This document discusses various medical conditions that can cause calcification in the spleen that are identifiable on clinical imaging. It provides 8 figures showing examples of calcification from specific conditions, such as histoplasmosis causing multiple small calcifications, brucellosis producing a large calcified granuloma, a huge calcified nonparasitic splenic cyst, and calcification of the splenic artery or from a splenic artery aneurysm. Sickle cell anemia is also noted as potentially increasing splenic density on imaging.

1. 51Spleen Calcification

2. CLINICAL IMAGAGING
AN ATLAS OF DIFFERENTIAL DAIGNOSIS
EISENBERG
DR. Muhammad Bin Zulfiqar
PGR-FCPS III SIMS/SHL

3. • Fig GI 51-1 Histoplasmosis. CT scan shows
multiple small calcifications in the spleen.

4. • Fig GI 51-2 Brucellosis. Large calcified splenic
granulomas.

5. • Fig GI 51-3 Huge calcified nonparasitic splenic
cyst.

6. • Fig GI 51-4 Calcified hydatid cyst of the spleen
(echinococcal disease).

7. • Fig GI 51-5 Calcified splenic hematoma.

8. • Fig GI 51-6 Calcification of the splenic artery.

9. • Fig GI 51-7 Splenic artery aneurysm producing
bizarre, lobulated calcification.

10. • Fig GI 51-8 Sickle cell anemia causing
generalized increase in splenic density
(arrows).