The document summarizes several drug approvals and updates from the FDA in August 2017. Mavyret was approved for treating HCV genotypes 1-6 without cirrhosis or with compensated cirrhosis. Carospir received approval as an oral suspension for heart failure, hypertension, and hepatic edema. Duzallo was approved as a combination of lesinurad and allopurinol for treating gout in patients not at target uric acid levels on allopurinol alone. Vabomere was approved for complicated UTIs caused by designated bacteria. Other notable approvals included Idhifa for AML, Besponsa for ALL, and Benznidazole for Chagas disease in pediatric patients.
Gazyva is a medicine that works with the body’s own immune system to attack blood cells called B-cells that have a certain marker on their surface (CD20). B-cells are the cause of common blood cancers.1,2
Gazyva is FDA-approved for the treatment of people with previously untreated chronic lymphocytic leukemia (CLL) in combination with chlorambucil chemotherapy.3
Phase III clinical data showed that Gazyva plus chlorambucil chemotherapy helped people with CLL live longer without the disease worsening than chlorambucil chemotherapy alone.3
Captopril 25 mg tablets smpc taj pharmaceuticalsTaj Pharma
Captopril Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Captopril Dosage & Rx Info | Captopril Uses, Side Effects -: Indications, Side Effects, Warnings, Captopril - Drug Information - Taj Pharma, Captopril dose Taj pharmaceuticals Captopril interactions, Taj Pharmaceutical Captopril contraindications, Captopril price, Captopril Taj Pharma Captopril 25 mg Tablets.SMPC- Taj Pharma . Stay connected to all updated on Captopril Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Cabazitaxel 60 mg concentrate and solvent for solution for infusion smpc taj...Taj Pharma
CABAZITAXEL - Drug Information - Taj Pharma, CABAZITAXEL dose Taj pharmaceuticals CABAZITAXEL interactions, Taj Pharmaceutical CABAZITAXEL contraindications, CABAZITAXEL price, CABAZITAXEL Taj Pharma Cancer, oncologyCABAZITAXEL 60 mg concentrate and solvent for solution for infusion. SMPC- Taj Pharma . Stay connected to all updated on CABAZITAXEL Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Telbivudine Tablet 600mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Telbivudine Dosage & Rx Info | Telbivudine Uses, Side Effects Telbivudine: Indications, Side Effects, Warnings, Telbivudine -Drug Information –Taj Pharma, Telbivudine dose Taj pharmaceuticals Telbivudine interactions, Taj Pharmaceutical Telbivudine contraindications, Telbivudine price, Telbivudine Taj Pharma Telbivudine SmPC-Taj Pharma Stay connected to all updated on Telbivudine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Gazyva is a medicine that works with the body’s own immune system to attack blood cells called B-cells that have a certain marker on their surface (CD20). B-cells are the cause of common blood cancers.1,2
Gazyva is FDA-approved for the treatment of people with previously untreated chronic lymphocytic leukemia (CLL) in combination with chlorambucil chemotherapy.3
Phase III clinical data showed that Gazyva plus chlorambucil chemotherapy helped people with CLL live longer without the disease worsening than chlorambucil chemotherapy alone.3
Captopril 25 mg tablets smpc taj pharmaceuticalsTaj Pharma
Captopril Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Captopril Dosage & Rx Info | Captopril Uses, Side Effects -: Indications, Side Effects, Warnings, Captopril - Drug Information - Taj Pharma, Captopril dose Taj pharmaceuticals Captopril interactions, Taj Pharmaceutical Captopril contraindications, Captopril price, Captopril Taj Pharma Captopril 25 mg Tablets.SMPC- Taj Pharma . Stay connected to all updated on Captopril Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Cabazitaxel 60 mg concentrate and solvent for solution for infusion smpc taj...Taj Pharma
