The Gregorian calendar is a solar calendar that is currently used worldwide. It was introduced in 1582 by Pope Gregory XIII as a modification of the Julian calendar to correct its small error in specifying the tropical year. The Gregorian calendar averages 365.2425 days per year via a rule that 3 years out of every 400 will not be leap years, keeping its drift from the vernal equinox at approximately 1 day every 3,030 years. It consists of 12 months with 28-31 days in a common year and 29 days in February of a leap year, which occurs when the year is divisible by 4, except for centennial years not divisible by 400.
Contents
The Big Bang Theory
The Big Bang Phase
Expanding Universe
Testing Big Bang Model
Dark matter & Dark energy
Evidence of dark matter
After time period of Big Bang
Life cycle of star
Lines of Latitude and Longitude – PowerPointYaryalitsa
PowerPoint on Lines of Latitude, Lines of Longitude, Climate Zones, Equinoxes, Solstices, The Three Norths, Prime Meridian, International Date Line, Greenwich Mean Time, Coordinated Universal Time.
Lines of Latitude and Longitude – Worksheet at:
http://www.slideshare.net/yaryalitsa/lines-of-latitude-and-longitude-worksheet
This is a self-made presentation about The Big Bang Theory (NOT the TV show :P) to be given to a lecturer and students of University level. Intended for all those to download who may have presentations to give and can't find a good enough topic :). Everyone else is free to download it for other purposes as well!!
Contents
The Big Bang Theory
The Big Bang Phase
Expanding Universe
Testing Big Bang Model
Dark matter & Dark energy
Evidence of dark matter
After time period of Big Bang
Life cycle of star
Lines of Latitude and Longitude – PowerPointYaryalitsa
PowerPoint on Lines of Latitude, Lines of Longitude, Climate Zones, Equinoxes, Solstices, The Three Norths, Prime Meridian, International Date Line, Greenwich Mean Time, Coordinated Universal Time.
Lines of Latitude and Longitude – Worksheet at:
http://www.slideshare.net/yaryalitsa/lines-of-latitude-and-longitude-worksheet
This is a self-made presentation about The Big Bang Theory (NOT the TV show :P) to be given to a lecturer and students of University level. Intended for all those to download who may have presentations to give and can't find a good enough topic :). Everyone else is free to download it for other purposes as well!!
Learn about comets, what they’re made of, and how they move from the university that has discovered 52% of all known near-Earth objects, including comets.
A "lunar eclipse" and a "solar eclipse" refer to events involving three celestial bodies: the Sun ("solar"), the moon ("lunar"), and the Earth. A lunar eclipse occurs when the Earth passes between the Moon and the Sun, and the Earth's shadow obscures the moon or a portion of it. A solar eclipse occurs when the Moon passes between the Earth and the Sun, blocking all or a portion of the Sun.
Learn about comets, what they’re made of, and how they move from the university that has discovered 52% of all known near-Earth objects, including comets.
A "lunar eclipse" and a "solar eclipse" refer to events involving three celestial bodies: the Sun ("solar"), the moon ("lunar"), and the Earth. A lunar eclipse occurs when the Earth passes between the Moon and the Sun, and the Earth's shadow obscures the moon or a portion of it. A solar eclipse occurs when the Moon passes between the Earth and the Sun, blocking all or a portion of the Sun.
Earth rotates from which direction? The earth rotates from west to east around a straight line passing through the north and south poles. Therefore, it seems that celestial bodies such as the sun and the moon are turning from east to west.
Galileo said in the 17th century that the earth was spinning, but he couldn’t believe it.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Multi-source connectivity as the driver of solar wind variability in the heli...
A case study on Gregorian Calendar
1. A Case Study on
Gregorian Calendar
Submitted By:
L.Ramkiran
Submitted to:
G.S.Gisa
2. WHAT IS A CALENDAR?
• A calendar is a system of organizing days for social, religious, commercial or administrative purposes.
• This is done by giving names to periods of time, like days, weeks, months and years.
• A date is the designation of a single, specific day within such a system.
• A calendar is also a physical record (often paper) of such a system.
• A calendar can also mean a list of planned events, such as a court calendar or a partly or fully
chronological list of documents, such as a calendar of wills.
4. THE MAIN REASONS FOR USING A CALENDAR.
• Planning the daily activates
• Keeping a track of events
• Staying organized and enhancing productivity
• Planning efficiently and meeting the deadlines
• Remembering birthdays and keeping commitments
• Managing the daily schedule
• Remembering important festival dates and many more…..
5. WHEN WAS THE FIRST CALENDAR CONSTRUCTED?
• British archaeology experts have discovered what they believe to be the world's oldest 'calendar', created by hunter-
gatherer societies and dating back to around 8,000 BC.
