A 420 Med Evaluations Guide On Different Forms Of Cannabis Consumption.pptx
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Lesson B9.pdfLesson B.9 Dr. W.J. Racz CANNA.docx
Lesson B9.pdf
Lesson B.9 Dr. W.J. Racz
CANNABIS
Reference: A Primer of Drug Action, 12
th
ed.
Objectives
At the conclusion of this lesson, you should be able to: (1) describe the history of cannabis use,
(2) state the mechanism of action of the cannabinoids, (3) state the time of onset and duration of
response to smoking marijuana, (4) list the accepted medical and proposed medical uses of the
cannabinoids, (5) describe the effects of short-term, low-dose and high-dose use of cannabis, (6)
describe the effects of chronic high-dose use of cannabis, and (7) describe the degree and type of
tolerance and dependence associated with cannabis.
Introduction
The term “cannabis” refers to the drug-containing forms of the hemp plant, Cannabis sativa,
which is an herbaceous annual. There are two varieties of Cannabis sativa – resin-producing and
fibre-producing. In Cannabis sativa, there are 420 chemical compounds, many of which are
common to other plants. There are 60 compounds that are found only in Cannabis sativa, and
these compounds are referred to as cannabinoids. Of these compounds, l-trans-Δ
9
-
tetrahydrocannabinol (THC) is the most potent psychoactive agent in cannabis, and THC
accounts for most, but not all, of the psychoactive effects of cannabis. Common names for
cannabis or its products include marijuana, hashish, hashish oil, charas, bhang, ganja, and dagga.
Marijuana, hashish and hashish oil are the cannabis preparations most common to North
America.
History
2700 BC – 1800’s Cannabis plant was used for manufacturing rope; marijuana was used for
its mild intoxicating effects as it was considered less harmful than alcohol.
1920’s – 1930’s Public concern was raised over the effects of marijuana on individuals and
society (“menace of marijuana”). Legislation was enacted to outlaw the
use of marijuana, which was considered to be a narcotic.
1960’s – 1970’s Increased use of cannabis, primarily in the form of marijuana. Survey in
1972: more than two million people in the U.S.A. reported daily use of
marijuana. Survey in 1977: 60% of young adults in the U.S.A. reported
some experience (?) with marijuana. A 1979 survey in Ontario revealed
that approximately 50% of students aged 16 or over reported some use of
marijuana in the preceding 12 months.
1978 U.S.A.-sponsored project using the herbicide, paraquat, was initiated in an
Lesson B.9 CANNABIS
______________________________________________________________________________
2
attempt to destroy cannabis crops in Mexico. It failed. U.S.A. citizens
were smoking cannabis products containing paraquat, which can produce
lung toxicity.
1980’s In the early 1980’s, the use of marijuana began to stabilize. In 1982, 42%
of high school students in the U.S.A. reported use of the drug in the
previous year and 5.5% used it daily. The figures in Ontario were similar.
1990’s ...
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You may have heard that cannabis has a lot of health benefits. The plant of marijuana is filled with unique chemicals and compounds that have positive impact when they interact with receptors in our bodies.
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Getting high by taking too much cannabis is common. Learn how long a cannabis high last and how to sober up quickly. Visit medicalmarijuanacardanaheim.com
Lesson B9.pdfLesson B.9 Dr. W.J. Racz CANNA.docx
Lesson B9.pdf
Lesson B.9 Dr. W.J. Racz
CANNABIS
Reference: A Primer of Drug Action, 12
th
ed.
Objectives
At the conclusion of this lesson, you should be able to: (1) describe the history of cannabis use,
(2) state the mechanism of action of the cannabinoids, (3) state the time of onset and duration of
response to smoking marijuana, (4) list the accepted medical and proposed medical uses of the
cannabinoids, (5) describe the effects of short-term, low-dose and high-dose use of cannabis, (6)
describe the effects of chronic high-dose use of cannabis, and (7) describe the degree and type of
tolerance and dependence associated with cannabis.
Introduction
The term “cannabis” refers to the drug-containing forms of the hemp plant, Cannabis sativa,
which is an herbaceous annual. There are two varieties of Cannabis sativa – resin-producing and
fibre-producing. In Cannabis sativa, there are 420 chemical compounds, many of which are
common to other plants. There are 60 compounds that are found only in Cannabis sativa, and
these compounds are referred to as cannabinoids. Of these compounds, l-trans-Δ
9
-
tetrahydrocannabinol (THC) is the most potent psychoactive agent in cannabis, and THC
accounts for most, but not all, of the psychoactive effects of cannabis. Common names for
cannabis or its products include marijuana, hashish, hashish oil, charas, bhang, ganja, and dagga.
Marijuana, hashish and hashish oil are the cannabis preparations most common to North
America.
History
2700 BC – 1800’s Cannabis plant was used for manufacturing rope; marijuana was used for
its mild intoxicating effects as it was considered less harmful than alcohol.
1920’s – 1930’s Public concern was raised over the effects of marijuana on individuals and
society (“menace of marijuana”). Legislation was enacted to outlaw the
use of marijuana, which was considered to be a narcotic.
1960’s – 1970’s Increased use of cannabis, primarily in the form of marijuana. Survey in
1972: more than two million people in the U.S.A. reported daily use of
marijuana. Survey in 1977: 60% of young adults in the U.S.A. reported
some experience (?) with marijuana. A 1979 survey in Ontario revealed
that approximately 50% of students aged 16 or over reported some use of
marijuana in the preceding 12 months.
1978 U.S.A.-sponsored project using the herbicide, paraquat, was initiated in an
Lesson B.9 CANNABIS
______________________________________________________________________________
2
attempt to destroy cannabis crops in Mexico. It failed. U.S.A. citizens
were smoking cannabis products containing paraquat, which can produce
lung toxicity.
1980’s In the early 1980’s, the use of marijuana began to stabilize. In 1982, 42%
of high school students in the U.S.A. reported use of the drug in the
previous year and 5.5% used it daily. The figures in Ontario were similar.
1990’s ...
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Cannabis (also known as marijuana) is the most frequently used illicit psychoactive substance in the world, with more than 500 components. Cannabinoids are psychoactive compounds extracted from the cannabis plants (cannabis stavia), and classified mainly into 5 classes: classical cannabinoids, non-classical cannabinoids, hybrid cannabinoids, aminoalkylindoles, and eicosanoids cannabinoids. Cannabinoids are endogenous in humans, animals and plants, or synthetically produced. In recent years, the use of synthetic cannabinoids as a substitute for cannabis has been on the increase. However, there is also some concern about their potential effects on users. Cannabidiol and tetrahydrocannabinol (THC) are the most studied cannabinoids and both interact with endocannabinoid receptors in various human tissues, so there are a trend to use cannabinoids in Medicine and Pharmacology. Cannabis plants produce many compounds of possible medical importance. In this article, we discuss the natural cannabis and synthetic cannabinoids and their extraction, their principle components, their abuses, and their effects on the human body, and their roles in medicine and pharmacology, also we discus the biosynthesis of cannabinoids, and the synthetic cannabinoid classification system.
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THE MARIJUANA FACTS BOOK AND GIFT BOOK.pdf
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Get ready to immerse yourself in some of the most curious and astonishing facts known to cannabis enthusiasts! Uncover the secrets of the cannabis world and be the go-to person for intriguing tidbits that will leave everyone wanting to join in on the fun.
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This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
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Physiology of Chemical Sensation of smell.pdf
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
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Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Physiology of Special Chemical Sensation of Taste
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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