The document summarizes several new drug approvals and formulations by the FDA in October and November 2017. Key approvals included:
- Abilify Mycite (aripiprazole tablets with sensor), approved to track drug ingestion in real-time.
- Fasenra (benralizumab), approved for add-on maintenance treatment of severe asthma.
- Prevymis (letermovir), approved to prevent cytomegalovirus infection in transplant recipients.
- Vyzulta (latanoprostene bunod), approved to reduce eye pressure in glaucoma as an alternative to latanoprost.
- Juluca (dolutegra
Generic Vardenafil Medications to Effectively Treat Erectile DysfunctionThe Swiss Pharmacy
Generic Vardenafil Hydrochloride is used for the treatment of erectile dysfunction in adult men, a medical condition which implies the inability to attain or maintain a penile erection long enough to satisfactorily complete sexual activity.
After the penis is stroked, Vardenafil maintains an erection by increasing blood flow. Without physical activity, such as that occurring during sexual intercourse, Vardenafil will not cause an erection.
Telbivudine Tablet 600mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Telbivudine Dosage & Rx Info | Telbivudine Uses, Side Effects Telbivudine: Indications, Side Effects, Warnings, Telbivudine -Drug Information –Taj Pharma, Telbivudine dose Taj pharmaceuticals Telbivudine interactions, Taj Pharmaceutical Telbivudine contraindications, Telbivudine price, Telbivudine Taj Pharma Telbivudine SmPC-Taj Pharma Stay connected to all updated on Telbivudine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Ibugesic Plus (Generic Ibuprofen and Paracetamol Tablets) The Swiss Pharmacy
Ibugesic Plus contains 2 ingredients: Ibuprofen And Acetaminophen (Paracetamol). This medicine is used for the management of mild to moderate pain and inflammation in conditions such as dysmenorrhoea, headache, including migraine, post-operative pain, dental pain, musculoskeletal and joint disorders, peri-articular disorders and soft tissue disorders (sprains and strains).This combination product works by blocking your body's production of certain natural substances that cause inflammation. This effect helps to decrease swelling, pain, or fever.
Generic Vardenafil Medications to Effectively Treat Erectile DysfunctionThe Swiss Pharmacy
Generic Vardenafil Hydrochloride is used for the treatment of erectile dysfunction in adult men, a medical condition which implies the inability to attain or maintain a penile erection long enough to satisfactorily complete sexual activity.
After the penis is stroked, Vardenafil maintains an erection by increasing blood flow. Without physical activity, such as that occurring during sexual intercourse, Vardenafil will not cause an erection.
Telbivudine Tablet 600mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Telbivudine Dosage & Rx Info | Telbivudine Uses, Side Effects Telbivudine: Indications, Side Effects, Warnings, Telbivudine -Drug Information –Taj Pharma, Telbivudine dose Taj pharmaceuticals Telbivudine interactions, Taj Pharmaceutical Telbivudine contraindications, Telbivudine price, Telbivudine Taj Pharma Telbivudine SmPC-Taj Pharma Stay connected to all updated on Telbivudine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Ibugesic Plus (Generic Ibuprofen and Paracetamol Tablets) The Swiss Pharmacy
Ibugesic Plus contains 2 ingredients: Ibuprofen And Acetaminophen (Paracetamol). This medicine is used for the management of mild to moderate pain and inflammation in conditions such as dysmenorrhoea, headache, including migraine, post-operative pain, dental pain, musculoskeletal and joint disorders, peri-articular disorders and soft tissue disorders (sprains and strains).This combination product works by blocking your body's production of certain natural substances that cause inflammation. This effect helps to decrease swelling, pain, or fever.
