醫學專欄~陳俊廷-淺談藥物性肝炎

1. B C
10%
5%
A：內因性毒性(intrinsic toxicity)引
起的肝傷害
(1)
(predictable) (2)
(dose dependent) (3)
(high incidence) (4)
(experimental reproducibility) (5)
(rapid
onset)
(direct) (indirect)
(hepatocyte) (duct epithelium)
(hepatocyte
necrosis) (steatosis)
(cholestasis)
CCl4
paraquat
acetaminophen,steroi
d,methotrexate
B：特異性體質(host idiosyncratics)
引起的肝傷害
(1)
(2) (3) (4)

2. (5)
(immunologic idiosyncrasy)
(cellular) (humoral)
(eosinophilia)
phenytoin, halothane
(metabolic idiosyncrasy)
isoniazid
methyldopa sulfa drug
insoniazid
1.
2.
B C
3.
4.
5.
acetaminophen
acetylcysteine