CABAZITAXEL - Drug Information - Taj Pharma, CABAZITAXEL dose Taj pharmaceuticals CABAZITAXEL interactions, Taj Pharmaceutical CABAZITAXEL contraindications, CABAZITAXEL price, CABAZITAXEL Taj Pharma Cancer, oncologyCABAZITAXEL 60 mg concentrate and solvent for solution for infusion. SMPC- Taj Pharma . Stay connected to all updated on CABAZITAXEL Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Telbivudine Tablet 600mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Telbivudine Dosage & Rx Info | Telbivudine Uses, Side Effects Telbivudine: Indications, Side Effects, Warnings, Telbivudine -Drug Information –Taj Pharma, Telbivudine dose Taj pharmaceuticals Telbivudine interactions, Taj Pharmaceutical Telbivudine contraindications, Telbivudine price, Telbivudine Taj Pharma Telbivudine SmPC-Taj Pharma Stay connected to all updated on Telbivudine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Levosimendan for Injection Taj Pharma SmPCTajPharmaQC
Levosimendan for Injection 12.5mg, 25mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Levosimendan Dosage & Rx Info | Levosimendan Uses, Side Effects Levosimendan: Indications, Side Effects, Warnings, Levosimendan -Drug Information –Taj Pharma, Levosimendan dose Taj pharmaceuticals Levosimendan interactions, Taj Pharmaceutical Levosimendan contraindications, Levosimendan price, Levosimendan Taj Pharma Levosimendan SmPC-Taj Pharma Stay connected to all updated on Levosimendan Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Axitinib 1 mg, 3mg, 5mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
Axitinib - Drug Information - Taj Pharma, Axitinib dose Taj pharmaceuticals Axitinib interactions, Taj Pharmaceutical Axitinib contraindications, Axitinib price, Axitinib Taj Pharma Cancer, oncologyAxitinib 1 mg, 3mg, 5mg, 7mg film-coated tablets SMPC- Taj Pharma . Stay connected to all updated on Axitinib Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Albendazole 400 mg tablets smpc taj pharmaceuticalsTaj Pharma
Albendazole Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Albendazole Dosage & Rx Info | Albendazole Uses, Side Effects -: Indications, Side Effects, Warnings, Albendazole - Drug Information - Taj Pharma, Albendazole dose Taj pharmaceuticals Albendazole interactions, Taj Pharmaceutical Albendazole contraindications, Albendazole price, Albendazole Taj Pharma Albendazole Tablets 400 mg SMPC- Taj Pharma . Stay connected to all updated on Albendazole Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Captopril Tablets SmPC Taj PharmaceuticalsTajPharmaQC
Captopril Tablets USP 25mg, 50mg, 100mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Captopril Dosage & Rx Info | Captopril Uses, Side Effects Captopril: Indications, Side Effects, Warnings, Captopril -Drug Information –Taj Pharma, Captopril dose Taj pharmaceuticals Captopril interactions, Taj Pharmaceutical Captopril contraindications, Captopril price, Captopril Taj Pharma Captopril SmPC- Taj Pharma Stay connected to all updated on Captopril Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Pregabalin SR Capsules Sustained Release 100mg/150mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Pregabalin Dosage & Rx Info | Pregabalin Uses, Side Effects Vecuronium bromide: Indications, Side Effects, Warnings, Pregabalin-Drug Information –Taj Pharma, Pregabalin dose Taj pharmaceuticals Pregabalin interactions, Taj Pharmaceutical Pregabalin contraindications, Pregabalin price, Pregabalin Taj Pharma Pregabalin SmPC-Taj Pharma Stay connected to all updated on Pregabalin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Oxaliplatin for Injection Taj Pharma SmPCTajPharmaQC
Oxaliplatin for Injection 50mg, 100mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Oxaliplatin Dosage & Rx Info | Oxaliplatin Uses, Side Effects Oxaliplatin: Indications, Side Effects, Warnings, Oxaliplatin -Drug Information –Taj Pharma, Oxaliplatin dose Taj pharmaceuticals Oxaliplatin interactions, Taj Pharmaceutical Oxaliplatin contraindications, Oxaliplatin price, Oxaliplatin Taj Pharma Oxaliplatin SmPC-Taj Pharma Stay connected to all updated on Oxaliplatin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Chloroquine phosphate 250 mg tablets smpc taj pharmaceuticalsTaj Pharma