Tigecycline 50 mg powder for solution for infusion smpc taj pharmaceuticalsTaj Pharma
TIGECYCLINE Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, TIGECYCLINE Dosage & Rx Info | TIGECYCLINE Uses, Side Effects -: Indications, Side Effects, Warnings, TIGECYCLINE - Drug Information - Taj Pharma, TIGECYCLINE dose Taj pharmaceuticals TIGECYCLINE interactions, Taj Pharmaceutical TIGECYCLINE contraindications, TIGECYCLINE price, TIGECYCLINE Taj Pharma Tigecycline 50 mg powder for solution for infusionSMPC- Taj Pharma . Stay connected to all updated on TIGECYCLINE Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Dexona Tablets (Dexamethasone) is used to treat symptoms such as inflammation, certain immune disorders and in replacement therapy of an inactive or underactive adrenal gland. Dexamethasone may be prescribed for skin allergies, asthma, leukaemia, blood disorders, selected rheumatic disorders, gastrointestinal disorders, skin problems, certain abnormal growths (cancers) and excessive calcium in the blood.
Voriconazole for Injection Taj Pharma PILTajPharmaQC
Voriconazole for Injection 200mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Voriconazole Dosage & Rx Info | Voriconazole Uses, Side Effects Voriconazole: Indications, Side Effects, Warnings, Voriconazole -Drug Information –Taj Pharma, Voriconazole dose Taj pharmaceuticals Voriconazole interactions, Taj Pharmaceutical Voriconazole contraindications, Voriconazole price, Voriconazole Taj Pharma Voriconazole SmPC-Taj Pharma Stay connected to all updated on Voriconazole Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Gazyva is a medicine that works with the body’s own immune system to attack blood cells called B-cells that have a certain marker on their surface (CD20). B-cells are the cause of common blood cancers.1,2
Gazyva is FDA-approved for the treatment of people with previously untreated chronic lymphocytic leukemia (CLL) in combination with chlorambucil chemotherapy.3
Phase III clinical data showed that Gazyva plus chlorambucil chemotherapy helped people with CLL live longer without the disease worsening than chlorambucil chemotherapy alone.3
Voriconazole for Injection Taj Pharma SmPCTajPharmaQC
Voriconazole for Injection 200mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Voriconazole Dosage & Rx Info | Voriconazole Uses, Side Effects Voriconazole: Indications, Side Effects, Warnings, Voriconazole -Drug Information –Taj Pharma, Voriconazole dose Taj pharmaceuticals Voriconazole interactions, Taj Pharmaceutical Voriconazole contraindications, Voriconazole price, Voriconazole Taj Pharma Voriconazole SmPC-Taj Pharma Stay connected to all updated on Voriconazole Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
EMERGING APPROACHES TO COMBINATION THERAPIES IN AMD & DME - Aerpio TherapeuticsHealthegy
Presentation by Aerpio Therapeutics at OIS@ASRS 2016.
Participant:
Joseph Gardner, President & CEO - Aerpio Therapeutics
Powered by:
Healthegy
For more ophthalmology innovation
Visit us at www.ois.net
Generic Cipro (Ciplox Tablets) is used for the treatment of infections of the lungs, skin, bones and joints, kidney and bladder, prostate and bowel. Generic Cipro works by killing the bacteria that are causing your infection.
Tadalafil Dapoxetine Tablets to treat Erectile Dysfunction and Premature Eja...The Swiss Pharmacy
Tadalafil and Dapoxetine Combination medication is a combination containing Tadalafil 20mg and Dapoxetine 60mg in a single tablet.
Tadalafil Dapoxetine Tablets are used for the treatment of male erectile dysfunction as well as treatment of premature ejaculation in men at the same time.
Generic Cephalexin (Cephadex Capsules) is a Cephalosporin antibacterial drug used to treat infections caused by bacteria, including upper respiratory infections, ear infections, skin infections, and urinary tract infections.
Generic Accutane for Treatment of Moderate to Severe AcneThe Swiss Pharmacy
Generic Accutane (Isotroin Capsules) an extremely powerful and potent acne-controlling medicine, is used in the treatment of moderate to severe acne that has failed other therapy.
