
. However, in the subset of patients
with acute cholecystitis who have associated physiological
compromise, an operative approach is unattractive owing
to the additional stress associated with the procedure.
A percutaneous cholecystostomy offers an alternative
treatment, which in its widest use of the definition can
be termed a damage control strategy before definitive
repair. This bedside drainage procedure, performed under
local anaesthetic, removes the septic source with minimal
physiological stress to the patient58,59
. Efforts may then
focus on physiological restoration, and definitive surgical
resection of the gallbladder may be deferred to a later date.
Subtotal cholecystectomy may also offer an abbreviated
procedure to minimize the additional physiological stress
of a total cholecystectomy60. However, this operation is
usually performed for severe inflammation encountered
unexpectedly about Calot’s triangle, rather than being
required owing to physiological exhaustion of the patient.
By definition, this technique can be considered a damage
control strategy only when undertaken as a result of the
physiological compromise.
Future directions
The clinical applications of damage control principles
are well ahead of the available clinical evidence.
Unfortunately, it is hard to conduct randomized trials
in situations where the accepted practice is already in
place before high-level evidence exists. Thus, the best
way forward may be to categorize patients based on their
physiological derangement (from haemorrhage or sepsis)
and clinical diagnosis category (intestinal obstruction,
perforation, vascular occlusion, etc.) in prospective cohorts.
Observational studies can then generate hypotheses for
groups of patients for whom randomization may be deemed
potentially ethical and feasible, and for which a trial can be
designed. To facilitate this, standardization of terminology
and definitions regarding the clinical syndromes affecting
critically ill patients will be required.
Current understanding of the basic science of septic
shock is incomplete. Recent advances in understanding
the sepsis syndrome, in addition to advances in critical
care, imaging and minimally invasive procedures, have
already altered the clinical phenotype of inflammation from
sepsis. The persistent inflammation–immunosuppression
catabolism syndrome has been proposed recently as the
most common clinical expression of these inflammatory
syndromes in patients who fail to recover from multiple
organ failure in intensive care12.
Trauma surgeons have become the leaders of traumatic
and haemorrhagic shock research in both clinical and
laboratory sciences1,5,12. Emergency general surgeons
should take leadership in surgical sepsis research and
translate that knowledge to everyday clinical practice,
including treatment strategies such as damage control
in abdominal emergencies. The role of damage control
surgery for non-traumatic abdominal emergencies will
continue to evolve as further research into the precise
indications, timing and techniques of resuscitation and
surgery becomes available.
Disclosure
The authors declare no conflict of interest.
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