Chloroquine phosphate 250 mg Tablets SMPC: Indications, Side Effects, Warnings, Chloroquinen - Drug Information - Taj Pharma, Chloroquinen dose Taj pharmaceuticals Chloroquinen interactions, Taj Pharmaceutical Chloroquinen contraindications, Chloroquinen price, Chloroquinen , Taj Pharma Chloroquine phosphate 250 mg Tablets SMPC - Taj Pharma . Stay connected to all updated on Chloroquinen Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Carboplatin Injection BP 50mg/5ml, 150mg/15ml, 450mg/45ml, 600mg/60ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Carboplatin Dosage & Rx Info | Carboplatin Uses, Side Effects Carboplatin: Indications, Side Effects, Warnings, Carboplatin -Drug Information –Taj Pharma, Carboplatin dose Taj pharmaceuticals Carboplatin interactions, Taj Pharmaceutical Carboplatin contraindications, Carboplatin price, Carboplatin Taj Pharma Carboplatin SmPC-Taj Pharma Stay connected to all updated on Carboplatin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Ledipasvir and Sofosbuvir Tablets Taj Pharma SmPCTajPharmaQC
Ledipasvir and Sofosbuvir Tablets 90mg/400mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Ledipasvir and Sofosbuvir Dosage & Rx Info | Ledipasvir and Sofosbuvir Uses, Side Effects Ledipasvir and Sofosbuvir: Indications, Side Effects, Warnings, Ledipasvir and Sofosbuvir -Drug Information –Taj Pharma, Ledipasvir and Sofosbuvir dose Taj pharmaceuticals Ledipasvir and Sofosbuvir interactions, Taj Pharmaceutical Ledipasvir and Sofosbuvir contraindications, Ledipasvir and Sofosbuvir price, Ledipasvir and Sofosbuvir Taj Pharma Ledipasvir and Sofosbuvir SmPC-Taj Pharma Stay connected to all updated on Ledipasvir and Sofosbuvir Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Diclofenac potassium 50 mg tablets smpc taj pharmaceuticalsTaj Pharma
Diclofenac Potassium Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Diclofenac Potassium Dosage & Rx Info | Diclofenac Potassium Uses, Side Effects -: Indications, Side Effects, Warnings, Diclofenac Potassium - Drug Information - Taj Pharma, Diclofenac Potassium dose Taj pharmaceuticals Diclofenac Potassium interactions, Taj Pharmaceutical Diclofenac Potassium contraindications, Diclofenac Potassium price, Diclofenac Potassium Taj Pharma Diclofenac Potassium 50 mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Diclofenac Potassium Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Carboplatin 10 mgml intravenous infusion smpc taj pharmaceuticalsTaj Pharma
CARBOPLATIN - Drug Information - Taj Pharma, CARBOPLATIN dose Taj pharmaceuticals CARBOPLATINinteractions, Taj Pharmaceutical CARBOPLATIN contraindications, CARBOPLATIN price, CARBOPLATIN Taj Pharma Cancer, oncologyCarboplatin 10 mg/ml Intravenous Infusion SMPC- Taj Pharma . Stay connected to all updated on CARBOPLATIN Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Doxorubin 10 mg, 50mg powder for solution for injection smpc taj pharmaceuti...Taj Pharma
Warnings, DOXORUBIN Dosage & Rx Info | DOXORUBIN Uses, Side Effects -: Indications, Side Effects, Warnings, DOXORUBIN - Drug Information - Taj Pharma, DOXORUBIN dose Taj pharmaceuticals DOXORUBIN interactions, Taj Pharmaceutical DOXORUBIN contraindications, DOXORUBIN price, DOXORUBIN Taj Pharma Cancer, oncologyDoxorubin 10 mg, 50mg powder for solution for Injection. SMPC- Taj Pharma . Stay connected to all updated on DOXORUBIN Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Epirubicin hydrochloride 2 mgml solution for injection or infusion smpc taj ...Taj Pharma
EPIRUBICIN HYDROCHLORIDE - Drug Information - Taj Pharma, EPIRUBICIN HYDROCHLORIDE dose Taj pharmaceuticals EPIRUBICIN HYDROCHLORIDE interactions, Taj Pharmaceutical EPIRUBICIN HYDROCHLORIDE contraindications, EPIRUBICIN HYDROCHLORIDE price, EPIRUBICIN HYDROCHLORIDE Taj Pharma Cancer, oncologyEpirubicin Hydrochloride 2mg/ml solution for injection or infusion SMPC- Taj Pharma . Stay connected to all updated on EPIRUBICIN HYDROCHLORIDE Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Levosimendan for Injection Taj Pharma SmPCTajPharmaQC