• The Mesolithic monument was originally excavated in Aberdeen shire, Scotland, by the National Trust for Scotland in 2004.
Now analysis by a team led by the University of Birmingham, published today (July 15, 2013) in the journal Internet
Archaeology, sheds remarkable new light on the luni-solar device, which pre-dates the first formal time-measuring devices
known to Man, found in the Near East, by nearly 5,000 years.
• The capacity to measure time is among the most important of human achievements and the issue of when time was
'created' by humankind is critical in understanding how society has developed.
• Until now the first formal calendars appear to have been created in Mesopotamia c, 5000 years ago. But during this
project, the researchers discovered that a monument created by hunter gatherers in Aberdeen shire nearly 10,000 years
ago appears to mimic the phases of the Moon in order to track lunar months over the course of a year.
6. TYPES OF CALENDAR
• There are umpteen number of calendars as each civilization had their own calendar.
• But they all are based on these below mentioned types:
• Fixed (No. of days varies based on the civilization)
• Lunar
• Solar
• Lunisolar/Seasonal
7. LUNAR CALENDAR
• A lunar calendar is a calendar based upon the monthly cycles of
the Moon's phases (synodic months).
• List of lunar calendars
• Gezer Calendar
• Haida
• Islamic calendar
• Nepal Sambat
• Javanese calendar
• Assyrian calendar
• Yoruba calendar
• Igbo calendar
8. LUNISOLAR CALENDAR
• A lunisolar calendar is a calendar in many cultures whose date indicates both the Moon phase and the
time of the solar year. If the solar year is defined as a tropical year, then a lunisolar calendar will give an
indication of the season; if it is taken as a sidereal year, then the calendar will predict
the constellation near which the full moon may occur.
• As with all calendars which divide the year into months there is an additional requirement that the year
have a whole number of months. In this case ordinary years consist of twelve months but every second
or third year is an embolismic year, which adds a thirteenth intercalary, embolismic, or leap month.
• The Hebrew, Jain, Buddhist, Hindu and Kurdish as well as the
traditional Burmese, Chinese, Japanese, Tibetan, Vietnamese, Mongolian and Korean calendars (in
the east Asian cultural sphere), plus the ancient Hellenic, Coligny, and Babylonian calendars are all
lunisolar.
9. SOLAR CALENDAR
• A solar calendar is a calendar whose dates indicate the season or almost equivalently the
apparent position of the Sun relative to the stars.
• The oldest solar calendars include the Julian calendar and the Coptic calendar. They both have a year of
365 days, which is extended to 366 once every four years, without exception, so have a mean year of
365.25 days. As solar calendars became more accurate, they evolved into two types.
• Bengali calendar (National and official calendar in Bangladesh)
• Iranian calendar (Jalāli calendar)
• Indian national calendar (Saka calendar)
10. FIXED DAYS
• They just have fixed number of days for a year and they repeat in cycles as time proceeds.
• Examples are:
• Egyptian calendar- 365 Days
• Tonalpohualli- 260 Days
• Qumran Calendrical texts- 364 days.
• Pawukon Calendar- 210 days.
11. SO WHICH CALENDAR DO YOU THINK GREGORIAN
CALENDAR IS?
Solar Calendar
12. HISTORY OF GREGORIAN CALENDAR
• It is named after Pope Gregory XIII, who introduced it in October 1582. The calendar spaces leap
years to make the average year 365.2425 days long, approximating the 365.2422-day tropical year that
is determined by the Earth's revolution around the Sun.
• The calendar was developed as a correction to the Julian calendar, shortening the average year by
0.0075 days to stop the drift of the calendar with respect to the equinoxes. To deal with the 10 days'
difference (between calendar and reality) that this drift had already reached, the date was advanced so
that 4 October 1582 was followed by 15 October 1582.
• There was no discontinuity in the cycle of weekdays or of the Anno Domini calendar era. The reform
also altered the lunar cycle used by the Church to calculate the date for Easter (computus), restoring it
to the time of the year as originally celebrated by the early Church.
13. THERE’S A RULE FOR A LEAP YEAR IN THIS CALENDAR
• Every year that is exactly divisible by four is a leap year, except for years that
are exactly divisible by 100, but these centurial years are leap years if they are
exactly divisible by 400. For example, the years 1700, 1800, and 1900 are not
leap years, but the year 2000 is.
