Building on the sell-out success of the launch event, SMi Group is delighted to announce the return of 3D Cell Culture, taking place on 21st and 22nd of February 2018, in London UK. 3D Cell Culture is rapidly growing with incredible potential for industrial application and a widespread reach that can be seen across many different fields, such as 3D bioprinting and microfluidics. The 2nd annual conference will explore these overlapping areas and will combine pioneering breakthroughs with scientific research to strengthen your commercial success. Join us for exclusive insight into key topics such as disease models, organoids, organ-on-a-chip technologies, Ipsc advances and CRISPR technology. Notable speakers on the agenda for 2018 will include experts from Aurelia Bioscience, ReInnervate Ltd, Cell and Gene Therapy Catapult, University College London, Novartis Institutes for Biomedical Research, Kugelmeiers, GSK, AstraZeneca, Roche and more!

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www.3D-CellCulture.com
Register online or fax your registration to +44 (0) 870 9090 712 or call +44 (0) 870 9090 711
ACADEMIC & GROUP DISCOUNTS AVAILABLE @SMIPHARM
Combining pioneering breakthroughs with scientific
research to strengthen your commercial success
SMi presents the 2nd Annual Conference on…
3D Cell Culture
WORKSHOPS: 20TH
CONFERENCE:
21ST - 22ND
FEB
2018Holiday Inn Kensington Forum, London, UK
HIGHLIGHTS IN 2018:
• Uncover the biology of human neurodevelopment diseases in
3D by merging cutting edge technologies in CRISPR editing and
single cell sequencing
• Take a 3D biology approach to overcome challenges for well
based screening with exclusive insight into electrospun micro-
scaffold based biology
• Develop strategies for optimising placement of cells in printing
by identifying key developments in the overlap of 3D bioprinting
and 3D cell culturing
• Discover new approaches to predictive substance testing through
innovative case study insight into multi-organ-chip technology
• Benefit from an agenda tailored towards driving clinical
development through ground breaking case studies on the
Zika virus and tuberous sclerosis
• Two part exclusive spotlight on regenerative medicine and
drug screening
CHAIRS FOR 2018:
• Stefan Przyborski, Professor of Cell Technology,
University of Durham
• Gary Allenby, Business Development Director
and Chief Scientific Officer, Aurelia Bioscience
FEATURED SPEAKERS:
• Christopher Schofield, Investigator, GSK
• Tudor Petreus, PostDoctoral Researcher, AstraZeneca
• Stefan Kustermann, Lab Head, Roche
• Max Salick, Post-Doctoral Researcher,
Novartis Institutes for Biomedical Research
• Vitor Santo, Senior Scientist, Immunocore
• David Pan, Programme Manager UK Regenerative Medicine
Platform, Medical Research Council
• Patrick Kugelmeier, Director of Science, Kugelmeiers
ATTENDEE TESTIMONIALS FROM 2017
“Very good presentations and a few
outstanding ones... I made some
useful contacts” ASTERAND BIOSCIENCE
“The conference was wonderfully
organised” NOVARTIS
“Good start, love to see the event
occur again” THERMO FISHER SCIENTIFIC
PLUS AN INTERACTIVE HALF-DAY PRE-CONFERENCE WORKSHOP
Tuesday 20th February 2018, Holiday Inn Kensington Forum, London, UK
3D Bioprinting and Other Biofabrication Approaches
13.00 - 17.30
Workshop Leaders: Dr Nick Leslie, Professor, Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot Watt University and
Dr Daniela Loessner, Reader, Barts Cancer Institute, CRUK Centre of Excellence, Queen Mary University of London
Sponsored by

2. Register online at www.3D-CellCulture.com
SPONSORSHIP AND EXHIBITION OPPORTUNITIES
SMi offer sponsorship, exhibition, advertising and branding packages, uniquely tailored to complement your company’s marketing strategy.