Levosimendan for Injection 12.5mg, 25mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Levosimendan Dosage & Rx Info | Levosimendan Uses, Side Effects Levosimendan: Indications, Side Effects, Warnings, Levosimendan -Drug Information –Taj Pharma, Levosimendan dose Taj pharmaceuticals Levosimendan interactions, Taj Pharmaceutical Levosimendan contraindications, Levosimendan price, Levosimendan Taj Pharma Levosimendan SmPC-Taj Pharma Stay connected to all updated on Levosimendan Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Axitinib 1 mg, 3mg, 5mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
Axitinib - Drug Information - Taj Pharma, Axitinib dose Taj pharmaceuticals Axitinib interactions, Taj Pharmaceutical Axitinib contraindications, Axitinib price, Axitinib Taj Pharma Cancer, oncologyAxitinib 1 mg, 3mg, 5mg, 7mg film-coated tablets SMPC- Taj Pharma . Stay connected to all updated on Axitinib Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Albendazole 400 mg tablets smpc taj pharmaceuticalsTaj Pharma
Albendazole Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Albendazole Dosage & Rx Info | Albendazole Uses, Side Effects -: Indications, Side Effects, Warnings, Albendazole - Drug Information - Taj Pharma, Albendazole dose Taj pharmaceuticals Albendazole interactions, Taj Pharmaceutical Albendazole contraindications, Albendazole price, Albendazole Taj Pharma Albendazole Tablets 400 mg SMPC- Taj Pharma . Stay connected to all updated on Albendazole Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Captopril Tablets SmPC Taj PharmaceuticalsTajPharmaQC
Captopril Tablets USP 25mg, 50mg, 100mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Captopril Dosage & Rx Info | Captopril Uses, Side Effects Captopril: Indications, Side Effects, Warnings, Captopril -Drug Information –Taj Pharma, Captopril dose Taj pharmaceuticals Captopril interactions, Taj Pharmaceutical Captopril contraindications, Captopril price, Captopril Taj Pharma Captopril SmPC- Taj Pharma Stay connected to all updated on Captopril Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Pregabalin SR Capsules Sustained Release 100mg/150mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Pregabalin Dosage & Rx Info | Pregabalin Uses, Side Effects Vecuronium bromide: Indications, Side Effects, Warnings, Pregabalin-Drug Information –Taj Pharma, Pregabalin dose Taj pharmaceuticals Pregabalin interactions, Taj Pharmaceutical Pregabalin contraindications, Pregabalin price, Pregabalin Taj Pharma Pregabalin SmPC-Taj Pharma Stay connected to all updated on Pregabalin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Oxaliplatin for Injection Taj Pharma SmPCTajPharmaQC
Oxaliplatin for Injection 50mg, 100mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Oxaliplatin Dosage & Rx Info | Oxaliplatin Uses, Side Effects Oxaliplatin: Indications, Side Effects, Warnings, Oxaliplatin -Drug Information –Taj Pharma, Oxaliplatin dose Taj pharmaceuticals Oxaliplatin interactions, Taj Pharmaceutical Oxaliplatin contraindications, Oxaliplatin price, Oxaliplatin Taj Pharma Oxaliplatin SmPC-Taj Pharma Stay connected to all updated on Oxaliplatin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Chloroquine phosphate 250 mg tablets smpc taj pharmaceuticalsTaj Pharma
Chloroquine phosphate 250 mg Tablets SMPC: Indications, Side Effects, Warnings, Chloroquinen - Drug Information - Taj Pharma, Chloroquinen dose Taj pharmaceuticals Chloroquinen interactions, Taj Pharmaceutical Chloroquinen contraindications, Chloroquinen price, Chloroquinen , Taj Pharma Chloroquine phosphate 250 mg Tablets SMPC - Taj Pharma . Stay connected to all updated on Chloroquinen Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Carboplatin Injection BP 50mg/5ml, 150mg/15ml, 450mg/45ml, 600mg/60ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Carboplatin Dosage & Rx Info | Carboplatin Uses, Side Effects Carboplatin: Indications, Side Effects, Warnings, Carboplatin -Drug Information –Taj Pharma, Carboplatin dose Taj pharmaceuticals Carboplatin interactions, Taj Pharmaceutical Carboplatin contraindications, Carboplatin price, Carboplatin Taj Pharma Carboplatin SmPC-Taj Pharma Stay connected to all updated on Carboplatin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Ledipasvir and Sofosbuvir Tablets Taj Pharma SmPCTajPharmaQC
