Neoplatonism began in Alexandria in the 3rd century AD and was characterized by a categorical opposition between the spiritual and physical realms. It hypothesized mediating agencies like the nous and world soul that transmit divine power from the One to the many. Neoplatonism advocated for ascetic discipline as a means of liberation from the material world through rigorous spiritual practices. While it had some institutional support through academies like those founded by Marsilio Ficino, Renaissance Platonism lacked coherence as a unified school or movement of thought.