Prime networking opportunities exist to entertain, enhance and expand your client base within the context of an independent discussion specific
to your industry. Should you wish to join the increasing number of companies benefiting from sponsoring our conferences please call:
Alia Malick on +44 (0) 20 7827 6168 or email: amalick@smi-online.co.uk
08.30 Registration & Coffee
09.00 Chair’s Opening Remarks
Stefan Przyborski, Professor of Cell Technology,
University of Durham
TECHNICAL ADVANCEMENTS TO ENHANCE 3D CULTURE SYSTEMS
KEYNOTE ADDRESS
09.10 3D Cell Culture – A Rapidly Developing Series of Technologies
Enabling the Evolution of Complex Models of Human Tissues
and In Vitro Assays
• 3D vs 2D cell culture – the similarities and differences
between both methods
• Demand for 3D cell culture
• No one solution - alternative techniques: organoids,
spheroids, hydrogels and scaffolds
• Examples of current applications – simple 3D cultures to
engineering complex tissues
• Case example – building layered tissue structures to model
the anatomy and physiology of native counterparts
• New developments in 3D cell culture and related
technologies
Stefan Przyborski, Professor of Cell Technology,
University of Durham
09.50 Electrospun micro-scaffold based biology – a 3-D biology approach
to overcome many challenges for well-based screening
• Electrospun scaffold material is used in regenerative medicine to
grow, differentiate and deliver stem cells into patients – we have
developed practical approaches to use this material for 3-D
screening purposes. Our primary cells, differentiated stem cells
and recombinant cells grow on and into micro-scaffold islands,
effectively 3-D micro-tissues on a matrix in micro-wells and in media.
By incorporating iron particles into the scaffold material, we can
physically manipulate the micro-scaffolds with magnetism, moving
these around wells of plates and tubes in culture. We will show data
from a number of assay readouts to exemplify the simplicity of
the approach for cell-based phenotypic screening together with
advantages of this approach for assay biology.
Gary Allenby, Business Development Director and Chief
Scientific Officer, Aurelia Bioscience
10.30 Morning Coffee
11.00 Next generation jellyfish collagen
– Applications for 3D cell culture
• Jellyfish collagen biomaterials and why considered
to be next generation
• 2D applications
• Overview of possible 3D applications
• Future potential for research and
medical applications
Andrew Spragg, CEO, Jellagen Pty Ltd
11.40 The potential of advanced cell culture models for the
understanding of disease and compound testing
• There is an increasing demand for the application of more
predictable cell models in drug discovery. These models
should be able to reflect human tissue properties and
functionality more faithfully, enabling to recapitulate in vitro
certain features of tissue microenvironment.
• Pathophysiological-relevant cell models require the existence
of cell-cell, cell-extracellular matrix and soluble factors to
caption tissue complexity at a certain extent.
• Increase in complexity of model design must be
accompanied by the application of more advanced
characterization tools and read-outs.
Vitor Santo, Senior Scientist, Immunocore
12.20 Networking Lunch
REGENERATIVE MEDICINE AND DRUG SCREENING PART I
13.30 Direct tissue engineering approaches for regenerative biology
and medicine
• Technological application in cell culture and expansion
• Biological model development
• Tissues development in a dish, for drug development and
screening etc.
• Reconstruction of tissues for repair, replacement and
rejuvenation
Suwan Jaysinghe, Professor of Bioengineering,
University College London
14.10 Can 3D cell culture improve the prediction of hepatotoxicity
in early phase screening?
