This document discusses inherited diseases and provides examples. It explains that inherited diseases can be recessive, which requires mutations from both parents, or dominant, which only requires one parent. Examples given are cystic fibrosis and Huntington's disease. Cystic fibrosis is caused by thick mucus and leads to lung infections and early death. Huntington's disease is a neurological condition caused by brain cell deterioration that results in movement and cognitive issues and usually death 15-20 years after onset. The document states that inherited diseases are caused by changes in DNA that get passed down from parents and affect the body's growth and function.

1. Inherited Diseases
© 2013 Project Lead The Way, Inc.Medical Detectives

2. Types of Inherited Diseases
• Recessive
– Requires a mutated
copy of the gene
from each parent for
child to have the
disease.

3. Types of Inherited Diseases
• Dominant
– Requires a mutated
copy of the gene
from only one parent
for the child to have
the disease.

4. Examples of Inherited Diseases
• Tay Sachs
• Hemophilia
• Cystic Fibrosis
• Huntington’s Disease
• Polycystic Kidney Disease
• Hemachromatosis
• Sickle Cell Disease

5. Cystic Fibrosis
What is it? A recessive genetic disease caused
by the production of abnormal, thick,
sticky mucus.
What is the
outcome?
Death caused by lung infections
usually before age 35.
What are
the
symptoms?
•Coughing and wheezing
•Diarrhea
•Chronic lung infections

6. What is it? A dominant genetic disease caused
by the deterioration of nerve cells in
the brain.
What is the
outcome?
Continual decline in mental and
physical ability; death usually occurs
15 to 20 years after onset.
What are
the
symptoms?
•Difficulty walking
•Uncontrollable body movements
•Memory and cognitive impairment
Huntington’s Disease

7. What Causes Inherited Diseases?
• Genetic material of a cell is changed, causing a
change in the cell’s and ultimately the body’s
function which lead to a disease.
• The genetic material is deoxyribonucleic acid
(DNA) and contains the instructions for the
growth and development of the individual.
• The changed genetic material is passed from
parent to child.

8. Image Resources
By Français : Domaina [CC-BY-SA-3.0
(http://creativecommons.org/licenses/by-sa/3.0)], via Wikimedia
Commons
By Kashmiri, based on earlier work by Domaina [CC-BY-SA-3.0
(http://creativecommons.org/licenses/by-sa/3.0)], via Wikimedia
Commons
By KES47 (File:Chromosome zh.svg) [CC-BY-3.0
(http://creativecommons.org/licenses/by/3.0)], via Wikimedia
Commons