14. MONTHS IN GREGORIAN CALENDAR• Months
• The Gregorian calendar continued to employ the Julian months, which have Latinate names and irregular numbers of days:
• January (31 days), from Latin mēnsis Iānuārius, "Month of Janus", the Roman god of gates, doorways, beginnings and endings
• February (28 days in common and 29 in leap years), from Latin mēnsis Februārius, "Month of the Februa", the Roman
festival of purgation and purification, cognate with fever, the Etruscan death god Februus ("Purifier"), and the PIE word
for sulfur
• March (31 days), from Latin mēnsis Mārtius, "Month of Mars", the Roman war god
• April (30 days), from Latin mēnsis Aprīlis, of uncertain meaning but usually derived from some form of the verb aperire ("to
open") or the name of the goddess Aphrodite
• May (31 days), from Latin mēnsis Māius, "Month of Maia", a Roman vegetation goddess whose name is cognate with
Latin magnus ("great") and English major
• June (30 days), from Latin mēnsis Iūnius, "Month of Juno", the Roman goddess of marriage, childbirth, and rule
• July (31 days), from Latin mēnsis Iūlius, "Month of Julius Caesar", the month of Caesar's birth, instituted in 44 BC as part of his
calendrical reforms
• August (31 days), from Latin mēnsis Augustus, "Month of Augustus", instituted by Augustus in 8 BC in agreement with July
and from the occurrence during the month of several important events during his rise to power.
• September (30 days), from Latin mēnsis september, "seventh month", from its position in the Roman calendar before 153 BC
• October (31 days), from Latin mēnsis octōber, "eighth month", from its position in the Roman calendar before 153 BC
• November (30 days), from Latin mēnsis november, "ninth month", from its position in the Roman calendar before 153 BC
• December (31 days), from Latin mēnsis december, "tenth month", from its position in the Roman calendar before 153 BC
15. A SONG ON HOW TO
REMEMBER THE NO. DAYS
IN EACH MONTH.
16. WEEKS IN GREGORIAN CALENDAR
• In conjunction with the system of months there is a system of weeks. A physical or electronic calendar
provides conversion from a given date to the weekday, and shows multiple dates for a given weekday
and month. Calculating the day of the week is not very simple, because of the irregularities in the
Gregorian system. When the Gregorian calendar was adopted by each country, the weekly cycle
continued uninterrupted. For example, in the case of the few countries that adopted the reformed
calendar on the date proposed by Gregory XIII for the calendar's adoption, Friday, 15 October 1582, the
preceding date was Thursday, 4 October 1582 (Julian calendar).
• Opinions vary about the numbering of the days of the week. ISO 8601, in common use worldwide,
starts with Monday=1; printed monthly calendar grids often list Mondays in the first (left) column of
dates and Sundays in the last. In North America, the week typically begins on Sunday and ends on
Saturday.
17. ACCURACY
• The Gregorian calendar improves the approximation made by the Julian calendar by skipping three
Julian leap days in every 400 years, giving an average year of 365.2425 mean solar days long.
• This approximation has an error of about one day per 3,030 years with respect to the current value of
the mean tropical year.
• However, because of the precession of the equinoxes, which is not constant, and the movement of
the perihelion (which affects the Earth's orbital speed) the error with respect to the astronomical vernal
equinox is variable; using the average interval between vernal equinoxes near 2000 of 365.24237
days implies an error closer to 1 day every 7,700 years.
• By any criterion, the Gregorian calendar is substantially more accurate than the 1 day in 128 years error
of the Julian calendar (average year 365.25 days).
Have you ever thought how life would be without a calendar? Just imagine what would happen if all the calendars just disappeared. We would be clueless and helpless at the same time coz we are so used to it. We have been using this since the beginning of civilization. Of course, all of them are of different versions. We need a calendar because it a way that keeps things organized.
The Indian national calendar, sometimes called the Shalivahana Shaka calendar. It is used, alongside the Gregorian calendar, by The Gazette of India, in news broadcasts by All India Radio and in calendars and communications issued by the Government of India.[1] The Saka calendar is also used in Java and Bali among Indonesian Hindus. Nyepi, the "Day of Silence", is a celebration of the Saka new year in Bali. Nepal's Nepal Sambat evolved from the Saka calendar. Prior to colonization, the Philippines used to apply the Saka calendar as well as suggested by the Laguna Copperplate Inscription.
Sept, Oct, Nov, Dec 9,10,11,12 Why?
This image shows the difference between the Gregorian calendar and the astronomical seasons.
The y-axis is the date in June and the x-axis is Gregorian calendar years.
Each point is the date and time of the June solstice in that particular year. The error shifts by about a quarter of a day per year. Centurial years are ordinary years, unless they are divisible by 400, in which case they are leap years. This causes a correction in the years 1700, 1800, 1900, 2100, 2200, and 2300.
For instance, these corrections cause 23 December 1903 to be the latest December solstice, and 20 December 2096 to be the earliest solstice—about 2.35 days of variation compared with the seasonal event.