Ledipasvir and Sofosbuvir Tablets 90mg/400mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Ledipasvir and Sofosbuvir Dosage & Rx Info | Ledipasvir and Sofosbuvir Uses, Side Effects Ledipasvir and Sofosbuvir: Indications, Side Effects, Warnings, Ledipasvir and Sofosbuvir -Drug Information –Taj Pharma, Ledipasvir and Sofosbuvir dose Taj pharmaceuticals Ledipasvir and Sofosbuvir interactions, Taj Pharmaceutical Ledipasvir and Sofosbuvir contraindications, Ledipasvir and Sofosbuvir price, Ledipasvir and Sofosbuvir Taj Pharma Ledipasvir and Sofosbuvir SmPC-Taj Pharma Stay connected to all updated on Ledipasvir and Sofosbuvir Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Diclofenac potassium 50 mg tablets smpc taj pharmaceuticalsTaj Pharma
Diclofenac Potassium Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Diclofenac Potassium Dosage & Rx Info | Diclofenac Potassium Uses, Side Effects -: Indications, Side Effects, Warnings, Diclofenac Potassium - Drug Information - Taj Pharma, Diclofenac Potassium dose Taj pharmaceuticals Diclofenac Potassium interactions, Taj Pharmaceutical Diclofenac Potassium contraindications, Diclofenac Potassium price, Diclofenac Potassium Taj Pharma Diclofenac Potassium 50 mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Diclofenac Potassium Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Carboplatin 10 mgml intravenous infusion smpc taj pharmaceuticalsTaj Pharma
CARBOPLATIN - Drug Information - Taj Pharma, CARBOPLATIN dose Taj pharmaceuticals CARBOPLATINinteractions, Taj Pharmaceutical CARBOPLATIN contraindications, CARBOPLATIN price, CARBOPLATIN Taj Pharma Cancer, oncologyCarboplatin 10 mg/ml Intravenous Infusion SMPC- Taj Pharma . Stay connected to all updated on CARBOPLATIN Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Doxorubin 10 mg, 50mg powder for solution for injection smpc taj pharmaceuti...Taj Pharma
Warnings, DOXORUBIN Dosage & Rx Info | DOXORUBIN Uses, Side Effects -: Indications, Side Effects, Warnings, DOXORUBIN - Drug Information - Taj Pharma, DOXORUBIN dose Taj pharmaceuticals DOXORUBIN interactions, Taj Pharmaceutical DOXORUBIN contraindications, DOXORUBIN price, DOXORUBIN Taj Pharma Cancer, oncologyDoxorubin 10 mg, 50mg powder for solution for Injection. SMPC- Taj Pharma . Stay connected to all updated on DOXORUBIN Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Epirubicin hydrochloride 2 mgml solution for injection or infusion smpc taj ...Taj Pharma
EPIRUBICIN HYDROCHLORIDE - Drug Information - Taj Pharma, EPIRUBICIN HYDROCHLORIDE dose Taj pharmaceuticals EPIRUBICIN HYDROCHLORIDE interactions, Taj Pharmaceutical EPIRUBICIN HYDROCHLORIDE contraindications, EPIRUBICIN HYDROCHLORIDE price, EPIRUBICIN HYDROCHLORIDE Taj Pharma Cancer, oncologyEpirubicin Hydrochloride 2mg/ml solution for injection or infusion SMPC- Taj Pharma . Stay connected to all updated on EPIRUBICIN HYDROCHLORIDE Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Direct oral anticoagulants (DOACs) have quickly become attractive alternatives to the long‐standing standard of care in anticoagulation, vitamin K antagonist. DOACs are indicated for prevention and treatment of several cardiovascular conditions. Since the first approval in 2010, DOACs have emerged as leading therapeutic alternatives that provide both clinicians and patients with more effective, safe, and convenient treatment options in thromboembolic settings. With the expanding role of DOACs, clinicians are faced with increasingly complex decisions relating to appropriate agent, duration of treatment, and use in special populations. This review will provide an overview of DOACs and act as a practical reference for clinicians to optimize DOAC use among common challenging scenarios. Topics addressed include (1) appropriate indications; (2) use in patients with specific comorbidities; (3) monitoring parameters; (4) transitioning between anticoagulant regimens; (5) major drug interactions; and (6) cost considerations.
