1. 폴리클 5조 38번 유고은
Evaluation of chlorhexidine 0.05%
with the adjunct of fluoride 0.05% in
the inhibition of plaque formation

2. Introduction
 The control of plaque accumulation on teeth surface
→ fundamental for the prevention of oral pathology
 Chlorhexidine(CHX) :
- one of the most used oral antimicrobial agents
- shows good substantivity
- high(0.2% or more) concentration → bactericidal
- low concentration → reduce the bacterial metabolism
 0.12 and 0.2% CHX mouthwashes
→ useful in the reduction of plaque & gingival index

3. Aim
To evaluate the effect of mouthrinses containing
( 0.05% chlorhexidine + 0.05% fluoride) solution
on early dental plaque regrowth

4. Sample size & randomization
 30 periodontally healthy subjects
 15 used test product , the other used 15 placebo
 topical antimicrobial treatment within 4weeks before
beginning the study
 Full-mouth bleeding score(FMBS%)
Full-mouth plaque score(FMPS%)
measured at baseline evaluation

5. Treatment protocols & timing
 crossover 4-day plaque regrowth protocol

6. Parameters evaluation
 Full mouth plaque score (FMPS%)
: the percentage of teeth surface with plaque
accumlation evaluated using a periodontal probe
 Full mouth bleeding score (FMBS%)
: the percentage of sites with bleeding on probing
 Presence of pigmentation on teeth surface
 Occurrence of complications

7. Results 1

8. Result 2

9. Discussion
 to evaluate the capacity of the product itself to inhibit
plaque neoformation
 Present study
: NO significant difference between the two groups
 Stoeken study (2010)
: 0.12% CHX gel vs. 1% CHX gel
→ higher concentration of CHX resulted in higher effect
in inhibition of plaque accumulation

10. Discussion
 The similar outcomes of the two experimental groups
suggest that the two products have an equivalent effect
on early dental plaque regrowth
 Santos (2004) study
: 0.05%CHX + 0.05%CPC for 15 days
only plaque accumulation index was significantly lower
in test group
 Escribano (2010) study
: 0.05%CHX + 0.05%CPC for 30 days
useful in the reduction of plaque & gingival index

11. Discussion
 We cannot exclude that the same tested product could
have a positive effect in medium or long term
 Further medium or long term studies will be useful in
deeply evaluating the effect of a low concentration of
CHX mouthwash with the adjunct of fluoride in reducing
plaque accumlations