Gefitinib 250 mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
GEFITINIB Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, GEFITINIB Dosage & Rx Info | GEFITINIB Uses, Side Effects -: Indications, Side Effects, Warnings, GEFITINIB - Drug Information - Taj Pharma, GEFITINIB dose Taj pharmaceuticals GEFITINIB interactions, Taj Pharmaceutical GEFITINIB contraindications, GEFITINIB price, GEFITINIB Taj Pharma Cancer, oncologyGefitinib 250 mg film-coated tablets. SMPC- Taj Pharma
Anidulafungin for Injection Taj Pharma SmPCTajPharmaQC
Anidulafungin for Injection 100mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Anidulafungin Dosage & Rx Info | Anidulafungin Uses, Side Effects Anidulafungin: Indications, Side Effects, Warnings, Anidulafungin -Drug Information –Taj Pharma, Anidulafungin dose Taj pharmaceuticals Anidulafungin interactions, Taj Pharmaceutical Anidulafungin contraindications, Anidulafungin price, Anidulafungin Taj Pharma Anidulafungin SmPC-Taj Pharma Stay connected to all updated on Anidulafungin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Posterior Segment Company Showcase - AerpioHealthegy
Posterior Segment Company Showcase - Aerpio at OIS@AAO 2016.
Presenter:
Joseph Gardner, President & CEO
Powered by:
Healthegy
For more ophthalmology innovation
Visit us at www.ois.net
Coronavirus disease (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus.
Most people infected with the virus will experience mild to moderate respiratory illness and recover without requiring special treatment. However, some will become seriously ill and require medical attention. Older people and those with underlying medical conditions like cardiovascular disease, diabetes, chronic respiratory disease, or cancer are more likely to develop serious illness. Anyone can get sick with COVID-19 and become seriously ill or die at any age.
The best way to prevent and slow down transmission is to be well informed about the disease and how the virus spreads. Protect yourself and others from infection by staying at least 1 metre apart from others, wearing a properly fitted mask, and washing your hands or using an alcohol-based rub frequently. Get vaccinated when it’s your turn and follow local guidance.
The virus can spread from an infected person’s mouth or nose in small liquid particles when they cough, sneeze, speak, sing or breathe. These particles range from larger respiratory droplets to smaller aerosols. It is important to practice respiratory etiquette, for example by coughing into a flexed elbow, and to stay home and self-isolate until you recover if you feel unwell.
The Infection prevention and control in the context of coronavirus disease 2019 (COVID-19): a living guideline consolidates technical guidance developed and published during the COVID-19 pandemic into evidence-informed recommendations for infection prevention and control (IPC). This living guideline is available both online and PDF.
This version of the living guideline (version 6.0) includes fifteen statements on IPC measures in health-care settings (screening and patient placement, ventilation, physical barriers, environmental cleaning, waste management, amongst others) as well as one statement on mask fit in the community context.
Understanding the updated section
The update to this guideline considers the transition from critical emergency-response activities to longer-term, sustained COVID-19 disease prevention, control and management, and a shift towards integration of IPC activities into routine systems and practices. This includes a return to standard and transmission-based precautions in health-care settings, and the adoption of public health practices for community settings. Updated recommendations for health-care facilities include a focus on the hierarchy of control measures, source control, standard and transmission-based precautions. The prevention of health care-associated infections involves a multi-pronged and multi-factorial approach that includes infection prevention and control and occupational health and safety measures.
Tigecycline 50 mg powder for solution for infusion smpc taj pharmaceuticalsTaj Pharma
TIGECYCLINE Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, TIGECYCLINE Dosage & Rx Info | TIGECYCLINE Uses, Side Effects -: Indications, Side Effects, Warnings, TIGECYCLINE - Drug Information - Taj Pharma, TIGECYCLINE dose Taj pharmaceuticals TIGECYCLINE interactions, Taj Pharmaceutical TIGECYCLINE contraindications, TIGECYCLINE price, TIGECYCLINE Taj Pharma Tigecycline 50 mg powder for solution for infusionSMPC- Taj Pharma . Stay connected to all updated on TIGECYCLINE Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Dexona Tablets (Dexamethasone) is used to treat symptoms such as inflammation, certain immune disorders and in replacement therapy of an inactive or underactive adrenal gland. Dexamethasone may be prescribed for skin allergies, asthma, leukaemia, blood disorders, selected rheumatic disorders, gastrointestinal disorders, skin problems, certain abnormal growths (cancers) and excessive calcium in the blood.