Direct oral anticoagulants (DOACs)—dabigatran (Pradaxa), rivaroxaban (Xarelto), apixaban (Eliquis), edoxaban (Savaysa), and betrixaban (Bevyxxa) are anticoagulation pharmacotherapy used for the prevention of thrombosis in several cardiovascular contexts.1 DOACs are categorized into 2 main classes: oral direct factor Xa inhibitors (ie, rivaroxaban, apixaban, edoxaban, and betrixaban) and direct thrombin inhibitors (ie, dabigatran). In 2010, the US Food and Drug Administration (FDA) approved its first DOAC, dabigatran, followed by rivaroxaban, apixaban, edoxaban, and betrixaban in the following years. DOACs are relatively new agents demonstrating superiority or noninferiority to prior standards of care, anticoagulation with vitamin K antagonists (VKA; ie, warfarin), or low‐molecular‐weight heparins (LMWHs), in reducing risk of thromboembolic complications with similar or reduced bleeding risk.2, 3, 4, 5 Advantages of DOACs compared with VKAs include fewer monitoring requirements, less frequent follow‐up, more immediate drug onset and offset effects (important for periprocedural and acute bleeding management), and fewer drug and food interactions.6 As a result, DOAC prescriptions exceeded those for warfarin by 2013, with apixaban being the most frequently prescribed DOAC for patients with nonvalvular atrial fibrillation (NVAF).7
Over the past decade, DOACs have been the subject of extensive investigation in many clinical scenarios. Though guidelines and review articles have provided detailed and in‐depth analyses of the immense literature base, these can be too cumbersome and challenging to integrate into everyday clinical use
In general, FDA‐approved indications for each of the DOACs are comparable (see Table 1). Dabigatran, rivaroxaban, apixaban, and edoxaban are approved for the lowering the risk of stroke and embolism in NVAF as well as deep vein thrombosis and pulmonary embolism treatment/prophylaxis.8, 9, 10, 11 Unique indications
Rabeprazole 20mg gastro resistant tablets smpc- taj pharmaceuticalsTaj Pharma
Rabeprazole Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Rabeprazole Dosage & Rx Info | Rabeprazole Uses, Side Effects -: Indications, Side Effects, Warnings, Rabeprazole - Drug Information - Taj Pharma, Rabeprazole dose Taj pharmaceuticals Rabeprazole interactions, Taj Pharmaceutical Rabeprazole contraindications, Rabeprazole price, Rabeprazole Taj Pharma Rabeprazole 20mg Gastro-resistant Tablets SMPC- Taj Pharma . Stay connected to all updated on Rabeprazole Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Rabicip (Generic Rabeprazole Sodium Tablets) is used to treat Gastroesophageal Reflux Disease (GERD), treat heartburn, treat or prevent GI (gastrointestinal) ulcers caused by infection, treat or prevent ulcers of the swallowing tube (esophagus)and treat syndromes caused by lots of stomach acid including Zollinger-Ellison syndrome in adults and treatment of symptomatic GERD in adolescent patients 12 years of age and older.
Similar to A Dose of Education - August Update (20)
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
Contact us if you are interested:
Email / Skype : kefaya1771@gmail.com
Threema: PXHY5PDH
New BATCH Ku !!! MUCH IN DEMAND FAST SALE EVERY BATCH HAPPY GOOD EFFECT BIG BATCH !
Contact me on Threema or skype to start big business!!
Hot-sale products:
NEW HOT EUTYLONE WHITE CRYSTAL!!
5cl-adba precursor (semi finished )
5cl-adba raw materials
ADBB precursor (semi finished )
ADBB raw materials
APVP powder
5fadb/4f-adb
Jwh018 / Jwh210
Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
Metonitazene CAS: 14680-51-4
Payment terms: Western Union,MoneyGram,Bitcoin or USDT.
Deliver Time: Usually 7-15days
Shipping method: FedEx, TNT, DHL,UPS etc.Our deliveries are 100% safe, fast, reliable and discreet.
Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...
A Dose of Education - August Update
1. A MONTHLY
DOSE OF EDUCATION
Brian Pelletier, PharmD, BCGP, FASCP
CEO, A Dose of Education, LLC
August 2017
2. FDA Approval
• Mavyret® (glecaprevir and pibrentasvir) – approved 8/3/2017
• A fixed-dose combination of glecaprevir, a hepatitis C virus (HCV) NS3/4A
protease inhibitor, and pibrentasvir, an HCV NS5A inhibitor
• Indicated for the treatment of patients with chronic HCV genotype (GT)
1, 2, 3, 4, 5 or 6 infection without cirrhosis and with compensated
cirrhosis (Child-Pugh A).
