This document discusses Crossref's importance to PLOS and how they use Crossref features. PLOS uses Crossref for content registration including DOIs, the Crossmark button to show article updates, and as a source for citation counts. PLOS has registered over 264,000 article DOIs and over 4 million component DOIs with Crossref. The document also lists some desired improvements like better support for component DOIs and the peer review deposit schema.