• Development of a 3D primary human hepatocyte in vitro
model
• Comparison to current 2D and other complex in vitro models
• Industrialisation for compound screening and further
characterisation
• The results of a validation compound set
Christopher Schofield, Investigator, GSK
14.50 Afternoon Tea
15.20 Merging CRISPR-editing and single cell sequencing
technologies to uncover the biology of human
neurodevelopmental diseases in 3D: case studies with Zika
virus and tuberous sclerosis
• CRISPR-engineered human stem cell lines mimic disease
phenotypes during 3D cerebral organoid differentiation
• Selective removal of target genes in cerebral organoids
reveals the biology of Zika virus infection
• Whole-genome CRISPR screens enable the discovery of new
proteins linked to tropism of emerging infectious diseases
• Single cell sequencing allows researchers to investigate
cell-type specific effects of mutations, treatments, or other
perturbations in complex 3D tissues
Max Salick, Postdoctoral Researcher, Novartis Institutes For
Biomedical Research
16.00 The UKRMP – a national strategic initiative
• What are the key challenges for regenerative medicine?
• What is the ambition and of the UK’s strategic approach?
• Overview of developments, current standings and forward
plans
David Pan, Programme Manager UK Regenerative Medicine
Platform, Medical Research Council
16.40 Chair’s Closing Remarks and Close of Day One
3D Cell Culture
Day One | Wednesday 21st February 2018 www.3D-CellCulture.com
Sponsored by
Jellagen Pty Ltd is a Med-Tech business manufacturing next generation collagen products sourced from Jellyfish
for application in 2D and 3D cell culture and medical devices. Jellagen’s research grade materials are distributed
into the global cell culture and stem cell research markets. Jellagen’s collagen products offers the potential of in
vitro to in vivo applications as well as batch to batch consistency offering advantages to research and medical
applications. www.jellagen.co.uk
Nexcelom’s Cellometer and Celigo S image cytometry products are designed for cell analysis in life science
and biomedical research. The Cellometer instruments cover basic cell counting, viability and cell-based assays
with 20uL of sample. The Celigo S is a high throughput fast micro-well 2D and 3D image cytometer. Nexcelom
products are help researchers all over the world. www.nexcelomcom

3. Alternatively fax your registration to +44 (0)870 9090 712 or call +44 (0)870 9090 711
MARKETING OPPORTUNITIES
Want to know how you can get involved? Interested in promoting your services to this market?
Contact Teri Arri, SMi Marketing on +44 (0) 207 827 6162 or email: tarri@smi-online.co.uk
3D Cell Culture
www.3D-CellCulture.com Day Two | Thursday 22nd February 2018
Supported byOfficial Media Partners
08.30 Registration & Coffee
09.00 Chair’s Opening Remarks
Gary Allenby, Business Development Director and Chief
Scientific Officer, Aurelia Bioscience
3D BIOPRINTING AND ORGAN-ON-A-CHIP TECHNOLOGIES
KEYNOTE ADDRESS
09.10 The overlap of 3D bioprinting and 3D cell culturing in
Cancer Research
• Overview of 3D bioprinting
• The reliance of 3D bioprinting on spheroid models and cell
organisation
• How to achieve correct architecture, based on different
disease models
• How improving placement of cells in printing can translate
into improved model
• The synonymy of 3D bioprinting and 3D cell culture
Nicholas Leslie, Professor, Heriot-Watt University
09.50 Multi-Organ-Chip technology: A completely new approach to
predictive substance testing
• Definition and overview of Organ-on-a-Chip (OOC) systems
• Scientific concept, design principles and fabrication of OOC
• Case studies on industrial applications off OOC
• Qualification and validation of OOC
• Roadmap towards individual “Patients-on-a-Chip”
Reyk Horland, Head of Business Development, TissUse GmbH
10.30 Morning Coffee
11.00 Complex co-cultured spheroids to validate tumour models
in microfluidic devices
• Overview on the tumour-on-chip models
• Development of in vitro prevascularized minitumours –
current progress and optimization
• Prevascularized tumour models in cancer research
Tudor Petreus, PostDoctoral Researcher, AstraZeneca
REGENERATIVE MEDICINE AND DRUG SCREENING PART II
11.40 Keep up to speed with fast whole well imaging using the Celigo
image cytometer for all your 2D and 3D assay needs
• 2D and 3D immuno-oncology screening
• Immunotherapy and cellular therapy immunology
based assay
• Direct cell counting assays for immunotherapy
Scott Cribbes, Director of New Technologies
and Emerging Markets, Nexcelom
12.20 Networking Lunch
13.30 3D cellular models for drug safety assessment: an industry
perspective
• There is a strong need for complex in vitro models for drug
safety assessment recapitulating human physiology to
a high degree
• This is supported by an ever increasing complexity of
modalities and targets with a strong need for human
in vitro models
• Novel human 3D cellular models will be presented and
their impact for drug safety assessment will be discussed
Stefan Kustermann, Lab Head, Roche
14.10 How laws of nature should guide the development of 3D cell
culture for regenerative medicine
• We are learning the language of life. Stem cell
communication principles.