Voriconazole for Injection Taj Pharma PILTajPharmaQC
Voriconazole for Injection 200mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Voriconazole Dosage & Rx Info | Voriconazole Uses, Side Effects Voriconazole: Indications, Side Effects, Warnings, Voriconazole -Drug Information –Taj Pharma, Voriconazole dose Taj pharmaceuticals Voriconazole interactions, Taj Pharmaceutical Voriconazole contraindications, Voriconazole price, Voriconazole Taj Pharma Voriconazole SmPC-Taj Pharma Stay connected to all updated on Voriconazole Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Gazyva is a medicine that works with the body’s own immune system to attack blood cells called B-cells that have a certain marker on their surface (CD20). B-cells are the cause of common blood cancers.1,2
Gazyva is FDA-approved for the treatment of people with previously untreated chronic lymphocytic leukemia (CLL) in combination with chlorambucil chemotherapy.3
Phase III clinical data showed that Gazyva plus chlorambucil chemotherapy helped people with CLL live longer without the disease worsening than chlorambucil chemotherapy alone.3
Voriconazole for Injection Taj Pharma SmPCTajPharmaQC
Voriconazole for Injection 200mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Voriconazole Dosage & Rx Info | Voriconazole Uses, Side Effects Voriconazole: Indications, Side Effects, Warnings, Voriconazole -Drug Information –Taj Pharma, Voriconazole dose Taj pharmaceuticals Voriconazole interactions, Taj Pharmaceutical Voriconazole contraindications, Voriconazole price, Voriconazole Taj Pharma Voriconazole SmPC-Taj Pharma Stay connected to all updated on Voriconazole Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
EMERGING APPROACHES TO COMBINATION THERAPIES IN AMD & DME - Aerpio TherapeuticsHealthegy
Presentation by Aerpio Therapeutics at OIS@ASRS 2016.
Participant:
Joseph Gardner, President & CEO - Aerpio Therapeutics
Powered by:
Healthegy
For more ophthalmology innovation
Visit us at www.ois.net
Generic Cipro (Ciplox Tablets) is used for the treatment of infections of the lungs, skin, bones and joints, kidney and bladder, prostate and bowel. Generic Cipro works by killing the bacteria that are causing your infection.
Tadalafil Dapoxetine Tablets to treat Erectile Dysfunction and Premature Eja...The Swiss Pharmacy
Tadalafil and Dapoxetine Combination medication is a combination containing Tadalafil 20mg and Dapoxetine 60mg in a single tablet.
Tadalafil Dapoxetine Tablets are used for the treatment of male erectile dysfunction as well as treatment of premature ejaculation in men at the same time.
Generic Cephalexin (Cephadex Capsules) is a Cephalosporin antibacterial drug used to treat infections caused by bacteria, including upper respiratory infections, ear infections, skin infections, and urinary tract infections.
Generic Accutane for Treatment of Moderate to Severe AcneThe Swiss Pharmacy
Generic Accutane (Isotroin Capsules) an extremely powerful and potent acne-controlling medicine, is used in the treatment of moderate to severe acne that has failed other therapy.
Gefitinib 250 mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
GEFITINIB Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, GEFITINIB Dosage & Rx Info | GEFITINIB Uses, Side Effects -: Indications, Side Effects, Warnings, GEFITINIB - Drug Information - Taj Pharma, GEFITINIB dose Taj pharmaceuticals GEFITINIB interactions, Taj Pharmaceutical GEFITINIB contraindications, GEFITINIB price, GEFITINIB Taj Pharma Cancer, oncologyGefitinib 250 mg film-coated tablets. SMPC- Taj Pharma
Anidulafungin for Injection Taj Pharma SmPCTajPharmaQC
Anidulafungin for Injection 100mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Anidulafungin Dosage & Rx Info | Anidulafungin Uses, Side Effects Anidulafungin: Indications, Side Effects, Warnings, Anidulafungin -Drug Information –Taj Pharma, Anidulafungin dose Taj pharmaceuticals Anidulafungin interactions, Taj Pharmaceutical Anidulafungin contraindications, Anidulafungin price, Anidulafungin Taj Pharma Anidulafungin SmPC-Taj Pharma Stay connected to all updated on Anidulafungin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Posterior Segment Company Showcase - AerpioHealthegy
Posterior Segment Company Showcase - Aerpio at OIS@AAO 2016.
