Inadequate dosing for nephrotoxic or renally cleared drugs in patients with acute kidney injury is common, though recent clinical decision support systems have proven successful in decreasing errors. Within the care provider order entry (CPOE) system, we developed a set of interventions with varying levels of workflow intrusiveness. The interventions alert providers about significant changes in renal function, defined as a 0.5 mg/dl change in serum creatinine, and advise discontinuation or modification of nephrotoxic or renally cleared drugs. Passive alerts appear as persistent text within the CPOE system and on rounding reports, requiring no provider response. More intrusive exit check alerts interrupt the provider at the end of the CPOE session, requiring the provider to modify or discontinue the drug order, assert the current dose as correct, or defer the alert. We evaluated the initial provider response to the interventions, using as our outcomes the resulting actions for alerted orders and the responses selected by providers as required by the exit check alert. Preliminary analysis shows the interventions to be effective in significantly improving provider response to changes in renal function, though initial provider response suggests future enhancements to increase success.