• First principle reasoning – how stem cell communication
principles influence medical device development
• Challenges on the way to the largest evolution of medicine
in history
Patrick Kugelmeier, Director of Science, Kugelmeiers
14.50 Afternoon Tea
15.20 Towards bioprinting industrialisation
• Designing and manufacturing bio-printed products for
regenerative medicine
• Preclinical research and evaluation of the efficacy of
cosmetic products and ingredients
• The ability to design and manufacture tissues with a single
cell resolution
• Ensuring precise control of the manufacturing process and
guarantee the reproducibility and reliability of bio-printed
products
Fabien Guillemot, CEO, Poietis
16.00 3D-culture strategies for the generation of stem cell-derived
beta cells
• Comparison of 2D vs 3D culture on stem cell derived
pancreatic models.
• 3D-culture effect on islets phenotype and function in vitro.
• Applications of decellularized pancreas tissue for stem cell
differentiation
Diana Ribeiro, Industrial PhD Student, AstraZeneca
16.40 Development of processing platforms for allogeneic cell
therapy manufacturing
• Expansion of pluripotent stem cells in 2D and 3D culture
systems
• Starting materials compliant with industry standards and
regulatory requirements
• Medium performance
• Process intensification
Ricardo Baptista, Lead Scientist Process Development,
Cell and Gene Therapy Catapult
17.20 Chair’s Closing Remarks and Close of Day Two

4. 3D Bioprinting and
Other Biofabrication Approaches
Overview of the workshop:
This workshop will describe and discuss 3D bioprinting and
other biofabrication approaches, answering emerging
questions and challenges to these young and evolving
fields. There will be particular focus on the materials used in
3D bioprinting, and how to apply the technique for diverse
cell-based applications; multi-cellular, multi-material and
multi-modal technologies. The workshop leaders are experts
in biofabrication technologies as well as cell biology offering
expert insight into the current and future 3D bioprinting field, in
terms of techniques, research, diagnostics, tissue engineering
and regenerative medicine.
Reasons to attend:
• To learn about the practical implementation of
biofabrication technologies including 3D bioprinting
• To see future directions and applications for biofabrication
and 3D bioprinting
• To learn about the development of bioengineered 3D cell
cultures to establish preclinical disease models
• To meet other scientists and engineers engaged in these
emerging technologies
Programme
13.00 Registration and Coffee
13.30 Opening Remarks and Introductions
• Introductions to Biofabrication and 3D
Bioprinting
14.00 Biofabrication
• Biofabrication methodologies, e.g. melt
electrospinning
• Suitable cell types
• 3D cell cultures
14.30 Current Bioprinting methods and applications
• Current printing equipment and materials
• Current applications
• Challenges to 3D bioprinting in research,
diagnostics, modelling and medicine
15.00 Afternoon Tea
15.30 Supporting Methods and Analysis
• Analytical tools
• Cell viability, maintenance and post-printing
progression
• Technology validation and reproducibility
16.00 Future Applications and Challenges
• Looking to the future: how do we adopt and
implement wide use of 3D bioprinting methods?