Presenter:
Joseph Gardner, President & CEO
Powered by:
Healthegy
For more ophthalmology innovation
Visit us at www.ois.net
Coronavirus disease (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus.
Most people infected with the virus will experience mild to moderate respiratory illness and recover without requiring special treatment. However, some will become seriously ill and require medical attention. Older people and those with underlying medical conditions like cardiovascular disease, diabetes, chronic respiratory disease, or cancer are more likely to develop serious illness. Anyone can get sick with COVID-19 and become seriously ill or die at any age.
The best way to prevent and slow down transmission is to be well informed about the disease and how the virus spreads. Protect yourself and others from infection by staying at least 1 metre apart from others, wearing a properly fitted mask, and washing your hands or using an alcohol-based rub frequently. Get vaccinated when it’s your turn and follow local guidance.
The virus can spread from an infected person’s mouth or nose in small liquid particles when they cough, sneeze, speak, sing or breathe. These particles range from larger respiratory droplets to smaller aerosols. It is important to practice respiratory etiquette, for example by coughing into a flexed elbow, and to stay home and self-isolate until you recover if you feel unwell.
The Infection prevention and control in the context of coronavirus disease 2019 (COVID-19): a living guideline consolidates technical guidance developed and published during the COVID-19 pandemic into evidence-informed recommendations for infection prevention and control (IPC). This living guideline is available both online and PDF.
This version of the living guideline (version 6.0) includes fifteen statements on IPC measures in health-care settings (screening and patient placement, ventilation, physical barriers, environmental cleaning, waste management, amongst others) as well as one statement on mask fit in the community context.
Understanding the updated section
The update to this guideline considers the transition from critical emergency-response activities to longer-term, sustained COVID-19 disease prevention, control and management, and a shift towards integration of IPC activities into routine systems and practices. This includes a return to standard and transmission-based precautions in health-care settings, and the adoption of public health practices for community settings. Updated recommendations for health-care facilities include a focus on the hierarchy of control measures, source control, standard and transmission-based precautions. The prevention of health care-associated infections involves a multi-pronged and multi-factorial approach that includes infection prevention and control and occupational health and safety measures.
Nursing Education: Appetite Stimulants for Elderly PatientsPaul Pasco
A handout I formulated to bolster nursing education during an internship/Advanced Pharmacy Practice Experience (APPE) in medication safety at a hospital.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
1. A MONTHLY
DOSE OF EDUCATION
Brian Pelletier, PharmD, BCGP, FASCP
CEO, A Dose of Education, LLC
October/November 2017
2. FDA Approval
• Abilify Mycite® (aripiprazole tablets with sensor) – approved
11/13/2017 (New dosage form)
• Drug-device combination product comprised of aripiprazole tablets
embedded with an Ingestible Event Marker (IEM) sensor intended to
track drug ingestion
• Indicated for:
• Treatment of adults with schizophrenia
• Treatment of bipolar I disorder:
• Acute treatment of adults with manic and mixed episodes as monotherapy and as
adjunct to lithium or valproate
• Maintenance treatment of adults as monotherapy and as adjunct to lithium or
valproate
• Adjunctive treatment of adults with major depressive disorder (MDD)
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/207202lbl.pdf
3. Abilify Mycite®
• Formulation / Administration:
• Tablets with sensor: 2 mg, 5 mg, 10 mg, 15 mg, 20 mg, and 30 mg
• Administer once daily without regard to meals
• Swallow whole; do not divide, crush, or chew
• Warnings/Precautions:
• The ability of Abilify Mycite® to improve patient compliance or modify
aripiprazole dosage has not been established.