• Also indicated for the treatment of adult patients with HCV genotype 1
infection, who previously have been treated with a regimen containing
an HCV NS5A inhibitor or an NS3/4A protease inhibitor, but not both
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209394s000lbl.pdf
3. Mavyret® (glecaprevir and pibrentasvir)
• Formulation / Administration
• Prior to the initiation of therapy, test all patients for HBV infection by
measuring HBsAg and anti-HBc
• Available as a tablet: 100mg of glecaprevir and 40 mg pibrentasvir
• Recommended dosage: Three tablets (total daily dose: glecaprevir 300
mg and pibrentasvir 120 mg) taken orally once daily with food
• Dose adjustments in Renal/Hepatic Impairment:
• Not recommended in patients with moderate hepatic impairment (Child-
Pugh B); and is contraindicated in patients with severe hepatic
impairment (Child-Pugh C)
• No dosage adjustment is required in patients with mild, moderate or
severe renal impairment, including those on dialysis
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209394s000lbl.pdf
4. Mavyret® (glecaprevir and pibrentasvir)
• Duration as listed below: • 1. In clinical trials, subjects were
treated with prior regimens containing
ledipasvir and sofosbuvir or daclatasvir
with pegylated interferon and ribavirin.
• 2. In clinical trials, subjects were
treated with prior regimens containing
simeprevir and sofosbuvir, or
simeprevir, boceprevir, or telaprevir
with pegylated interferon and ribavirin
• 3. PRS=Prior treatment experience with
regimens containing interferon,
pegylated interferon, ribavirin, and/or
sofosbuvir, but no prior treatment
experience with an HCV NS3/4A PI or
NS5A inhibitor.
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209394s000lbl.pdf
5. Mavyret® (glecaprevir and pibrentasvir)
• Drug Interactions:
• Contraindicated for coadministration with atazanavir and rifampin
• Carbamazepine, efavirenz, and St. John’s wort may decrease
concentrations of glecaprevir and pibrentasvir
• Coadministration of carbamazepine, efavirenz containing regimens, and
St. John’s wort with glecaprevir and pibrentasvir is not recommended
• Digoxin: Measure serum digoxin concentrations before initiating. Reduce
digoxin concentrations by decreasing the dose by approximately 50% or
by modifying the dosing frequency and continue monitoring
• Atazanavir: Coadministration is contraindicated
• Darunavir, Lopinavir, Ritonavir: Coadministration is not recommended
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209394s000lbl.pdf
6. Mavyret® (glecaprevir and pibrentasvir)
• Drug Interactions (continued):
• Statins: Coadministration may increase the concentration of atorvastatin,
lovastatin, and simvastatin. Increased statin concentrations may increase
the risk of myopathy, including rhabdomyolysis. Coadministration with
these statins is not recommended.
• Reduce pravastatin dose by 50%
• Rosuvastatin may be administered at a dose that does not exceed 10 mg
• Use the lowest approved dose of fluvastatin or pitavastatin. If higher doses are
needed, use the lowest necessary statin dose based on a risk/benefit
assessment
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209394s000lbl.pdf
7. FDA Approval
• Carospir® (spirinolactone) oral suspension –Approved 8/4/2017
• Is an antagonist of aldosterone indicated for:
• Treatment of NYHA Class III-IV heart failure and reduced ejection fraction
to increase survival, manage edema, and to reduce the need for
hospitalization for heart failure
• Add-on therapy for the treatment of hypertension, to lower blood
pressure. Lowering blood pressure reduces the risk of fatal and nonfatal
cardiovascular events, primarily strokes and myocardial infarctions
• The management of edema in adult cirrhotic patients when edema is not
responsive to fluid and sodium restrictions
• Initial approval in US – 1960!
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209478s000lbl.pdf
8. Carospir® (spirinolactone)
• Formulations / Administration:
• Oral suspension: 25mg/5ml
• Can be taken with or without food, but should be taken consistently with
respect to food
• Not therapeutically equivalent to Aldactone
• In patients requiring a dose greater than 100 mg, use another formulation.
Doses of the suspension greater than 100 mg may result in spironolactone
concentrations higher than expected
• Heart Failure: Initiate treatment at 20 mg once daily
• Hypertension: Initiate treatment at 20 to 75 mg daily in either single or
divided doses
• Edema associated with Hepatic Cirrhosis: Initiate therapy in a hospital
setting and titrate slowly. The initial recommended daily dose is 75 mg in
either single or divided doses
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209478s000lbl.pdf
9. FDA Approval
• Duzallo® (lesinurad and allopurinol) – Approved 8/18/2017
• A combination of lesinurad, a URAT1 inhibitor, and allopurinol, a xanthine
oxidase inhibitor
• Indicated for the treatment of hyperuricemia associated with gout in
patients who have not achieved target serum uric acid levels with a
medically appropriate daily dose of allopurinol alone.