• Solutions to technical needs and approaches
especially for tissues and organs
• Printing resolution, neural and vascular networks
• Overcoming challenges to 3D bioprinting
17.30 End of Workshop
About the workshop leaders:
Nick is a cancer cell biologist and a Professor at Heriot
Watt University (HWU) in Edinburgh. He studied Genetics at
Cambridge and Glasgow Universities before research work
at the Beatson Institute for Cancer Research and Dundee
University, addressing cellular control mechanisms which are
disturbed in many cancers. At HWU, much of his lab’s research
is in collaboration with engineers, applying biofabrication
methods including 3D bioprinting and other new technologies
to cancer research. His 80+ publications currently accumulate
>400 citations per year.
Daniela is a cancer cell biologist and a Reader at Barts
Cancer Institute in London. She studied Biological Sciences
and received her PhD from the Technical University of Munich
in Germany. She established the interdisciplinary 3D Cancer
Models Team at Queensland University of Technology in
Brisbane, Australia. In March 2017, she joined the Barts Cancer
Institute to introduce patient-derived cells into these 3D
models using the Cross Institute Advanced Tissue Engineering
(CREATE) biofabrication facility at Queen Mary University of
London. Her 45+ publications currently accumulate >200
citations per year.
About the organisation:
Heriot-Watt is one of the world’s leading universities for
pioneering research informed by the needs of business and
industry. We are ranked in the top 10 universities in the UK and
1st in Scotland for research impact (REF2014).
The Barts Cancer Institute is one of the top 5 leading UK Cancer
Research Centres and has a long tradition in pioneering
research and innovation through translational oncology
research and experimental cancer medicine.
Workshop Leaders:
Dr Nick Leslie, Professor, Institute of Biological Chemistry,
Biophysics and Bioengineering, Heriot Watt University and
Dr Daniela Loessner, Reader, Barts Cancer Institute, CRUK
Centre of Excellence, Queen Mary University of London
HALF-DAY PRE-CONFERENCE WORKSHOP
Tuesday 20th February 2018
13.00 – 17.30
Holiday Inn Kensington Forum, London, UK

5. SPONSORSHIP AND EXHIBITION OPPORTUNITIES
SMi offer sponsorship, exhibition, advertising and
branding packages, uniquely tailored to complement
your company’s marketing strategy. Prime networking
opportunities exist to entertain, enhance and expand
your client base within the context of an independent
discussion specific to your industry. Should you wish to
join the increasing number of companies benefiting
from sponsoring our conferences please call:
Alia Malick on +44 (0) 20 7827 6168 or
email: amalick@smi-online.co.uk
SMi Pharmaceutical
Forward Planner
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Pricing & Reimbursement
11th - 12th October 2017
London, UK
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Diseases
18th - 19th October 2017
London, UK
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13th - 14th November 2017
New Jersey, USA
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13th - 14th November 2017
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15th - 16th November 2017
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16th - 17th November 2017
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28th - 29th November 2017
London, UK
DECEMBER 2017
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13th - 14th December 2017
London, UK
JANUARY 2018
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17th - 18th January 2018
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22nd - 23rd January 2018
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Social Media in the
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22nd - 23rd January 2018
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FEBRUARY 2018
Parallel Trade
6th - 7th February 2018
London, UK
3D Cell Culture
21st - 22nd February 2018
London, UK
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21st - 22nd February 2018
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MARCH 2018
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19th - 20th March 2018
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21st - 22nd March 2018
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in Clinical Trials
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11th - 12th April 2018
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11th - 12th June 2018
London, UK
Molecular Diagnostics
13th - 14th June 2018
London, UK
BioBanking
13th - 14th June 2018
London, UK

6. 3D CELL CULTURE
Conference: Wednesday 21st & Thursday 22nd February 2018, Holiday Inn Kensington Forum, London, UK
Workshop: Tuesday 20th Febuary 2018, Holiday Inn Kensington Forum, London, UK
4 WAYS TO REGISTER
www.3D-CellCulture.com
FAX your booking form to +44 (0) 870 9090 712
PHONE on +44 (0) 870 9090 711
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