• Use to track drug ingestion in “real-time” or during an emergency is not
recommended because detection may be delayed or not occur
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/207202lbl.pdf
4. Abilify Mycite®
• Drug Interactions:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/207202lbl.pdf
5. Abilify Mycite®
• Adverse Reactions:
• All previous ADRs remain unchanged (some specific info noted below)
• Includes Black box warning for elderly patients with dementia-related
psychosis and suicidal thoughts and behaviors
• Commonly observed (incidence ≥5% and at least twice that for placebo)
in adult patients:
• Schizophrenia: akathisia
• Bipolar mania (monotherapy): akathisia, sedation, restlessness, tremor, and
extrapyramidal disorder
• Bipolar mania (adjunctive therapy with lithium or valproate): akathisia,
insomnia, and extrapyramidal disorder
• MDD (adjunctive treatment to antidepressant therapy): akathisia, restlessness,
insomnia, constipation, fatigue, and blurred vision
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/207202lbl.pdf
6. FDA Approval
• Fasenra® (benralizumab) – approved 11/8/17
• An interleukin-5 receptor alpha-directed cytolytic monoclonal antibody
(IgG1, kappa)
• Indicated for the add-on maintenance treatment of patients with severe
asthma aged 12 years and older, and with an eosinophilic phenotype
• Adverse Reactions:
• Most common (incidence greater than or equal to 5%) include headache
and pharyngitis
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/761070s000lbl.pdf
7. Fasenra® (benralizumab)
• Formulation / Administration:
• Injection: 30mg/mL solution in a single-dose prefilled syringe (see below)
• Administer by subcutaneous injection
• Recommended dose is 30mg every 4 weeks for the first 3 doses, followed
by once every 8 weeks thereafter
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/761070s000lbl.pdf
8. Fasenra® (benralizumab)
• Warnings/Precautions:
• Not for treatment of other eosinophilic conditions
• Not for relief of acute bronchospasm or status asthmaticus
• Hypersensitivity reactions (e.g., anaphylaxis, angioedema, urticaria, rash)
have occurred after. Discontinue in the event of a hypersensitivity
reaction.
• Do not discontinue systemic or inhaled corticosteroids abruptly upon
initiation of therapy with. Decrease corticosteroids gradually, if
appropriate.
• Parasitic (Helminth) Infection: Treat patients with pre-existing helminth
infections before therapy. If patients become infected while receiving
Fasenra® and do not respond to anti-helminth treatment, discontinue
until the parasitic infection resolves.
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/761070s000lbl.pdf
9. FDA Approval
• Prevymis® (letermovir) – approved 11/14/17
• A CMV DNA terminase complex inhibitor
• Indicated for prophylaxis of cytomegalovirus (CMV) infection and disease
in adult CMV-seropositive recipients [R+] of an allogeneic hematopoietic
stem cell transplant (HSCT)
• Formulation / Administration:
• Tablet: 240mg; 480mg
• Injection: 240mg/12mL (20mg/mL) or 480mg/24mL (20mg/mL) in a
single-dose vial
• Usual Dosing: 480mg administered once daily orally or as an intravenous
(IV) infusion over 1 hour through 100 days post-transplant
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209939Orig1s000,209940Orig1s000lbl.pdf
10. Prevymis® (letermovir)
• Dose adjustments:
• If co-administered with cyclosporine, the dosage should be decreased to
240mg once daily
• Closely monitor serum creatinine levels in patients with CLcr less than
50mL/min
• Not recommended for patients with severe (Child-Pugh C) hepatic
impairment
• Contraindicated with:
• Pimozide
• Ergot Akaloids
• Pitavastatin and simvastatin when co-administered with cyclosporine
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209939Orig1s000,209940Orig1s000lbl.pdf
11. Prevymis® (letermovir)
• Other Drug Interactions:
• Prevymis® is a moderate inhibitor of CYP3A and of OATP1B1/3
transporters
• Can increase concentrations of the following medications:
• Amiodarone
• HMG Co-A Reductase Inhibitors
• CYP3A substrates
• Can decrease concentrations of the following medications:
• Warfarin
• Phenytoin
• Omeprazole / Pantoprazole
• Administration with rifampin is NOT recommended
