This document provides an illustrative guide for reviewing or writing a scientific manuscript. It outlines key screening questions and points to consider when evaluating different sections of a manuscript, including the title, abstract, introduction, methods, results, figures/tables, discussion, citations, and overall structure. The goal is to determine if the manuscript presents novel, original research that is important to its field and properly formatted according to journal guidelines. Sections are evaluated for clarity, coherence, appropriate length, proper syntax, and adherence to reporting standards. The reviewer is advised to provide specific, constructive criticism in a good tone when determining the manuscript's suitability for publication.