This document summarizes a study analyzing CO2 arc welding parameters to maximize depth of penetration in AISI 1022 steel plates. Response Surface Methodology (RSM) was used to develop models relating welding current, voltage, wire feed rate, and gas pressure to depth of penetration. Central composite design was employed to conduct experiments, from which a quadratic RSM model was developed showing the relationships between parameters and depth of penetration with over 90% accuracy. Linear effects of voltage, wire feed rate, and gas pressure were found to significantly impact depth of penetration, while their interactions did not have significant effects.