• Formulation / Administration:
• Available in two strengths – 200mg lesinurad/300mg allopurinol and
200mg lesinurad/200mg allopurinol (both tablets)
• Should be taken in the morning with food and water
• Patients should be instructed to stay well hydrated
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209203s000lbl.pdf
10. Duzallo® (lesinurad and allopurinol)
• Dose adjustments in Renal/Hepatic impairment:
• Do not use in patients with eCLcr less than 45 ml/min; recommend
discontinuing if eCLcr persistently falls below 45 ml/min
• Lower dose of 200mg/200mg recommended for eCLcr 45 – 60 ml/min
• Not recommended in patients with severe hepatic impairment
• Other Precautions:
• Do not take more than one tablet of Duzallo® per day
• Do not combine Duzallo® with Zurampic® (lesinurad)
• Use one tablet in place of equivalent portion of the total daily allopurinol
dose. TDD of allopurinol should be maintained at the time of initiating
Duzallo®
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209203s000lbl.pdf
11. Duzallo® (lesinurad and allopurinol)
• Contraindications:
• Severe renal impairment, end stage renal disease, kidney transplant
recipients, or patients on dialysis
• Tumor lysis syndrome or Lesch-Nyhan syndrome
• Known hypersensitivity to allopurinol, including previous occurrence of
skin rash
• Drug Interactions:
• Mercaptopurine or Azathioprine: Reduce mercaptopurine or azathioprine
dose to approximately one-third to one-fourth of the usual dose and
closely monitor for therapeutic response and the appearance of toxicity.
• Warfarin: Carefully monitor prothrombin time.
• Moderate Cytochrome P450 2C9 (CYP2C9) Inhibitors: Use with caution.
• CYP3A Substrates: Monitor for efficacy of the CYP3A substrate.
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209203s000lbl.pdf
12. FDA Approval
• Vabomere® (meropenem/vaborbactam) – Approved 8/29/2017
• Combination of meropenem, a penem antibacterial, and vaborbactam, a
beta-lactamase inhibitor
• Indicated for the treatment of patients 18 years and older with
complicated urinary tract infections (cUTI) including pyelonephritis
caused by designated susceptible bacteria
• Formulation / Administration:
• Administer 4 grams (meropenem 2 grams and vaborbactam 2 grams)
every 8 hours by intravenous infusion over 3 hours for up to 14 days, in
patients 18 years of age and older with an estimated glomerular filtration
rate (eGFR) ≥50 mL/min/1.73m2
• Each vial is 2 grams (meropenem 1 gram and vaborbactam 1 gram)
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209776lbl.pdf
13. Vabomere® (meropenem/vaborbactam)
• Dose adjustments in Renal Impairment:
• Dosage adjustment is recommended in patients with renal impairment
who have an eGFR less than 50 mL/min
• Doses adjusted for renal impairment should be administered after a
hemodialysis session
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209776lbl.pdf
14. Vabomere® (meropenem/vaborbactam)
• Drug Interactions:
• Valproic Acid:
• The valproic acid concentrations may drop below the therapeutic
range as a result of this interaction, therefore increasing the risk of
breakthrough seizures
• Co-administration of probenecid is not recommended
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209776lbl.pdf
15. Other August FDA Approvals
• Idhifa® (enasidenib) - 8/1/17
• An isocitrate dehydrogenase-2 inhibitor indicated for the treatment of
adult patients with relapsed or refractory acute myeloid leukemia (AML)
with an isocitrate dehydrogenase-2 (IDH2) mutation as detected by an
FDA- approved test.
• https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209606s00
0lbl.pdf
• Besponsa® (inotuzumab ozogamicin) – 8/17/2017
• A CD22-directed antibody-drug conjugate (ADC) indicated for the
treatment of adults with relapsed or refractory B-cell precursor acute
lymphoblastic leukemia (ALL).
• https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/761040s00
0lbl.pdf
16. Other August FDA Approvals
• Benznidazole
• A nitroimidazole antimicrobial, is indicated in pediatric patients 2 to 12
years of age for the treatment of Chagas disease (American
trypanosomiasis), caused by Trypanosoma cruzi .
• This indication is approved under accelerated approval based on the
number of treated patients who became Immunoglobulin G (IgG)
antibody negative against the recombinant antigens of T. cruzi. Continued
approval for this indication may be contingent upon verification and
description of clinical benefit in confirmatory trial.
• https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209570lbl.
pdf