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209939Orig1s000,209940Orig1s000lbl.pdf
12. Prevymis® (letermovir)
• Adverse Reactions:
• Most common are nausea, diarrhea, vomiting, peripheral edema, cough,
headache, fatigue, and abdominal pain
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209939Orig1s000,209940Orig1s000lbl.pdf
13. FDA Approval
• Vyzulta® (latanoprostene bunod ophthalmic solution) –
approved 11/2/17
• A prostaglandin analog
• Indicated for the reduction of intraocular pressure in patients with open-
angle glaucoma or ocular hypertension
• Formulation / Administration:
• Topical ophthalmic solution: 0.24 mg/mL latanoprostene bunod (0.024%)
• One drop in the affected eye(s) once daily in the evening
• Contact lenses should be removed prior to the administration because
this product contains benzalkonium chloride. Lenses may be reinserted
15 minutes after administration
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/207795Orig1s000lbl.pdf
14. Vyzulta® (latanoprostene bunod ophthalmic
solution)
• Storage
• Unopened bottle should be stored refrigerated at 2 - 8℃ (36 - 46℉). Once
a bottle is opened it may be stored at 2 - 25℃ (36 - 77℉) for 8 weeks
• Warnings/Precautions:
• Increased pigmentation of the iris and periorbital tissue (eyelid) can
occur. Iris pigmentation is likely to be permanent
• Gradual changes to eyelashes including increased length, increased
thickness and number of eyelashes. Usually reversible upon
discontinuation of treatment
• Adverse Reactions:
• Most common ocular adverse reactions with incidence ≥ 2% are
conjunctival hyperemia (6%), eye irritation (4%), eye pain (3%), and
instillation site pain (2%)
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/207795Orig1s000lbl.pdf
15. Another Me Too Drug?
• Vyzulta® is nearly identical to that of latanoprost
• Distinguished, however, by the integration of an NO-donating moiety (a
terminal butyl nitrate ester functional group) in lieu of an isopropyl ester
• Hydrolyzed by endogenous corneal esterases into latanoprost acid – the
active component of latanoprost – and butanediol mononitrate, which is
further metabolized to NO and the inactive 1,4-butanediol
Clin Ophthalmol. 2016; 10: 2035–2050.
16. FDA Approval
• Juluca® (dolutegravir; rilpivirine) – approved 11/21/17
• A two-drug combination of dolutegravir, a human immunodeficiency
virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI), and
rilpivirine, a HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI)
• Indicated as a complete regimen for the treatment of HIV-1 infection in
adults to replace the current antiretroviral regimen in those who are
virologically suppressed (HIV-1 RNA less than 50 copies per mL) on a
stable antiretroviral regimen for at least 6 months with no history of
treatment failure and no known substitutions associated with resistance
to the individual components
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/210192s000lbl.pdf
17. Juluca® (dolutegravir; rilpivirine)
• Formulation / Administration:
• Each tablet contains: 50mg of dolutegravir (equivalent to 52.6mg
dolutegravir sodium) and 25mg of rilpivirine (equivalent to 27.5mg
rilpivirine hydrochloride)
• One tablet taken orally once daily with a meal
• Rifabutin co-administration: Take an additional 25-mg tablet of rilpivirine
with Juluca® once daily with a meal for the duration of the rifabutin co-
administration
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/210192s000lbl.pdf
18. Juluca® (dolutegravir; rilpivirine)
• Warnings/Precautions:
• Severe skin and hypersensitivity reactions characterized by rash,
constitutional findings, and sometimes organ dysfunction, including liver
injury, have been reported with the individual components. Discontinue
immediately if signs or symptoms of severe skin or hypersensitivity
reactions develop, as a delay in stopping treatment may result in a life-
threatening reaction
• Hepatotoxicity has been reported in patients receiving a dolutegravir-or
rilpivirine-containing regimen. Monitoring for hepatotoxicity is
recommended
• Depressive disorders have been reported with the use of rilpivirine-or
dolutegravir-containing regimens. Immediate medical evaluation is
recommended for severe depressive symptoms
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/210192s000lbl.pdf
19. Juluca® (dolutegravir; rilpivirine)
• Drug Interactions:
• Because Juluca® is a complete regimen, co-administration with other
antiretroviral medications for the treatment of HIV-1 infection is not
recommended
• Drugs that induce or inhibit CYP3A4 or UGT1A1 may affect the plasma
concentrations
• Drugs that increase gastric pH or containing polyvalent cations may
decrease plasma concentrations
• Consider alternatives with drugs with a known risk of Torsade de Pointes
• Contraindicated with:
• Anticonvulsants, PPIs, St. John’s wort (see table 1 and 4 for additional
medications and explanation)
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/210192s000lbl.pdf
20. Juluca® (dolutegravir; rilpivirine)
• Dose adjustments:
• Renal impairment:
• In patients with severe renal impairment (creatinine clearance less than 30
mL/min) or end-stage renal disease, increased monitoring for adverse effect s
is recommended
• Hepatic impairment:
• The effect of severe hepatic impairment (Child-P ugh Score C) on the
pharmacokinetics of dolutegravir or rilpivirine is unknown
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/210192s000lbl.pdf
21. Other October FDA Approvals
• Lyrica CR® (pregabalin)
1
– 10/11/2017:
• New Formulation: Extended release tablets (82.5mg, 165mg, and 330mg)
• Byurdeon® Bcise™ (exanatide)
2
– 10/20/2017:
• New Dose Form: Extended-release injectable suspension
• Varubi® (rolapitant)3 – 10/25/2017:
• New Dosage Form: Injectable emulsion, for intravenous use
1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209501s000lbl.pdf
2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209210s000lbl.pdf
3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208399s000lbl.pdf
22. Other October FDA Approvals
• Daptomycin
1
– 10/20/2017
• New Formulation: 350 mg/vial for the treatment of adult patients with
Complicated Skin and Skin Structure Infections (cSSSI) and
Staphylococcus aureus Bloodstream Infections (Bacteremia), including
those with Right-Sided Infective Endocarditis, caused by Methicillin-
Susceptible and Methicillin-Resistant Isolates
• Calquence® (acalabrutinib)
2
– 10/31/2017
• New Molecular Entity: To treat adults with mantle cell lymphoma
1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209949s000lbl.pdf
2. https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&varApplNo=210259
23. Other October FDA “Tentative” Approvals
• Fosaprepitant
1
- 10/12/2017
• New Formulation: 150mg/ml vial
• Pemfexy® (pemetrexed)
2
– 10/26/2017
• New Formulation: 25mg/ml vial
• Prexxartan® (valsartan)
3
– 10/30/2017
• New Dosage Form: Oral solution – 4mg/ml
1. https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=210064
2. https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=209472
3. https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=209139
24. Other November FDA Approvals
• Civanti® (aprepitant)1 – 11/9/2017:
• New Dosage Form: injectable emulsion; a substance P/neurokinin-1
(NK1) receptor antagonist, indicated in adults, in combination with other
antiemetic agents, for the prevention of:
• Acute and delayed nausea and vomiting associated with initial and repeat
courses of highly emetogenic cancer chemotherapy (HEC) including high- dose
cisplatin
• Nausea and vomiting associated with initial and repeat courses of moderately
emetogenic cancer chemotherapy (MEC)
• Tekturna® (aliskiren)2 – 11/14/2017:
• New Dosage Form: oral pellets; renin inhibitor (RI) indicated for
the treatment of hypertension in adults and children 6 years of age and
older, to lower blood pressure
1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209296s000lbl.pdf
2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/210709s000lbl.pdf
25. Other November FDA Approvals
• Hemlibra® (emicizumab)
1
– 11/16/2017
• To prevent or reduce the frequency of bleeding episodes in adult and
pediatric patients with hemophilia A who have developed antibodies
called Factor VIII (FVIII) inhibitors
• Mepsevii® (vestronidase alfa-vjbk)
2
– 11/15/2017
• To treat pediatric and adult patients with an inherited metabolic
condition called mucopolysaccharidosis type VII (MPS VII), also known as
Sly syndrome.
1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/761083s000lbl.pdf
2. https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&varApplNo=761047